Protein Alignment Gart and GART

DIOPT Version :10

• Sequence 1: NP_523497.2
• Gene: Gart / 33986
• FlyBaseID: FBgn0000053
• Length: 1353
• Species: Drosophila melanogaster
• Sequence 2: NP_000810.1
• Gene: GART / 2618
• HGNCID: 4163
• Length: 1010
• Species: Homo sapiens
• Alignment Length: 1359
• Identity: 499/1359 - (36%)
• Similarity: 683/1359 - (50%)
• Gaps: 380/1359 - (27%)

  Fly     1 MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWS 65
            |:.|||:||||||||.:.|||:||..|.|:...||:.|....||..|   ..:...|..|:|::.
Human     1 MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISN---TAISISDHTALAQFC 62

  Fly    66 KENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESF 130
            ||.:|..||||||.|||.|:...|:|||:.||||..:.||:|:.|::||:||.|||||||::::|
Human    63 KEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAF 127

  Fly   131 TDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEEL 195
            |..|:|.:||.||.:|||||||:||||||||:||.:.:|||:||.||:.:..:|.||.|:|:|||
Human   128 TKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEEL 192

  Fly   196 LEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLER 260
            |:|||||.|.|||||:|..|.||||||||..||.||||||||||||.|.:|...|..::..||:|
Human   193 LDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQR 257

  Fly   261 AVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKL- 324
            .|.|:.:|...|.|:||||:|||::||:||||||||||||.|||||||:|||::|:::...|.|
Human   258 TVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLC 322

  Fly   325 DKIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGR 389
            ..:|: |....:|:.|::||.|||...|||..|:|.|.|......|||:|.|:...| .:|:|||
Human   323 TSLPV-WLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGK-VVTHGGR 385

  Fly   390 VLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTP-GLSYKDSGVDIDA 453
            ||...|:..:|..|..:|.|...:|.|  .||.||.|:..:|  ||....| .|:||:|||||.|
Human   386 VLAVTAIRENLISALEEAKKGLAAIKF--EGAIYRKDVGFRA--IAFLQQPRSLTYKESGVDIAA 446

  Fly   454 GDALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHELYEN 518
            |:.||::|:||::.|.|.|....||||.|||.||...:|:|::|..|.|||.|:.:|.....::.
Human   447 GNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDT 511

  Fly   519 VGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPS 583
            :|.||.|:..||:|..||||:.||||.:||||.:.:...:|.|:|..|..|.|||:||||||||.
Human   512 IGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPD 576

  Fly   584 LYAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRER 648
            :|.||::|:||:.||.:|:
Human   577 MYPPGEYDLAGFAVGAMER---------------------------------------------- 595

  Fly   649 SPVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDF 713
                                    .|.||||::
Human   596 ------------------------DQKLPHLER-------------------------------- 604

  Fly   714 GAVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSG 778
                                                                             
Human   605 ----------------------------------------------------------------- 604

  Fly   779 SPVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKD 843
                                                                             
Human   605 ----------------------------------------------------------------- 604

  Fly   844 PILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKEV 908
                                                                             
Human   605 ----------------------------------------------------------------- 604

  Fly   909 HSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLDEIQPGDVLIGLPS 973
                                                                 |..|||::|:.|
Human   605 -----------------------------------------------------ITEGDVVVGIAS 616

  Fly   974 SGVHSNGFSLVHAVLKRVGLGLHDKAP--FSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALA 1036
            ||:||||||||..::.:..|.....||  ..|:|||:.||.||:||..:|..:|..|.  :||.|
Human   617 SGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGH--VKAFA 679

  Fly  1037 HITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPT 1101
            |||||||.|||||||.:.|.|.|||..:::|.||:||...|::|..|:.||:|||:|.||||:..
Human   680 HITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKE 744

  Fly  1102 EVEDVLKEL-RYPQRAAVVGEVVARKDPKKSQVVVQNFEASLARTQKML-----------SQRRK 1154
            :.|.:|::: ::.:.|.|:|.||||.: ...:|.|:|...|:.....:|           .:::.
Human   745 QTEQILRDIQQHKEEAWVIGSVVARAE-GSPRVKVKNLIESMQINGSVLKNGSLTNHFSFEKKKA 808

  Fly  1155 RVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKTGVLGLQRATQAGIPSLVISHKDFASR 1219
            ||||||||||||||||||:||:.......|:  |||||..|.||.:|.:||||:.||:||.:.:|
Human   809 RVAVLISGTGSNLQALIDSTREPNSSAQIDI--VISNKAAVAGLDKAERAGIPTRVINHKLYKNR 871

  Fly  1220 EVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAGE 1284
            ..:|:.:...|:...:|::|||||||:||.|||::|.|:::||||||||.:.|.:..:||||.|.
Human   872 VEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGV 936

  Fly  1285 KESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNGT 1343
            ..:|||||||.|.||.|.||:|.|||:...|...:|::|:..|||..||.||.::.:||
Human   937 TVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGT 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gart	NP_523497.2	PurD	4..433	CDD:439921	225/429 (52%)
		PurM	438..753	CDD:439920	86/315 (27%)
		PurM	840..1123	CDD:100032	77/285 (27%)
		PurN	1153..1342	CDD:440068	97/188 (52%)
GART	NP_000810.1	PurD	4..427	CDD:439921	225/431 (52%)
		PurM	431..778	CDD:439920	168/699 (24%)
		AIRS domain. /evidence=ECO:0000250|UniProtKB:P21872	434..809		171/727 (24%)
		FMT_core_GART	809..991	CDD:187714	97/183 (53%)
		GART domain. /evidence=ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:12755606, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1NJS	810..1010		98/188 (52%)