DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and crb2a

DIOPT Version :10

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001038764.1 Gene:crb2a / 723994 ZFINID:ZDB-GENE-060612-1 Length:1466 Species:Danio rerio


Alignment Length:1697 Identity:419/1697 - (24%)
Similarity:608/1697 - (35%) Gaps:517/1697 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2056 CEQDIDECASQPCYNGGQCKDLPQGYRCECP---AGYSGINCQEEASDCGNDTCPARAMCKNEPG 2117
            |....|.|||.||.||..|.|....|.|.|.   ..|.|.:|:|..:.|....|..   |::|.|
Zfish    27 CSGSSDLCASSPCQNGATCVDTMDDYVCLCSREGVRYMGRDCEELYNACMFAECEG---CESELG 88

  Fly  2118 YKNVTC-----LCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCEQ 2177
            ..:.||     .|:||           ||....:.|.|       ||..|||.|.||:.|..|..
Zfish    89 TDHYTCPEDKDECKSG-----------PCVGPHSECVN-------EQNGYKCLCPPGFGGEDCSH 135

  Fly  2178 NINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKHGT-CVDRLFDHECVC 2241
            .|.||.:.|||....|..:|:.|:|||..||.|:.||:.:|.|.|.||::|. |:|.:..::|.|
Zfish   136 RITDCIDEPCLNNGTCRRIVDGFECACSDGFRGETCEEDLDECDSHPCQNGAICLDGVNKYQCFC 200

  Fly  2242 HPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATC 2306
            .||:.|..|:|:|::|.:|||.|.|||::..|.|.|:|..||||.||:..||:|.|||||:||||
Zfish   201 VPGYQGHNCEIDINECASRPCWNNGTCINGKDRYLCDCLLGYTGVNCELEIDECESNPCQNGATC 265

  Fly  2307 VDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCR-DGFKGPLCATDI 2370
            .|.:..::|.|..|:.|..||..||||.|.||...|.  |.|..:.:||.|. .|:.|..|..||
Zfish   266 HDLVGLYTCDCVQGFEGSDCEINIDECESGPCQNGGL--CHDRIDSYECECEGTGYMGDHCEEDI 328

  Fly  2371 DDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQ------- 2428
            .:|.:.||.:.|.|.:.:..:.|.|.||:.|..||..:..| |.|||:||..|.:...       
Zfish   329 PECASHPCQHGGTCLEGINHYNCSCWPGFEGGNCEVDIDEC-ADAPCENDGECFEKSNPEHWETD 392

  Fly  2429 ---------DYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYE 2484
                     .|.|.|..|..|:||......|:.:||.:||.|:|..:|..|.||..::|:.|:..
Zfish   393 WEFTYATAVGYVCQCQPGYTGENCSVNINECVSEPCHNGGSCKDLVNGYMCECPEGFTGVECEVN 457

  Fly  2485 YDACEEHVCQNGATCVDNGAGYSCQC--------PPGFTGRNCEQDIVDCKDNSCPPGATCVDL- 2540
            .|.||...|.||..|.|..|.|.|.|        |.|  |..|...::.|..:.|..||||:.. 
Zfish   458 IDECESAPCLNGGVCEDGVAEYKCHCAEAEEGLLPWG--GPQCTVQLLGCIGHECQNGATCLPWL 520

  Fly  2541 ---TNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQK 2602
               |:|..|.||.....|.|  :||..:.  ||.|.                             
Zfish   521 DGETHGHTCLCPPGFYDDVC--SIQTTFS--FSSPR----------------------------- 552

  Fly  2603 DDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSF--------------GEYT 2653
                 ||.   ::...:.::||.....|..||::......||..|.|              ||..
Zfish   553 -----FFL---IELPSLERRRRETEPEHPLGVRLRFRTTLPDMLLFFRGNAEFFLSLEIVGGELR 609

  Fly  2654 S-----------------VNDGQWHHVAVVWDGISGQLQLITEGL--------IASKMEYG---- 2689
            :                 |:||.||...|..:....:|.|..:|.        :..|::.|    
Zfish   610 ARATSKEEGSLEAQLPGLVSDGDWHEAIVNINEHDIRLVLQVKGANCNNQACRVEDKLQDGHETF 674

  Fly  2690 -AGGSLPGYLWAVLGLPQPY-GLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEP 2752
             ...||....  |.|:|:.| ||:    .|..||.|.:...||                  ...|
Zfish   675 LHHDSLTKVY--VGGVPEEYIGLT----LSGQGFLGCMEDLQV------------------DGHP 715

  Fly  2753 VLYPGLILNWAGYE---VTSGGVE----RNVPSLCGQR-KCPVGYTGANCQQLVVDKEPPVVEHC 2809
            ||...|     |:|   |..|.|:    :..|..|.|: .|...:|...|...    .|...:.|
Zfish   716 VLPHDL-----GHEEESVELGCVKTEWCQEDPQPCSQQGHCVDLWTSYRCDCY----RPHYGQDC 771

  Fly  2810 PGDL--WVIA-KNGSAVVSWD-EPHFSDNIGVT---KIYERNG-----HRSGTTLLWGTYDITY- 2861
            ..|:  |... :|.::.:::: ...|..|..|:   :..:.:|     .|||   :.||.|..| 
Zfish   772 SKDMPTWTFGHENSTSFLAFELLSDFGSNFSVSFFLRSLKSSGLLFQLRRSG---VQGTEDEPYF 833

  Fly  2862 ----------IASDAAG----------------------------NTASCSFKVSLLTDFCPALA 2888
                      :.|.|..                            |.....:.:.||.|......
Zfish   834 TIYLEMGRLQVTSMAESPILSSPVFVSNGEKPLLQVDIQDGQVFFNHGGYRYGLGLLPDLEVLEG 898

  Fly  2889 D-----PVGGSQVCKDWGAGGQFKVCEIACNAGLRFSE---PVPEFYTCGAEGFWRPTREPSMPL 2945
            |     .|.|.:....|  ||.||    .|...||..:   .|.:         |..|...|:.:
Zfish   899 DLLYIGGVPGEEGATVW--GGHFK----GCLQDLRLDDVHLDVED---------WNNTLSESIYI 948

  Fly  2946 ------VYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNG--LNRDWN--FCSY 3000
                  |.|.|:                ||..|          |:...:||  ....||  .||.
Zfish   949 ASDSENVLPGCT----------------SDDTC----------KMEPCLNGGACTVTWNDFICSC 987

  Fly  3001 AIEGTRE------------------CKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVV 3047
            ..:.|.:                  |.|:....:|.......|..:...||..   :::   ||.
Zfish   988 PKDFTGKTCETRVWCVSDPCINGGHCVDLLDGFECIANATFDNTPLHYSAKGS---LLD---PVT 1046

  Fly  3048 NDDDDDLTLTGRQGRQQTG-------GDTYTLEIAFPAANDPVVHTS--------TGERSTVKQL 3097
            |     :|:..|. ||:.|       |:...|.....::....:||:        :|:|......
Zfish  1047 N-----VTMKLRT-RQENGVLLRAWRGEELLLIGLLDSSIHVEIHTANSVEPVKFSGQRRIADGN 1105

  Fly  3098 LEKLILEDDQFAVQE---------ILPNTVPDPASLELGSEYACPVGQVVMIPD-CVPCAIGTFY 3152
            ..:|:     ||:..         :|.:.:.|      ||......|.:..:.| ....|:...:
Zfish  1106 WHRLL-----FAMAHPEHDASQWFVLVDGIID------GSSAPVLAGSLNFLKDISSEVALAETF 1159

  Fly  3153 DSANKTCIACSR--GTY------------------QSEAGQLQCSKCPVIAGRPGVTAGPGARSA 3197
            ..    |:...|  |.|                  ..|...|.|...||....|       .|..
Zfish  1160 TG----CLGAVRVGGVYLPFVDNTKSPQTTRFWRRPDEHVHLGCFGAPVCRSHP-------CRRG 1213

  Fly  3198 ADCKE-------RCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECR 3255
            ..|.:       :||:|.                    ||:. ||                ||. 
Zfish  1214 GTCVDLFNKFGCKCPSGW--------------------EGNI-CE----------------KEI- 1240

  Fly  3256 DECSSGQQLGADGRCEPCPRGTYRLQGVQPSCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNA 3320
            |||.||..|  .|:|:.      :|.|....|.....|.|.    :.::::|....|..|     
Zfish  1241 DECISGPCL--HGKCKD------KLNGFDCLCHPGYAGPTC----SENIDDCKGSRCKNG----- 1288

  Fly  3321 TQNMCIECRKGYYQSESQQTSCLQCPPNHS-TKITGATSKSECTNPCEHIAEGKPHCDVNAYCIM 3384
              ..|::....:        :|: |||.:| |:........:|....|        |:.:..|..
Zfish  1289 --GTCVDGVNDF--------TCI-CPPKYSGTRCQYNYPPLKCALDVE--------CENDGVCHD 1334

  Fly  3385 VPETSDFKCECKPGFNGTGMAC---TDVC-DGFCENSGACVKDLKGTPSCRCVGSFTGPHC---- 3441
            .|..::  |.|.|||  ||..|   .|.| ...|.|.|:|: |......|.|...|:|..|    
Zfish  1335 TPWGAN--CTCPPGF--TGERCEREIDECASSPCLNGGSCL-DRLNRFQCLCPAGFSGQFCETNK 1394

  Fly  3442 -AERSEFAYIAGGIAGAVIFIIIIVL-LIWMICVRSTKRRDPKKMLTPAIDQTGSQVNFYYGAHT 3504
             |::....::|..:..|...|:::.: ||:|:.....||:..                   |.::
Zfish  1395 QAQQDHIPWLAIAVPLACGCILLVAIGLIFMLMTARKKRQSE-------------------GTYS 1440

  Fly  3505 PYAESIA 3511
            |..:.:|
Zfish  1441 PSHQEVA 1447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
PHA02639 697..>834 CDD:165022
FA58C 833..976 CDD:330301
FXa_inhibition 988..>1016 CDD:464251
CCP 1051..1106 CDD:153056
FA58C 1303..1443 CDD:330301
HYR 1463..1547 CDD:460572
HYR 1548..1631 CDD:460572
Ephrin_rec_like 1862..1909 CDD:429604
Ephrin_rec_like 1916..1966 CDD:429604
Ephrin_rec_like 1973..2020 CDD:429604
EGF 2025..2055 CDD:394967
EGF_CA 2059..2095 CDD:238011 15/38 (39%)
EGF_CA 2138..2176 CDD:238011 13/37 (35%)
EGF_CA 2178..2214 CDD:238011 15/35 (43%)
EGF_CA 2253..2289 CDD:238011 18/35 (51%)
EGF_CA 2292..2327 CDD:238011 17/34 (50%)
EGF_CA 2369..2405 CDD:238011 12/35 (34%)
EGF_CA 2411..2444 CDD:238011 14/48 (29%)
EGF_CA 2486..2520 CDD:238011 15/41 (37%)
EGF_CA 2522..2557 CDD:238011 12/38 (32%)
LamG 2590..2735 CDD:473984 38/189 (20%)
HYR 2799..2877 CDD:460572 19/128 (15%)
Ephrin_rec_like 3149..3200 CDD:429604 11/70 (16%)
Ephrin_rec_like 3207..3254 CDD:429604 6/46 (13%)
Ephrin_rec_like 3268..3307 CDD:429604 7/38 (18%)
Ephrin_rec_like 3315..3362 CDD:429604 8/47 (17%)
crb2aNP_001038764.1 EGF_CA 32..69 CDD:238011 15/36 (42%)
EGF_CA 97..133 CDD:238011 16/53 (30%)
EGF_CA <144..172 CDD:238011 12/27 (44%)
EGF_CA 174..210 CDD:238011 13/35 (37%)
EGF_CA 212..248 CDD:238011 18/35 (51%)
EGF_CA 251..286 CDD:238011 17/34 (50%)
EGF_CA 288..325 CDD:238011 15/38 (39%)
EGF_CA 327..363 CDD:238011 12/35 (34%)
EGF_CA 365..416 CDD:238011 13/51 (25%)
EGF_CA 419..455 CDD:238011 12/35 (34%)
EGF_CA 457..>485 CDD:214542 12/27 (44%)
LamG 576..712 CDD:238058 32/159 (20%)
LamG 786..929 CDD:238058 28/151 (19%)
EGF_CA <969..997 CDD:238011 7/27 (26%)
LamG 1046..1168 CDD:238058 23/142 (16%)
EGF_CA <1208..1237 CDD:238011 8/56 (14%)
EGF_CA 1240..1273 CDD:238011 12/41 (29%)
EGF_CA 1276..1312 CDD:238011 10/51 (20%)
EGF_CA 1320..1353 CDD:238011 12/44 (27%)
EGF_CA 1356..1391 CDD:238011 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

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