DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and Notch3

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_064472.3 Gene:Notch3 / 56761 RGDID:620761 Length:2319 Species:Rattus norvegicus


Alignment Length:1770 Identity:457/1770 - (25%)
Similarity:613/1770 - (34%) Gaps:572/1770 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1787 QLYDLCGSTLNLIFDLSVPYASAVIDDLLNIANIGN-QCPPLRALKSQISRGFNCNVGEVLNMDT 1850
            ||.|.|.|.         |.|...:.....:|.:.. .|..||..     ||.:|::     .|.
  Rat    79 QLEDPCHSG---------PCAGRGVCQSSVVAGVARFSCRCLRGF-----RGPDCSL-----PDP 124

  Fly  1851 SDVPRCLH---CPAGTYVSEGQNSCTYCPRGYYQNRDRQGTCLRCPAGTYTKEEG----TKSQAD 1908
            .....|.|   |..|   |:|:.:|. ||.| ||.|:.:.....|.||...:..|    |.....
  Rat   125 CFSSPCAHGAPCSVG---SDGRYACA-CPPG-YQGRNCRSDIDECRAGASCRHGGTCINTPGSFH 184

  Fly  1909 CIPVCGY-GTYSPTGLVPCLECP-RNSFTAEPPTGGFKDCQACPAQSFTYQPAASNKDLCRA-KC 1970
            |:...|| |......:|||...| ||..|....:....||...|  .|..|....|.|.|.. :|
  Rat   185 CLCPLGYTGLLCENPIVPCAPSPCRNGGTCRQSSDVTYDCACLP--GFEGQNCEVNVDDCPGHRC 247

  Fly  1971 APGTYSATGL----APCSPCPLHHYQGAAGAQSCNECPSNMRTDSPASKGREQCKPVVCGEGACQ 2031
            ..|.....|:    ..|.|    .:.|....:..:||               |.:|     .||.
  Rat   248 LNGGTCVDGVNTYNCQCPP----EWTGQFCTEDVDEC---------------QLQP-----NACH 288

  Fly  2032 HGGLCVPM--GHDIQCFCPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINC 2094
            :||.|..:  ||  .|.|..|::|..|.|:||:||:..|::|..|.|....:.|.||.|.:|:.|
  Rat   289 NGGTCFNLLGGH--SCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLC 351

  Fly  2095 QEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQ 2159
            ..:.: |.::.|...|:|...|......|.|..|:||..||..:|.|:...|||.:...| ...|
  Rat   352 HLDDA-CVSNPCHEDAICDTNPVSGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRC-VNTQ 414

  Fly  2160 GRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEP 2224
            |.:.|:|..|:.|..||.::|:|...||...|.|.|.:..|.|.|..||||..||..||.|.|.|
  Rat   415 GSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTFCEVDIDECQSSP 479

  Fly  2225 CKH-GTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNC 2288
            |.: |.|.||:....|.|..|::||.|.:::|:|.:.||.|...|||..|||.|.|..|:.|..|
  Rat   480 CVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC 544

  Fly  2289 QHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKF 2353
            :..:|||:.:||.|| .|||.:..|||.|.|||.|:.||:::|||.|.||...|  :||||.:|:
  Rat   545 ERNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGIRCESQVDECRSQPCRYGG--KCLDLVDKY 606

  Fly  2354 ECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQ 2418
            .|.|..|..|..|..:||||.:.|| ..|:|||.:..::|.|:||::|..|..::..| |.:||.
  Rat   607 LCRCPPGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINEC-ASSPCG 669

  Fly  2419 NDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQY 2483
            ...||:|....:.|:||.|:....|......|...||.| |.|.|...|..|.|...:||..|..
  Rat   670 EGGSCVDGENGFHCLCPPGSLPPLCLPVNHPCAHKPCSH-GVCHDAPGGFQCVCEPGWSGPRCSQ 733

  Fly  2484 EY--DACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCE-------------------------- 2520
            ..  ||||...||.|.||..:|.|:.|.|.|||.|..||                          
  Rat   734 SLAPDACESQPCQAGGTCTSDGIGFHCTCAPGFQGHQCEVLSPCTPSLCEHGGHCESDPDQLTVC 798

  Fly  2521 ------------QDIVDCKDNS-CPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDP 2572
                        ||:.:|...| |.|..||.:|...|.|.|....||..|      |.|:...||
  Rat   799 SCPPGWQGPRCQQDVDECAGASPCGPHGTCTNLPGSFRCICHGGYTGPFC------DQDIDDCDP 857

  Fly  2573 SRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIF--FTLYGVQSARMTQQRRMLLQAHSSGVQ 2635
            :          |.....|.          :|..|.|  ..|.|....|..:              
  Rat   858 N----------PCLNGGSC----------QDGVGSFSCSCLSGFAGPRCAR-------------- 888

  Fly  2636 VSLFEDQPDAFLS--FGEYTSVNDGQWHHVA----VVWDGISGQLQLITEGLIASKMEYGAGGSL 2694
                  ..|..||  .|..|..:     |||    ....|..| ....|:.|..|......||:.
  Rat   889 ------DVDECLSSPCGPGTCTD-----HVASFTCTCPPGYGG-FHCETDLLDCSPSSCFNGGTC 941

  Fly  2695 PGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLI 2759
            ..            |:::.......|:.||               ..|.:|..|.|.|.|:.| |
  Rat   942 VD------------GVNSFSCLCRPGYTGT---------------HCQYKVDPCFSRPCLHGG-I 978

  Fly  2760 LN--WAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKNGSA 2822
            .|  .:|:|.|                |..|:||..||.                          
  Rat   979 CNPTHSGFECT----------------CREGFTGNQCQN-------------------------- 1001

  Fly  2823 VVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVSLLTDFCPAL 2887
            .|.|          .::...:||.|...|   |.|.|                        ||  
  Rat  1002 PVDW----------CSQAPCQNGGRCVQT---GAYCI------------------------CP-- 1027

  Fly  2888 ADPVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSMPLVYPSCSP 2952
                      .:|..    .:|:|                             ||:|     |:.
  Rat  1028 ----------PEWSG----PLCDI-----------------------------PSLP-----CTE 1044

  Fly  2953 SKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDWNFCSYAIEGT--RECKDIQID- 3014
            : .|....|::.      ||...||.:            ::|.:......||.  ..|:. ::| 
  Rat  1045 A-AAHMGVRLEQ------LCQAGGQCI------------DKDHSHYCVCPEGRMGSHCEQ-EVDP 1089

  Fly  3015 ---VKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDD-DDDLTLTGRQGRQQTGGDTYTLEIA 3075
               ..|.| .||....:       |.||.|.......|. :||:.....|..|..|         
  Rat  1090 CTAQPCQH-GGTCRGYM-------GGYVCECPAGYSGDSCEDDVDECASQPCQNGG--------- 1137

  Fly  3076 FPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLELGSEY--ACPVGQVV 3138
                                                          :.::|.:.|  :||.|.:.
  Rat  1138 ----------------------------------------------SCIDLVAHYLCSCPPGTLG 1156

  Fly  3139 MI-----PDCVPCAIGTFYDSANKTCIACSRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSAA 3198
            ::     .||.|   |...||..: |:  ..||.....|..:|: ||     ||.|   |....|
  Rat  1157 VLCEINEDDCGP---GPSLDSGLR-CL--HNGTCVDLVGGFRCN-CP-----PGYT---GLHCEA 1206

  Fly  3199 DCKERCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDE-CSSGQ 3262
            |..| |..|....|.|   |.|    .|...|.|.| :|..|.|....: |:...|..: |..| 
  Rat  1207 DINE-CRPGTCHAAHT---RDC----LQDPGGHFRC-ICLPGFTGPRCQ-TALFPCESQPCQHG- 1260

  Fly  3263 QLGADGRCEP-CPRG---TYRLQGVQP-----------SC--AACPLGRTTPKVGASSVEECTLP 3310
                 |:|.| ..||   |:....|||           ||  ..||:|                 
  Rat  1261 -----GQCRPSLGRGGGLTFTCHCVQPFWGLRCERVARSCRELQCPVG----------------- 1303

  Fly  3311 VCSAGTYLNATQNMCIECRKGYYQSESQQTS----CLQCPPNHS--------TKITGATSKSECT 3363
                           |.|         |||:    | .|||..|        ...:|||:.|...
  Rat  1304 ---------------IPC---------QQTARGPRC-ACPPGLSGPSCRVSRASPSGATNTSCAA 1343

  Fly  3364 NPCEHIAEGKPHCDVNAYCIMVPETSDFKCECKPGFNG----TGMACTDV--------------- 3409
            .||.|          ...|:.|.....|:|.|.||:.|    |..|..:|               
  Rat  1344 TPCLH----------GGSCLPVQSVPFFRCVCAPGWGGPRCETPSAAPEVPEEPRCPRAACQAKR 1398

  Fly  3410 ----CDGFCENSGAC 3420
                ||..| ||..|
  Rat  1399 GDQNCDREC-NSPGC 1412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 15/50 (30%)
GCC2_GCC3 1916..1966 CDD:285001 15/50 (30%)
GCC2_GCC3 1973..2020 CDD:285001 7/50 (14%)
EGF 2025..2055 CDD:278437 11/31 (35%)
EGF_CA 2059..2095 CDD:238011 13/35 (37%)
EGF_CA 2138..2176 CDD:238011 12/37 (32%)
EGF_CA 2178..2214 CDD:238011 14/35 (40%)
EGF_CA 2253..2289 CDD:238011 15/35 (43%)
EGF_CA 2292..2327 CDD:238011 18/34 (53%)
EGF_CA 2330..2366 CDD:238011 16/35 (46%)
EGF_CA 2369..2405 CDD:238011 15/35 (43%)
EGF_CA 2411..2444 CDD:238011 11/32 (34%)
EGF_CA 2486..2520 CDD:238011 17/33 (52%)
EGF_CA 2522..2557 CDD:238011 13/35 (37%)
LamG 2590..2735 CDD:304605 26/152 (17%)
DUF5011 2799..2877 CDD:295940 9/77 (12%)
GCC2_GCC3 3149..3200 CDD:285001 15/50 (30%)
GCC2_GCC3 3207..3254 CDD:285001 13/46 (28%)
GCC2_GCC3 3268..3307 CDD:285001 14/55 (25%)
GCC2_GCC3 3315..3362 CDD:285001 14/58 (24%)
Notch3NP_064472.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
EGF_CA 160..197 CDD:238011 9/36 (25%)
EGF_CA 238..274 CDD:238011 9/39 (23%)
EGF_CA 276..313 CDD:238011 15/58 (26%)
EGF_CA 316..351 CDD:238011 13/34 (38%)
EGF_CA 393..431 CDD:238011 12/38 (32%)
EGF_CA 433..469 CDD:238011 14/35 (40%)
EGF_CA 471..507 CDD:238011 15/35 (43%)
EGF_CA 509..545 CDD:238011 15/35 (43%)
EGF_CA 547..582 CDD:238011 18/35 (51%)
EGF_CA 585..620 CDD:238011 16/36 (44%)
EGF_CA 622..656 CDD:238011 15/34 (44%)
EGF_CA 660..>688 CDD:238011 10/28 (36%)
EGF_CA 698..731 CDD:238011 12/33 (36%)
EGF_CA 738..772 CDD:238011 17/33 (52%)
EGF_CA 812..848 CDD:238011 13/35 (37%)
EGF_CA 851..886 CDD:238011 10/54 (19%)
EGF_CA 889..924 CDD:238011 10/40 (25%)
EGF_CA 931..962 CDD:238011 7/57 (12%)
EGF_CA 965..1000 CDD:238011 15/51 (29%)
EGF_CA 1087..1122 CDD:238011 10/42 (24%)
EGF_CA 1124..1160 CDD:238011 9/90 (10%)
EGF_CA 1173..1205 CDD:238011 13/43 (30%)
NL 1382..1419 CDD:197463 7/32 (22%)
LNR 1 1389..1429 6/25 (24%)
NL 1423..1460 CDD:197463
LNR 2 1430..1467
LNR 3 1469..1507
Notch 1473..1502 CDD:395019
NOD 1510..1562 CDD:399654
NODP 1580..1639 CDD:400155
JMTM_Notch3 1620..1711 CDD:411987
ANKYR <1779..1895 CDD:223738
ANK repeat 1790..1838 CDD:293786
ANK repeat 1840..1871 CDD:293786
ANK 1 1840..1869
ANKYR 1860..2026 CDD:223738
ANK repeat 1873..1905 CDD:293786
ANK 2 1873..1903
ANK repeat 1907..1938 CDD:293786
ANK 3 1907..1936
ANK repeat 1940..1971 CDD:293786
ANK 4 1940..1969
ANK repeat 1973..2004 CDD:293786
ANK 5 1973..2002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2026..2046
PHA03247 <2029..2316 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2197..2319
DUF3454 2213..2269 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11400
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.920

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