DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and Notch4

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001002827.1 Gene:Notch4 / 406162 RGDID:1303282 Length:1961 Species:Rattus norvegicus


Alignment Length:1995 Identity:478/1995 - (23%)
Similarity:642/1995 - (32%) Gaps:664/1995 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1625 CHFQVSVKASPCVDWELQPPANG------------------------AINCLPGDRGIECIA--- 1662
            |.|     ..||  |:.|...||                        :..|..|..|..|.:   
  Rat    59 CQF-----PDPC--WDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTCPSGFTGDRCQSPLE 116

  Fly  1663 -TCKPGFRFTDGEPLKTFSCETSRLWRPTSVVPDCVSE---NTEQAAYHVTASITYRANGAVAQS 1723
             .|.|.|....|.      |...     .|..|.|..|   ..||.......|....|||.|   
  Rat   117 ELCPPSFCSNGGH------CSVQ-----VSGRPQCSCEPGWTGEQCQLRDFCSANPCANGGV--- 167

  Fly  1724 CLGQYQEVLAQHYGGLNQLLSQRCSAVNVNMNVTFVKSVPMLLEENVVKMDF---ILSILPAVRQ 1785
            ||..|.::..            ||               |...|.::.:.|.   .|...|..|.
  Rat   168 CLATYPQIQC------------RC---------------PTGFEGHICERDVNECFLEPGPCPRG 205

  Fly  1786 PQLYDLCGSTLNLIFDLSVPYASAVIDDLLNIANIGNQCPPLRALKSQISRGFNCNVGEVLNMDT 1850
            ...::..||     |....|           :...|.||        ::.:| .|..|..||..|
  Rat   206 TSCHNTLGS-----FQCLCP-----------VGQEGPQC--------KLRKG-ACLPGTCLNGGT 245

  Fly  1851 SD-VPR-------CLHCPAGTYVSEGQNSCTYCPRGYYQNRDRQGTCLRCPAGTYT--------- 1898
            .. ||.       || ||.|   ..|.| |...|....:|:.:.|...:...||||         
  Rat   246 CQLVPEGDTTFHLCL-CPPG---FTGLN-CEMNPDDCVRNQCQNGATCQDGLGTYTCLCPKTWKG 305

  Fly  1899 ---KEEGTKSQADCIPVCGYGTYSPTGLVPCLECPRNSFTAEPPTGGFKDCQACPAQSFTYQPAA 1960
               .|:..:.:|...|.|                 ||..|.:...||| .| .| ...:..:...
  Rat   306 WDCSEDIDECEAQGPPRC-----------------RNGGTCQNSAGGF-HC-VC-VSGWGGEGCD 350

  Fly  1961 SNKDLC-RAKCAPGT--YSATGLAPCSPCP------LHHYQGAAGAQSCN---ECPSNMRTDS-- 2011
            .|.|.| .|.||.|:  ....|...|. ||      |.|.:.....|.|:   :|.:|..|.|  
  Rat   351 ENLDDCAAATCALGSTCIDRVGSFSCL-CPPGRTGLLCHLEDMCLRQPCHVNAQCSTNPLTGSTL 414

  Fly  2012 ----PASKG------REQCKPVVCGEGACQHGGLCVPMGHDIQCFCPAGFSGRRCEQDIDECASQ 2066
                |...|      .::|:....|...|:|||.|:.......|.|..|::|.|||.|.:||.||
  Rat   415 CICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQ 479

  Fly  2067 PCYNGGQCKDLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTG 2131
            ||:.|..|.||...::|.||.|..|..|:.|.::|.::.|..:|.|.::  .....|||..|:||
  Rat   480 PCHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACHDQ--LNGFLCLCLPGFTG 542

  Fly  2132 DQCDVTIDPCTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDL 2196
            .:|:..:|.|::  .||.||..||. :.|.:.|||:||:||..||...::|..:||.:||:|.||
  Rat   543 ARCEKDMDECSS--APCANGGHCQD-QPGAFHCECLPGFEGPRCETEADECRSDPCPVGASCLDL 604

  Fly  2197 VNDFQCACPPGFTGKRCEQKIDLC---LSE------------------------------PCKHG 2228
            ...|.|.|.|||||:.||  :.||   |.:                              ||.||
  Rat   605 PGAFLCLCRPGFTGQLCE--VPLCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAEDDCPCHHG 667

  Fly  2229 TCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTID 2293
            .|...|    |||:.||||..|:..:..|.:.|||:.|||.....||:|:|..||||..|...|.
  Rat   668 HCQRSL----CVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTCSEEIT 728

  Fly  2294 DCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCR 2358
            .|.|.||.:|.:|....:|:||.|.|.:.|..|:..:|.|.|..|...||  |:.....|.|.|.
  Rat   729 ACHSGPCLNGGSCSIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGT--CMSKPGTFFCHCA 791

  Fly  2359 DGFKGPLCATDI-DDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAP------ 2416
            .||:|..|...| ..|...||.|...|:|...|..|.|.||::|..|:..:..| |:.|      
  Rat   792 TGFQGLHCEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLC-ARKPCPHTAR 855

  Fly  2417 -----------------------------------------CQNDASCIDLFQDYFCVCPSGTDG 2440
                                                     |||...|||....|||.||.|.:|
  Rat   856 CLQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQGVEISNLCQNGGLCIDTGSSYFCRCPPGFEG 920

  Fly  2441 KNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHVCQNGATCVDNGAG 2505
            |.|:.....|...||:||..|....:|..|.|...|.|..|...:|||:...|.|..||.....|
  Rat   921 KLCQDTVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQNCSKVHDACQSGPCHNHGTCTPRPGG 985

  Fly  2506 YSCQCPPGFTGRNCEQDIVDCKDNSCPPG--ATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLY 2568
            :.|.|||||.|..||.|:.:|.|..|.|.  |:|..|.|.|||||....||..|    :|:.||.
  Rat   986 FHCACPPGFVGLRCEGDVDECLDRPCHPSGTASCHSLANAFYCQCLPGHTGQRC----EVEMDLC 1046

  Fly  2569 FSDP-SRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSS 2632
            .|.| |...:.:|.   ||.....|...                                     
  Rat  1047 QSQPCSNGGSCEVT---TGPPPGFTCRC------------------------------------- 1071

  Fly  2633 GVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAG------ 2691
                      |:.|                                ||...|:.....|      
  Rat  1072 ----------PEGF--------------------------------EGPTCSRKAPACGNHHCHN 1094

  Fly  2692 GSLPGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYP 2756
            |.        |.||.|...|..|....|||.|.                      ||.:.|. .|
  Rat  1095 GG--------LCLPSPKPGSPPLCACLSGFGGP----------------------DCLTPPA-PP 1128

  Fly  2757 GLILNWAGYEVTSGGVERNVPSLC----------------GQRKCPVGYTGANCQQLVVDKEPPV 2805
            |.                ..||.|                .|..||....|..||:       |.
  Rat  1129 GC----------------GPPSPCMHNGSCTETPGLGNPGFQCTCPPDSPGPRCQR-------PG 1170

  Fly  2806 VEHCPGDLWVIAKNGSAVV---------SWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITY 2861
            ...|.|      :.|....         .||....|  :||...::.....|...||:       
  Rat  1171 ANGCEG------RGGDGACDAGCSGPGGDWDGGDCS--LGVPDPWKGCPPHSQCWLLF------- 1220

  Fly  2862 IASDAAGNTASCSFKVSLLTDF-C--PALADPVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPV 2923
              .|...: ..|..:..|...: |  |....| ...|.|:|....|.   ||..||..       
  Rat  1221 --RDGRCH-PQCDSEECLFDGYDCEIPPTCTP-AYDQYCRDHFHNGH---CEKGCNNA------- 1271

  Fly  2924 PEFYTCGAE-GFWRPTRE-----PSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQ 2982
                .||.: |..||..:     ||:.|:.....|:...|.:...::|    .|..:.|..|.:.
  Rat  1272 ----QCGWDGGDCRPEGDDSEGGPSLALLVVLSPPALDQQLLALARVL----SLTLRVGLWVRKD 1328

  Fly  2983 KVTNSVNGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRV-RRQAKD------------ 3034
            .     .|.|     ..:...|||..:::.         ||:::.. .|||..            
  Rat  1329 S-----EGRN-----MVFPYPGTRAKEELS---------GTRDSSSWERQAPHTQTPGKETESLG 1374

  Fly  3035 -GGVYVMEAELPVVNDD--------DDDLTLTGRQGRQQTGGDTYTLEIAFPAANDPVV--HTST 3088
             |.|.||..:|.....:        |..|.|.........|    .||...|.   |::  |...
  Rat  1375 AGFVVVMGVDLSRCGPEHPASRCPRDSGLLLRFLAAMAAVG----ALEPLLPG---PLLAAHPQA 1432

  Fly  3089 GERSTVKQL---------LEKLILEDDQFAVQEIL-------------PNTVPDPASLELGSEYA 3131
            |..|...:|         :..|:|......|.:::             |..:..|.:.:......
  Rat  1433 GTGSPATRLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPHRRR 1497

  Fly  3132 CPVGQ------------------VVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSEAGQLQCSK 3178
            .|:|:                  |||                   |.....|..:..|...:|..
  Rat  1498 PPLGEDNIGLKALKPEAEVDEDGVVM-------------------CSGPEEGEAEKTASASRCQL 1543

  Fly  3179 CPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTT 3243
            .|:.:|..|:..........:|:...|     |::|     ||.....|   ..|...||..|:|
  Rat  1544 WPLRSGCEGLPQAVMLTPPQECESELP-----DSDT-----CGPDGVTP---LMSAVFCGGVQST 1595

  Fly  3244 RSTEATSRKECRDECSSGQQLGADGRCEP---------CPRGTYRLQGVQPSCAACPLGRTT--- 3296
                            :.|:||. |..||         ||:......|..|...|....|.|   
  Rat  1596 ----------------TVQRLGL-GNPEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAAR 1643

  Fly  3297 ---------------------PKVGASSVEECTLPVCSAGTYLNA 3320
                                 ..|.|.:.|.|.|.:.|..|.::|
  Rat  1644 RLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTAVDA 1688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940 2/5 (40%)
GCC2_GCC3 1862..1909 CDD:285001 13/58 (22%)
GCC2_GCC3 1916..1966 CDD:285001 10/49 (20%)
GCC2_GCC3 1973..2020 CDD:285001 15/69 (22%)
EGF 2025..2055 CDD:278437 10/29 (34%)
EGF_CA 2059..2095 CDD:238011 16/35 (46%)
EGF_CA 2138..2176 CDD:238011 16/37 (43%)
EGF_CA 2178..2214 CDD:238011 16/35 (46%)
EGF_CA 2253..2289 CDD:238011 15/35 (43%)
EGF_CA 2292..2327 CDD:238011 13/34 (38%)
EGF_CA 2330..2366 CDD:238011 13/35 (37%)
EGF_CA 2369..2405 CDD:238011 13/36 (36%)
EGF_CA 2411..2444 CDD:238011 17/79 (22%)
EGF_CA 2486..2520 CDD:238011 15/33 (45%)
EGF_CA 2522..2557 CDD:238011 16/36 (44%)
LamG 2590..2735 CDD:304605 18/150 (12%)
DUF5011 2799..2877 CDD:295940 14/86 (16%)
GCC2_GCC3 3149..3200 CDD:285001 7/50 (14%)
GCC2_GCC3 3207..3254 CDD:285001 10/46 (22%)
GCC2_GCC3 3268..3307 CDD:285001 13/71 (18%)
GCC2_GCC3 3315..3362 CDD:285001 2/6 (33%)
Notch4NP_001002827.1 EGF_CA 191..>224 CDD:284955 8/48 (17%)
EGF_CA 311..349 CDD:238011 11/57 (19%)
EGF_CA 352..387 CDD:238011 11/35 (31%)
EGF_CA 429..470 CDD:238011 12/40 (30%)
EGF_CA 472..508 CDD:238011 16/35 (46%)
EGF_CA 511..546 CDD:238011 10/36 (28%)
EGF_CA 548..584 CDD:238011 16/38 (42%)
EGF_CA 588..622 CDD:238011 16/33 (48%)
EGF_CA <696..723 CDD:238011 14/26 (54%)
EGF_CA 765..800 CDD:238011 13/36 (36%)
EGF_CA <810..839 CDD:238011 11/28 (39%)
EGF_CA 892..924 CDD:238011 14/31 (45%)
EGF_CA 927..961 CDD:238011 11/33 (33%)
EGF_CA 966..1000 CDD:238011 15/33 (45%)
EGF_CA 1002..1040 CDD:238011 17/41 (41%)
Notch 1207..1242 CDD:278494 6/44 (14%)
Notch 1245..1281 CDD:278494 12/50 (24%)
NOD 1291..1337 CDD:284282 11/59 (19%)
NODP 1376..>1415 CDD:284987 8/38 (21%)
Ank_2 <1571..1656 CDD:289560 23/109 (21%)
ANK 1625..1732 CDD:238125 13/64 (20%)
ANK repeat 1626..1656 CDD:293786 5/29 (17%)
Ank_2 1630..1723 CDD:289560 11/59 (19%)
ANK repeat 1658..1690 CDD:293786 8/31 (26%)
ANK 1687..1811 CDD:238125 1/2 (50%)
ANK repeat 1692..1723 CDD:293786
Ank_2 1697..1789 CDD:289560
ANK repeat 1725..1756 CDD:293786
ANK repeat 1758..1789 CDD:293786
ANK repeat 1791..1827 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I11755
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.920

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