DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gart and F38B6.4

DIOPT Version :9

Sequence 1:	NP_001285698.1	Gene:	Gart / 33986	FlyBaseID:	FBgn0000053	Length:	1353	Species:	Drosophila melanogaster
Sequence 2:	NP_509122.2	Gene:	F38B6.4 / 180935	WormBaseID:	WBGene00018174	Length:	975	Species:	Caenorhabditis elegans

Alignment Length:	1343	Identity:	426/1343 - (31%)
Similarity:	609/1343 - (45%)	Gaps:	391/1343 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWSKENQ 69
            ||::||||||||:.||:.|||||..:...||:.|     ....:|   ::..|.:|:|.:.:::.
Worm     3 VLIVGSGGREHALAWKMKQSPKVKNVIVAPGNGG-----HSERID---INSNDLDAVADFCEKHN 59

  Fly    70 IALVVVGPEDPLALGLGD--VLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARY--ESF 130
            |..|::|||:||:.||.|  :.....:..|||.|.|||:|..|.::|.||..:|:|||.:  .|.
Worm    60 IHCVLIGPEEPLSNGLADHLIRIHPNLMVFGPLKDGAQLETSKSFSKHFMKEYGLPTADFVTVSI 124

  Fly   131 TDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEEL 195
            .:.:.........|:...||||.||||||||::..|..||.:|...||.. ::|.||.|:::||.
Worm   125 ENVKSLDCVFERLPWKNSVVKADGLAAGKGVIIPRNNAEAVEAARSILHG-QFGNAGRTVIIEER 188

  Fly   196 LEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLER 260
            |||.|||.||||||.|.:.|...:|||||...|.||||||||...|..:..:...::.:  :.|:
Worm   189 LEGYEVSALAFTDGISFKRMPLGKDHKRLLESDLGPNTGGMGVVAPVSVPKEVDRQIDE--IFEK 251

  Fly   261 AVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKLD 325
            .::||...:|.|.||||||.|:....|.:||||||||||||||::.|||||||:::.:|.:..|:
Worm   252 TLKGLADRKIKYCGVLYAGFMIVDQKPLLLEFNCRFGDPETQVLMRLLESDLFEIISSCVNQTLN 316

  Fly   326 KIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAV-NAQKEALTNGGR 389
            ...:.| :..|..||:|||..||::..||..|:.:|:.:: |.:|||:|.:| |:|  .:|||||
Worm   317 TCDINW-STKSVCGVVLASGNYPKSGDKGSPITEIPSPDS-TNVVFHAGTSVINSQ--IVTNGGR 377

  Fly   390 VLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTPGLSYKDSGVDIDAG 454
            :|...:|..:|.:|...|.|:|.:|.|:|.  |:|.||.    |.....||.|||..|||:||.|
Worm   378 ILCVTSLADTLHDAREHANKIAQNIQFTGK--QFRKDIG----KTIDIGTPSLSYGSSGVNIDEG 436

  Fly   455 DALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHELYENV 519
            :..|:.||.|.:.|..||. ..:||||.:..||:
Worm   437 NQFVEDIKLLVKKTLLPGA-AQIGGFGAVLDLKK------------------------------- 469

  Fly   520 GYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPSL 584

Worm   470 ----------------------------------------------------------------- 469

  Fly   585 YAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRERS 649
                                                        |||:
Worm   470 --------------------------------------------AGFS----------------- 473

  Fly   650 PVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFG 714

Worm   474 ----------------------------------------------------------------- 473

  Fly   715 AVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSGS 779

Worm   474 ----------------------------------------------------------------- 473

  Fly   780 PVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKDP 844
                                                                          .|.
Worm   474 --------------------------------------------------------------NDS 476

  Fly   845 ILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKEVH 909
            .|::|.||||||:::|...|..|.||.|:|||||||::|:.|:||:|..|:.||..:..:|.:|.
Worm   477 QLVVGIDGVGTKIEVATHCNNFTGVGYDVVAMCVNDVICHCAKPIAFLDYFVCGKLERSMATQVL 541

  Fly   910 SGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHT-GILPLLDEIQPGDVLIGLPS 973
            :.:.|...:|..|.|...:|.:|.:|....:||||.|:...|.| .:|||..||:.|||::||||
Worm   542 TSISEACVEAECSLIGGETAEMPGVYSTHQWDLAGCAIAARESTWPMLPLSSEIRDGDVILGLPS 606

  Fly   974 SGVHSNGFSLVHAVLKRVGLGLHDKAPFSDK-TLGEELLVPTKIYVKALSTLLSRGKHGIKALAH 1037
            ||:|||||||...:|...|:..:|..|:..| |.|.|||..||:|||.:..|||.|.  :|..||
Worm   607 SGLHSNGFSLARKILTVNGVKYNDPLPWDSKSTFGTELLRGTKLYVKKVLPLLSTGL--VKGCAH 669

  Fly  1038 ITGGGLSENIPRVLRKDL--AVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAP 1100
            ||||||:||..|||.|:.  ::.:|...::...:|.|:||||.:.:.|:.||:|||:||||:|:|
Worm   670 ITGGGLTENAIRVLDKNSKDSLVIDCASWKFREIFNWMAAAGPVDTKEMIRTFNCGIGMVLIVSP 734

  Fly  1101 TEVEDVLKELR-YPQRAAVVGEVVARKDPKKSQVVVQNFEASLARTQKMLSQRRK-RVAVLISGT 1163
            ..||.|.|:|| :.:....:|.|   ::.|..:.:....|..:.:.:|..:||:: |||:|||||
Worm   735 DNVEKVKKQLRKHEEEFYEIGHV---ENSKNGEAIKFVNEEKMFQREKYTTQRKRVRVAILISGT 796

  Fly  1164 GSNLQALIDATRDSAQGIHADVVLVISNKTGVLGLQRATQAGIPSLVISHKDFASREVYDAELTR 1228
            |:|:|.||:  |......:.|||||:|||.|..||..|...|||:.|:.|.  |.|...|.||.:
Worm   797 GTNMQKLIE--RSKTPDSNCDVVLVVSNKEGAGGLTIAASYGIPTKVVPHT--ADRVTGDTELAQ 857

  Fly  1229 NLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAGEKESGCTVHF 1293
            .||....:|:||.|:||:||..|:.::..|::||||||||.:.|.|..:.||..|.:..|||.||
Worm   858 VLKDFGTELVCLGGYMRILSPCFISQFPSRIINIHPSLLPAFKGAHALQDALNFGVRIVGCTAHF 922

  Fly  1294 VDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRAL 1336
            |||.||.|.||.|..|.:...|..:::.|:|...||..||.|:
Worm   923 VDELVDHGDIIAQRPVVVEDTDTIETVRQKIQLQEHEMFPNAM 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gart	NP_001285698.1	PRK00885	4..433	CDD:234856	181/432 (42%)
		GARS_N	4..107	CDD:280931	41/103 (40%)
		GARS_A	108..301	CDD:279419	86/194 (44%)
		GARS_C	337..430	CDD:280930	38/93 (41%)
		PRK05385	442..752	CDD:235439	25/309 (8%)
		PurM	485..752	CDD:100032	5/266 (2%)
		PRK05385	836..1122	CDD:235439	127/290 (44%)
		PurM	840..1123	CDD:100032	127/287 (44%)
		FMT_core_GART	1155..1339	CDD:187714	84/182 (46%)
F38B6.4	NP_509122.2	PRK00885	1..415	CDD:234856	181/432 (42%)
		GARS_N	2..99	CDD:280931	41/103 (40%)
		GARS_A	100..292	CDD:279419	86/194 (44%)
		GARS_C	328..415	CDD:280930	38/95 (40%)
		PRK05385	424..757	CDD:235439	152/684 (22%)
		PurM	456..758	CDD:100032	137/655 (21%)
		FMT_core_GART	788..968	CDD:187714	84/182 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167593
Domainoid	1	1.000	160	1.000	Domainoid score	I2470
eggNOG	1	0.900	-	-		E1_COG0151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H637
Inparanoid	1	1.050	506	1.000	Inparanoid score	I730
Isobase	1	0.950	-	0	Normalized mean entropy	S947
OMA	1	1.010	-	-		QHG55216
OrthoDB	1	1.010	-	-		D105366at2759
OrthoFinder	1	1.000	-	-		FOG0003222
OrthoInspector	1	1.000	-	-		oto19329
orthoMCL	1	0.900	-	-		OOG6_100441
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1035
SonicParanoid	1	1.000	-	-		X2637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.650