Protein Alignment GADL1 and Gad1

DIOPT Version :10

• Sequence 1: NP_997242.2
• Gene: GADL1 / 339896
• HGNCID: 27949
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_523914.2
• Gene: Gad1 / 38484
• FlyBaseID: FBgn0004516
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 232/516 - (44%)
• Similarity: 328/516 - (63%)
• Gaps: 27/516 - (5%)

Human    13 GDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKAT-DVNEKVCEWRP 76
            |.:...:::|:         .|..||.|     .:|:.:...::::.|  ||| |.||||.::..
  Fly    15 GKLTAYDLMPT---------TVTAGPET-----REFLLKVIDVLLDFV--KATNDRNEKVLDFHH 63

Human    77 PEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNP 141
            ||.:|:||||::.|...|..:|:|.|...:.|.|||.||.|||||..|||..|:...::|...|.
  Fly    64 PEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANT 128

Human   142 SVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSG 206
            :::|||::|||:|:|..||.||.|.|||..||.|..||||:||:||...||:|..|:.||.|..|
  Fly   129 NMFTYEIAPVFILMENVVLTKMREIIGWSGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVG 193

Human   207 SP-RLILFTSAECHYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVC 270
            .| .|::|||.:||||:|..|:..|:||::...|.:|..||||..|||:.:.:.:.:|..||.|.
  Fly   194 LPGTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVN 258

Human   271 ATSGTTVLGAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKLLH----GIHRADSVAWNP 331
            ||:|||||||||.::.|||||::::.|:|:||:|||..|||||||   |    |:.|||||.|||
  Fly   259 ATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHR---HPRFTGVERADSVTWNP 320

Human   332 HKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMT 396
            ||::.|.:||..:..|: ..||..|....|.|||..||.||:|||||||.|||.|..|.||.|:.
  Fly   321 HKLMGALLQCSTIHFKE-DGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQ 384

Human   397 WKALGTLGLEERVNRALALSRYLVDEIKKR-EGFKLLMEPEYANICFWYIPPSLREMEEGPEFWA 460
            |:|.||.|.|::.:|.:.|.:|.:..|::: :.|.|::|||..|:.|||:|..||.:....:...
  Fly   385 WRAKGTEGFEQQQDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEV 449

Human   461 KLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM 521
            :|..:.|.||.|||:||:||:||||...:.||||.::.|..|:..|:||:||||..||.|:
  Fly   450 ELGKICPIIKGRMMQKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GADL1	NP_997242.2	GadA	75..520	CDD:439846	215/450 (48%)
Gad1	NP_523914.2	Pyridoxal_deC	64..434	CDD:395219	181/373 (49%)