DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gart and Gart

DIOPT Version :9

Sequence 1:	NP_001285698.1	Gene:	Gart / 33986	FlyBaseID:	FBgn0000053	Length:	1353	Species:	Drosophila melanogaster
Sequence 2:	NP_001011899.2	Gene:	Gart / 288259	RGDID:	1308717	Length:	1010	Species:	Rattus norvegicus

Alignment Length:	1367	Identity:	515/1367 - (37%)
Similarity:	681/1367 - (49%)	Gaps:	384/1367 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWS 65
            |:.||||||||||||.:.|||:|||.|.|:...||:.|.....|..|   ..:...|..|:|::.
  Rat     1 MAARVLVIGSGGREHTLAWKLAQSPHVKQVLVAPGNAGTASAGKISN---AAVSINDHTALARFC 62

  Fly    66 KENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESF 130
            |:.:|.|||||||.|||.|:...|.|||:.||||..|.|.:|:.||:||:||.|||:|||::.:|
  Rat    63 KDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAALLESSKKFAKEFMDRHGVPTAQWRAF 127

  Fly   131 TDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEEL 195
            |..|.|.:||.||.:|||||||:||||||||:||.:..|||:||.||:.:..:|.||.|:|||||
  Rat   128 TSPEDACSFIMSADFPALVVKASGLAAGKGVIVAKSKAEACEAVQEIMQEKSFGAAGETVVVEEL 192

  Fly   196 LEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLER 260
            |||||||.|.|||||:|..|.||||||||.:||.||||||||||||.|.:.:..|..::..:|:|
  Rat   193 LEGEEVSCLCFTDGKTVAPMPPAQDHKRLLDGDRGPNTGGMGAYCPAPQVPKDLLVKIKNTILQR 257

  Fly   261 AVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKLD 325
            .|.|:.:|.:.|.|:||||:|||:|||:||||||||||||.|||||||:|||::|:::...|.|.
  Rat   258 TVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTFDGLLS 322

  Fly   326 KIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRV 390
            :.|..|....|||.|::||.|||...|||..|:|.|.|......|||:|.|:...| .:|:||||
  Rat   323 ESPPVWLENHSAVTVVMASGGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDAK-VVTSGGRV 386

  Fly   391 LIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTP-GLSYKDSGVDIDAG 454
            |...|:..:|..|..:|.|...::.|  .||.||.||..:|  :|....| ||:||||||||.||
  Rat   387 LTVTAVRENLMSALDEARKGLAALKF--EGAVYRKDIGFRA--VAFLQRPRGLTYKDSGVDIAAG 447

  Fly   455 DALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHELYENV 519
            :.||::|:||::.|.|||....||||.|||.||...:|:|::|..|.|||.|:.:|.....::::
  Rat   448 NMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDSI 512

  Fly   520 GYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPSL 584
            |.||.|:..||:|..||||:.||||.:||||.:.....:|.|:|..||.|.|||:||||||||.:
  Rat   513 GQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVVAGIAAACRQAGCALLGGETAEMPDM 577

  Fly   585 YAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRERS 649
            |.||::|:||:.||.:|:.:.||
  Rat   578 YPPGEYDLAGFAVGAMERHQKLP------------------------------------------ 600

  Fly   650 PVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFG 714

  Rat   601 ----------------------------------------------------------------- 600

  Fly   715 AVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSGS 779

  Rat   601 ----------------------------------------------------------------- 600

  Fly   780 PVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKDP 844
                     |||::|.
  Rat   601 ---------QLERIAE------------------------------------------------- 607

  Fly   845 ILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKEVH 909

  Rat   608 ----------------------------------------------------------------- 607

  Fly   910 SGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLDEIQPGDVLIGLPSS 974
                                                                   ||.:||:.||
  Rat   608 -------------------------------------------------------GDAVIGVASS 617

  Fly   975 GVHSNGFSLVHAVLKRVGLGLHDKAP--FSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALAH 1037
            |:||||||||..:::|..|.....||  ..|:|||:.||.||:||..:|..::..|:  :||.||
  Rat   618 GLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGR--VKAFAH 680

  Fly  1038 ITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPTE 1102
            ||||||.|||||||.:.|.|.|||..:::|.||:||...|.:|..|:.||:|||:|..|||:..:
  Rat   681 ITGGGLLENIPRVLPRKLGVDLDAYTWRVPKVFSWLQQEGQLSEEEMARTFNCGVGAALVVSKDQ 745

  Fly  1103 VEDVLKELRYPQRAA-VVGEVV--ARKDPK------------KSQVVVQNFEASLARTQKMLSQR 1152
            .|.:|.::|..|..| |:|.||  ....|:            |..||...|..|...:|    |:
  Rat   746 TEQILHDIRQHQEDAWVIGSVVECPEDSPRVRVKNLIETMQTKGSVVTNGFLRSNFPSQ----QK 806

  Fly  1153 RKRVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKTGVLGLQRATQAGIPSLVISHKDFA 1217
            :.||||||||||||||||||:|||.....|  :|||||||..|.||.||.:||||:.||:||.:.
  Rat   807 KARVAVLISGTGSNLQALIDSTRDPKSSSH--IVLVISNKAAVAGLDRAERAGIPTRVINHKLYK 869

  Fly  1218 SREVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEA 1282
            ||..:|..:...|:...||::|||||||:||.||||:|.|:::||||||||.:.|.:..:|.|||
  Rat   870 SRVEFDNAVDHVLEEFSVDIVCLAGFMRILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEA 934

  Fly  1283 GEKESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNGTALIS 1347
            |...:|||||||.|.||.|.||:|.|||:..||...:|::|:..|||..||.||.::.:|...:.
  Rat   935 GVTITGCTVHFVAEDVDAGQIILQEAVPVQRDDTVATLSERVKAAEHKIFPAALQLVASGAVQLG 999

  Fly  1348 PE 1349
            .:
  Rat  1000 ED 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gart	NP_001285698.1	PRK00885	4..433	CDD:234856	229/428 (54%)
		GARS_N	4..107	CDD:280931	51/102 (50%)
		GARS_A	108..301	CDD:279419	120/192 (63%)
		GARS_C	337..430	CDD:280930	39/92 (42%)
		PRK05385	442..752	CDD:235439	85/309 (28%)
		PurM	485..752	CDD:100032	58/266 (22%)
		PRK05385	836..1122	CDD:235439	77/288 (27%)
		PurM	840..1123	CDD:100032	77/285 (27%)
		FMT_core_GART	1155..1339	CDD:187714	105/183 (57%)
Gart	NP_001011899.2	PRK00885	4..427	CDD:234856	226/422 (54%)
		GARS_N	4..104	CDD:280931	50/99 (51%)
		GARS_A	105..298	CDD:279419	118/192 (61%)
		GARS_C	334..424	CDD:280930	36/89 (40%)
		PRK05385	435..766	CDD:235439	88/331 (27%)
		PurM	469..767	CDD:100032	68/297 (23%)
		FMT_core_GART	809..991	CDD:187714	15/181 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354142
Domainoid	1	1.000	254	1.000	Domainoid score	I1989
eggNOG	1	0.900	-	-		E1_COG0151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H637
Inparanoid	1	1.050	697	1.000	Inparanoid score	I649
OMA	1	1.010	-	-		QHG55216
OrthoDB	1	1.010	-	-		D105366at2759
OrthoFinder	1	1.000	-	-		FOG0003222
OrthoInspector	1	1.000	-	-		oto96292
orthoMCL	1	0.900	-	-		OOG6_100441
Panther	1	1.100	-	-	LDO	PTHR10520
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2637
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770