Protein Alignment Ugt307A1 and UGT1A5

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 142/532 - (26%)
• Similarity: 232/532 - (43%)
• Gaps: 96/532 - (18%)

  Fly    18 IFLLADSP---------APVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHH---LTLVTTLPL 70
            :.||:..|         .|.:..|.|.:     |..|       |.|..|||.   |||...:.:
Human    17 LLLLSVQPWAESGKVLVVPTDGSHWLSM-----REAL-------RDLHARGHQVVVLTLEVNMYI 69

  Fly    71 EEQEIQGNVSHIYIPWQQPKEE----------VSSSDLILRLERMFRRLEHSG-----DLLDLPE 120
            :|:.. ..::...|.|.|.:.:          ..:..|:::..|....:.:..     ..::|..
Human    70 KEENF-FTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLH 133

  Fly   121 WKMFLRNQPNTPYDLLLLG-YHFNDHLLGVAAHFNCPVAIVSTQQP--TGFVNSLMGNPEERWYV 182
            .:..:|:...|.:|::|.. :|....:|  |.:.:.|........|  ..|..:...||..  |:
Human   134 NEALIRHLHATSFDVVLTDPFHLCAAVL--AKYLSIPAVFFLRNIPCDLDFKGTQCPNPSS--YI 194

  Fly   183 PQPYDGQQRSGISAWVFGMWEKFMEILAR-----RVLARIYRLHFPEPQYPSF--ETMRRSV-VL 239
            |:             :.......|..|.|     ..||..|..|.....|.|.  |..:|.| |:
Human   195 PR-------------LLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQREVSVV 246

  Fly   240 ALSNH--------HMISEGPIAPLIPSMVDIGGI------VLEQQLDKTPLEISA-GNRSLIIFS 289
            .|.:|        ..:.:.| .|::|:||.||||      .|.|:.:   ..|:| |...:::||
Human   247 DLVSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANGKPLSQEFE---AYINASGEHGIVVFS 307

  Fly   290 LGTRFTWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYPHLKVAKWWPQTQMWQSGK 354
            ||:..:.....|.:  ....|..:.|. .:.|.|.|...|.::   .:..:.||.||..:.....
Human   308 LGSMVSEIPEKKAM--AIADALGKIPQ-TVLWRYTGTRPSNLA---NNTILVKWLPQNDLLGHPM 366

  Fly   355 VRLFITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAITRM 419
            .|.||||.|...|.|::..||||:.:||.|||.||.:||::|..|:||:...:|...|..|:..:
Human   367 TRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAV 431

  Fly   420 LSDSSYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVY-FI 483
            ::|.||.|.|::.|.|::||||.|.||..:|:|:::|||||.:|...|..|...:|||:||. |:
Human   432 INDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL 496

  Fly   484 VYGLLILTIAIL 495
            :  .::||:|.:
Human   497 L--AVVLTVAFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	119/461 (26%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	139/520 (27%)