DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and notch1a

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_571516.1 Gene:notch1a / 30718 ZFINID:ZDB-GENE-990415-173 Length:2437 Species:Danio rerio


Alignment Length:1966 Identity:495/1966 - (25%)
Similarity:690/1966 - (35%) Gaps:618/1966 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1783 VRQPQLYDLCGSTLNLIFDLSVPYASAVIDDLLNIANIGNQCPPLRALKSQISRGFNCNVGEVLN 1847
            |.:||:.   |:.:.:..|..:.::     |.|.:..:.:.|     :.|....|..|:   :|.
Zfish    72 VCRPQMQ---GNEVGVKCDCVLGFS-----DRLCLTPVNHAC-----MNSPCRNGGTCS---LLT 120

  Fly  1848 MDTSDVPRCL------------HCPAGTYVSEGQNS-------CTYCPRGYYQNRDRQ------- 1886
            :||... ||.            .|.:....:.||.|       || ||..::....||       
Zfish   121 LDTFTC-RCQPGWSGKTCQLADPCASNPCANGGQCSAFESHYICT-CPPNFHGQTCRQDVNECAV 183

  Fly  1887 --------GTCL--------RCP----------------------AGTYTKEEGTKSQADCIP-- 1911
                    |||:        |||                      .||..:...|.....|:|  
Zfish   184 SPSPCRNGGTCINEVGSYLCRCPPEYTGPHCQRLYQPCLPSPCRSGGTCVQTSDTTHTCSCLPGF 248

  Fly  1912 ---VCGYGTYSPTGLV-----PCLE--------CPRNSFTAEPPTGGFKDCQACP---------- 1950
               .|.:.....|...     ||::        |.:: :|.:..|....:|:..|          
Zfish   249 TGQTCEHNVDDCTQHACENGGPCIDGINTYNCHCDKH-WTGQYCTEDVDECELSPNACQNGGTCH 312

  Fly  1951 ----------AQSFTYQPAASNKDLC-RAKCAPGT--------------YSATGLA--------- 1981
                      ...:|....:.|.|.| .|.|:.|.              :..|||.         
Zfish   313 NTIGGFHCVCVNGWTGDDCSENIDDCASAACSHGATCHDRVASFFCECPHGRTGLLCHLDDACIS 377

  Fly  1982 -PC---SPCPLHHYQGAAGAQSCNECPSNMRTDSPASKGREQCKPVVCGEGACQHGGLCVPMGHD 2042
             ||   |.|..:...|.|   .|. ||... |.|..::..::|.   .|...|:|||.|:.....
Zfish   378 NPCQKGSNCDTNPVSGKA---ICT-CPPGY-TGSACNQDIDECS---LGANPCEHGGRCLNTKGS 434

  Fly  2043 IQCFCPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEASDCGNDTCP 2107
            .||.|..|:.|.|||.|::||.|.||.|...|.|...|:.|.|..||.|:.||..:.||.:..| 
Zfish   435 FQCKCLQGYEGPRCEMDVNECKSNPCQNDATCLDQIGGFHCICMPGYEGVFCQINSDDCASQPC- 498

  Fly  2108 ARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYKCECVPGWEG 2172
            ....|.::  ..:..|.|..|::|..|.|.:|.|.:  .||.|||.|.. ...:|.|||.||:.|
Zfish   499 LNGKCIDK--INSFHCECPKGFSGSLCQVDVDECAS--TPCKNGAKCTD-GPNKYTCECTPGFSG 558

  Fly  2173 IHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKH-GTCVDRLFD 2236
            ||||.:||:|:.:||..|. |.|.|..|.|.|.||:||:.||..|:.|||:||:: |||.||...
Zfish   559 IHCELDINECASSPCHYGV-CRDGVASFTCDCRPGYTGRLCETNINECLSQPCRNGGTCQDRENA 622

  Fly  2237 HECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQ 2301
            :.|.|..|.||..|:||||||:.:|| :.|.|:|.::||.|.|||||:|..|...|||||.|||.
Zfish   623 YICTCPKGTTGVNCEINIDDCKRKPC-DYGKCIDKINGYECVCEPGYSGSMCNINIDDCALNPCH 686

  Fly  2302 HGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLC 2366
            :|.||:|.::.|:|.|..|:...:|.::.:||.|:||.. |:  |||..|.:.|||..|:.|..|
Zfish   687 NGGTCIDGVNSFTCLCPDGFRDATCLSQHNECSSNPCIH-GS--CLDQINSYRCVCEAGWMGRNC 748

  Fly  2367 ATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYF 2431
            ..:|::|.:.||:|.|.|:|...|:.|.|..|:||..|:..:..| |..||.|..||||....:.
Zfish   749 DININECLSNPCVNGGTCKDMTSGYLCTCRAGFSGPNCQMNINEC-ASNPCLNQGSCIDDVAGFK 812

  Fly  2432 CVCPSGTDGKNCETAPERCIGDPCMHGGKC---QDFGSGLNCSCPADYSGIGCQYEYDACEEHVC 2493
            |.|.....|:.||.....|...||.:||.|   :||.| .:|:|||.:.|..|:.:.:.|..:.|
Zfish   813 CNCMLPYTGEVCENVLAPCSPRPCKNGGVCRESEDFQS-FSCNCPAGWQGQTCEVDINECVRNPC 876

  Fly  2494 QNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCR 2558
            .||..|.:...|:.|:|.|||||..||.||.||:.|.|..|..|.|..|||.|.|.....|:.|.
Zfish   877 TNGGVCENLRGGFQCRCNPGFTGALCENDIDDCEPNPCSNGGVCQDRVNGFVCVCLAGFRGERCA 941

  Fly  2559 KAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQR 2623
            :    |.|...|.|.|:...     .|...||.|.:....|                        
Zfish   942 E----DIDECVSAPCRNGGN-----CTDCVNSYTCSCPAGF------------------------ 973

  Fly  2624 RMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEY 2688
                    ||:...:  :.||.    .|.:..|.|      ...||||.                
Zfish   974 --------SGINCEI--NTPDC----TESSCFNGG------TCVDGISS---------------- 1002

  Fly  2689 GAGGSLPGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPV 2753
                      ::.:.||              ||.|               :..|..|.:|.|.|.
Zfish  1003 ----------FSCVCLP--------------GFTG---------------NYCQHDVNECDSRPC 1028

  Fly  2754 LYPGLILNWAG-YEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLV--VDKEPPVVEHCPGDLWV 2815
            ...|...:..| |:.|                ||.||||.|||.||  .|..|            
Zfish  1029 QNGGSCQDGYGTYKCT----------------CPHGYTGLNCQSLVRWCDSSP------------ 1065

  Fly  2816 IAKNGSAVVSWDE-PHFSDNI--GVTKIY--------ERNGHRSGTTLLWGTYDITYIASDA--- 2866
             .|||.:  .|.: ..|:...  |.|.||        |....:.|.:       :..:...|   
Zfish  1066 -CKNGGS--CWQQGASFTCQCASGWTGIYCDVPSVSCEVAARQQGVS-------VAVLCRHAGQC 1120

  Fly  2867 --AGNTASCSFKVSLLTDFCPALAD-----PVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVP 2924
              ||||..|..:......:|....|     |......|.|:..|                     
Zfish  1121 VDAGNTHLCRCQAGYTGSYCQEQVDECQPNPCQNGATCTDYLGG--------------------- 1164

  Fly  2925 EFYTCGAEGFWRPTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVN 2989
              |:|                   .|.|......             |:|.....|.|...|.  
Zfish  1165 --YSC-------------------ECVPGYHGMN-------------CSKEINECLSQPCQNG-- 1193

  Fly  2990 GLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDDDDDL 3054
                          ||  |.|:....||...||||           ||: .|.::...:...|.|
Zfish  1194 --------------GT--CIDLVNTYKCSCPRGTQ-----------GVH-CEIDIDDCSPSVDPL 1230

  Fly  3055 T-----LTGRQGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEIL 3114
            |     ..|.:...:.||........|           .|||           .|.|   |.|.|
Zfish  1231 TGEPRCFNGGRCVDRVGGYGCVCPAGF-----------VGER-----------CEGD---VNECL 1270

  Fly  3115 PNTVPDPASLELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSEAGQLQCSKC 3179
            .:.. ||:    || |.|    |.:|.| ..|...|.|  ..|.|.....|          |...
Zfish  1271 SDPC-DPS----GS-YNC----VQLIND-FRCECRTGY--TGKRCETVFNG----------CKDT 1312

  Fly  3180 PVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLC---RSCGHGFY---QPNEGSFSCELCG 3238
            |                   ||           ..|.|   .:..||:.   ||.....|||.  
Zfish  1313 P-------------------CK-----------NGGTCAVASNTKHGYICKCQPGYSGSSCEY-- 1345

  Fly  3239 LGQTTRSTEATSRKECRD--ECSSGQQLGADGRCEPCPRGTYRLQGVQPSCAA--CPLGRTTPKV 3299
                  .:::.....||:  .|.|| .|.....|.|...|......:...|..  |..|.|...:
Zfish  1346 ------DSQSCGSLRCRNGATCVSG-HLSPRCLCAPGFSGHECQTRMDSPCLVNPCYNGGTCQPI 1403

  Fly  3300 GASSVEECTLP------VC-------SAGTYLNATQNMCIECRKGYYQSESQQTSCL---QCPPN 3348
            ..:....|:.|      :|       |.|...:....:.:|.|....|.|.:..:.:   || .|
Zfish  1404 SDAPFYRCSCPANFNGLLCHILDYSFSGGQGRDIAPPVEVEIRCEIAQCEGRGGNAICDTQC-NN 1467

  Fly  3349 HSTKITGATSKSECTNPCEHIA----------EGKPHCD---VNAYCIMVPETSDFKC-----EC 3395
            |:....|........:|.::.:          :||  ||   ..|.|:.    ..|.|     :|
Zfish  1468 HACGWDGGDCSLNFDDPWQNCSAALQCWRYFNDGK--CDEQCATAGCLY----DGFDCQRLEGQC 1526

  Fly  3396 KPGFNGTGMACTD-VCDGFCENSGACVKDLKGTPSCRCVGSFTGPHCAERSEFAYIAGGIAGAVI 3459
            .|.::   ..|.| ..||.|:         :|..:..|  .:.|..||:........|.      
Zfish  1527 NPLYD---QYCRDHYADGHCD---------QGCNNAEC--EWDGLDCADDVPQKLAVGS------ 1571

  Fly  3460 FIIIIVLLIWMICVR---STKRRDPKKMLTPAI----DQTGSQVNF-YYGAHTPYAESIAPSHHS 3516
              :::|:.|....:|   |:..|:...:|...:    |..|..:.| |||           |.|.
Zfish  1572 --LVLVVHIPPDELRNRSSSFLRELSSLLHTNVVFRRDANGEALIFPYYG-----------SEHE 1623

  Fly  3517 TYAHYYDDEEDGWEMP 3532
            ...|...|    |..|
Zfish  1624 LSKHKRSD----WTDP 1635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 18/98 (18%)
GCC2_GCC3 1916..1966 CDD:285001 11/82 (13%)
GCC2_GCC3 1973..2020 CDD:285001 15/73 (21%)
EGF 2025..2055 CDD:278437 11/29 (38%)
EGF_CA 2059..2095 CDD:238011 15/35 (43%)
EGF_CA 2138..2176 CDD:238011 17/37 (46%)
EGF_CA 2178..2214 CDD:238011 16/35 (46%)
EGF_CA 2253..2289 CDD:238011 19/35 (54%)
EGF_CA 2292..2327 CDD:238011 16/34 (47%)
EGF_CA 2330..2366 CDD:238011 15/35 (43%)
EGF_CA 2369..2405 CDD:238011 14/35 (40%)
EGF_CA 2411..2444 CDD:238011 12/32 (38%)
EGF_CA 2486..2520 CDD:238011 13/33 (39%)
EGF_CA 2522..2557 CDD:238011 15/34 (44%)
LamG 2590..2735 CDD:304605 19/144 (13%)
DUF5011 2799..2877 CDD:295940 19/93 (20%)
GCC2_GCC3 3149..3200 CDD:285001 7/50 (14%)
GCC2_GCC3 3207..3254 CDD:285001 9/52 (17%)
GCC2_GCC3 3268..3307 CDD:285001 7/40 (18%)
GCC2_GCC3 3315..3362 CDD:285001 10/49 (20%)
notch1aNP_571516.1 EGF_CA 141..174 CDD:238011 8/33 (24%)
EGF_CA 177..215 CDD:238011 6/37 (16%)
EGF_CA 294..331 CDD:238011 3/36 (8%)
EGF_CA 334..369 CDD:238011 9/34 (26%)
EGF_CA 411..449 CDD:238011 13/40 (33%)
EGF_CA 451..487 CDD:238011 15/35 (43%)
EGF_CA 491..524 CDD:238011 8/35 (23%)
EGF_CA 526..562 CDD:238011 17/38 (45%)
EGF_CA 564..599 CDD:238011 16/35 (46%)
EGF_CA 601..637 CDD:238011 16/35 (46%)
EGF_CA 676..711 CDD:238011 16/34 (47%)
EGF_CA 716..748 CDD:238011 15/34 (44%)
EGF_CA 751..787 CDD:238011 14/35 (40%)
EGF_CA 789..825 CDD:238011 12/36 (33%)
EGF_CA 867..903 CDD:238011 13/35 (37%)
EGF_CA 905..940 CDD:238011 15/34 (44%)
EGF_CA 943..979 CDD:238011 12/72 (17%)
EGF_CA 986..1017 CDD:238011 12/91 (13%)
EGF_CA 1019..1055 CDD:238011 15/51 (29%)
EGF_CA 1144..1178 CDD:238011 9/88 (10%)
EGF_CA 1182..1217 CDD:238011 15/64 (23%)
EGF_CA 1219..1263 CDD:238011 10/65 (15%)
EGF_CA 1265..1303 CDD:238011 17/53 (32%)
NL 1440..1477 CDD:197463 9/37 (24%)
LNR 1 1447..1487 8/40 (20%)
Notch 1485..1520 CDD:278494 7/40 (18%)
LNR 2 1488..1525 8/42 (19%)
Notch 1523..1559 CDD:278494 10/49 (20%)
LNR 3 1526..1566 12/53 (23%)
NOD 1565..1616 CDD:284282 9/58 (16%)
NODP 1664..1721 CDD:284987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1770..1790
Ank_2 <1860..1946 CDD:289560
ANK 1862..2003 CDD:238125
ANK repeat 1867..1913 CDD:293786
ANK 1 1867..1910
ANK repeat 1915..1946 CDD:293786
ANK 2 1915..1944
Ank_2 1920..2013 CDD:289560
ANK repeat 1948..1979 CDD:293786
ANK 3 1948..1978
ANK 1977..2101 CDD:238125
ANK 4 1982..2011
Ank_2 1987..2079 CDD:289560
ANK repeat 2015..2079 CDD:293786
ANK 5 2015..2044
ANK 6 2048..2077
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2127..2174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2356..2437
DUF3454 2364..2424 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10660
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12916
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
44.020

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