DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and SCUBE1

DIOPT Version :10

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_766638.2 Gene:SCUBE1 / 80274 HGNCID:13441 Length:988 Species:Homo sapiens


Alignment Length:1394 Identity:272/1394 - (19%)
Similarity:392/1394 - (28%) Gaps:667/1394 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly  2087 AGYSGINCQEEASDC--GNDTCPARAMCKNEPGYKNVTCLCRSGYTGD--QCDVTIDPCTANGNP 2147
            ||.||:....:..:|  |.|.|...|:|:|.|  |:..|||:.||.|:  ||: .||.|.   |.
Human    23 AGGSGLPGSVDVDECSEGTDDCHIDAICQNTP--KSYKCLCKPGYKGEGKQCE-DIDECE---ND 81

  Fly  2148 CGNGA---SCQALEQGRYKCECVPGW----EGIHCEQNINDCSENPCLLGANCTDLVNDFQCACP 2205
            ..||.   .|..: .|.|:|.|..|:    :|.:| .::::|.:|                    
Human    82 YYNGGCVHECINI-PGNYRCTCFDGFMLAHDGHNC-LDVDECQDN-------------------- 124

  Fly  2206 PGFTGKRCEQKIDLCLSEPCKHGTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGT--- 2267
                ...|:|             .||:.:..:||.||.|:..|.   |...|.:|  :|||.   
Human   125 ----NGGCQQ-------------ICVNAMGSYECQCHSGFFLSD---NQHTCIHR--SNEGMNCM 167

  Fly  2268 -----CVDLV-----DGYSCNCEPGY----TGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCR 2318
                 |..:.     .|.:|:|.||:    ..|:|..|. :..:..|||  :|.|...|.:|.|.
Human   168 NKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTC-NYGNGGCQH--SCEDTDTGPTCGCH 229

  Fly  2319 PGYV----GLSCEAEIDECLSDPCNPVGTER-CLDLDNKFECVCRDGF----KGPLCATDIDDCE 2374
            ..|.    |.:|   |:.|   ..|..|.:| |.|......|.|..||    .|..| .||::| 
Human   230 QKYALHSDGRTC---IETC---AVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC-KDINEC- 286

  Fly  2375 AQPCLNNG----ICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCP 2435
               .:|||    .||:.||.|||||..|:..:..|:   ||.....|..:.:|     |:.|:..
Human   287 ---LVNNGGCDHFCRNTVGSFECGCRKGYKLLTDER---TCQDIDECSFERTC-----DHICINS 340

  Fly  2436 SGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQY--EYDAC--EEHVCQNG 2496
            .|:                             ..|.|...|...|..:  :.|.|  ....|..|
Human   341 PGS-----------------------------FQCLCHRGYILYGTTHCGDVDECSMSNGSCDQG 376

  Fly  2497 ATCVDNGAGYSCQCPPG----FTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDC 2557
              ||:....|.|.||||    :.|::|.:                                    
Human   377 --CVNTKGSYECVCPPGRRLHWNGKDCVE------------------------------------ 403

  Fly  2558 RKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQ 2622
                                       ||:.                          .|...|..
Human   404 ---------------------------TGKC--------------------------LSRAKTSP 415

  Fly  2623 RRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKME 2687
            |..|..:.:.||:        ..|||                                       
Human   416 RAQLSCSKAGGVE--------SCFLS--------------------------------------- 433

  Fly  2688 YGAGGSLPGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEP 2752
                                                                        |.:..
Human   434 ------------------------------------------------------------CPAHT 438

  Fly  2753 VLYPGLILNWAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLVVDKEPPVVEHC--PGDLWV 2815
            :..|                                           |.|...|..|  ||    
Human   439 LFVP-------------------------------------------DSENSYVLSCGVPG---- 456

  Fly  2816 IAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVSLL 2880
              ..|.|                 :.:|||..||                               
Human   457 --PQGKA-----------------LQKRNGTSSG------------------------------- 471

  Fly  2881 TDFCPALADPVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSMPL 2945
                                                                             
Human   472 ----------------------------------------------------------------- 471

  Fly  2946 VYPSCS--PSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDWNFCSYAIEGTREC 3008
            :.||||  |:.|.::..|.|:   .|..|:....:..|.|.|.....|:              .|
Human   472 LGPSCSDAPTTPIKQKARFKI---RDAKCHLRPHSQARAKETARQPLLD--------------HC 519

  Fly  3009 KDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDDDDDLTLTGRQGRQQTGGDTYTLE 3073
            ....:.:|||   .::..|..|::....|..:.||..:             :.:.:...||...:
Human   520 HVTFVTLKCD---SSKKRRRGRKSPSKEVSHITAEFEI-------------ETKMEEASDTCEAD 568

  Fly  3074 IAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQ------EILPNTVPDPASLELGSEYAC 3132
            .....|...:       ::.:|.|.:.  :...||.||      |:...    ||. .|..:.||
Human   569 CLRKRAEQSL-------QAAIKTLRKS--IGRQQFYVQVSGTEYEVAQR----PAK-ALEGQGAC 619

  Fly  3133 PVGQVVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSA 3197
            ..|||:....||.|..||.:......|::|..||||...|||.|:.||...|. |:   ||||:.
Human   620 GAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGL-GL---PGARNV 680

  Fly  3198 ADCKERCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECSSGQ 3262
            ::|..:|..| :|.|:         || :|                                   
Human   681 SECGGQCSPG-FFSAD---------GF-KP----------------------------------- 699

  Fly  3263 QLGADGRCEPCPRGTYRLQGVQPSCAACPLGRTTPKVGASSVEECTLPV-CSAGTYLNATQNMCI 3326
                   |:.||.|||:.:..:..|..|..|..|...|.:|.::|...| ||.|.:.|.|.:.||
Human   700 -------CQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCI 757

  Fly  3327 ECRKGYYQSESQQTSCLQCPPNHSTKITGATSKSECTNPCEHIAEGKPHC--------------- 3376
            .|..|.||.|..|..|:.||.|.||...|:|:.:.|.|         .||               
Human   758 RCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKN---------QHCGGELGDYTGYIESPN 813

  Fly  3377 -----DVNAYC-------------IMVPE 3387
                 ..||.|             |:|||
Human   814 YPGDYPANAECVWHIAPPPKRRILIVVPE 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
PHA02639 697..>834 CDD:165022
FA58C 833..976 CDD:330301
FXa_inhibition 988..>1016 CDD:464251
CCP 1051..1106 CDD:153056
FA58C 1303..1443 CDD:330301
HYR 1463..1547 CDD:460572
HYR 1548..1631 CDD:460572
Ephrin_rec_like 1862..1909 CDD:429604
Ephrin_rec_like 1916..1966 CDD:429604
Ephrin_rec_like 1973..2020 CDD:429604
EGF 2025..2055 CDD:394967
EGF_CA 2059..2095 CDD:238011 4/7 (57%)
EGF_CA 2138..2176 CDD:238011 13/44 (30%)
EGF_CA 2178..2214 CDD:238011 2/35 (6%)
EGF_CA 2253..2289 CDD:238011 13/52 (25%)
EGF_CA 2292..2327 CDD:238011 10/38 (26%)
EGF_CA 2369..2405 CDD:238011 16/39 (41%)
EGF_CA 2411..2444 CDD:238011 6/32 (19%)
EGF_CA 2486..2520 CDD:238011 13/39 (33%)
EGF_CA 2522..2557 CDD:238011 0/34 (0%)
LamG 2590..2735 CDD:473984 9/144 (6%)
HYR 2799..2877 CDD:460572 13/79 (16%)
Ephrin_rec_like 3149..3200 CDD:429604 20/50 (40%)
Ephrin_rec_like 3207..3254 CDD:429604 6/46 (13%)
Ephrin_rec_like 3268..3307 CDD:429604 12/38 (32%)
Ephrin_rec_like 3315..3362 CDD:429604 19/46 (41%)
SCUBE1NP_766638.2 EGF_3 37..72 CDD:463759 15/36 (42%)
FXa_inhibition 84..115 CDD:464251 9/31 (29%)
FXa_inhibition 121..156 CDD:464251 13/74 (18%)
FXa_inhibition 166..202 CDD:464251 7/35 (20%)
FXa_inhibition 206..241 CDD:464251 10/37 (27%)
FXa_inhibition 245..280 CDD:464251 11/37 (30%)
FXa_inhibition 286..321 CDD:464251 15/41 (37%)
vWFA <318..354 CDD:469594 11/72 (15%)
FXa_inhibition 366..401 CDD:464251 12/36 (33%)
Ephrin_rec_like 636..683 CDD:429604 20/50 (40%)
Ephrin_rec_like 690..737 CDD:429604 18/99 (18%)
Ephrin_rec_like 746..793 CDD:429604 19/46 (41%)
CUB 798..909 CDD:238001 8/45 (18%)
Blue background indicates that the domain is not in the aligned region.

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