DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gart and GART

DIOPT Version :9

Sequence 1:NP_001285698.1 Gene:Gart / 33986 FlyBaseID:FBgn0000053 Length:1353 Species:Drosophila melanogaster
Sequence 2:NP_000810.1 Gene:GART / 2618 HGNCID:4163 Length:1010 Species:Homo sapiens


Alignment Length:1359 Identity:499/1359 - (36%)
Similarity:683/1359 - (50%) Gaps:380/1359 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWS 65
            |:.|||:||||||||.:.|||:||..|.|:...||:.|....||..|   ..:...|..|:|::.
Human     1 MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISN---TAISISDHTALAQFC 62

  Fly    66 KENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESF 130
            ||.:|..||||||.|||.|:...|:|||:.||||..:.||:|:.|::||:||.|||||||::::|
Human    63 KEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWKAF 127

  Fly   131 TDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEEL 195
            |..|:|.:||.||.:|||||||:||||||||:||.:.:|||:||.||:.:..:|.||.|:|:|||
Human   128 TKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEEL 192

  Fly   196 LEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLER 260
            |:|||||.|.|||||:|..|.||||||||..||.||||||||||||.|.:|...|..::..||:|
Human   193 LDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQR 257

  Fly   261 AVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKL- 324
            .|.|:.:|...|.|:||||:|||::||:||||||||||||.|||||||:|||::|:::...|.| 
Human   258 TVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLC 322

  Fly   325 DKIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGR 389
            ..:|: |....:|:.|::||.|||...|||..|:|.|.|......|||:|.|:...| .:|:|||
Human   323 TSLPV-WLENHTALTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGK-VVTHGGR 385

  Fly   390 VLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTP-GLSYKDSGVDIDA 453
            ||...|:..:|..|..:|.|...:|.|  .||.||.|:..:|  ||....| .|:||:|||||.|
Human   386 VLAVTAIRENLISALEEAKKGLAAIKF--EGAIYRKDVGFRA--IAFLQQPRSLTYKESGVDIAA 446

  Fly   454 GDALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHELYEN 518
            |:.||::|:||::.|.|.|....||||.|||.||...:|:|::|..|.|||.|:.:|.....::.
Human   447 GNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDT 511

  Fly   519 VGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPS 583
            :|.||.|:..||:|..||||:.||||.:||||.:.:...:|.|:|..|..|.|||:||||||||.
Human   512 IGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPD 576

  Fly   584 LYAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRER 648
            :|.||::|:||:.||.:|:                                              
Human   577 MYPPGEYDLAGFAVGAMER---------------------------------------------- 595

  Fly   649 SPVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDF 713
                                    .|.||||::                                
Human   596 ------------------------DQKLPHLER-------------------------------- 604

  Fly   714 GAVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSG 778
                                                                             
Human   605 ----------------------------------------------------------------- 604

  Fly   779 SPVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKD 843
                                                                             
Human   605 ----------------------------------------------------------------- 604

  Fly   844 PILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKEV 908
                                                                             
Human   605 ----------------------------------------------------------------- 604

  Fly   909 HSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLDEIQPGDVLIGLPS 973
                                                                 |..|||::|:.|
Human   605 -----------------------------------------------------ITEGDVVVGIAS 616

  Fly   974 SGVHSNGFSLVHAVLKRVGLGLHDKAP--FSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALA 1036
            ||:||||||||..::.:..|.....||  ..|:|||:.||.||:||..:|..:|..|.  :||.|
Human   617 SGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGH--VKAFA 679

  Fly  1037 HITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPT 1101
            |||||||.|||||||.:.|.|.|||..:::|.||:||...|::|..|:.||:|||:|.||||:..
Human   680 HITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLVVSKE 744

  Fly  1102 EVEDVLKEL-RYPQRAAVVGEVVARKDPKKSQVVVQNFEASLARTQKML-----------SQRRK 1154
            :.|.:|::: ::.:.|.|:|.||||.: ...:|.|:|...|:.....:|           .:::.
Human   745 QTEQILRDIQQHKEEAWVIGSVVARAE-GSPRVKVKNLIESMQINGSVLKNGSLTNHFSFEKKKA 808

  Fly  1155 RVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKTGVLGLQRATQAGIPSLVISHKDFASR 1219
            ||||||||||||||||||:||:.......|:  |||||..|.||.:|.:||||:.||:||.:.:|
Human   809 RVAVLISGTGSNLQALIDSTREPNSSAQIDI--VISNKAAVAGLDKAERAGIPTRVINHKLYKNR 871

  Fly  1220 EVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAGE 1284
            ..:|:.:...|:...:|::|||||||:||.|||::|.|:::||||||||.:.|.:..:||||.|.
Human   872 VEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGV 936

  Fly  1285 KESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNGT 1343
            ..:|||||||.|.||.|.||:|.|||:...|...:|::|:..|||..||.||.::.:||
Human   937 TVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGT 995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GartNP_001285698.1 PRK00885 4..433 CDD:234856 225/429 (52%)
GARS_N 4..107 CDD:280931 50/102 (49%)
GARS_A 108..301 CDD:279419 119/192 (62%)
GARS_C 337..430 CDD:280930 38/92 (41%)
PRK05385 442..752 CDD:235439 85/309 (28%)
PurM 485..752 CDD:100032 60/266 (23%)
PRK05385 836..1122 CDD:235439 77/288 (27%)
PurM 840..1123 CDD:100032 77/285 (27%)
FMT_core_GART 1155..1339 CDD:187714 97/183 (53%)
GARTNP_000810.1 purD 4..426 CDD:273315 225/430 (52%)
GARS_N 4..104 CDD:280931 50/102 (49%)
GARS_A 105..298 CDD:279419 119/192 (62%)
GARS_C 334..424 CDD:280930 38/92 (41%)
AIRS 434..809 171/727 (24%)
PRK05385 435..766 CDD:235439 162/682 (24%)
PurM 469..767 CDD:100032 144/649 (22%)
FMT_core_GART 809..991 CDD:187714 97/183 (53%)
GART 810..1010 98/188 (52%)
5'-phosphoribosylglycinamide binding 818..820 1/1 (100%)
10-formyltetrahydrofolate binding 896..899 2/2 (100%)
10-formyltetrahydrofolate binding 947..951 1/3 (33%)
5'-phosphoribosylglycinamide binding 977..980 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160074
Domainoid 1 1.000 249 1.000 Domainoid score I2137
eggNOG 1 0.900 - - E1_COG0151
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H637
Inparanoid 1 1.050 682 1.000 Inparanoid score I714
Isobase 1 0.950 - 0 Normalized mean entropy S947
OMA 1 1.010 - - QHG55216
OrthoDB 1 1.010 - - D105366at2759
OrthoFinder 1 1.000 - - FOG0003222
OrthoInspector 1 1.000 - - oto89166
orthoMCL 1 0.900 - - OOG6_100441
Panther 1 1.100 - - LDO PTHR10520
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1035
SonicParanoid 1 1.000 - - X2637
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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