DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment uif and N

DIOPT Version :10

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_476859.2 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:2277 Identity:505/2277 - (22%)
Similarity:728/2277 - (31%) Gaps:902/2277 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1603 IKIGNFENVTVTATDK-----------YNNRAACHFQVSVKA----------------SPCVDWE 1640
            :...|..| ||..||.           ..|...|..|::.|.                :||....
  Fly    41 LAFANLPN-TVRGTDTALVAASCTSVGCQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPCNSMR 104

  Fly  1641 LQPPANGAINCLPGDRGIECIATCKPGFRFTDGEPLKTFSCETSRLWRPTSVVPDCVSENTEQAA 1705
            .|......:....|..||.|  .|..||    .|.|    ||.:        ||:        |.
  Fly   105 CQNGGTCQVTFRNGRPGISC--KCPLGF----DESL----CEIA--------VPN--------AC 143

  Fly  1706 YHVTASITYRANGAVAQ-SCLGQYQEVLAQHYGGLNQLLSQRCSAVNVNMNVTFVKSVPMLLEEN 1769
            .|||.     .||...| ..|.:|....|..|.|      :||...|                  
  Fly   144 DHVTC-----LNGGTCQLKTLEEYTCACANGYTG------ERCETKN------------------ 179

  Fly  1770 VVKMDFILSILPAVRQPQLYDLCGSTLNLIFDLSVPYAS-AVIDDLLNIANIGNQCPPLRALKSQ 1833
                                 ||.|:         |..: |....|...::....|||       
  Fly   180 ---------------------LCASS---------PCRNGATCTALAGSSSFTCSCPP------- 207

  Fly  1834 ISRGFN---------------CNVGEVLNMDTSDVPRCLHCPAGTYVSEG--------------- 1868
               ||.               |..|... ::|....:|: ||.| |..:.               
  Fly   208 ---GFTGDTCSYDIEECQSNPCKYGGTC-VNTHGSYQCM-CPTG-YTGKDCDTKYKPCSPSPCQN 266

  Fly  1869 -----QNSCTY---CPRGY-----YQNRD--------RQGTCL--------RCP---AGTYTKEE 1901
                 .|..:|   ||:|:     .||.|        ..|||:        |||   .|.:.:::
  Fly   267 GGICRSNGLSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDD 331

  Fly  1902 GTKSQADCIPVC--------GYGTYSPTGLVPC--------LECPRNS-----------FTAEPP 1939
            ..:......|||        .:|:||      |        |:|..|:           .|....
  Fly   332 VDECAQRDHPVCQNGATCTNTHGSYS------CICVNGWAGLDCSNNTDDCKQAACFYGATCIDG 390

  Fly  1940 TGGFKDCQACPAQS--FTYQPAASNKDLCRAKCAPGTYSATGLAPCSPCPLHHYQGAAGAQSCNE 2002
            .|.|. ||....::  ..:...|...:.|.|.....|....|...|| |.. .|:|...::..:|
  Fly   391 VGSFY-CQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACS-CAT-GYKGVDCSEDIDE 452

  Fly  2003 C---------------PSNMRTDSPASKGREQCKPVV--CGEGACQHGGLCVPMGHDIQCFCPAG 2050
            |               |.:.|.:........:|:..:  |....||:.|.|:......:|.|..|
  Fly   453 CDQGSPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPG 517

  Fly  2051 FSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAMCKNE 2115
            |:|.:||.|||||.|.||.|.|.|.|...|::|.|..|::|..||....||.:..|..|.:|.:.
  Fly   518 FTGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDS 582

  Fly  2116 -PGYKNVTCLCRSGYTGDQCDVTIDPCTAN----------------------------------- 2144
             .||   :|.|..||||..|::.|:.|.:|                                   
  Fly   583 IAGY---SCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECE 644

  Fly  2145 GNPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFT 2209
            .|||.....||. ..|.|.|:|..|..|.:||.|:|:|..|||..||.|.|.:|.::|.|.||||
  Fly   645 SNPCQFDGHCQD-RVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFT 708

  Fly  2210 GKRCEQKIDLCLSEPC-KHGTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVD 2273
            |:.||:.:|.|:|.|| .:|.|:|::..::|.|..|:..:.|..::|:|.:.||.|||.|.|.::
  Fly   709 GQHCEKNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGIN 773

  Fly  2274 GYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPC 2338
            .:.|:|.||||||.|:..||:|:|||||||.||.|:|:.|||:|.|||.|..||..||:|:::||
  Fly   774 EFICHCPPGYTGKRCELDIDECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPC 838

  Fly  2339 NPVGTERCLDLDNKFECVC------RD----------------------------------GFKG 2363
            ...||  |:|..|.::|||      ||                                  |:.|
  Fly   839 GNGGT--CIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTG 901

  Fly  2364 PLCATDIDDCE-AQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLF 2427
            ..|..|||:|. :.||.|...|.:..|.:.|.|..|:.|..|......| |..||||..:|:|..
  Fly   902 RYCDEDIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDC-ASFPCQNGGTCLDGI 965

  Fly  2428 QDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHV 2492
            .||.|:|..|.|||:|||....|:..||.:|..|..:.:...|:||..:|||.||...:.|.|..
  Fly   966 GDYSCLCVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESS 1030

  Fly  2493 CQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDC 2557
            |.||.:|:|...||:|.|..|::|.||:..:..|..|.|..||||.:..|.:.|.||...||..|
  Fly  1031 CLNGGSCIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQC 1095

  Fly  2558 RKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQ 2622
            .:  .||:.......:.:|.:|               |..||:.|...|....|..||:...   
  Fly  1096 SE--YVDWCGQSPCENGATCSQ---------------MKHQFSCKCSAGWTGKLCDVQTISC--- 1140

  Fly  2623 RRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKME 2687
                             :|..|.                      .|:|.: ||...|   :..:
  Fly  1141 -----------------QDAADR----------------------KGLSLR-QLCNNG---TCKD 1162

  Fly  2688 YGAGGSLPGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEP 2752
            ||                     ::.:.|...|:.|               |..||::.:|:|:|
  Fly  1163 YG---------------------NSHVCYCSQGYAG---------------SYCQKEIDECQSQP 1191

  Fly  2753 VLYPGLILNWAGYEVTSGGVERNVPSLCG--QRKCPVGYTGANCQQLVVDKEPPVVEH------- 2808
                          ..:||..|:   |.|  :.:|..|:.|.||:..:.|..|...::       
  Fly  1192 --------------CQNGGTCRD---LIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDR 1239

  Fly  2809 -------C-PGDLWVIAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASD 2865
                   | ||.:.:|.:     ::.|:                                 ....
  Fly  1240 VMNFSCSCPPGTMGIICE-----INKDD---------------------------------CKPG 1266

  Fly  2866 AAGNTASCSFKVSLLTDFCPALADPVGGSQ-VCKDWGAG----GQFKVC--EIACNAGLRFSEPV 2923
            |..|..||              .|.|||.: ||:....|    |....|  ....|||......:
  Fly  1267 ACHNNGSC--------------IDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTLDCVQL 1317

  Fly  2924 PEFYTCGAEGFWRPTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQK----V 2984
            ...|.|                   :|.|.... |....|:.|.:...|...|...:||.    :
  Fly  1318 VNNYHC-------------------NCRPGHMG-RHCEHKVDFCAQSPCQNGGNCNIRQSGHHCI 1362

  Fly  2985 TNS--------VNGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVME 3041
            .|:        ::|.:.|.|.|..   |.....|.....:|:..|||                  
  Fly  1363 CNNGFYGKNCELSGQDCDSNPCRV---GNCVVADEGFGYRCECPRGT------------------ 1406

  Fly  3042 AELPVVNDDDDDLTLTGRQGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDD 3106
                                                          .||...:..|         
  Fly  1407 ----------------------------------------------LGEHCEIDTL--------- 1416

  Fly  3107 QFAVQEILPNTVPDPASLELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSEA 3171
                .|..||                            |||.|.          ||     :...
  Fly  1417 ----DECSPN----------------------------PCAQGA----------AC-----EDLL 1434

  Fly  3172 GQLQC--------SKCPVI-AGRPGVTAGPGA---RSAADCKERCPAGKYFDAETGLC--RSC-- 3220
            |..:|        .:|.:. |..||...|.|:   |.|||.::          :..:|  |.|  
  Fly  1435 GDYECLCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYAADLEQ----------QRAMCDKRGCTE 1489

  Fly  3221 --GHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECSSGQQLGADGRCEPCPRGTYRLQGV 3283
              |:|....:..:::|...|                 ::||                     .|:
  Fly  1490 KQGNGICDSDCNTYACNFDG-----------------NDCS---------------------LGI 1516

  Fly  3284 QPSCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPN 3348
            .|                               :.|.|.|.|                       
  Fly  1517 NP-------------------------------WANCTANEC----------------------- 1527

  Fly  3349 HSTKITGATSKSECTN-PCE---HIAEGK-PHCDVNAYCIMVPETSDFKCECKPGFNGTGMACTD 3408
             ..|........||.| .|.   |..|.| ..||           |.|...|:..:.        
  Fly  1528 -WNKFKNGKCNEECNNAACHYDGHDCERKLKSCD-----------SLFDAYCQKHYG-------- 1572

  Fly  3409 VCDGFCE---NSGACVKDLKGTPSCRCVGSFTGPHCAERSEFAYIAGGIAGAVIFIIII------ 3464
              ||||:   |:..|              |:.|..|..:::...:|.| |.:|:.::.:      
  Fly  1573 --DGFCDYGCNNAEC--------------SWDGLDCENKTQSPVLAEG-AMSVVMLMNVEAFREI 1620

  Fly  3465 --------------------------VLLIWMICVRSTKRRDP------KKMLTPAIDQTGSQVN 3497
                                      :::.|...||..:..|.      |.:.|..:.|||.|:.
  Fly  1621 QAQFLRNMSHMLRTTVRLKKDALGHDIIINWKDNVRVPEIEDTDFARKNKILYTQQVHQTGIQIY 1685

  Fly  3498 -----------FYYGAH-TPYAESIAPSH--------HSTYAHYYDDEEDGWEMPNFYNETYMKD 3542
                       |.:... ..:..:.|..|        ||........:||..|.|  .|..|:..
  Fly  1686 LEIDNRKCTECFTHAVEAAEFLAATAAKHQLRNDFQIHSVRGIKNPGDEDNGEPP--ANVKYVIT 1748

  Fly  3543 GL 3544
            |:
  Fly  1749 GI 1750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
PHA02639 697..>834 CDD:165022
FA58C 833..976 CDD:330301
FXa_inhibition 988..>1016 CDD:464251
CCP 1051..1106 CDD:153056
FA58C 1303..1443 CDD:330301
HYR 1463..1547 CDD:460572
HYR 1548..1631 CDD:460572 9/38 (24%)
Ephrin_rec_like 1862..1909 CDD:429604 17/93 (18%)
Ephrin_rec_like 1916..1966 CDD:429604 13/70 (19%)
Ephrin_rec_like 1973..2020 CDD:429604 11/61 (18%)
EGF 2025..2055 CDD:394967 10/29 (34%)
EGF_CA 2059..2095 CDD:238011 17/35 (49%)
EGF_CA 2138..2176 CDD:238011 14/72 (19%)
EGF_CA 2178..2214 CDD:238011 18/35 (51%)
EGF_CA 2253..2289 CDD:238011 17/35 (49%)
EGF_CA 2292..2327 CDD:238011 22/34 (65%)
EGF_CA 2369..2405 CDD:238011 13/36 (36%)
EGF_CA 2411..2444 CDD:238011 16/32 (50%)
EGF_CA 2486..2520 CDD:238011 14/33 (42%)
EGF_CA 2522..2557 CDD:238011 13/34 (38%)
LamG 2590..2735 CDD:473984 20/144 (14%)
HYR 2799..2877 CDD:460572 11/92 (12%)
Ephrin_rec_like 3149..3200 CDD:429604 14/62 (23%)
Ephrin_rec_like 3207..3254 CDD:429604 7/52 (13%)
Ephrin_rec_like 3268..3307 CDD:429604 2/38 (5%)
Ephrin_rec_like 3315..3362 CDD:429604 5/46 (11%)
NNP_476859.2 EGF_CA 179..214 CDD:238011 12/92 (13%)
EGF_CA 217..252 CDD:238011 8/37 (22%)
EGF_CA 260..291 CDD:238011 5/30 (17%)
EGF_CA 295..329 CDD:238011 8/33 (24%)
EGF_CA 331..369 CDD:238011 8/43 (19%)
EGF_CA 449..486 CDD:238011 4/36 (11%)
EGF_CA 488..524 CDD:238011 10/35 (29%)
EGF_CA 526..562 CDD:238011 17/35 (49%)
EGF_CA 564..600 CDD:238011 13/38 (34%)
EGF_CA 602..637 CDD:238011 3/34 (9%)
EGF_CA 640..675 CDD:238011 11/35 (31%)
EGF_CA 677..713 CDD:238011 18/35 (51%)
EGF_CA 715..750 CDD:238011 11/34 (32%)
EGF_CA 753..789 CDD:238011 17/35 (49%)
EGF_CA 791..827 CDD:238011 22/35 (63%)
EGF_CA 829..865 CDD:238011 15/37 (41%)
EGF_CA 907..943 CDD:238011 13/35 (37%)
EGF_CA 946..982 CDD:238011 16/36 (44%)
EGF_CA 984..1020 CDD:238011 11/35 (31%)
EGF_CA 1027..1058 CDD:238011 13/30 (43%)
EGF_CA 1062..1095 CDD:238011 13/32 (41%)
EGF_CA 1184..1219 CDD:238011 12/51 (24%)
EGF_CA 1221..1257 CDD:238011 6/35 (17%)
EGF_CA 1259..1295 CDD:238011 12/82 (15%)
EGF_CA 1297..1335 CDD:238011 9/57 (16%)
EGF_CA 1338..1373 CDD:238011 6/34 (18%)
EGF_CA 1417..1450 CDD:238011 11/75 (15%)
NL 1476..1512 CDD:197463 7/62 (11%)
Notch 1519..1553 CDD:459658 10/57 (18%)
Notch 1565..1593 CDD:459658 9/51 (18%)
NOD 1598..1652 CDD:462014 4/54 (7%)
NODP 1679..1731 CDD:462229 9/51 (18%)
JMTM_dNotch 1719..1806 CDD:411989 9/34 (26%)
ANK repeat 1902..1948 CDD:293786
ANKYR 1936..2139 CDD:440430
ANK repeat 1951..1981 CDD:293786
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.