DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvf2 and VEGFD

DIOPT Version :9

Sequence 1:	NP_523499.2	Gene:	Pvf2 / 33994	FlyBaseID:	FBgn0031888	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_004460.1	Gene:	VEGFD / 2277	HGNCID:	3708	Length:	354	Species:	Homo sapiens

Alignment Length:	339	Identity:	72/339 - (21%)
Similarity:	117/339 - (34%)	Gaps:	121/339 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 QGDDNH-----LSSDAAVDGSDDYPSDQPGDLTVLKERIAEQNSVEKLRTMKYNNN------RTR 185
            ||..|.     .||.:.::.|:              ::|...:|:|:|..:.::.:      |.|
Human    20 QGSSNEHGPVKRSSQSTLERSE--------------QQIRAASSLEELLRITHSEDWKLWRCRLR 70

  Fly   186 -----ELKKRVEAHR-------------LMMAKEGICRV---PRPEVVHITRE----TNTFYSPR 225
                 .:..|..:||             |.:..|...|.   ||...|.:..|    ||||:.|.
Human    71 LKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPP 135

  Fly   226 ATILHRCSDKVGCCN-AGWTCQMKRNETVDR-VFDKVDGRSNEP--IVISMENHTECGCVKVETR 286
            ...:.||.   |||| ....|.......:.: :|:.....::.|  :.:.:.|||.|.|:....|
Human   136 CVNVFRCG---GCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPR 197

  Fly   287 RKRSPI-----------C-----LCPKHFKDFSWAGSRA----QWEN-----EEHLELR------ 320
            ...|.|           |     |||   .|..|..::.    |.||     |:|..|:
Human   198 HPYSIIRRSIQIPEEDRCSHSKKLCP---IDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCG 259

  Fly   321 ---LWERREQRCRCDC----------HLSDETCKRLKNGVEGFSVMERRRIQSGEVSPPFCNYGA 372
               :::  |.||.|.|          |..:.:|...|..:|  :..::.::    ..|..|:.
Human   260 PHMMFD--EDRCECVCKTPCPKDLIQHPKNCSCFECKESLE--TCCQKHKL----FHPDTCSC-- 314

  Fly   373 YDVRNGRCP---RP 383
                ..|||   ||
Human   315 ----EDRCPFHTRP 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvf2	NP_523499.2	PDGF	204..280	CDD:294083	23/86 (27%)
VEGFD	NP_004460.1	PDGF	109..193	CDD:197537	23/86 (27%)
VEGFD	NP_004460.1	4 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-C	222..318		21/112 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1364454at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920