DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and NOTCH3

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens


Alignment Length:1820 Identity:462/1820 - (25%)
Similarity:616/1820 - (33%) Gaps:651/1820 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1787 QLYDLCGSTLNLIFDLSVPYA------SAVIDDLLNIANIGNQCP----------PLRALKSQIS 1835
            ||.|.|.|.         |.|      |:|:   ...|....:||          |...|.|..:
Human    77 QLEDPCHSG---------PCAGRGVCQSSVV---AGTARFSCRCPRGFRGPDCSLPDPCLSSPCA 129

  Fly  1836 RGFNCNVGEVLNMDTSDVPRCLHCPAGTYVSEGQNSCTYCPRGYYQNRDRQ-------------- 1886
            .|..|:||                |.|.::      |: ||.||.....|.              
Human   130 HGARCSVG----------------PDGRFL------CS-CPPGYQGRSCRSDVDECRVGEPCRHG 171

  Fly  1887 GTCL--------RCPAGTYTKEEGTKSQADCIPVCGYGTYSPTGLVPCLECP-RNSFTAEPPTGG 1942
            ||||        :|||| ||.           |:|    .:|.  |||...| ||..|.......
Human   172 GTCLNTPGSFRCQCPAG-YTG-----------PLC----ENPA--VPCAPSPCRNGGTCRQSGDL 218

  Fly  1943 FKDCQACPAQSFTYQPAASNKDLCRA-KCAPGTYSATGL----APCSP-------------CPLH 1989
            ..||...|  .|..|....|.|.|.. :|..|.....|:    ..|.|             |.|.
Human   219 TYDCACLP--GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQ 281

  Fly  1990 ----HYQGAA----GAQSCNECPSNMRTDSPASKGREQCKPVVCGEGACQHG------------- 2033
                |..|..    |..|| .| .|..|....|:..:.|...||..||..|.             
Human   282 PNACHNGGTCFNTLGGHSC-VC-VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGK 344

  Fly  2034 -GL-------CV-------------PMGHDIQCFCPAGFSGRRCEQDIDECA--SQPCYNGGQCK 2075
             ||       ||             |:.....|.||.||:|..|:||:|||:  :.||.:.|:|.
Human   345 TGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV 409

  Fly  2076 DLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDP 2140
            :....:.|:|..||:|..|:.:.::|.:..|..:|.|.:..|  ..||:|.:|:||..|:|.||.
Human   410 NTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIG--QFTCICMAGFTGTYCEVDIDE 472

  Fly  2141 CTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACP 2205
            |  ..:||.||..|:....| :.|.|..|:.|..|:.::::|:..||..||.|.|..:.::|.|.
Human   473 C--QSSPCVNGGVCKDRVNG-FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCA 534

  Fly  2206 PGFTGKRCEQKIDLCLSEPCKHGTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVD 2270
            .||.|..|::.:|.|..:||.||.|||.:....|.|.||:||:.|:..:|:|.::||.:.|.|:|
Human   535 EGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLD 599

  Fly  2271 LVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLS 2335
            |||.|.|.|..|.||.||:..|||||||||..| .|.|.::.:.|.|:||:.|..|..||:||.|
Human   600 LVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCRDGINRYDCVCQPGFTGPLCNVEINECAS 663

  Fly  2336 DPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWS 2400
            .||...|:  |:|.:|.|.|:|..|...|||......|..:|| ::|||.|..|||.|.||||||
Human   664 SPCGEGGS--CVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWS 725

  Fly  2401 GMRCEQQVT--TCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCE-TAPERCIGDPCMHGGKCQ 2462
            |.||.|.:.  .|.:| ||:...:|......:.|.||.|..|:.|| .:|  |..:||.|||:|:
Human   726 GPRCSQSLARDACESQ-PCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSP--CTPNPCEHGGRCE 787

  Fly  2463 DFGSGLN-CSCPADYSGIGCQYEYDACEEHV-CQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVD 2525
            .....|. ||||..:.|..||.:.|.|.... |.....|.:....:||.|..|:||.:|:|||.|
Human   788 SAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDIND 852

  Fly  2526 CKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDP------SRSTAAQVVPFP 2584
            |..|.|..|.:|.|....|.|.|.....|..|.:    |.|...|:|      :...|:.....|
Human   853 CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR----DVDECLSNPCGPGTCTDHVASFTCTCP 913

  Fly  2585 TGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLS- 2648
            .|                         ||                   |....  :|.||...| 
Human   914 PG-------------------------YG-------------------GFHCE--QDLPDCSPSS 932

  Fly  2649 -FGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYLWAVLGLPQPYGLSN 2712
             |...|.|            ||::....|..                |||..|            
Human   933 CFNGGTCV------------DGVNSFSCLCR----------------PGYTGA------------ 957

  Fly  2713 ELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLI-LNWAGYEVTSGGVERNV 2776
                                       ..|.:...|.|.|.|:.|:. ....|:..|        
Human   958 ---------------------------HCQHEADPCLSRPCLHGGVCSAAHPGFRCT-------- 987

  Fly  2777 PSLCGQRKCPVGYTGANCQQLV--VDKEPPVVEHCPGDLWVIAKNGSAVVSWDEPHFSDNIGVTK 2839
                    |...:||..||.||  ..::|     |                              
Human   988 --------CLESFTGPQCQTLVDWCSRQP-----C------------------------------ 1009

  Fly  2840 IYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVSLLTDFCPALADPVGGSQVCKDWGAGG 2904
               :||.|...|   |.|               |         .||                .|.
Human  1010 ---QNGGRCVQT---GAY---------------C---------LCP----------------PGW 1028

  Fly  2905 QFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSD 2969
            ..::|:|..                      .|.||.:             ||...|::.     
Human  1029 SGRLCDIRS----------------------LPCREAA-------------AQIGVRLEQ----- 1053

  Fly  2970 VLCNKAGQAVLRQKVTNSVNGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKD 3034
             ||...||.|........|....|..:.|...::   .|    :...|.| .||....:      
Human  1054 -LCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVD---PC----LAQPCQH-GGTCRGYM------ 1103

  Fly  3035 GGVYVMEAELPVVNDD--DDDLTLTGRQGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQL 3097
             |.|:.|. ||..|.|  :||:.                     ..|:.|..|..          
Human  1104 -GGYMCEC-LPGYNGDNCEDDVD---------------------ECASQPCQHGG---------- 1135

  Fly  3098 LEKLILEDDQFAVQEILPNTVPDPASLELGSEY--ACPVGQVVMI-----PDCVPCAIGTFYDSA 3155
                                    :.::|.:.|  :||.|.:.::     .||.|   |...||.
Human  1136 ------------------------SCIDLVARYLCSCPPGTLGVLCEINEDDCGP---GPPLDSG 1173

  Fly  3156 NKTCIACSRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLCRSC 3220
            .: |:  ..||.....|..:|: ||     ||.|   |.|..||..| |.:|....|.|   |.|
Human  1174 PR-CL--HNGTCVDLVGGFRCT-CP-----PGYT---GLRCEADINE-CRSGACHAAHT---RDC 1222

  Fly  3221 GHGFYQPNEGSFSCELCGLG------QTTRSTEATSRKECRDE-CSSGQQLGADGRCEPCPRG-- 3276
                .|...|.|.| ||..|      ||..|       .|..: |..|      |:|.|.|..  
Human  1223 ----LQDPGGGFRC-LCHAGFSGPRCQTVLS-------PCESQPCQHG------GQCRPSPGPGG 1269

  Fly  3277 --TYRLQGVQP-----------SC--AACPLG---RTTPKVGASSVEECTLPVCSAGTYLNATQN 3323
              |:.....||           ||  ..||:|   :.||:     ...|..|...:|.       
Human  1270 GLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR-----GPRCACPPGLSGP------- 1322

  Fly  3324 MCIECRKGYYQSESQQTSCLQCPPNHSTKITGATSKSECTNPCEHIAEGKPHCDVNAYCIMVPET 3388
               .||           |....||       ||::.|....||.|          ...|...|..
Human  1323 ---SCR-----------SFPGSPP-------GASNASCAAAPCLH----------GGSCRPAPLA 1356

  Fly  3389 SDFKCECKPGFNGTGMACTDVCDGFCENSGACVKDLKGTPSC------------RCVGSFTGPHC 3441
            ..|:|.|..|:  ||..|         .:.|...::...|.|            ||......|.|
Human  1357 PFFRCACAQGW--TGPRC---------EAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGC 1410

  Fly  3442  3441
            Human  1411  1410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 17/68 (25%)
GCC2_GCC3 1916..1966 CDD:285001 15/50 (30%)
GCC2_GCC3 1973..2020 CDD:285001 15/71 (21%)
EGF 2025..2055 CDD:278437 15/63 (24%)
EGF_CA 2059..2095 CDD:238011 13/37 (35%)
EGF_CA 2138..2176 CDD:238011 13/37 (35%)
EGF_CA 2178..2214 CDD:238011 12/35 (34%)
EGF_CA 2253..2289 CDD:238011 17/35 (49%)
EGF_CA 2292..2327 CDD:238011 17/34 (50%)
EGF_CA 2330..2366 CDD:238011 15/35 (43%)
EGF_CA 2369..2405 CDD:238011 19/35 (54%)
EGF_CA 2411..2444 CDD:238011 10/32 (31%)
EGF_CA 2486..2520 CDD:238011 10/34 (29%)
EGF_CA 2522..2557 CDD:238011 13/34 (38%)
LamG 2590..2735 CDD:304605 17/146 (12%)
DUF5011 2799..2877 CDD:295940 9/77 (12%)
GCC2_GCC3 3149..3200 CDD:285001 16/50 (32%)
GCC2_GCC3 3207..3254 CDD:285001 15/52 (29%)
GCC2_GCC3 3268..3307 CDD:285001 14/58 (24%)
GCC2_GCC3 3315..3362 CDD:285001 9/46 (20%)
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011 12/52 (23%)
EGF_CA 236..272 CDD:238011 8/35 (23%)
EGF_CA 274..311 CDD:238011 10/38 (26%)
EGF_CA 314..349 CDD:238011 8/34 (24%)
EGF_CA 391..429 CDD:238011 13/37 (35%)
EGF_CA 431..467 CDD:238011 11/37 (30%)
EGF_CA 469..505 CDD:238011 13/38 (34%)
EGF_CA 507..542 CDD:238011 12/34 (35%)
EGF_CA 545..580 CDD:238011 15/34 (44%)
EGF_CA 583..618 CDD:238011 17/34 (50%)
EGF_CA 620..654 CDD:238011 17/34 (50%)
EGF_CA 657..>686 CDD:214542 14/30 (47%)
EGF_CA 810..846 CDD:238011 10/35 (29%)
EGF_CA 849..884 CDD:238011 13/34 (38%)
EGF_CA 887..922 CDD:238011 10/78 (13%)
EGF_CA 929..960 CDD:238011 11/97 (11%)
EGF_CA 1085..1120 CDD:238011 12/50 (24%)
EGF_CA 1122..1158 CDD:238011 9/90 (10%)
EGF_CA 1171..1203 CDD:238011 14/43 (33%)
Notch 1384..1418 CDD:278494 6/27 (22%)
LNR 1 1387..1427 5/24 (21%)
Notch 1425..1459 CDD:278494
LNR 2 1428..1458
Notch 1464..1500 CDD:278494
LNR 3 1467..1505
NOD 1508..1557 CDD:284282
NODP 1578..1637 CDD:284987
ANKYR <1777..1893 CDD:223738
ANK <1779..1892 CDD:238125
ANK repeat 1788..1836 CDD:293786
ANK repeat 1838..1869 CDD:293786
ANK 1 1838..1867
Ank_5 1858..1913 CDD:290568
ANK 1866..1992 CDD:238125
ANK repeat 1871..1903 CDD:293786
ANK 2 1871..1901
ANK repeat 1905..1936 CDD:293786
ANK 3 1905..1934
Ank_2 1910..2002 CDD:289560
ANK repeat 1938..1969 CDD:293786
ANK 4 1938..1967
ANK repeat 1971..2002 CDD:293786
ANK 5 1971..2000
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321
DUF3454 2212..2273 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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