Protein Alignment Caper and SRSF1

DIOPT Version :10

• Sequence 1: NP_609095.1
• Gene: Caper / 33989
• FlyBaseID: FBgn0031883
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Alignment Length: 254
• Identity: 70/254 - (27%)
• Similarity: 85/254 - (33%)
• Gaps: 99/254 - (38%)

  Fly    56 SGGGSSHKKQSKRSRSRSGSRDGKSRRDRGNERSSHRDKDKE---------RD---RNRDGG--- 105
            ||||.        .|..:|:.|  .|...||.....|.||.|         ||   :||.||
Human     2 SGGGV--------IRGPAGNND--CRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPF 56

  Fly   106 -------DRDR----HRREGGDRDRERERERERDRSRRSRSRDERGGG------GRYGDRDKDRR 153
                   .||.    :.|:|.|.|..|.|. |..||.|...|...|||      ||||  ...||
Human    57 AFVEFEDPRDAEDAVYGRDGYDYDGYRLRV-EFPRSGRGTGRGGGGGGGGGAPRGRYG--PPSRR 118

  Fly   154 SRDR-------------------------------RGGSKSLQVDRSRDKRRRSRSRDQQRKR-- 185
            |.:|                               |.|:..::..|..|.....|..|..:.|
Human   119 SENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKFRSH 183

  Fly   186 --------------LSP----IRERKRSHSRSRDRNSRRRGTNSPRRRSPPNGADRTTP 226
                          .||    .|.|.||.||||.|::.|..:.||||   ..|:.|.:|
Human   184 EGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSRSNSRSRSYSPRR---SRGSPRYSP 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Caper	NP_609095.1	SF-CC1	213..578	CDD:273721	5/14 (36%)
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	24/80 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		15/47 (32%)
		RRM2_SRSF1	113..196	CDD:410160	12/84 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		19/52 (37%)
		Interaction with SAFB1	198..247		19/45 (42%)