Protein Alignment Ugt307A1 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_609097.2
• Gene: Ugt307A1 / 33993
• FlyBaseID: FBgn0031887
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 147/556 - (26%)
• Similarity: 225/556 - (40%)
• Gaps: 131/556 - (23%)

  Fly    12 WMG----YTCIFLLADSP-------APVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHHLTLV 65
            |.|    |.|:.|.....       .|::..|...:            .:|...|:.|||.:.:|
Human     6 WTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTM------------QSVVEKLILRGHEVVVV 58

  Fly    66 --------------------TTLPLEEQEIQGNVSHIYIPWQQPKEEVSSSDLILRLERMFRRLE 110
                                |:..||:|:.:..| .....|..|            |...|..|.
Human    59 MPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMV-FADARWTAP------------LRSAFSLLT 110

  Fly   111 HSGD-LLDLPEWKMFLRNQPNTPYDLLLLGY------------HFNDHLLGVAAHFNCPVAIVST 162
            .|.: :.||     |..|..:...|..|:.|            .|:...|.||.:|:.|..:.:.
Human   111 SSSNGIFDL-----FFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFAR 170

  Fly   163 QQPTGFVNSLMGNPEERWYVPQPYDGQQRSGISAWVF--GMWEKFM------------------- 206
            .....::......|....|||:...|..    .|..|  .:|...|
Human   171 GIFCHYLEEGAQCPAPLSYVPRLLLGFS----DAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIA 231

  Fly   207 -EILARRVLARIYRLHFPEPQYPSFETMRRSVVLALSNHHMISEGPIAPLIPSMVDIGGIVLEQQ 270
             |||...|.|  |.|:    .:.|...:|...||         |.| .|::|:|:.||||...|.
Human   232 SEILQTPVTA--YDLY----SHTSIWLLRTDFVL---------EYP-KPVMPNMIFIGGINCHQG 280

  Fly   271 LDKTPLEISA-----GNRSLIIFSLGTRFTWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSA 330
             ...|:|..|     |...:::||||:..:.....|.:  ....|..:.|. .:.|.|.|...|.
Human   281 -KPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAM--AIADALGKIPQ-TVLWRYTGTRPSN 341

  Fly   331 ISLDYPHLKVAKWWPQTQMWQSGKVRLFITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQS 395
            ::   .:..:.||.||..:......|.||||.|...|.|::..||||:.:||.|||.||.:||::
Human   342 LA---NNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMET 403

  Fly   396 KNWGLTLSTNNLTHWKLAKAITRMLSDSSYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGA 460
            |..|:||:...:|...|..|:..:::|.||.|.|::.|.|::||||.|.||..:|:|:::|||||
Human   404 KGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGA 468

  Fly   461 KNLHNPARQLNIIEYHSIDVY-FIVYGLLILTIAIL 495
            .:|...|..|...:|||:||. |::  .::||:|.:
Human   469 PHLRPAAHDLTWYQYHSLDVIGFLL--AVVLTVAFI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt307A1	NP_609097.2	GT1_Gtf-like	32..450	CDD:340817	122/477 (26%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	142/536 (26%)