Protein Alignment Ugt307A1 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 134/505 - (26%)
• Similarity: 224/505 - (44%)
• Gaps: 114/505 - (22%)

  Fly    55 LLQRGHHLTLVTT--------------------LPLEEQEIQGNVSHIYIPWQQ-PKEEVSSSDL 98
            |:||||.:|::.:                    ..|.:.|::..:......|.. ||:     ..
Human    46 LIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKD-----TF 105

  Fly    99 ILRLERMFRRLEHSGDLL-----DLPEWKMFLRNQPNTPYDLLLLGYHFNDHLLG----VAAHFN 154
            .|...::...:...||:.     |:...|.|::....:.:|::     |.|.:..    :|..||
Human   106 WLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVI-----FADAIFPCSELLAELFN 165

  Fly   155 CPVAIVSTQQPTGFVNSLMGNPEERWYVPQPYDGQQRSGISAWVFG-------MWE-----KFME 207
            .|           ||.||..:|        .|..::.||  .::|.       |.|     .|||
Human   166 IP-----------FVYSLSFSP--------GYTFEKHSG--GFIFPPSYVPVVMSELTDQMTFME 209

  Fly   208 ILARRVLARIYRLH-------FPEPQYPSF------------ETMRRSVVLALSNHHMISEGPIA 253
                ||...||.|:       |...::..|            |||.::.|..:.|.... :.|.
Human   210 ----RVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNF-QFPY- 268

  Fly   254 PLIPSMVDIGGIVLEQQLDKTPLEI-----SAGNRSLIIFSLGTRFTWRKSTKELVRTFTKAFAQ 313
            ||:|::..:||:.. :.....|.|:     |:|...:::||||:..:  ..|:|.......|.||
Human   269 PLLPNVDFVGGLHC-KPAKPLPKEMEDFVQSSGENGVVVFSLGSMVS--NMTEERANVIASALAQ 330

  Fly   314 FPDYDIYWTYDGPNGSAISLDYPHLKVAKWWPQTQMWQSGKVRLFITHGGKGSVSEALFYGVPML 378
            .|. .:.|.:||.....:.|   :.::.||.||..:....|.|.||||||...:.||:::|:||:
Human   331 IPQ-KVLWRFDGNKPDTLGL---NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMV 391

  Fly   379 GLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAITRMLSDSSYGETILKASQLYRDRPVSP 443
            |:||..||.||:..|:::...:.:..|.::...|..|:.|:::|.||.|.::|.|::..|:||.|
Human   392 GIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKP 456

  Fly   444 SDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVYFIVYGLLILTIA 493
            .|...:|||:::||||||:|...|..|...:|||:|    |.|.|::.:|
Human   457 LDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLD----VIGFLLVCVA 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	114/460 (25%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	134/505 (27%)