DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mnn1 and MEN1

DIOPT Version :9

Sequence 1:NP_001036342.1 Gene:Mnn1 / 33991 FlyBaseID:FBgn0031885 Length:763 Species:Drosophila melanogaster
Sequence 2:XP_016873254.1 Gene:MEN1 / 4221 HGNCID:7010 Length:657 Species:Homo sapiens


Alignment Length:759 Identity:271/759 - (35%)
Similarity:363/759 - (47%) Gaps:200/759 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 SLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQ-----AAQAAAAAVAA 81
            :||||:|..||:.||...| ...||||.|||:|:|::|..|........     ..|.:.|....
Human     9 TLFPLRSIDDVVRLFAAEL-GREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPP 72

  Fly    82 GDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQT-ILSVVE---KPKPHRQATREVIKKVS 142
            |.::.               |||....:||.||.:|.. |...|:   .|:....::||::||||
Human    73 GGLTY---------------FPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVS 122

  Fly   143 DVIWNSLIRSSYKDRAHLQNLYSYLS-----GNKLDCFGVALAVVAGCQLLGYKDVRLAISEDHA 202
            |||||||.||.:|||||:|:|:|:::     |.|||..|||.|||..||.||.:||.||:|||||
Human   123 DVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHA 187

  Fly   203 WVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAICAALNISL 267
            |||||....:|.||||||||:||:|||.:..|:...|||||.|..:.|:|.||||.:..|:|.|:
Human   188 WVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSI 252

  Fly   268 TSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREAIESARTH 332
            ..::|.:|:.:|||:|||||||||||:|||||||.|.:|||:..|........||.:.|.||:|:
Human   253 DLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTY 317

  Fly   333 YRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIR---------------------------- 369
            ||:.|:|||.|...|:.|....|:|..|||:.|.||:                            
Human   318 YRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQETVSNLQCLTTIIQQWDFHPRPHAPLLI 382

  Fly   370 -------------LYTYQCRDDEEIYKELLDIANELIPYVMK-------------------TESS 402
                         |:...||:|||||||..::||::||.::|                   |:|.
Human   383 LAFFLWADPDSIILHYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQ 447

  Fly   403 GHSARSILRDSEVFANLLRFYDGICQWEEDSLTPILHIGWAKPLVNNITKFDYDIRSQVVIKLPE 467
            |    |.|:|.|.||:|||||||||:|||.|.||:||:|||..||.::.:|:..:|.:|.|    
Human   448 G----SALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRI---- 504

  Fly   468 DLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNN--RMATKEEKSKNSELPTTLADLTAAC 530
                         ..:|| ||.|::|..|.||.||...  |..:|.|:....:.|.....|    
Human   505 -------------VSREA-EAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGL---- 551

  Fly   531 GEKILNPDFLLQGGGQPFADQKQQPSGGESDNPELHNNNNNSNSNNNNNNHNADKKEAAATTTNA 595
                        |.||          |..|..|                     :|........|
Human   552 ------------GTGQ----------GAVSGPP---------------------RKPPGTVAGTA 573

  Fly   596 TTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQLGKPQHKEAKKEETSDDYDPFEIMLKRPVIT 660
            .....||...|..|.:|.....                                       ||:|
Human   574 RGPEGGSTAQVPAPTASPPPEG---------------------------------------PVLT 599

  Fly   661 LYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVASRKVRGVEKHS 704
            ..|:||||:|:||:|.|:|:.||.||:||||....|.:.|...|
Human   600 FQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPS 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mnn1NP_001036342.1 Menin 17..464 CDD:271218 216/515 (42%)
Menin 18..714 CDD:282857 271/759 (36%)
MEN1XP_016873254.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155528
Domainoid 1 1.000 398 1.000 Domainoid score I745
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7418
Inparanoid 1 1.050 448 1.000 Inparanoid score I1624
Isobase 1 0.950 - 0 Normalized mean entropy S6534
OMA 1 1.010 - - QHG49672
OrthoDB 1 1.010 - - D346541at33208
OrthoFinder 1 1.000 - - FOG0006939
OrthoInspector 1 1.000 - - oto89085
orthoMCL 1 0.900 - - OOG6_108783
Panther 1 1.100 - - LDO PTHR12693
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5031
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.860

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