DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43322 and DNAJC28

DIOPT Version :9

Sequence 1:	NP_609092.1	Gene:	CG43322 / 33984	FlyBaseID:	FBgn0263027	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001035282.1	Gene:	DNAJC28 / 54943	HGNCID:	1297	Length:	388	Species:	Homo sapiens

Alignment Length:	339	Identity:	129/339 - (38%)
Similarity:	193/339 - (56%)	Gaps:	37/339 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KRKEVYMECFRILGVHESADQNTVRHAYLDLVKRVHPDSGTEEASAERFQQVDEAFR-----VLQ 82
            |.|:...|.:|:|.|.|....:.||.::..|.|:.|||||:..|.:..|.::::|:|     |::
Human    44 KSKKKIREYYRLLNVEEGCSADEVRESFHKLAKQYHPDSGSNTADSATFIRIEKAYRKVLSHVIE 108

  Fly    83 EKFAKGRRNIQEDEEGAMEFDIKHTAPQHRQYLSNEGIGVGTPFQRQKQYQQVRAMKAQERVLEH 147
            :..|...:.  |:||...:|  |:..||||.|||.||||.|||.||:|.|:|.||.:|.|:|:|:
Human   109 QTNASQSKG--EEEEDVEKF--KYKTPQHRHYLSFEGIGFGTPTQREKHYRQFRADRAAEQVMEY 169

  Fly   148 RIDKAAAGEKTLMSKGGSHFRKHAI----------KTKYGIDRVVEDLIQEAMSKGDFNNLNGSG 202
            :..|       |.|:   :|....|          |....|:|:|||||||:|:||||:||:|.|
Human   170 QKQK-------LQSQ---YFPDSVIVKNIRQSKQQKITQAIERLVEDLIQESMAKGDFDNLSGKG 224

  Fly   203 KPLSSAQSQNPYLDFTTHKLNKIMLDNGFTPEWISLGKDIRDAIAQLKTKLRQERKYYGEWPLQR 267
            |||... |...|:|..||.||:|::|||:.||||...|:|.|.|.||:..:...||..|. |: .
Human   225 KPLKKF-SDCSYIDPMTHNLNRILIDNGYQPEWILKQKEISDTIEQLREAILVSRKKLGN-PM-T 286

  Fly   268 PDDLAAWKIFTLNHQDDVKQLNKLIDKYNLIVPILENQFFRLHLDRMAEPIFKDPELQRNVIR-P 331
            |.:...|.......|:::::|||.|:.:|||||||..|  ::|.|...| |.:..::...:|: .
Human   287 PTEKKQWNHVCEQFQENIRKLNKRINDFNLIVPILTRQ--KVHFDAQKE-IVRAQKIYETLIKTK 348

  Fly   332 EMKSKPSSNLENQG 345
            |:..:..:||: ||
Human   349 EVTDRNPNNLD-QG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43322	NP_609092.1	DnaJ	29..84	CDD:197617	19/59 (32%)
		PLN03085	<168..313	CDD:215566	64/154 (42%)
		DUF1992	181..250	CDD:286440	39/68 (57%)
DNAJC28	NP_001035282.1	DnaJ	51..104	CDD:99751	18/52 (35%)
		PLN03085	<200..338	CDD:215566	65/143 (45%)
		DUF1992	203..271	CDD:286440	39/68 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148063
Domainoid	1	1.000	82	1.000	Domainoid score	I8446
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9869
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3798
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49972
OrthoDB	1	1.010	-	-		D1394654at2759
OrthoFinder	1	1.000	-	-		FOG0007523
OrthoInspector	1	1.000	-	-		oto91519
orthoMCL	1	0.900	-	-		OOG6_106015
Panther	1	1.100	-	-	LDO	PTHR24016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5522
SonicParanoid	1	1.000	-	-		X6411
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900