Protein Alignment Ugt307A1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 139/533 - (26%)
• Similarity: 230/533 - (43%)
• Gaps: 113/533 - (21%)

  Fly    27 PVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHHLTLVTTLPLEEQEIQGNVSHIY----IPWQ 87
            ||.||....|.:.|..|..:..|...:.|.||||.  :|...|.....|:....:..    :|:|
Human    22 PVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHE--IVVLAPDASLYIRDGAFYTLKTYPVPFQ 84

  Fly    88 QPKEEVSSS------------DLILRLERMFRRLEHSGDLL-----DLPEWKMFLRNQPNTPYDL 135
              :|:|..|            ..:.|:.:.:::::....:|     .|...|..:.:...:.:|:
Human    85 --REDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDV 147

  Fly   136 LLLGYHFNDHLLG----VAAHFN-----------CPVAIVSTQQPTGFVNSLMGNPEERWYVPQP 185
            :|     .|..|.    ||.:.:           |.:...:||.|..|.           |||:|
Human   148 ML-----TDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFS-----------YVPRP 196

  Fly   186 YDGQ-------QRSGISAWVFGMWEKFM-------------EILARRVLARIYRLHFPEPQYPSF 230
            ....       ||  :...:....:.|:             |.|.|.|               :.
Human   197 LSSHSDHMTFLQR--VKNMLIAFSQNFLCDVVYSPYATLASEFLQREV---------------TV 244

  Fly   231 ETMRRSVVLALSNHHMISEGPIAPLIPSMVDIGGIVLEQQLDKTPLE------ISA-GNRSLIIF 288
            :.:..|..:.|.....:.:.| .|::|:||.:|||   ..|.:.||.      |:| |...:::|
Human   245 QDLLSSASVWLFRSDFVKDYP-RPIMPNMVFVGGI---NCLHQNPLSQEFEAYINASGEHGIVVF 305

  Fly   289 SLGTRFTWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYPHLKVAKWWPQTQMWQSG 353
            |||:..:.....|.:  ....|..:.|. .:.|.|.|...|.::   .:..:.||.||..:....
Human   306 SLGSMVSEIPEKKAM--AIADALGKIPQ-TVLWRYTGTRPSNLA---NNTILVKWLPQNDLLGHP 364

  Fly   354 KVRLFITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAITR 418
            ..|.||||.|...|.|::..||||:.:||.|||.||.:||::|..|:||:...:|...|..|:..
Human   365 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 429

  Fly   419 MLSDSSYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVY-F 482
            :::|.||.|.|::.|.|::||||.|.||..:|:|:::|||||.:|...|..|...:|||:||. |
Human   430 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 494

  Fly   483 IVYGLLILTIAIL 495
            ::  .::||:|.:
Human   495 LL--AVVLTVAFI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	116/480 (24%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	135/527 (26%)