Protein Alignment Mnn1 and men1

DIOPT Version :10

• Sequence 1: NP_523498.2
• Gene: Mnn1 / 33991
• FlyBaseID: FBgn0031885
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: NP_571028.1
• Gene: men1 / 30130
• ZFINID: ZDB-GENE-991110-12
• Length: 617
• Species: Danio rerio
• Alignment Length: 745
• Identity: 273/745 - (36%)
• Similarity: 369/745 - (49%)
• Gaps: 191/745 - (25%)

  Fly    24 FPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQAAQAAAAAVAAGDISQAT 88
            |||:....|:.||...|.|. ||||.|||:|:|::|..|..
Zfish    11 FPLRGIDGVVQLFESELNSP-EPDLALLSLVLGFVEHFLAV------------------------ 50

  Fly    89 TGGNDIIMGNSVP---------------FPVVTHELIAGLYKKFQT----ILSVVEKPKPHRQAT 134
               |.::..| ||               ||.|...|::.||::|..    .:.:.:..||...::
Zfish    51 ---NRVVPVN-VPGVRFEPLQPDSLNSCFPTVELNLLSALYERFMAQIRGAVDMSQYRKPSGASS 111

  Fly   135 REVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRLAISE 199
            ||::|||||||||||.||.:|||||:|:|:|.::|.|||..|||.||||.||:||.|||.||:||
Zfish   112 RELVKKVSDVIWNSLSRSYFKDRAHIQSLFSLITGTKLDSSGVAFAVVAACQVLGLKDVHLALSE 176

  Fly   200 DHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAICAALN 264
            |||||:||:...||.||||||||:||:|||.:..||...|||||.|..:.|.|.||||.:..|:|
Zfish   177 DHAWVIFGKGGEETAEVTWHGKGNEDRRGQTVSAGINERSWLYLKGSYMKCNRNMEVAFMVCAIN 241

  Fly   265 ISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREAIESA 329
            .||..::|..|:.:|||:|||||||.|.|:|||||:|||.:||:........|...::.:|:|||
Zfish   242 PSLDLHTDSTELIQLQQRLLWLLYDRGDLERYPMAMGTLADLEDQEPMTGKESPLSIHLKAVESA 306

  Fly   330 RTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIANELIP 394
            :.:|.|.|:|||.|...|:.|..:.|:|..:||.||.|::.|.| ||:|||||||..||||::||
Zfish   307 KKYYNNEHIYPYMYLAGYHYRHREVREALGSWAEAASVMQDYNY-CREDEEIYKEFFDIANDVIP 370

  Fly   395 YVMK-----TESSG------------HSARSILRDSEVFANLLRFYDGICQWEEDSLTPILHIGW 442
            .::|     .||.|            .:|.:.|:|.|.||:|||||||||:|||.|.||:||:||
Zfish   371 TLLKETAAAAESEGTDEAEKEDQPREAAALTALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGW 435

  Fly   443 AKPLVNNITKFDYDIRSQV--VIKLPEDLEAEQAKAELARAEQEAKEAKESK--EAAGSEAMEGN 503
            |..||.::::||..||.:|  :.|..|.::.:...:|..|..:.....:|||  |.|||
Zfish   436 ATYLVQSLSRFDAQIRQKVSIITKDTEPVDDDDQSSEDLREGRRRGPRRESKLDEPAGS------ 494

  Fly   504 NNRMATKEEKSKNSELPTTLADLTAACGEKILNPDFLLQGGGQPFADQKQQP----SGGESDNPE 564
                     .|.|..||.                             |.|.|    .|||
Zfish   495 ---------ASPNPALPA-----------------------------QNQNPVPKKVGGE----- 516

  Fly   565 LHNNNNNSNSNNNNNNHNADKKEAAATTTNATTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQ 629
                .....|:.:.....||.|...:           |.:.:..|....|...|
Zfish   517 ----GGRRRSSASTRGKEADGKNEPS-----------SPSPIPSPSQPPAVQGG----------- 555

  Fly   630 LGKPQHKEAKKEETSDDYDPFEIMLKRPVITLYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVAS 694
                                       ||:..:|:||||:|:||.|.|:|:.||.||:||||...
Zfish   556 ---------------------------PVVVFHSEKMKGMKELLSAAKVNSSAIKLQLTAQSQVQ 593

  Fly   695 RKVRGVEKHSATISATITAISSSSGDSVLS 724
            .|     :...|          :|||..||
Zfish   594 MK-----RQKPT----------ASGDYTLS 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mnn1	NP_523498.2	Menin	18..714	CDD:398642	268/733 (37%)
men1	NP_571028.1	Menin	2..615	CDD:398642	273/745 (37%)