DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and NOTCH4

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens


Alignment Length:1251 Identity:337/1251 - (26%)
Similarity:448/1251 - (35%) Gaps:360/1251 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1909 CIPVCGYGTYSPTGLV------PCLECPRNSFTAEPPTGGFKDCQACP---AQSFTYQPAASNKD 1964
            |:.|     ..|.||:      ||    .|..|....:.|...||..|   .::..:.....|..
Human    17 CVSV-----VRPRGLLCGSFPEPC----ANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQ 72

  Fly  1965 LCR--AKCAPGTYSATGLAPCSPCPLHH------YQGAAGAQSCNECPSNMRTDSPAS------- 2014
            ||:  ..|.....:..|| |.||.||..      ..|..|    ..|.:.:....|.|       
Human    73 LCQNGGSCQALLPAPLGL-PSSPSPLTPSFLCTCLPGFTG----ERCQAKLEDPCPPSFCSKRGR 132

  Fly  2015 -----KGREQCKPV------------VCGEGACQHGGLCVPMGHDIQCFCPAGFSGRRCEQDIDE 2062
                 .||.||..:            .|....|.:||:|:.....|||.||.||.|..||:|::|
Human   133 CHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNE 197

  Fly  2063 CASQP----------------------------------------CYNGGQCKDLPQG----YRC 2083
            |...|                                        |.|||.|:.:|:.    :.|
Human   198 CFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLC 262

  Fly  2084 ECPAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNP- 2147
            .||.|:.|.:|:....:|.:..|.....|::  |....||||...:||..|...:|.|...|.| 
Human   263 LCPPGFIGPDCEVNPDNCVSHQCQNGGTCQD--GLDTYTCLCPETWTGWDCSEDVDECETQGPPH 325

  Fly  2148 CGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKR 2212
            |.||.:||. ..|.:.|.||.||.|..||:|::||....|..|:.|.|.|..|.|.||||.||..
Human   326 CRNGGTCQN-SAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLL 389

  Fly  2213 CEQKIDLCLSEPCKHG--TCVDRLFDHE--CVCHPGWTGSACDINIDDC-----ENRPCANEGTC 2268
            |..: |:|||:|| ||  .|........  |:|.||::|..|..::|:|     ...||.:.|:|
Human   390 CHLE-DMCLSQPC-HGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSC 452

  Fly  2269 VDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDEC 2333
            ::....::|.|.|||||..|:...::|.|.||..|:||:|.|..|.|.|.||..|..||.|.:||
Human   453 LNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNEC 517

  Fly  2334 LSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPG 2398
            .|.||  :....|.||.|.|:|:|..||.|..|..|||:|.:.||.|.|.|:|:.|.|.|.|.||
Human   518 ASAPC--LNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPG 580

  Fly  2399 WSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCE------------------- 2444
            :.|.||:.:|..| ...||...|||:||...:||:||||..|:.||                   
Human   581 FEGPRCQTEVDEC-LSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQK 644

  Fly  2445 ---------------------------------------TAPE------RCIGDPCMHGGKCQDF 2464
                                                   |.||      .||..||.|||.|...
Human   645 DKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQ 709

  Fly  2465 GSGLNCSCPADYSGIGCQYEYDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDCKDN 2529
            .||.||:||..|:|..|..|..||....|.||.:|..:..||.|.|||..||..|:.....|...
Human   710 PSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSA 774

  Fly  2530 SCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTA-AQVVP------FPTGE 2587
            .|..|.|||:....|.|.|.....|..|...::..   ....|.|:.| .|..|      .|||.
Human   775 PCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPS---CADSPCRNRATCQDSPQGPRCLCPTGY 836

  Fly  2588 ANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSFGEY 2652
            ..                |...||..:.:.:...:....||...|                    
Human   837 TG----------------GSCQTLMDLCAQKPCPRNSHCLQTGPS-------------------- 865

  Fly  2653 TSVNDGQWHHVAVV-WDG-------ISGQLQLITEGLIASKMEYGAG---GSLPGYLWAVLGLPQ 2706
                   :|.:.:. |.|       .|.|...:::|:..|.:.:..|   .|.|.|         
Human   866 -------FHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSY--------- 914

  Fly  2707 PYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNWAGYEVTSGG 2771
                   ..:...||||::               .|..|..|.|.|              ..:|.
Human   915 -------FCHCPPGFQGSL---------------CQDHVNPCESRP--------------CQNGA 943

  Fly  2772 VERNVPS--LCGQRKCPVGYTGANC-QQLVVDKEPPVVEH-------------CPGDLWVIAKNG 2820
            .....||  ||   :|..||.|.|| ::|...:..|...|             ||.....:...|
Human   944 TCMAQPSGYLC---QCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEG 1005

  Fly  2821 SAVVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVSLLTDFCP 2885
            ......|:|               .|.:||.           |..:..|...|.........:|.
Human  1006 DVDECLDQP---------------CHPTGTA-----------ACHSLANAFYCQCLPGHTGQWCE 1044

  Fly  2886 ALADPVGGSQVCKDWGAGGQFKVCEIACNAGLRF-------------SEPVPE--FYTCGAEGFW 2935
            ...||. .||.|...|      .||....:.|.|             |...|.  |:.|...|..
Human  1045 VEIDPC-HSQPCFHGG------TCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLC 1102

  Fly  2936 RPTREPSMPLVYPSCS 2951
            .|:.:|..|   |.|:
Human  1103 LPSPKPGFP---PRCA 1115

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 337/1251 (27%)
GCC2_GCC3 1916..1966 CDD:285001 12/58 (21%)
GCC2_GCC3 1973..2020 CDD:285001 14/64 (22%)
EGF 2025..2055 CDD:278437 13/29 (45%)
EGF_CA 2059..2095 CDD:238011 15/79 (19%)
EGF_CA 2138..2176 CDD:238011 16/38 (42%)
EGF_CA 2178..2214 CDD:238011 16/35 (46%)
EGF_CA 2253..2289 CDD:238011 13/40 (33%)
EGF_CA 2292..2327 CDD:238011 15/34 (44%)
EGF_CA 2330..2366 CDD:238011 15/35 (43%)
EGF_CA 2369..2405 CDD:238011 18/35 (51%)
EGF_CA 2411..2444 CDD:238011 15/32 (47%)
EGF_CA 2486..2520 CDD:238011 14/33 (42%)
EGF_CA 2522..2557 CDD:238011 10/34 (29%)
LamG 2590..2735 CDD:304605 21/155 (14%)
DUF5011 2799..2877 CDD:295940 13/90 (14%)
GCC2_GCC3 3149..3200 CDD:285001
GCC2_GCC3 3207..3254 CDD:285001
GCC2_GCC3 3268..3307 CDD:285001
GCC2_GCC3 3315..3362 CDD:285001
NOTCH4NP_004548.3 EGF_CA 194..232 CDD:238011 4/37 (11%)
EGF_CA 314..353 CDD:238011 16/39 (41%)
EGF_CA 432..473 CDD:238011 13/40 (33%)
EGF_CA 475..511 CDD:238011 15/35 (43%)
EGF_CA 515..549 CDD:238011 15/35 (43%)
EGF_CA 551..587 CDD:238011 18/35 (51%)
EGF_CA 590..625 CDD:238011 16/35 (46%)
EGF_CA <699..726 CDD:238011 14/26 (54%)
EGF_CA <736..765 CDD:238011 12/28 (43%)
EGF_CA 769..803 CDD:238011 10/33 (30%)
EGF_CA <899..928 CDD:238011 8/59 (14%)
EGF_CA 931..965 CDD:238011 13/50 (26%)
EGF_CA 970..1004 CDD:238011 4/33 (12%)
Notch 1165..1203 CDD:321927
LNR 1 1170..1213
NL 1207..1245 CDD:197463
LNR 2 1214..1250
Notch 1249..1285 CDD:306554
LNR 3 1251..1294
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371
NODP 1380..>1420 CDD:311559
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508
ANK 1586..1721 CDD:238125
ANK repeat 1586..1630 CDD:293786
ANK 1 1633..1665
ANK repeat 1634..1664 CDD:293786
ANK 1661..1787 CDD:238125
ANK repeat 1666..1698 CDD:293786
ANK 2 1666..1698
ANK 3 1700..1732
ANK repeat 1700..1731 CDD:293786
ANK 4 1733..1765
ANK repeat 1733..1764 CDD:293786
Ank_5 1753..>1851 CDD:330893
ANK 5 1766..1798
ANK repeat 1766..1797 CDD:293786
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I11026
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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