Protein Alignment Ugt307A1 and UGT2B10

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 136/520 - (26%)
• Similarity: 230/520 - (44%)
• Gaps: 136/520 - (26%)

  Fly    51 VCRALLQRGHHLTLV-------------TTLPLEE---------------------QEIQGNVSH 81
            :.:.|:||||.:|::             :||.||.                     .|||.:.
Human    41 ILKELVQRGHEVTVLASSASILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDT-- 103

  Fly    82 IYIPWQQPKEEVSSSDLILR--------LERMFRRLEHS-------------GDLL----DLPEW 121
            .::|:.|.:|.:.:.:.|:|        .:::.::|:.|             |:||    ::|
Human   104 FWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIP-- 166

  Fly   122 KMFLRNQPNTPYDLLLLGYHFNDHLLG-VAAHFNCPVAIVSTQQPTGFV----NSLMGNPEERWY 181
              |:.:...:|      ||.|..|..| :......||.:........|:    |.|.....:.|:
Human   167 --FVYSHSFSP------GYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWF 223

  Fly   182 VPQPYDGQQRSGISAWVFGM--WEKF-MEILARRVLARIYRLHFPEPQYPSFETMRRSVVLALSN 243
                           .:|.|  |::| .|:|.|             |...| ||||::.:..:.|
Human   224 ---------------QIFNMKKWDQFYSEVLGR-------------PTTLS-ETMRKADIWLMRN 259

  Fly   244 H------HMISEGPIAPLIPSMVDIGGIVLE--QQLDKTPLEI--SAGNRSLIIFSLGTRFTWRK 298
            .      |        |.:|::..:||:..:  :.|.|...|.  |:|...:::||||:..:  .
Human   260 SWNFKFPH--------PFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVS--N 314

  Fly   299 STKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYPHLKVAKWWPQTQMWQSGKVRLFITHGG 363
            .|:|.......|.|:.|. .:.|.:||....|:.|   :.::.||.||..:....|.|.||||||
Human   315 MTEERANVIATALAKIPQ-KVLWRFDGNKPDALGL---NTRLYKWIPQNDLLGHPKTRAFITHGG 375

  Fly   364 KGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAITRMLSDSSYGET 428
            ...:.||:::|:||:|:||..||.||:..|::|...:.:..|.::...|..|:..:::|.||.|.
Human   376 ANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKEN 440

  Fly   429 ILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVYFIVYGLLILTIA 493
            |:|.|::..|:||.|.|...:|||:::||||||:|...|..|...:|||:|    |.|.|:..:|
Human   441 IMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLD----VIGFLLACVA 501

  Fly   494  493
            Human   502  501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	116/475 (24%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	136/520 (26%)