DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU1 and micu1

DIOPT Version :9

Sequence 1:	NP_001097110.1	Gene:	MICU1 / 33999	FlyBaseID:	FBgn0031893	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_012809601.1	Gene:	micu1 / 100127574	XenbaseID:	XB-GENE-953464	Length:	479	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	230/427 - (53%)
Similarity:	314/427 - (73%)	Gaps:	16/427 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 MLTPKVDADAGQRPSSAADVNGEDKSSESESEDSEDE-EAGSDLHLHEGKKIREKVGFRERKIIE 165
            :|..:.:|:|    .|:...:..:::||.|.||::.. |:..:....||||.:.:||||:||::|
Frog    50 LLWKRANAEA----QSSVKHSMREETSEKEKEDADQAVESSDEDQPQEGKKKKARVGFRDRKVME 110

  Fly   166 YENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMTPGMKQPDGLGLDQY--RRYDP 228
            ||||||.:|||||:||||||::|.......||:|||.||:.|:||..|||:.|||||:  :|||.
Frog   111 YENRIRAYSTPDKIFRYFATLKVIHESGESEVFMTPQDFVRSITPNEKQPENLGLDQFIIKRYDG 175

  Fly   229 K------SVGEQLNLHLEKNSIFYKLGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGDGD 287
            |      .:.::.....:::||||.||..|||:|||||||.||||..:|:|||||:||||||||:
Frog   176 KDFWQTEKISQEREKFADEDSIFYSLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGE 240

  Fly   288 VDCEEFEMVATLVRQQTSMGTRHRDHANTGNTFK-GVNSALITYFFGPNMDEKLTIEKFLDFQEQ 351
            ||.||||.|.:::|.|||||.||||.:.||||.| |.:|||.|||||.::..||||:.||:||.:
Frog   241 VDMEEFEQVQSIIRSQTSMGMRHRDRSTTGNTLKTGFSSALTTYFFGADLKGKLTIKNFLEFQRK 305

  Fly   352 LQREILSLEFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRFRDHGKGISKQDYL 416
            ||.::|.|||||.:|.| |:|||..|..:||||:|...||....||::|:||:| .:|::.::..
Frog   306 LQHDVLKLEFERHDPVD-GHITERQFGSMLLAYSGVQSKKLTHMLKQLKKRFKD-AEGLTFEEVE 368

  Fly   417 DFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSN 481
            :||.||.|||||||||:|||:||||:|:.|:|.||:|||.|.|||||.||||.:||.:.:.:|||
Frog   369 NFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSN 433

  Fly   482 KEFISVMKNRVQRGLEKPKDTGFLKMMRSVFKCAKET 518
            ||||::||.|:.||||||||.||.::||:::|||:||
Frog   434 KEFIAIMKQRLMRGLEKPKDMGFTRLMRAMWKCAQET 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh	<252..293	CDD:298682	31/40 (78%)
MICU1	NP_001097110.1	EF-hand_8	438..491	CDD:290545	33/52 (63%)
micu1	XP_012809601.1	EF-hand_5	226..249	CDD:289945	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3899
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4431
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1569
OMA	1	1.010	-	-		QHG54184
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	1	1.000	-	-		FOG0005802
OrthoInspector	1	1.000	-	-		oto104234
Panther	1	1.100	-	-	LDO	PTHR12294
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2643
SonicParanoid	1	1.000	-	-		X4777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110