DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment uif and ELAPOR1

DIOPT Version :9

Sequence 1:	NP_001162899.1	Gene:	uif / 33983	FlyBaseID:	FBgn0031879	Length:	3589	Species:	Drosophila melanogaster
Sequence 2:	NP_065826.3	Gene:	ELAPOR1 / 57535	HGNCID:	29618	Length:	1013	Species:	Homo sapiens

Alignment Length:	793	Identity:	164/793 - (20%)
Similarity:	237/793 - (29%)	Gaps:	300/793 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1624 AC-----HFQVSVKASPCVDWELQ-PPANGAINCLPGD-RGIECIATCKPGFRFTDGEPLKTFSC 1681
            ||     |::.:...|....|.:. |...|....||.. :|.||..:|..| .|.|   :|..||
Human    48 ACKESEYHYEYTACDSTGSRWRVAVPHTPGLCTSLPDPIKGTECSFSCNAG-EFLD---MKDQSC 108

  Fly  1682 ETSRLWRPTSVVPDCVSENTEQAAYHVTASITYRANGAVAQSCLGQYQEVLAQHYGGLNQLLSQR 1746
            :            .|.     :..|.:...|.:           .::.| |...:..|:..:...
Human   109 K------------PCA-----EGRYSLGTGIRF-----------DEWDE-LPHGFASLSANMELD 144

  Fly  1747 CSAVNVNMNVTFVKSVPMLLEENVVKMDFILS--------ILPAVRQPQLYDLCGSTLNLIFDLS 1803
            .||.....|.|..|.||        :.|:|.|        ::.||...|     ..|:|  |:..
Human   145 DSAAESTGNCTSSKWVP--------RGDYIASNTDECTATLMYAVNLKQ-----SGTVN--FEYY 194

  Fly  1804 VPYASAVIDDLLNIANIGNQCPP----LRALKS----------QISRGFNCNVGEVLNMDT---- 1850
            .|.:|.:.:..:.    .:||.|    .|.:|:          :::||.|     ||...|
Human   195 YPDSSIIFEFFVQ----NDQCQPNADDSRWMKTTEKGWEFHSVELNRGNN-----VLYWRTTAFS 250

  Fly  1851 --SDVPR-----------------CLHCPAGTYV-SEGQNSCTYCPRGYYQNRDRQGTCLRCPAG 1895
              :.||:                 |..|..|||. .:|.:.|..||...|.|:. :.:|.:|...
Human   251 VWTKVPKPVLVRNIAITGVAYTSECFPCKPGTYADKQGSSFCKLCPANSYSNKG-ETSCHQCDPD 314

  Fly  1896 TYTKEEGTKSQADCIPVCGYGTYSPTGLVPCLECPRNSFT------AEPPTGGFKDCQACPAQSF 1954
            .|: |:|: |..:..|.|....|..|...    |..|..|      |:|     |.|.. ..:..
Human   315 KYS-EKGS-SSCNVRPACTDKDYFYTHTA----CDANGETQLMYKWAKP-----KICSE-DLEGA 367

  Fly  1955 TYQPAASNKDLCRAKCAPGTYSATGLAPCSPCPLHHYQGAAGAQSC---------------NECP 2004
            ...||:..|..| ..|.||.:. |..:.|.|||...|...:....|               |..|
Human   368 VKLPASGVKTHC-PPCNPGFFK-TNNSTCQPCPYGSYSNGSDCTRCPAGTEPAVGFEYKWWNTLP 430

  Fly  2005 SNMRTDSPASKGREQCKPVVCGEGACQHGGLCVPMGHDIQCFCPAGFS------------GRRCE 2057
            :||.| :..|....:.|.:...|.|..|            .:..||.|            |.|..
Human   431 TNMET-TVLSGINFEYKGMTGWEVAGDH------------IYTAAGASDNDFMILTLVVPGFRPP 482

  Fly  2058 QDI----------------DECASQPC------------------YNGGQCK------------- 2075
            |.:                :...|..|                  :.|.:.|
Human   483 QSVMADTENKEVARITFVFETLCSVNCELYFMVGVNSRTNTPVETWKGSKGKQSYTYIIEENTTT 547

  Fly  2076 --------------------DLPQGYRCECPAGYSGI-----NCQEEASDCGND--TCPARAMCK 2113
                                |:.:.|........:|:     .|..||||.|:.  :|||
Human   548 SFTWAFQRTTFHEASRKYTNDVAKIYSINVTNVMNGVASYCRPCALEASDVGSSCTSCPA----- 607

  Fly  2114 NEPGYKNVTCLCRSGYTGDQCDVTIDPCTAN-----GNPCGNGASCQALEQGRYKCECVPGWEG- 2172
                          ||..|:...|...|..|     ..|.|..|             |||...|
Human   608 --------------GYYIDRDSGTCHSCPTNTILKAHQPYGVQA-------------CVPCGPGT 645

  Fly  2173 ----IH--CEQNINDCS---ENPC-LLGANCTDLVNDFQCACPPGFTGKRCEQ----KIDLCLSE 2223
                ||  |   .|||:   ..|. ....|.:.|.|....|..|.||.|..:.    .:.||.::
Human   646 KNNKIHSLC---YNDCTFSRNTPTRTFNYNFSALANTVTLAGGPSFTSKGLKYFHHFTLSLCGNQ 707

  Fly  2224 PCKHGTCVDRLFD 2236
            ..|...|.|.:.|
Human   708 GRKMSVCTDNVTD 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uif	NP_001162899.1	CLECT	36..167	CDD:214480
		LDLa	172..206	CDD:238060
		CUB	220..319	CDD:238001
		CUB	326..435	CDD:238001
		CUB	439..550	CDD:238001
		PHA02927	<568..733	CDD:222943
		CCP	675..731	CDD:153056
		CCP	736..791	CDD:153056
		EGF_CA	792..829	CDD:214542
		FA58C	828..977	CDD:214572
		FA58C	833..976	CDD:238014
		FXa_inhibition	988..>1016	CDD:291342
		CCP	1051..1106	CDD:153056
		FA58C	1297..1444	CDD:214572
		FA58C	1303..1443	CDD:238014
		DUF5011	1463..1547	CDD:295940
		DUF5011	1548..1631	CDD:295940	3/11 (27%)
		GCC2_GCC3	1862..1909	CDD:285001	15/47 (32%)
		GCC2_GCC3	1916..1966	CDD:285001	12/55 (22%)
		GCC2_GCC3	1973..2020	CDD:285001	14/61 (23%)
		EGF	2025..2055	CDD:278437	7/41 (17%)
		EGF_CA	2059..2095	CDD:238011	7/107 (7%)
		EGF_CA	2138..2176	CDD:238011	11/49 (22%)
		EGF_CA	2178..2214	CDD:238011	12/39 (31%)
		EGF_CA	2253..2289	CDD:238011
		EGF_CA	2292..2327	CDD:238011
		EGF_CA	2330..2366	CDD:238011
		EGF_CA	2369..2405	CDD:238011
		EGF_CA	2411..2444	CDD:238011
		EGF_CA	2486..2520	CDD:238011
		EGF_CA	2522..2557	CDD:238011
		LamG	2590..2735	CDD:304605
		DUF5011	2799..2877	CDD:295940
		GCC2_GCC3	3149..3200	CDD:285001
		GCC2_GCC3	3207..3254	CDD:285001
		GCC2_GCC3	3268..3307	CDD:285001
		GCC2_GCC3	3315..3362	CDD:285001
ELAPOR1	NP_065826.3	VSP	275..>414	CDD:333463	42/153 (27%)
ELAPOR1	NP_065826.3	NCD3G	381..417	CDD:311495	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7782
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950