DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and crb1

DIOPT Version :10

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001038408.1 Gene:crb1 / 560942 ZFINID:ZDB-GENE-050208-382 Length:1428 Species:Danio rerio


Alignment Length:1692 Identity:388/1692 - (22%)
Similarity:600/1692 - (35%) Gaps:547/1692 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2063 CASQPCYNGGQCKDLPQGYRCECPAG---YSGINCQEEASDCGNDTCPARAMCK---NEPGYKNV 2121
            |...||.:..:|::....:.|:|...   :....|...::.|....|...|.|:   ..||  .:
Zfish    39 CLDNPCQHQSECREALSDFLCQCQTTVPVFPSTRCDSSSTLCQLSICQGNATCQPTGAHPG--EL 101

  Fly  2122 TCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQAL--EQGRYKCECVPGWEGIHCEQNINDCSE 2184
            .|.|.||..|..|..:...| |.|: ||:.|.|.|:  :...|.|.|..|:.|..||:.::.||.
Zfish   102 VCQCDSGLLGQDCLSSAQLC-AQGH-CGDSAHCLAVRDQSPGYACICQEGYTGRSCEKEVDHCSP 164

  Fly  2185 NPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKHG-TCVDRLFDHECVCHPGWTGS 2248
            |||...|.|....|...|.|.|||.|:.||.:::.|:|.||::| ||||::..:.|:|.||:.||
Zfish   165 NPCRNRAICRSRRNGPTCFCVPGFQGQLCEIEVNECVSRPCRNGATCVDKIGHYICLCRPGYMGS 229

  Fly  2249 ACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGF 2313
            :|::.||:|:::||.:..:|.|.::|::|.|..|:.|::|:..||:|...|||:||.|||:::.:
Zfish   230 SCELEIDECQSQPCLHGASCHDHINGFTCTCLAGFQGESCEINIDECRDQPCQNGALCVDEINSY 294

  Fly  2314 SCKC--RPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQ 2376
            .|.|  ...:.|:.||.....|.|.||  :.:..|.|....:.|.|..||:|..|..|:.:||:.
Zfish   295 RCDCSQTANFTGVDCEIPPPPCWSQPC--LNSALCEDQQENYTCNCWPGFEGRNCEVDVSECESS 357

  Fly  2377 PCLNNGICRD--------------------RVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDA 2421
            ||:|.|||.:                    ...||.|.|.||:||..|||..|.| ..:||.|.|
Zfish   358 PCVNEGICMELSWKTLYGTEPLFTARYNPRLASGFICKCPPGFSGALCEQNTTAC-TTSPCHNGA 421

  Fly  2422 SCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYD 2486
            :|.|....|.|:|||.::             |..::||:        |||.|           ..
Zfish   422 TCEDFLGSYKCICPSESE-------------DGVLYGGR--------NCSEP-----------LT 454

  Fly  2487 ACEEHVCQNGATCV----DNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQ 2547
            .||.|.|||||:|:    :...||||.|.||:||.                           |||
Zfish   455 GCEGHECQNGASCIPFLSEGVHGYSCICQPGYTGS---------------------------YCQ 492

  Fly  2548 CPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLY 2612
               .:|             ::..:.||:......|....|.                   :|.: 
Zfish   493 ---TLT-------------VFSFETSRAFLHLQTPLLGAET-------------------YFNI- 521

  Fly  2613 GVQSARMTQQRRMLLQAHSSGVQVSL------------FEDQPDAFLSFGEYTS--------VND 2657
             ..|.|...:..:|.|..|.||.:||            .:.||:|       ||        |:|
Zfish   522 -TLSFRTVLENTVLFQRGSGGVTLSLEIQETHLILDLKTDPQPNA-------TSWTLMLPQVVSD 578

  Fly  2658 GQWHHV-AVVWDGI----------------------SGQLQLITEGLIASKMEYG--AGGSLPGY 2697
            |:||.| ||:.:|.                      .|.|:|  |..:.|....|  .|||...:
Zfish   579 GEWHTVEAVLGEGTLLLQLLEPCQGGQNCGTTAQVKIGALEL--ESALLSTFVGGLDEGGSSRSF 641

  Fly  2698 LWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILN- 2761
            :          |...:|.. ||  |..|.:..:.:.|:::........| |.|.|....|..:| 
Zfish   642 I----------GCMRDLLV-DS--QLMIPEDWLSSSAVNVVQGCSHHDR-CLSGPCENHGECVNL 692

  Fly  2762 WAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQ-----------------LVVDKEPP----- 2804
            |.||                |.||...|.|.||.:                 ..::.||.     
Zfish   693 WQGY----------------QCKCLRPYVGQNCDEEYITTRFGQEDSTSYAVFTINDEPDSETLH 741

  Fly  2805 ---------------VVEHCPGD---LW-------VIAKN-----GSAVVSWDEPHFSDNIGVT- 2838
                           ::.:...|   :|       |...|     |..|::..|.||   :.|| 
Zfish   742 LSMFLRTRKDSGLLVLLANSTSDYLQMWLEKGKLTVQVNNLKTVTGERVLNDGERHF---VSVTI 803

  Fly  2839 ----KIYERNGHRSGTTLLWGTYDITYI--ASDAAGNTASCS--FKVSLLTDFCPALADPVGGSQ 2895
                ...:.:.|.         ::.||:  .|...|:|.:..  |.|..||.|            
Zfish   804 EDGMMTLQNSDHE---------FEATYVQPVSIQFGDTINVGGLFDVQALTAF------------ 847

  Fly  2896 VCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGF-WRPTREPSMP--------------- 2944
                   ||.||    .|...|:.:|...||:....... ::|.|...:.               
Zfish   848 -------GGHFK----GCLQDLQLNEKKLEFFPIDTSAMSYKPDRVVEVTAGCTSDDTCSKNPCQ 901

  Fly  2945 ---LVYPS-------CSPSKPAQRVFRIKML----FPSDVLCNKAGQA------VLRQKVTNSV- 2988
               :.:.|       |.|:...|....:...    .|...:|....|.      |..|:.|..| 
Zfish   902 NGGICFSSWDDFTCNCPPNTSGQHCEEVSWCDLNPCPPQAICKALNQGYECISNVTFQENTTLVY 966

  Fly  2989 --NGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYV--------MEAE 3043
              |||.            :|....|..::     |..:.|.:...|:.|..:|        :..|
Zfish   967 QGNGLI------------SRHLTSIVFNI-----RTRKRNAIVLHAESGSEFVTVSLQDGFLVLE 1014

  Fly  3044 L---PVVNDDDDDLTLTGRQGRQQTGGDTYTLEI--AFPAAN-------------DPVVHTS-TG 3089
            |   |..:.....:||  ...|....|:.:.:|:  |.|.:|             :|....| ||
Zfish  1015 LLSGPTTSSSLSPVTL--HSPRVVADGEWHVIELLMATPGSNSSHWIMVPLDEKDEPTKSDSMTG 1077

  Fly  3090 ERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLELGSEYACPVGQVVMIPDCVPCAIGTFY-- 3152
            ....:::            :|..:|....||..|..:|......:|.:|:          .:|  
Zfish  1078 NLDFLRE------------SVYIMLGGLGPDSGSNLIGCLSNVEIGGIVL----------PYYGQ 1120

  Fly  3153 ----------DSANKTCIACSRGTYQSEA-GQLQCSKCPVIAGRPGVTAGPGARSAADCKER--- 3203
                      :..||    .|....|:.. |::.|...|.:.|  |:           |.:.   
Zfish  1121 TEVRFPRTQEEMFNK----ISEEPVQTGCFGEVVCEPNPCLHG--GI-----------CDDHFNL 1168

  Fly  3204 ----C-P--AGKYFDAETGLCRS--CGHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECS 3259
                | |  .|.:.:..|..|.|  |.||:....:.:::| .|..|.|..:.|...     |.|:
Zfish  1169 FHCFCLPGWGGDHCELNTNTCASNPCRHGYCSVQDLTYNC-TCEDGYTGTNCEMKV-----DACA 1227

  Fly  3260 SGQQLGADGRCEPCPRGTYRLQGVQPSCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNM 3324
            ..:          |..|...|:|.......|             .::.|.|:|          |:
Zfish  1228 GHR----------CANGATCLRGFNMYSCLC-------------TDKFTGPLC----------NI 1259

  Fly  3325 CIECRKGYYQSESQQTSCLQCPPNHSTKITGATSKS-ECTNPCEHIAEGKPHCDVNAYCIMVPET 3388
            .||....|....:       .||.....|.|...:: .|.|       |....|.|         
Zfish  1260 QIEEVPWYVVVRN-------IPPKLPVSICGDEQQNYTCFN-------GGNCSDTN--------- 1301

  Fly  3389 SDFKCECKPGFNGTGMAC---TDVC-DGFCENSGACVKDLKGTPSCRCVGSFTGPHC-----AER 3444
              ..|:|.|||:|..  |   .|.| ...|:|.|.| :::.....|.|..:|.|..|     || 
Zfish  1302 --MPCDCHPGFSGHW--CELELDECRSNPCKNGGYC-QNMVNRFQCVCEMTFAGETCEVDLNAE- 1360

  Fly  3445 SEFAYIAGGIAGAVIFIIIIVLLIWMICVRSTKRRDPKKMLTPA-IDQTGSQVNFYYGAHTPYAE 3508
            |..:.:...|:...:.::::|..:....|.:..||..:...:|: .::.||:|..:.....|..|
Zfish  1361 SVTSQLLLSISLVCVVLLLVVFGVTTALVIALNRRATRGTYSPSRQEKEGSRVEMWNIVQPPPME 1425

  Fly  3509 SI 3510
            .:
Zfish  1426 RL 1427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
PHA02639 697..>834 CDD:165022
FA58C 833..976 CDD:330301
FXa_inhibition 988..>1016 CDD:464251
CCP 1051..1106 CDD:153056
FA58C 1303..1443 CDD:330301
HYR 1463..1547 CDD:460572
HYR 1548..1631 CDD:460572
Ephrin_rec_like 1862..1909 CDD:429604
Ephrin_rec_like 1916..1966 CDD:429604
Ephrin_rec_like 1973..2020 CDD:429604
EGF 2025..2055 CDD:394967
EGF_CA 2059..2095 CDD:238011 6/34 (18%)
EGF_CA 2138..2176 CDD:238011 13/39 (33%)
EGF_CA 2178..2214 CDD:238011 14/35 (40%)
EGF_CA 2253..2289 CDD:238011 12/35 (34%)
EGF_CA 2292..2327 CDD:238011 14/36 (39%)
EGF_CA 2369..2405 CDD:238011 17/55 (31%)
EGF_CA 2411..2444 CDD:238011 12/32 (38%)
EGF_CA 2486..2520 CDD:238011 18/37 (49%)
EGF_CA 2522..2557 CDD:238011 4/34 (12%)
LamG 2590..2735 CDD:473984 39/189 (21%)
HYR 2799..2877 CDD:460572 20/121 (17%)
Ephrin_rec_like 3149..3200 CDD:429604 10/63 (16%)
Ephrin_rec_like 3207..3254 CDD:429604 12/48 (25%)
Ephrin_rec_like 3268..3307 CDD:429604 5/38 (13%)
Ephrin_rec_like 3315..3362 CDD:429604 8/47 (17%)
crb1NP_001038408.1 EGF_CA 159..194 CDD:238011 14/34 (41%)
EGF_CA 197..232 CDD:238011 15/34 (44%)
EGF_CA 235..270 CDD:238011 12/34 (35%)
EGF_CA 272..310 CDD:238011 14/37 (38%)
EGF_CA <320..348 CDD:238011 9/29 (31%)
EGF_CA 413..441 CDD:214542 11/40 (28%)
EGF_CA 457..492 CDD:238011 18/61 (30%)
LamG 496..651 CDD:238058 39/195 (20%)
EGF_CA 676..709 CDD:238011 14/49 (29%)
Laminin_G_2 746..863 CDD:460494 28/151 (19%)
EGF_CA 896..927 CDD:238011 4/30 (13%)
LamG 956..1110 CDD:238058 35/184 (19%)
EGF 1151..1181 CDD:394967 8/42 (19%)
EGF_CA 1320..1354 CDD:238011 10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

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