DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MME1 and slc25a20

DIOPT Version :9

Sequence 1:	NP_609093.1	Gene:	MME1 / 33987	FlyBaseID:	FBgn0031881	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_957153.1	Gene:	slc25a20 / 393833	ZFINID:	ZDB-GENE-040426-1869	Length:	300	Species:	Danio rerio

Alignment Length:	295	Identity:	142/295 - (48%)
Similarity:	197/295 - (66%)	Gaps:	5/295 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISTEKKSNPVKSFIAGGVGGMCNVLVGHPLDTIKVRLQTMPTPPPGQPPRYKGVIDCAARTFRYE 70
            :|.::..:|:|:|.|||.||:|.|..|||||||||||||.|.|.||:..:|.|..||..:|...|
Zfish     1 MSKQQPISPMKNFFAGGFGGVCLVFAGHPLDTIKVRLQTQPKPRPGEVAQYAGTFDCFKKTLAKE 65

  Fly    71 GFRGFYRGISAPLVGVTPIYAVDFAVYAAGKRLFQ-TDDHIRLTYPQIFAAGALAGVCSALVTVP 134
            |.||.|:|::||::||||::||.|..:..||:|.| |.|.| |||||:||||.|:||.:..:..|
Zfish    66 GVRGLYKGMAAPIIGVTPMFAVCFFGFGLGKKLQQKTPDDI-LTYPQLFAAGMLSGVFTTAIMAP 129

  Fly   135 TDRIKVLLQTQTVSNGPLLYNGTIDTAAKLYRQGGIRSLFKGTCACILRDSP-TGFYFVTYEFLQ 198
            .:|||.|||.|..| |.:.|.|.:|...:|||:.|||.::|||...::||.| :|.||:|||:|:
Zfish   130 GERIKCLLQIQAAS-GQVKYAGPMDCVKQLYRESGIRGIYKGTALTLMRDVPASGMYFMTYEWLK 193

  Fly   199 E-LARKKSANGKISTTSTILSGGTAGIVFWTLAVPFDVLKSRLQSAPEGTYKHGIRSVFRNLMAT 262
            . |..:..:..::|..|.:.:||.|||..|.:|:|.||||||.|:||||.|.:|.|.|.|.|:..
Zfish   194 HALTPEGKSPSELSVPSILFAGGMAGIFNWAVAIPPDVLKSRFQTAPEGKYPNGFRDVLRELVRE 258

  Fly   263 EGPKALFRGILPILLRAFPSTAAVFFGVELTNDLL 297
            ||.::|::|...::|||||:.||.|.|.|:....|
Zfish   259 EGVRSLYKGFNAVMLRAFPANAACFLGFEVAMKFL 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MME1	NP_609093.1	Mito_carr	10..107	CDD:278578	51/97 (53%)
		Mito_carr	111..205	CDD:278578	45/95 (47%)
		Mito_carr	208..297	CDD:278578	41/88 (47%)
slc25a20	NP_957153.1	Mito_carr	5..101	CDD:278578	50/95 (53%)
		PTZ00169	10..276	CDD:240302	131/267 (49%)
		Mito_carr	107..197	CDD:278578	44/90 (49%)
		Mito_carr	204..293	CDD:278578	41/88 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6498
eggNOG	1	0.900	-	-		E1_KOG0758
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2239
OMA	1	1.010	-	-		QHG54095
OrthoDB	1	1.010	-	-		D1072378at2759
OrthoFinder	1	1.000	-	-		FOG0000326
OrthoInspector	1	1.000	-	-		mtm6581
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1756
SonicParanoid	1	1.000	-	-		X2353
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.970