DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caper and Lemd3

DIOPT Version :9

Sequence 1:	NP_609095.1	Gene:	Caper / 33989	FlyBaseID:	FBgn0031883	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001074662.2	Gene:	Lemd3 / 380664	MGIID:	3580376	Length:	918	Species:	Mus musculus

Alignment Length:	818	Identity:	162/818 - (19%)
Similarity:	254/818 - (31%)	Gaps:	285/818 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LEAPYMKNNVSAGSGGSGGRKRSGSSPGGGGGHDDDYAENGPRNGSGGGSS-------------- 61
            |.|...::.|:.||||:.....:||....|...|:...|..||..:|||.:
Mouse   105 LSASAAESPVAGGSGGAAAVPAAGSKVLLGFSSDESDVEASPREQAGGGGARRDRAALQYRGLRA 169

  Fly    62 -------------HKKQSKRSRSRSGSR--------------DGKSRRDRGNERSSHRDKDKE-- 97
                         |..:.::..|..|:|              || :..|...|.:...|:|.|
Mouse   170 PPAPPAAGEVTGGHPGERRKPHSWWGARRPAGPEPQPPAAGSDG-AAEDADEELADGEDRDPEAE 233

  Fly    98 --------------------RDRNRDGGDRDRHRREGGD----RDRERERERERDRSRRSRSR-- 136
                                |:...|..:.:....|.||    |...::....|.|.|||.|:
Mouse   234 EPLWASRTVNGSRLLPYSSCREHYSDSEEEEEEGEEDGDVAPARQVLKDDSLARHRPRRSHSKPF 298

  Fly   137 ---DERGGGGRYGDRDKDRRSRDRRGGSKSLQVDRSRDKRRRSRSRDQQR--------------- 183
               ..:.||        .|:....:||......||:.......|||:.:.
Mouse   299 SALTAKSGG--------SRQETSVQGGGALAMNDRAAAAGSLDRSRNLEEAAAEPGGGGGGGCGC 355

  Fly   184 -------------KRLSPIRERKRSHSRSRDRNSRRRGTNSPRRRS------------------- 216
                         |:|:|:..     ..|.|.:|.......|..::
Mouse   356 DPVDSIPRYRAGAKKLAPLLS-----PPSPDGDSTLESPTGPLLKTNNHIGGGAFGVDSPGLYAN 415

  Fly   217 --PP-------------NGADRT------------TPTELSPEER-------------------- 234
              ||             |.|:.|            .|....|||.
Mouse   416 SLPPGATAAAAPGTLRINHANHTGSNHTYLKTAYGKPKLCEPEEELLQQFKREEVSPTGSFSAHY 480

  Fly   235 ------DARTVFCIQLSQR---VRARDLEE--------FFSSVGKVR--DVRLITCNKTKRFKGI 280
                  .|..:|.:.|...   :|...:.|        |..:.||::  :..|:.....|....:
Mouse   481 LSMFLLTAACLFFLILGLTYLGMRGTGVPEDGGLIKNPFDETFGKIQESEKNLLMSTLYKLHDRL 545

  Fly   281 AYIEFDDPESVALALGLSGQRLLGVPIMVQHTQAEKNRLQNAAPAFQPKSHTGPMRLY------- 338
            |.|..|.      ..|.|.||:|.|       |.....|:|..|.::...:|..:.::
Mouse   546 AQIAGDH------ECGSSSQRMLSV-------QEAAAYLKNLGPEYEDVFNTSLLWIFKNGKDVG 597

  Fly   339 VGSLHFNITEDMLRGIFEPFGKIDAIQLIMDTETG-----RSKGYGFIT---------------- 382
            :..:.:...||:.        .|..:|.:..|...     |.: ..|||
Mouse   598 IRCVGYGPEEDLT--------NITDVQFLQSTRPQMPFWCRFR-RAFITVTHRLLLLCLGVVLVC 653

  Fly   383 ----YHNADDAKKALEQLNGFELAGRLMKVGNVTERLDMNTTSL-----------------DTDE 426
                |......|:..|....:::..:::.|..........|..|                 |..:
Mouse   654 VALRYMRYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQETKDLQPYMPLPHVRDSLIQPQDRKK 718

  Fly   427 M----DRTGIDLGAT-GRLQLMFKLAEGAGLAV-----PQAAANALLATAP-----QPAPLQQQE 476
            |    ||....|.|. .|::...:...||...|     |.|:.:..|....     |...|.::.
Mouse   719 MKKVWDRAVDFLAANESRVRTETRRVGGADFLVWRWIQPSASCDKTLVIPSKVWQGQAFHLDRRN 783

  Fly   477 VAPSIATQCFILSNMFDPRTETNPTWDVEIRDDVLEECAKHGGVLHIHVDTISHTGTVYVKCPST 541
            ..|:..|.|..:.|||||..|....|.:.|::.:||:|:.:.|::||.||..|..|.|||||.|.
Mouse   784 SPPNSLTPCLKIRNMFDPVMEIGDHWHLAIQEAILEKCSDNDGIVHIAVDRNSREGCVYVKCLSP 848

  Fly   542 TTAVLAVNALHGRWFAGRVITAAYVPVINYHTMFPDSI 579
            ..|..|..||||.||.|:::|..|:.:..||..||.::
Mouse   849 EYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQAL 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caper	NP_609095.1	RRM1_RBM39_like	238..310	CDD:240729	18/84 (21%)
		RRM2_RBM23_RBM39	337..409	CDD:240730	12/103 (12%)
		RBM39linker	425..500	CDD:292157	23/89 (26%)
		RRM3_RBM39_like	483..567	CDD:240731	37/83 (45%)
Lemd3	NP_001074662.2	LEM	10..48	CDD:295412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..97
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..392		5/25 (20%)
		MSC	<576..755	CDD:286487	27/187 (14%)
		Interaction with SMAD1, SMAD2, SMAD3 and SMAD5. /evidence=ECO:0000250	706..918		57/181 (31%)
		RRM_Man1	792..883	CDD:240732	38/90 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900