Protein Alignment GADL1 and Ddc

DIOPT Version :10

• Sequence 1: NP_997242.2
• Gene: GADL1 / 339896
• HGNCID: 27949
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 510
• Identity: 134/510 - (26%)
• Similarity: 210/510 - (41%)
• Gaps: 78/510 - (15%)

Human    42 AKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSG-EPPHKLLELCRD- 104
            ||....|:.|....|.|..||...          .|..||.|:.    |:. |.|.|..::.:|
  Fly    45 AKTMVDFIAEYLENIRERRVLPEV----------KPGYLKPLIP----DAAPEKPEKWQDVMQDI 95

Human   105 -------VIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAV--- 159
                   |.|:    :.|:|.........|.::||..::.|:....:|:..||....:|..:
  Fly    96 ERVIMPGVTHW----HSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDW 156

Human   160 LKKMI----EFIGWK--EGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLIL-----F 213
            |.||:    ||:...  :|.|:.....|.|.:.|:..|:.|...::||.........||     :
  Fly   157 LGKMLELPAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGY 221

Human   214 TSAECHYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVL 278
            .|.:.|.|:::|....|:...:   |:::.. :|....|||.:.|...||..||....|.|||..
  Fly   222 CSDQAHSSVERAGLLGGVKLRS---VQSENH-RMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNS 282

Human   279 GAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCA 343
            .|||.|||...:..:|:||:||||::.|||.:..::|.|:.||..|||..:||||.::....|.|
  Fly   283 CAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSA 347

Human   344 LLVKDKSDLLKKCYSAKASYLFQQDKFY---DVSYDTGDK---SIQCSRRPDAFKFWMTWKALGT 402
            :.:||.|.::.         .|..|..|   |:.....|.   .|...||..|.|.|...:..|.
  Fly   348 MWLKDPSWVVN---------AFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGV 403

Human   403 LGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYIPPSLREMEEGPEFWAKLNLVAP 467
            ..|:..:.|....::...|.......|:|..|.....:||     .|:...|..|
  Fly   404 ENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCF-----RLKGSNERNE---------- 453

Human   468 AIKERMMKKGSLMLGYQPHRGK-VNFFRQVVISPQVSREDMDFLLDEIDLLGKDM 521
            |:.:|:..:|.:.|  .|.:.| |.|.|..:.|.....|||::...|:.....:|
  Fly   454 ALLKRINGRGHIHL--VPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAADEM 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GADL1	NP_997242.2	GadA	75..520	CDD:439846	125/474 (26%)
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:395219	108/401 (27%)