DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment uif and notch1b

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:XP_005168706.1 Gene:notch1b / 794892 ZFINID:ZDB-GENE-990415-183 Length:2482 Species:Danio rerio


Alignment Length:2248 Identity:544/2248 - (24%)
Similarity:756/2248 - (33%) Gaps:802/2248 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1484 ENGGVLPVNFTEPTAVDNSGSIARLEIKPQNFRTPSYIFKDTVVKYVAFDYDGNVAICEINITVP 1548
            :|||.     .|||| |..|....|::    :..|:..|::...:...    .|..:|.: ||..
Zfish    28 QNGGT-----CEPTA-DGRGECKCLDL----YAGPACQFRNPCFQSPC----RNGGVCRL-ITSA 77

  Fly  1549 DVTPPLLQCPQSYVIELVDRQDSYTVNFNDTRKRIKTSDDTGDVRLQFSPESANIKIGN--FENV 1611
            :....:..|...|                        :|     ||..:|.: |:.:|.  ....
Zfish    78 NKVDFVCNCSLGY------------------------TD-----RLCLTPTN-NVCLGAPCRNGG 112

  Fly  1612 TVTATDKYNNRAAC----HFQVSVKASPCVDWELQPPANGAINCLPGDRGIECIATCKPGFRFTD 1672
            |...|..:|.|..|    ..:...:|.||..   .|.|||. .|.|.|....|  .|.|.|   .
Zfish   113 TCELTSIHNYRCKCPPGWSGKTCQQADPCAS---NPCANGG-QCSPFDSDFLC--HCTPYF---S 168

  Fly  1673 GEPLKTFSCETSRLWRPTSVVPDCVSENTEQAAYHVTASITYRANGAVAQSCLGQYQ-EVLAQHY 1736
            |:..|....|.:::..|..                         ||.|.::.:|.|. ...|::.
Zfish   169 GQTCKQDVNECAQIPSPCK-------------------------NGGVCENGVGTYHCNCPAEYT 208

  Fly  1737 GGLNQLLSQRCSAVNVNMNVTFVKSVPMLLEENVVKMDFILSILPAVRQPQLYDLCGSTLNLIFD 1801
            |...:.|.|.|:........|.|:.         .:..:..|.||.                   
Zfish   209 GKHCESLYQPCNPSPCLHGGTCVQK---------GETSYECSCLPG------------------- 245

  Fly  1802 LSVPYASAVIDDLLNIANIGNQCPPLRALKSQISRGFNCNVGEVLNMDTSDVPRCLHCP--AGTY 1864
            .|.......|||          ||..|.|     .|..|       :|..:...|...|  .|.:
Zfish   246 FSGQNCEENIDD----------CPDHRCL-----NGGTC-------VDGVNTYNCQCKPEWTGQF 288

  Fly  1865 VSEGQNSCTYCPRGYYQNRDRQGTCLRCPAG-------TYTKEEGTKSQADCI-PVCGYGTYSPT 1921
            .:|..|.|...|.. .||   .||||....|       .:|.::.:::..||. ..|..|.....
Zfish   289 CTEDVNECDLMPNS-CQN---GGTCLNTQGGYNCVCVNGWTGDDCSENIDDCADAACHTGATCHD 349

  Fly  1922 GLVPCL-ECPRNSFTAEPPTG---GFKD-CQACPAQSFTYQPAASNKDLCRAKCAPGTYSATGLA 1981
            .:...| |||...      ||   ...| |.:.|.|.      .||.|         |....|.|
Zfish   350 RVASFLCECPHGR------TGLLCHLDDACISNPCQK------GSNCD---------TNPVNGKA 393

  Fly  1982 PCSPCPLHHYQGAAGAQSCNECPSNMRTDSPASKGREQCKPVVCGEGACQHGGLCVPMGHDIQCF 2046
            .|: ||| .|.|.|..|..:||.                    .|...|:|.|.|:......||.
Zfish   394 ICT-CPL-GYVGPACDQDVDECS--------------------LGANPCEHAGKCINTKGSFQCK 436

  Fly  2047 CPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAM 2111
            |..|:.|.|||.||:||.|.||.|...|.|...|:.|.|..||.|:.||....:|.:..|.....
Zfish   437 CLQGYVGARCELDINECLSTPCQNDATCLDQIGGFHCICMPGYEGVFCQINTDECASMPCLNNGK 501

  Fly  2112 CKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCE 2176
            |.::  ..|..|.|.:|::|.||...||.|.:  .||.|||.|.. ....|.|:|..|:.|.|||
Zfish   502 CIDK--INNYQCECPTGFSGSQCQFDIDECAS--TPCKNGAKCMD-GPNMYTCQCTEGYTGQHCE 561

  Fly  2177 QNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKH-GTCVDRLFDHECV 2240
            .::::|..|||..| .|.|.:..|.|.|..||.|:.||..|:.|||:||:: |||.||...:.||
Zfish   562 TDVDECLSNPCHYG-TCKDGLASFTCVCRAGFMGRLCEININECLSQPCQNGGTCQDRENAYLCV 625

  Fly  2241 CHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGAT 2305
            |..|..|:.|:||:|||::.|| :.|.|:|.::||.|.||||||||.|...||:||.|||.:|.|
Zfish   626 CPKGTAGANCEINLDDCQSNPC-DFGRCIDKINGYECACEPGYTGKMCNINIDECAINPCHNGGT 689

  Fly  2306 CVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPC-------------------------------- 2338
            |||.::||:|.||.||...:|:::::||||:||                                
Zfish   690 CVDGVNGFTCLCREGYHDTTCQSQLNECLSNPCIHGHCEDKVNGYNCICDSGWSGVNCDINNNEC 754

  Fly  2339 --NPV---GTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPG 2398
              ||.   ||  |.|:.:.:.|.||.||.||.|.|:|::|.:.||||.|.|.|.|.|::|.|...
Zfish   755 ESNPCMNGGT--CKDMTSGYVCTCRAGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLP 817

  Fly  2399 WSGMRCEQQVTTCGAQAPCQNDASCIDL--FQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKC 2461
            ::|..||..:..||:: ||:|...|.:.  ::.:.||||:|..|:.||.....|:.:||.:...|
Zfish   818 YTGENCETLLAPCGSK-PCKNGGVCKESEDYESFSCVCPAGWQGQTCEVDINECVKNPCRNDAIC 881

  Fly  2462 QDFGSGLNCSCPADYSGIGCQYEYDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDC 2526
            |:......|||.|.|:|..|:.:.|.|:.:.|.||..|.|....::|.|.|||.|..||:||.:|
Zfish   882 QNSIGSYKCSCKAGYTGRNCETDIDDCKPNPCSNGGFCKDAVNAFACTCLPGFRGGRCEEDINEC 946

  Fly  2527 KDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSL 2591
            :.|.|..||.|.|..|.:.|.||...:|..|                             |.|: 
Zfish   947 ESNPCKNGANCTDCVNSYTCTCPPGFSGIHC-----------------------------ENNT- 981

  Fly  2592 TVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVN 2656
                                                               ||.    .|.:..|
Zfish   982 ---------------------------------------------------PDC----TESSCFN 991

  Fly  2657 DGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYLWAVLGLPQPYGLSNELAYSDSGF 2721
            .|      ...|||:....|..:                                        ||
Zfish   992 GG------TCVDGINSFTCLCPK----------------------------------------GF 1010

  Fly  2722 QGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNWAG-YEVTSGGVERNVPSLCGQRKC 2785
            .|               :..|..:.:|.|.|.:..|...:..| |:.|                |
Zfish  1011 TG---------------NYCQHDINECDSRPCMNGGTCQDSYGTYKCT----------------C 1044

  Fly  2786 PVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRSGT 2850
            |.||.|.|||:|                          |:|.:|....|.|:.:       :|||
Zfish  1045 PQGYHGLNCQEL--------------------------VNWCKPSPCKNGGICR-------QSGT 1076

  Fly  2851 TLL------W-GTY-DITYIASDA---------------------AGNTASCSFKVSLLTDFCPA 2886
            ...      | |.| |:..::.:.                     ||||..|..:......:|..
Zfish  1077 RYSCQCQTGWTGLYCDVPSVSCEVAAKQQGVDVVRLCRNSGQCLDAGNTHYCHCQAGYTGSYCEE 1141

  Fly  2887 LAD-----PVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSMPLV 2946
            ..|     |......|.|:..|                       |:|                 
Zfish  1142 QVDECIPNPCQNGATCTDYLGG-----------------------YSC----------------- 1166

  Fly  2947 YPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDWNFCSYAIEGTRECKDI 3011
              .|.|..             ..|.|:......|.|...|.                ||  |.|:
Zfish  1167 --ECVPGY-------------HGVNCSDEINECLSQPCQNG----------------GT--CIDL 1198

  Fly  3012 QIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDDD-----DDLTLTGR---QGR--QQTG 3066
            ....||...||||           ||:.      .:|.||     |.:|...:   |||  .:.|
Zfish  1199 INTYKCSCPRGTQ-----------GVHC------EINIDDCTPFTDPITHEPKCFNQGRCVDRVG 1246

  Fly  3067 GDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLELGSEYA 3131
            |  |.. |..|.        ..|||           .|.|   |.|.|.|.....:.::|.:.|.
Zfish  1247 G--YHC-ICPPG--------YVGER-----------CEGD---VNECLSNPCGTHSCIQLKNNYR 1286

  Fly  3132 CP-----VGQVV--MIPDC--VPCAIGTFYDSANKTCIACSRGTYQSEAGQLQCSKCPVIAGRPG 3187
            |.     .||..  :...|  .||..|       .||...|...:    |.: | |||     ||
Zfish  1287 CECRTGYTGQHCDKVFDGCKGKPCRNG-------GTCAVASNTPH----GFI-C-KCP-----PG 1333

  Fly  3188 VTAGPGARSAADCKE-RCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTTRSTEATSR 3251
            .|.......|..|.. :|..|       |.|.| ||       .|..| ||        |.|.:.
Zfish  1334 FTGSTCEYDAHACGSLQCKNG-------GTCVS-GH-------KSPKC-LC--------TPAFTG 1374

  Fly  3252 KECRDECSSGQQLGADGRC--EPCPRG---TYRLQGVQPSCAACPL---------------GRT- 3295
            .||:|  .||      |.|  .||..|   .|..:.....| .||.               |.| 
Zfish  1375 PECQD--PSG------GHCTTNPCYNGGTCEYITEEPYYHC-ICPTNFNGLFCHILDWSFPGGTG 1430

  Fly  3296 -----TPKVGAS-SVEECTL----PVCSAGTYLNATQNMCI-----ECRKGYYQSESQQTSCLQC 3345
                 .|||..| .:|:|.:    .:|.     :|..|...     :|...:.......::.|||
Zfish  1431 QDITPAPKVSVSCEIEQCKVKKGNKICD-----SACNNYACDWDGGDCSLNFNDPWKNCSAALQC 1490

  Fly  3346 PPNHSTKITGATSKSECTNPCEHIAEGKPHCDVNAYCIMVPETSDFKC-----ECKPGFNGTGMA 3405
                    ....:..:|...|.           |..|:.    ..|.|     :|.|.::   ..
Zfish  1491 --------WRYFNNGKCDEQCH-----------NTGCLY----DGFDCQRVEAQCNPLYD---QY 1529

  Fly  3406 CTD-VCDGFCENSGACVKDLKGTPSCRCVGSFTGPHCAERSEFAYIAGGIAGAVIFIIIIVLLIW 3469
            |.| ..||:|:         :|..:..|  .:.|..||..:.....||        ::::|:.|.
Zfish  1530 CKDHFADGYCD---------QGCNNAEC--EWDGLDCANDTPEKLAAG--------LLVVVVHIH 1575

  Fly  3470 MICVRSTK-----------------RRDPK--KMLTPAIDQTGSQVNFYYGAHTPYAESIAPSHH 3515
            ...:|:..                 |||.|  :|:.|           |||           :..
Zfish  1576 PDQLRNNSFGFLRELSRVLHTNVVFRRDSKGQEMIYP-----------YYG-----------NEQ 1618

  Fly  3516 STYAHYYDDEEDGWEMPNFYNETYMKDGLH-----GGK 3548
            ....|......|||...:....:.||:.::     ||:
Zfish  1619 ELKKHNIKRSLDGWNDASSDVLSSMKNSIYNIVVEGGR 1656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940 15/62 (24%)
DUF5011 1548..1631 CDD:295940 13/88 (15%)
GCC2_GCC3 1862..1909 CDD:285001 13/53 (25%)
GCC2_GCC3 1916..1966 CDD:285001 14/54 (26%)
GCC2_GCC3 1973..2020 CDD:285001 13/46 (28%)
EGF 2025..2055 CDD:278437 10/29 (34%)
EGF_CA 2059..2095 CDD:238011 16/35 (46%)
EGF_CA 2138..2176 CDD:238011 15/37 (41%)
EGF_CA 2178..2214 CDD:238011 13/35 (37%)
EGF_CA 2253..2289 CDD:238011 20/35 (57%)
EGF_CA 2292..2327 CDD:238011 19/34 (56%)
EGF_CA 2330..2366 CDD:238011 19/72 (26%)
EGF_CA 2369..2405 CDD:238011 14/35 (40%)
EGF_CA 2411..2444 CDD:238011 12/34 (35%)
EGF_CA 2486..2520 CDD:238011 13/33 (39%)
EGF_CA 2522..2557 CDD:238011 14/34 (41%)
LamG 2590..2735 CDD:304605 12/144 (8%)
DUF5011 2799..2877 CDD:295940 17/106 (16%)
GCC2_GCC3 3149..3200 CDD:285001 13/50 (26%)
GCC2_GCC3 3207..3254 CDD:285001 12/46 (26%)
GCC2_GCC3 3268..3307 CDD:285001 16/65 (25%)
GCC2_GCC3 3315..3362 CDD:285001 6/51 (12%)
notch1bXP_005168706.1 EGF_CA 175..213 CDD:238011 9/62 (15%)
EGF_CA 221..252 CDD:238011 6/58 (10%)
EGF_CA 254..290 CDD:238011 13/57 (23%)
EGF_CA 292..329 CDD:238011 11/40 (28%)
EGF_CA 332..367 CDD:238011 10/40 (25%)
EGF_CA 409..447 CDD:238011 13/57 (23%)
EGF_CA 449..485 CDD:238011 16/35 (46%)
EGF_CA 487..523 CDD:238011 9/37 (24%)
EGF_CA 525..561 CDD:238011 15/38 (39%)
EGF_CA 563..598 CDD:238011 13/35 (37%)
EGF_CA 600..636 CDD:238011 16/35 (46%)
EGF_CA 638..672 CDD:238011 20/34 (59%)
EGF_CA 675..711 CDD:238011 19/35 (54%)
EGF_CA 715..747 CDD:238011 6/31 (19%)
EGF_CA 752..786 CDD:238011 13/35 (37%)
EGF_CA 788..824 CDD:238011 14/35 (40%)
EGF_CA 866..902 CDD:238011 11/35 (31%)
EGF_CA 904..940 CDD:238011 13/35 (37%)
EGF_CA 942..978 CDD:238011 15/64 (23%)
EGF_CA 985..1016 CDD:238011 10/91 (11%)
EGF_CA 1018..1054 CDD:238011 13/51 (25%)
EGF 1060..1090 CDD:278437 8/36 (22%)
EGF_CA 1143..1177 CDD:238011 10/88 (11%)
EGF_CA 1181..1216 CDD:238011 15/69 (22%)
EGF_CA 1218..1262 CDD:238011 16/65 (25%)
EGF_CA 1264..1298 CDD:238011 10/36 (28%)
EGF_CA <1309..1340 CDD:238011 14/48 (29%)
NL 1437..1473 CDD:197463 9/40 (23%)
Notch 1481..1516 CDD:278494 8/57 (14%)
NL 1515..1555 CDD:197463 11/53 (21%)
NOD 1561..1612 CDD:284282 10/58 (17%)
NODP 1667..1724 CDD:284987
Ank_2 <1867..1953 CDD:289560
ANK repeat 1874..1920 CDD:293786
ANK 1917..2029 CDD:238125
ANK repeat 1922..1953 CDD:293786
Ank_2 1927..2020 CDD:289560
ANK repeat 1955..1986 CDD:293786
ANK 1984..2108 CDD:238125
ANK repeat 1989..2053 CDD:293786
Ank_2 1994..2086 CDD:289560
ANK repeat 2055..2086 CDD:293786
DUF3454 2404..2467 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10660
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.920

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