DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment uif and N

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:2277 Identity:505/2277 - (22%)
Similarity:728/2277 - (31%) Gaps:902/2277 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1603 IKIGNFENVTVTATDK-----------YNNRAACHFQVSVKA----------------SPCVDWE 1640
            :...|..| ||..||.           ..|...|..|::.|.                :||....
  Fly    41 LAFANLPN-TVRGTDTALVAASCTSVGCQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPCNSMR 104

  Fly  1641 LQPPANGAINCLPGDRGIECIATCKPGFRFTDGEPLKTFSCETSRLWRPTSVVPDCVSENTEQAA 1705
            .|......:....|..||.|  .|..||    .|.|    ||.:        ||:        |.
  Fly   105 CQNGGTCQVTFRNGRPGISC--KCPLGF----DESL----CEIA--------VPN--------AC 143

  Fly  1706 YHVTASITYRANGAVAQ-SCLGQYQEVLAQHYGGLNQLLSQRCSAVNVNMNVTFVKSVPMLLEEN 1769
            .|||.     .||...| ..|.:|....|..|.|      :||...|                  
  Fly   144 DHVTC-----LNGGTCQLKTLEEYTCACANGYTG------ERCETKN------------------ 179

  Fly  1770 VVKMDFILSILPAVRQPQLYDLCGSTLNLIFDLSVPYAS-AVIDDLLNIANIGNQCPPLRALKSQ 1833
                                 ||.|:         |..: |....|...::....|||       
  Fly   180 ---------------------LCASS---------PCRNGATCTALAGSSSFTCSCPP------- 207

  Fly  1834 ISRGFN---------------CNVGEVLNMDTSDVPRCLHCPAGTYVSEG--------------- 1868
               ||.               |..|... ::|....:|: ||.| |..:.               
  Fly   208 ---GFTGDTCSYDIEECQSNPCKYGGTC-VNTHGSYQCM-CPTG-YTGKDCDTKYKPCSPSPCQN 266

  Fly  1869 -----QNSCTY---CPRGY-----YQNRD--------RQGTCL--------RCP---AGTYTKEE 1901
                 .|..:|   ||:|:     .||.|        ..|||:        |||   .|.:.:::
  Fly   267 GGICRSNGLSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDD 331

  Fly  1902 GTKSQADCIPVC--------GYGTYSPTGLVPC--------LECPRNS-----------FTAEPP 1939
            ..:......|||        .:|:||      |        |:|..|:           .|....
  Fly   332 VDECAQRDHPVCQNGATCTNTHGSYS------CICVNGWAGLDCSNNTDDCKQAACFYGATCIDG 390

  Fly  1940 TGGFKDCQACPAQS--FTYQPAASNKDLCRAKCAPGTYSATGLAPCSPCPLHHYQGAAGAQSCNE 2002
            .|.|. ||....::  ..:...|...:.|.|.....|....|...|| |.. .|:|...::..:|
  Fly   391 VGSFY-CQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACS-CAT-GYKGVDCSEDIDE 452

  Fly  2003 C---------------PSNMRTDSPASKGREQCKPVV--CGEGACQHGGLCVPMGHDIQCFCPAG 2050
            |               |.:.|.:........:|:..:  |....||:.|.|:......:|.|..|
  Fly   453 CDQGSPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPG 517

  Fly  2051 FSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAMCKNE 2115
            |:|.:||.|||||.|.||.|.|.|.|...|::|.|..|::|..||....||.:..|..|.:|.:.
  Fly   518 FTGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDS 582

  Fly  2116 -PGYKNVTCLCRSGYTGDQCDVTIDPCTAN----------------------------------- 2144
             .||   :|.|..||||..|::.|:.|.:|                                   
  Fly   583 IAGY---SCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECE 644

  Fly  2145 GNPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFT 2209
            .|||.....||. ..|.|.|:|..|..|.:||.|:|:|..|||..||.|.|.:|.::|.|.||||
  Fly   645 SNPCQFDGHCQD-RVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFT 708

  Fly  2210 GKRCEQKIDLCLSEPC-KHGTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVD 2273
            |:.||:.:|.|:|.|| .:|.|:|::..::|.|..|:..:.|..::|:|.:.||.|||.|.|.::
  Fly   709 GQHCEKNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGIN 773

  Fly  2274 GYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPC 2338
            .:.|:|.||||||.|:..||:|:|||||||.||.|:|:.|||:|.|||.|..||..||:|:::||
  Fly   774 EFICHCPPGYTGKRCELDIDECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPC 838

  Fly  2339 NPVGTERCLDLDNKFECVC------RD----------------------------------GFKG 2363
            ...||  |:|..|.::|||      ||                                  |:.|
  Fly   839 GNGGT--CIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTG 901

  Fly  2364 PLCATDIDDCE-AQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLF 2427
            ..|..|||:|. :.||.|...|.:..|.:.|.|..|:.|..|......| |..||||..:|:|..
  Fly   902 RYCDEDIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDC-ASFPCQNGGTCLDGI 965

  Fly  2428 QDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHV 2492
            .||.|:|..|.|||:|||....|:..||.:|..|..:.:...|:||..:|||.||...:.|.|..
  Fly   966 GDYSCLCVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESS 1030

  Fly  2493 CQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDC 2557
            |.||.:|:|...||:|.|..|::|.||:..:..|..|.|..||||.:..|.:.|.||...||..|
  Fly  1031 CLNGGSCIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQC 1095

  Fly  2558 RKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQ 2622
            .:  .||:.......:.:|.:|               |..||:.|...|....|..||:...   
  Fly  1096 SE--YVDWCGQSPCENGATCSQ---------------MKHQFSCKCSAGWTGKLCDVQTISC--- 1140

  Fly  2623 RRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKME 2687
                             :|..|.                      .|:|.: ||...|   :..:
  Fly  1141 -----------------QDAADR----------------------KGLSLR-QLCNNG---TCKD 1162

  Fly  2688 YGAGGSLPGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEP 2752
            ||                     ::.:.|...|:.|               |..||::.:|:|:|
  Fly  1163 YG---------------------NSHVCYCSQGYAG---------------SYCQKEIDECQSQP 1191

  Fly  2753 VLYPGLILNWAGYEVTSGGVERNVPSLCG--QRKCPVGYTGANCQQLVVDKEPPVVEH------- 2808
                          ..:||..|:   |.|  :.:|..|:.|.||:..:.|..|...::       
  Fly  1192 --------------CQNGGTCRD---LIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDR 1239

  Fly  2809 -------C-PGDLWVIAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASD 2865
                   | ||.:.:|.:     ::.|:                                 ....
  Fly  1240 VMNFSCSCPPGTMGIICE-----INKDD---------------------------------CKPG 1266

  Fly  2866 AAGNTASCSFKVSLLTDFCPALADPVGGSQ-VCKDWGAG----GQFKVC--EIACNAGLRFSEPV 2923
            |..|..||              .|.|||.: ||:....|    |....|  ....|||......:
  Fly  1267 ACHNNGSC--------------IDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTLDCVQL 1317

  Fly  2924 PEFYTCGAEGFWRPTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQK----V 2984
            ...|.|                   :|.|.... |....|:.|.:...|...|...:||.    :
  Fly  1318 VNNYHC-------------------NCRPGHMG-RHCEHKVDFCAQSPCQNGGNCNIRQSGHHCI 1362

  Fly  2985 TNS--------VNGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVME 3041
            .|:        ::|.:.|.|.|..   |.....|.....:|:..|||                  
  Fly  1363 CNNGFYGKNCELSGQDCDSNPCRV---GNCVVADEGFGYRCECPRGT------------------ 1406

  Fly  3042 AELPVVNDDDDDLTLTGRQGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDD 3106
                                                          .||...:..|         
  Fly  1407 ----------------------------------------------LGEHCEIDTL--------- 1416

  Fly  3107 QFAVQEILPNTVPDPASLELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSEA 3171
                .|..||                            |||.|.          ||     :...
  Fly  1417 ----DECSPN----------------------------PCAQGA----------AC-----EDLL 1434

  Fly  3172 GQLQC--------SKCPVI-AGRPGVTAGPGA---RSAADCKERCPAGKYFDAETGLC--RSC-- 3220
            |..:|        .:|.:. |..||...|.|:   |.|||.::          :..:|  |.|  
  Fly  1435 GDYECLCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYAADLEQ----------QRAMCDKRGCTE 1489

  Fly  3221 --GHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECSSGQQLGADGRCEPCPRGTYRLQGV 3283
              |:|....:..:::|...|                 ::||                     .|:
  Fly  1490 KQGNGICDSDCNTYACNFDG-----------------NDCS---------------------LGI 1516

  Fly  3284 QPSCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPN 3348
            .|                               :.|.|.|.|                       
  Fly  1517 NP-------------------------------WANCTANEC----------------------- 1527

  Fly  3349 HSTKITGATSKSECTN-PCE---HIAEGK-PHCDVNAYCIMVPETSDFKCECKPGFNGTGMACTD 3408
             ..|........||.| .|.   |..|.| ..||           |.|...|:..:.        
  Fly  1528 -WNKFKNGKCNEECNNAACHYDGHDCERKLKSCD-----------SLFDAYCQKHYG-------- 1572

  Fly  3409 VCDGFCE---NSGACVKDLKGTPSCRCVGSFTGPHCAERSEFAYIAGGIAGAVIFIIII------ 3464
              ||||:   |:..|              |:.|..|..:::...:|.| |.:|:.::.:      
  Fly  1573 --DGFCDYGCNNAEC--------------SWDGLDCENKTQSPVLAEG-AMSVVMLMNVEAFREI 1620

  Fly  3465 --------------------------VLLIWMICVRSTKRRDP------KKMLTPAIDQTGSQVN 3497
                                      :::.|...||..:..|.      |.:.|..:.|||.|:.
  Fly  1621 QAQFLRNMSHMLRTTVRLKKDALGHDIIINWKDNVRVPEIEDTDFARKNKILYTQQVHQTGIQIY 1685

  Fly  3498 -----------FYYGAH-TPYAESIAPSH--------HSTYAHYYDDEEDGWEMPNFYNETYMKD 3542
                       |.:... ..:..:.|..|        ||........:||..|.|  .|..|:..
  Fly  1686 LEIDNRKCTECFTHAVEAAEFLAATAAKHQLRNDFQIHSVRGIKNPGDEDNGEPP--ANVKYVIT 1748

  Fly  3543 GL 3544
            |:
  Fly  1749 GI 1750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940 9/38 (24%)
GCC2_GCC3 1862..1909 CDD:285001 17/93 (18%)
GCC2_GCC3 1916..1966 CDD:285001 13/70 (19%)
GCC2_GCC3 1973..2020 CDD:285001 11/61 (18%)
EGF 2025..2055 CDD:278437 10/29 (34%)
EGF_CA 2059..2095 CDD:238011 17/35 (49%)
EGF_CA 2138..2176 CDD:238011 14/72 (19%)
EGF_CA 2178..2214 CDD:238011 18/35 (51%)
EGF_CA 2253..2289 CDD:238011 17/35 (49%)
EGF_CA 2292..2327 CDD:238011 22/34 (65%)
EGF_CA 2330..2366 CDD:238011 17/75 (23%)
EGF_CA 2369..2405 CDD:238011 13/36 (36%)
EGF_CA 2411..2444 CDD:238011 16/32 (50%)
EGF_CA 2486..2520 CDD:238011 14/33 (42%)
EGF_CA 2522..2557 CDD:238011 13/34 (38%)
LamG 2590..2735 CDD:304605 20/144 (14%)
DUF5011 2799..2877 CDD:295940 11/92 (12%)
GCC2_GCC3 3149..3200 CDD:285001 14/62 (23%)
GCC2_GCC3 3207..3254 CDD:285001 7/52 (13%)
GCC2_GCC3 3268..3307 CDD:285001 2/38 (5%)
GCC2_GCC3 3315..3362 CDD:285001 5/46 (11%)
NNP_001245510.1 EGF_CA 179..214 CDD:238011 12/92 (13%)
EGF_CA 217..252 CDD:238011 8/37 (22%)
EGF_CA 260..291 CDD:238011 5/30 (17%)
EGF_CA 295..329 CDD:238011 8/33 (24%)
EGF_CA 331..369 CDD:238011 8/43 (19%)
EGF_CA 449..486 CDD:238011 4/36 (11%)
EGF_CA 488..524 CDD:238011 10/35 (29%)
EGF_CA 526..562 CDD:238011 17/35 (49%)
EGF_CA 564..600 CDD:238011 13/38 (34%)
EGF_CA 602..637 CDD:238011 3/34 (9%)
EGF_CA 640..675 CDD:238011 11/35 (31%)
EGF_CA 677..713 CDD:238011 18/35 (51%)
EGF_CA 715..750 CDD:238011 11/34 (32%)
EGF_CA 753..789 CDD:238011 17/35 (49%)
EGF_CA 791..827 CDD:238011 22/35 (63%)
EGF_CA 829..865 CDD:238011 15/37 (41%)
EGF_CA 907..943 CDD:238011 13/35 (37%)
EGF_CA 946..982 CDD:238011 16/36 (44%)
EGF_CA 984..1020 CDD:238011 11/35 (31%)
EGF_CA 1027..1058 CDD:238011 13/30 (43%)
EGF_CA 1062..1095 CDD:238011 13/32 (41%)
EGF_CA 1184..1219 CDD:238011 12/51 (24%)
EGF_CA 1221..1257 CDD:238011 6/35 (17%)
EGF_CA 1259..1295 CDD:238011 12/82 (15%)
EGF_CA 1297..1335 CDD:238011 9/57 (16%)
EGF_CA 1417..1450 CDD:238011 11/75 (15%)
NL 1476..1512 CDD:197463 7/62 (11%)
Notch 1519..1553 CDD:278494 10/57 (18%)
Notch 1565..1593 CDD:278494 9/51 (18%)
NOD 1599..1648 CDD:284282 4/49 (8%)
NODP 1680..1731 CDD:284987 8/50 (16%)
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11294
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.920

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