Protein Alignment Ugt307A1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 138/573 - (24%)
• Similarity: 245/573 - (42%)
• Gaps: 146/573 - (25%)

  Fly     6 ISW--SLLWMGYTCIFLLADSPA----PVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHHLTL 64
            :.|  :||.:..:|.|.......    |.|..|    ::|:.        .:...|:||||.:|:
Human     3 MKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSH----WMNIK--------TILDELVQRGHEVTV 55

  Fly    65 V-------------TTLPLE-------EQEIQGNVSHIYIPWQQ-PKEEVSS------------S 96
            :             :||..|       :.|.:..:..:...|.: ||:...|            :
Human    56 LASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN 120

  Fly    97 DLILRL-------ERMFRRLEHS-----------------GDLLDLPEWKMFLRNQPNTPYDLLL 137
            |::.:.       :::.::|:.|                 .:||.:| :...||..|
Human   121 DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIP-FVYSLRFSP-------- 176

  Fly   138 LGYHFNDH---LLGVAAHFNCPVAIVSTQQPTGFV----NSLMGNPEERWYVPQPYDGQQRSGIS 195
             ||....|   ||...::  .||.:........|:    |.:.....|.|:  |.:|.::
Human   177 -GYAIEKHSGGLLFPPSY--VPVVMSELSDQMTFIERVKNMIYVLYFEFWF--QIFDMKK----- 231

  Fly   196 AWVFGMWEKF-MEILARRVLARIYRLHFPEPQYPSFETMRRSVVLALSNH------HMISEGPIA 253
                  |::| .|:|.|             |...| |||.::.:..:.|:      |
Human   232 ------WDQFYSEVLGR-------------PTTLS-ETMAKADIWLIRNYWDFQFPH-------- 268

  Fly   254 PLIPSMVDIGGIVLE--QQLDKTPLEI--SAGNRSLIIFSLGTRFTWRKSTKELVRTFTKAFAQF 314
            ||:|::..:||:..:  :.|.|...|.  |:|...:::||||:..:  .:::|.......|.|:.
Human   269 PLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVS--NTSEERANVIASALAKI 331

  Fly   315 PDYDIYWTYDGPNGSAISLDYPHLKVAKWWPQTQMWQSGKVRLFITHGGKGSVSEALFYGVPMLG 379
            |. .:.|.:||.....:.|   :.::.||.||..:....|.|.||||||...:.||:::|:||:|
Human   332 PQ-KVLWRFDGNKPDTLGL---NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVG 392

  Fly   380 LPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAITRMLSDSSYGETILKASQLYRDRPVSPS 444
            :||..||.||:..|::|...::|..:.::...|..|:..:::|..|.|..:|.|:::.|:||.|.
Human   393 VPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPL 457

  Fly   445 DLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVYFIVYGLLILTIAILRK 497
            |...:|||:::||||||:|...|..|...:|||:||...:...:...|.|:.|
Human   458 DRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	111/492 (23%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	133/552 (24%)