DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and crb1

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001038408.1 Gene:crb1 / 560942 ZFINID:ZDB-GENE-050208-382 Length:1428 Species:Danio rerio


Alignment Length:1692 Identity:388/1692 - (22%)
Similarity:600/1692 - (35%) Gaps:547/1692 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2063 CASQPCYNGGQCKDLPQGYRCECPAG---YSGINCQEEASDCGNDTCPARAMCK---NEPGYKNV 2121
            |...||.:..:|::....:.|:|...   :....|...::.|....|...|.|:   ..||  .:
Zfish    39 CLDNPCQHQSECREALSDFLCQCQTTVPVFPSTRCDSSSTLCQLSICQGNATCQPTGAHPG--EL 101

  Fly  2122 TCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQAL--EQGRYKCECVPGWEGIHCEQNINDCSE 2184
            .|.|.||..|..|..:...| |.|: ||:.|.|.|:  :...|.|.|..|:.|..||:.::.||.
Zfish   102 VCQCDSGLLGQDCLSSAQLC-AQGH-CGDSAHCLAVRDQSPGYACICQEGYTGRSCEKEVDHCSP 164

  Fly  2185 NPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKHG-TCVDRLFDHECVCHPGWTGS 2248
            |||...|.|....|...|.|.|||.|:.||.:::.|:|.||::| ||||::..:.|:|.||:.||
Zfish   165 NPCRNRAICRSRRNGPTCFCVPGFQGQLCEIEVNECVSRPCRNGATCVDKIGHYICLCRPGYMGS 229

  Fly  2249 ACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGF 2313
            :|::.||:|:::||.:..:|.|.::|::|.|..|:.|::|:..||:|...|||:||.|||:::.:
Zfish   230 SCELEIDECQSQPCLHGASCHDHINGFTCTCLAGFQGESCEINIDECRDQPCQNGALCVDEINSY 294

  Fly  2314 SCKC--RPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQ 2376
            .|.|  ...:.|:.||.....|.|.||  :.:..|.|....:.|.|..||:|..|..|:.:||:.
Zfish   295 RCDCSQTANFTGVDCEIPPPPCWSQPC--LNSALCEDQQENYTCNCWPGFEGRNCEVDVSECESS 357

  Fly  2377 PCLNNGICRD--------------------RVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDA 2421
            ||:|.|||.:                    ...||.|.|.||:||..|||..|.| ..:||.|.|
Zfish   358 PCVNEGICMELSWKTLYGTEPLFTARYNPRLASGFICKCPPGFSGALCEQNTTAC-TTSPCHNGA 421

  Fly  2422 SCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYD 2486
            :|.|....|.|:|||.::             |..::||:        |||.|           ..
Zfish   422 TCEDFLGSYKCICPSESE-------------DGVLYGGR--------NCSEP-----------LT 454

  Fly  2487 ACEEHVCQNGATCV----DNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQ 2547
            .||.|.|||||:|:    :...||||.|.||:||.                           |||
Zfish   455 GCEGHECQNGASCIPFLSEGVHGYSCICQPGYTGS---------------------------YCQ 492

  Fly  2548 CPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLY 2612
               .:|             ::..:.||:......|....|.                   :|.: 
Zfish   493 ---TLT-------------VFSFETSRAFLHLQTPLLGAET-------------------YFNI- 521

  Fly  2613 GVQSARMTQQRRMLLQAHSSGVQVSL------------FEDQPDAFLSFGEYTS--------VND 2657
             ..|.|...:..:|.|..|.||.:||            .:.||:|       ||        |:|
Zfish   522 -TLSFRTVLENTVLFQRGSGGVTLSLEIQETHLILDLKTDPQPNA-------TSWTLMLPQVVSD 578

  Fly  2658 GQWHHV-AVVWDGI----------------------SGQLQLITEGLIASKMEYG--AGGSLPGY 2697
            |:||.| ||:.:|.                      .|.|:|  |..:.|....|  .|||...:
Zfish   579 GEWHTVEAVLGEGTLLLQLLEPCQGGQNCGTTAQVKIGALEL--ESALLSTFVGGLDEGGSSRSF 641

  Fly  2698 LWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILN- 2761
            :          |...:|.. ||  |..|.:..:.:.|:::........| |.|.|....|..:| 
Zfish   642 I----------GCMRDLLV-DS--QLMIPEDWLSSSAVNVVQGCSHHDR-CLSGPCENHGECVNL 692

  Fly  2762 WAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQ-----------------LVVDKEPP----- 2804
            |.||                |.||...|.|.||.:                 ..::.||.     
Zfish   693 WQGY----------------QCKCLRPYVGQNCDEEYITTRFGQEDSTSYAVFTINDEPDSETLH 741

  Fly  2805 ---------------VVEHCPGD---LW-------VIAKN-----GSAVVSWDEPHFSDNIGVT- 2838
                           ::.:...|   :|       |...|     |..|::..|.||   :.|| 
Zfish   742 LSMFLRTRKDSGLLVLLANSTSDYLQMWLEKGKLTVQVNNLKTVTGERVLNDGERHF---VSVTI 803

  Fly  2839 ----KIYERNGHRSGTTLLWGTYDITYI--ASDAAGNTASCS--FKVSLLTDFCPALADPVGGSQ 2895
                ...:.:.|.         ::.||:  .|...|:|.:..  |.|..||.|            
Zfish   804 EDGMMTLQNSDHE---------FEATYVQPVSIQFGDTINVGGLFDVQALTAF------------ 847

  Fly  2896 VCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGF-WRPTREPSMP--------------- 2944
                   ||.||    .|...|:.:|...||:....... ::|.|...:.               
Zfish   848 -------GGHFK----GCLQDLQLNEKKLEFFPIDTSAMSYKPDRVVEVTAGCTSDDTCSKNPCQ 901

  Fly  2945 ---LVYPS-------CSPSKPAQRVFRIKML----FPSDVLCNKAGQA------VLRQKVTNSV- 2988
               :.:.|       |.|:...|....:...    .|...:|....|.      |..|:.|..| 
Zfish   902 NGGICFSSWDDFTCNCPPNTSGQHCEEVSWCDLNPCPPQAICKALNQGYECISNVTFQENTTLVY 966

  Fly  2989 --NGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYV--------MEAE 3043
              |||.            :|....|..::     |..:.|.:...|:.|..:|        :..|
Zfish   967 QGNGLI------------SRHLTSIVFNI-----RTRKRNAIVLHAESGSEFVTVSLQDGFLVLE 1014

  Fly  3044 L---PVVNDDDDDLTLTGRQGRQQTGGDTYTLEI--AFPAAN-------------DPVVHTS-TG 3089
            |   |..:.....:||  ...|....|:.:.:|:  |.|.:|             :|....| ||
Zfish  1015 LLSGPTTSSSLSPVTL--HSPRVVADGEWHVIELLMATPGSNSSHWIMVPLDEKDEPTKSDSMTG 1077

  Fly  3090 ERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLELGSEYACPVGQVVMIPDCVPCAIGTFY-- 3152
            ....:::            :|..:|....||..|..:|......:|.:|:          .:|  
Zfish  1078 NLDFLRE------------SVYIMLGGLGPDSGSNLIGCLSNVEIGGIVL----------PYYGQ 1120

  Fly  3153 ----------DSANKTCIACSRGTYQSEA-GQLQCSKCPVIAGRPGVTAGPGARSAADCKER--- 3203
                      :..||    .|....|:.. |::.|...|.:.|  |:           |.:.   
Zfish  1121 TEVRFPRTQEEMFNK----ISEEPVQTGCFGEVVCEPNPCLHG--GI-----------CDDHFNL 1168

  Fly  3204 ----C-P--AGKYFDAETGLCRS--CGHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECS 3259
                | |  .|.:.:..|..|.|  |.||:....:.:::| .|..|.|..:.|...     |.|:
Zfish  1169 FHCFCLPGWGGDHCELNTNTCASNPCRHGYCSVQDLTYNC-TCEDGYTGTNCEMKV-----DACA 1227

  Fly  3260 SGQQLGADGRCEPCPRGTYRLQGVQPSCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNM 3324
            ..:          |..|...|:|.......|             .::.|.|:|          |:
Zfish  1228 GHR----------CANGATCLRGFNMYSCLC-------------TDKFTGPLC----------NI 1259

  Fly  3325 CIECRKGYYQSESQQTSCLQCPPNHSTKITGATSKS-ECTNPCEHIAEGKPHCDVNAYCIMVPET 3388
            .||....|....:       .||.....|.|...:: .|.|       |....|.|         
Zfish  1260 QIEEVPWYVVVRN-------IPPKLPVSICGDEQQNYTCFN-------GGNCSDTN--------- 1301

  Fly  3389 SDFKCECKPGFNGTGMAC---TDVC-DGFCENSGACVKDLKGTPSCRCVGSFTGPHC-----AER 3444
              ..|:|.|||:|..  |   .|.| ...|:|.|.| :::.....|.|..:|.|..|     || 
Zfish  1302 --MPCDCHPGFSGHW--CELELDECRSNPCKNGGYC-QNMVNRFQCVCEMTFAGETCEVDLNAE- 1360

  Fly  3445 SEFAYIAGGIAGAVIFIIIIVLLIWMICVRSTKRRDPKKMLTPA-IDQTGSQVNFYYGAHTPYAE 3508
            |..:.:...|:...:.::::|..:....|.:..||..:...:|: .::.||:|..:.....|..|
Zfish  1361 SVTSQLLLSISLVCVVLLLVVFGVTTALVIALNRRATRGTYSPSRQEKEGSRVEMWNIVQPPPME 1425

  Fly  3509 SI 3510
            .:
Zfish  1426 RL 1427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001
GCC2_GCC3 1916..1966 CDD:285001
GCC2_GCC3 1973..2020 CDD:285001
EGF 2025..2055 CDD:278437
EGF_CA 2059..2095 CDD:238011 6/34 (18%)
EGF_CA 2138..2176 CDD:238011 13/39 (33%)
EGF_CA 2178..2214 CDD:238011 14/35 (40%)
EGF_CA 2253..2289 CDD:238011 12/35 (34%)
EGF_CA 2292..2327 CDD:238011 14/36 (39%)
EGF_CA 2330..2366 CDD:238011 11/35 (31%)
EGF_CA 2369..2405 CDD:238011 17/55 (31%)
EGF_CA 2411..2444 CDD:238011 12/32 (38%)
EGF_CA 2486..2520 CDD:238011 18/37 (49%)
EGF_CA 2522..2557 CDD:238011 4/34 (12%)
LamG 2590..2735 CDD:304605 39/189 (21%)
DUF5011 2799..2877 CDD:295940 20/121 (17%)
GCC2_GCC3 3149..3200 CDD:285001 10/63 (16%)
GCC2_GCC3 3207..3254 CDD:285001 12/48 (25%)
GCC2_GCC3 3268..3307 CDD:285001 5/38 (13%)
GCC2_GCC3 3315..3362 CDD:285001 8/47 (17%)
crb1NP_001038408.1 EGF_CA 159..194 CDD:238011 14/34 (41%)
EGF_CA 197..232 CDD:238011 15/34 (44%)
EGF_CA 235..270 CDD:238011 12/34 (35%)
EGF_CA 272..310 CDD:238011 14/37 (38%)
EGF_CA <320..348 CDD:238011 9/29 (31%)
EGF_CA 413..441 CDD:214542 11/40 (28%)
EGF_CA 457..492 CDD:238011 18/61 (30%)
LamG 496..651 CDD:238058 39/195 (20%)
EGF_CA 676..709 CDD:238011 14/49 (29%)
Laminin_G_2 746..863 CDD:280389 28/151 (19%)
EGF_CA 896..927 CDD:238011 4/30 (13%)
Laminin_G_2 983..1113 CDD:280389 27/148 (18%)
EGF 1151..1181 CDD:278437 8/42 (19%)
EGF_CA 1320..1354 CDD:238011 10/34 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580590
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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