Protein Alignment Mnn1 and Men1

DIOPT Version :10

• Sequence 1: NP_523498.2
• Gene: Mnn1 / 33991
• FlyBaseID: FBgn0031885
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: XP_006230831.1
• Gene: Men1 / 29417
• RGDID: 3078
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 719
• Identity: 280/719 - (38%)
• Similarity: 376/719 - (52%)
• Gaps: 145/719 - (20%)

  Fly    12 PMALNGVIDA--SLFPLKSTADVINLFRRALTSGIEPDLTLLSIVVGYIELSLTTGEAAAQ---- 70
            |.|..|:..|  :||||:|..||:.||...| ...||||.|||:|:|::|..|........
  Rat     3 PPAAMGLKAAQKTLFPLRSIDDVVRLFAAEL-GREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE 66

  Fly    71 -AAQAAAAAVAAGDISQATTGGNDIIMGNSVPFPVVTHELIAGLYKKFQT-ILSVVE---KPKPH 130
             ..|.:.|....|.::.               |||....:||.||.:|.. |...|:   .|:..
  Rat    67 LTFQPSPAPDPPGGLTY---------------FPVADLSIIAALYARFTAQIRGAVDLSLYPREG 116

  Fly   131 RQATREVIKKVSDVIWNSLIRSSYKDRAHLQNLYSYLSGNKLDCFGVALAVVAGCQLLGYKDVRL 195
            ..::||::|||||||||||.||.:|||||:|:|:|:::|.|||..|||.|||..||.||.:||.|
  Rat   117 GVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHL 181

  Fly   196 AISEDHAWVVFGQKRVETIEVTWHGKGSEDKRGQDIRPGIESGSWLYLGGLAVVCERGMEVAAIC 260
            |:||||||||||....:|.||||||||:||:|||.:..|:...|||||.|..:.|:|.||||.:.
  Rat   182 ALSEDHAWVVFGSNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV 246

  Fly   261 AALNISLTSNSDCVEVAELQQQLLWLLYDLGHLKRYPMALGTLGELEEIHRTHPSISCEQLYREA 325
            .|:|.|:..::|.:|:.:|||:|||||||||||:|||||||.|.:|||:..|........||.:.
  Rat   247 CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKG 311

  Fly   326 IESARTHYRNHHVYPYTYQGNYYNRLLKYRDAFAAWANAADVIRLYTYQCRDDEEIYKELLDIAN 390
            |.||:|:|::.|:|||.|...|:.|....|:|..|||:.|.||:.|.| ||:|||||||..::||
  Rat   312 IASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNY-CREDEEIYKEFFEVAN 375

  Fly   391 ELIPYVMKTESS---------GHSAR------SILRDSEVFANLLRFYDGICQWEEDSLTPILHI 440
            ::||.::|..:|         |..|:      |.|:|.|.||:|||||||||:|||.|.||:||:
  Rat   376 DVIPNLLKEAASLLEAGEERPGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHV 440

  Fly   441 GWAKPLVNNITKFDYDIRSQVVIKLPEDLEAEQAKAELARAEQEAKEAKESKEAAGSEAMEGNNN 505
            |||..||.::.:|:..:|.:|.|                 ..:|| ||.|::|..|.||.||
  Rat   441 GWATFLVQSLGRFEGQVRQKVHI-----------------VSREA-EAAEAEEPWGDEAREG--- 484

  Fly   506 RMATKEEKSKNSELPTTLADLTAACGEKILNPDFLLQGGGQPFADQKQQPSGGESDNPELHNNNN 570
            |......:||..|.|..                      .:|..|  :.|..|:|
  Rat   485 RRRGPRRESKPEEPPPP----------------------KKPALD--KGPGSGQS---------- 515

  Fly   571 NSNSNNNNNNHNADKKEAAATTTNATTTSNGSGTSVQLPVSSEANNAGQAQSQVQINDQLGKPQH 635
                              |.:.....|:...|||:....|||.|.....|.|
  Rat   516 ------------------AGSGPPRKTSGTVSGTARGTEVSSAAQAPAPAAS------------- 549

  Fly   636 KEAKKEETSDDYDPFEIMLKRPVITLYSQKMKGLKDLLLAEKLNTHAISLQVTAQSVASRKVRGV 700
                        .|.|    .||:|..|:||||:|:||:|.|:|:.||.||:||||....|.:.|
  Rat   550 ------------PPPE----GPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKV 598

  Fly   701 EKHS 704
            ...|
  Rat   599 STPS 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mnn1	NP_523498.2	Menin	18..714	CDD:398642	277/713 (39%)
Men1	XP_006230831.1	Menin	8..614	CDD:398642	278/714 (39%)