Protein Alignment Ugt307A1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 140/544 - (25%)
• Similarity: 234/544 - (43%)
• Gaps: 104/544 - (19%)

  Fly    10 LLWMGYTCIFLLADSP---------APVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHHLTLV 65
            |.|:....:.||:..|         .|::..|.|.:            ..|.|.|..|||...::
Human     9 LPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSM------------REVLRELHARGHQAVVL 61

  Fly    66 T---TLPLEEQEIQGNVSHIYIPWQQ---PKEEVSSSDLILRLERMFRRLEHSGDLL-------- 116
            |   .:.::|:.. ..::...|.|.|   .:..:..:.|....|...::...|..:|
Human    62 TPEVNMHIKEENF-FTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYH 125

  Fly   117 ----DLPEWKMFLRNQPNTPYDLLL----------LGYHFNDHLLGVAAHFNCPVAIVSTQQPTG 167
                :|...:..:|:...|.:|::|          |..:.:...:....:..|.:....||.|
Human   126 RSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCP-- 188

  Fly   168 FVNSLMGNPEERWYVPQPYDGQQRSGISAWVFGMWEKFMEILARRV--LARIYRLHFPEPQYPSF 230
                   ||..  |:|:........          ..||:.:...:  ||..|..|.....|.|.
Human   189 -------NPSS--YIPRLLTTNSDH----------MTFMQRVKNMLYPLALSYICHAFSAPYASL 234

  Fly   231 --ETMRRSV-VLALSNH--------HMISEGPIAPLIPSMVDIGGIVLEQQLDKTPLE------I 278
              |..:|.| |:.:.:|        ..:.:.| .|::|:||.||||   ...::.||.      |
Human   235 ASELFQREVSVVDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGI---NCANRKPLSQEFEAYI 295

  Fly   279 SA-GNRSLIIFSLGTRFTWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYPHLKVAK 342
            :| |...:::||||:..:.....|.:  ....|..:.|. .:.|.|.|...|.::   .:..:.|
Human   296 NASGEHGIVVFSLGSMVSEIPEKKAM--AIADALGKIPQ-TVLWRYTGTRPSNLA---NNTILVK 354

  Fly   343 WWPQTQMWQSGKVRLFITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNL 407
            |.||..:......|.||||.|...|.|::..||||:.:||.|||.||.:||::|..|:||:...:
Human   355 WLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEM 419

  Fly   408 THWKLAKAITRMLSDSSYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNI 472
            |...|..|:..:::|.||.|.|::.|.|::||||.|.||..:|:|:::|||||.:|...|..|..
Human   420 TSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 484

  Fly   473 IEYHSIDVY-FIVYGLLILTIAIL 495
            .:|||:||. |::  .::||:|.:
Human   485 YQYHSLDVIGFLL--AVVLTVAFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	115/465 (25%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	135/524 (26%)