DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and Notch2

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_077334.2 Gene:Notch2 / 29492 RGDID:3188 Length:2471 Species:Rattus norvegicus


Alignment Length:2001 Identity:490/2001 - (24%)
Similarity:690/2001 - (34%) Gaps:711/2001 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1696 CVSENTEQAAYHVTASITYRANGAVAQSC----LGQYQEVLAQH----------YGG--LNQLL- 1743
            ||:|.|         .:||. ||.....|    ||:|    .||          .||  :.|.: 
  Rat    35 CVNEGT---------CVTYH-NGTGYCRCPEGFLGEY----CQHRDPCEKNRCQNGGTCVTQAML 85

  Fly  1744 ---SQRCSAVNVNMNVTFVKSVPMLLE-----------------ENVVKMDFILSILPAVRQPQL 1788
               :.||:......:..:..|.|..:.                 |...::.|      ..:|.|.
  Rat    86 GKATCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGTCHMLSWDTYECTCQVGF------TGKQCQW 144

  Fly  1789 YDLCGSTLNLIFDLSVPYASAVIDDLLNIANIGNQCPPLRALKSQISRGFNCN-----VGEVLNM 1848
            .|:|         ||.|..:            |:.|       |.::..|:|.     .|:..:.
  Rat   145 TDVC---------LSHPCEN------------GSTC-------SSVANQFSCRCPAGITGQKCDA 181

  Fly  1849 DTS--DVP-RCLHCPAGTYVS-EGQNSCTYCPRGYY-QNRD------------RQGTCLRCPAGT 1896
            |.:  |:| ||.|  .||.:: .|...| .||:|:. |:.|            ..|||.:  .|.
  Rat   182 DINECDIPGRCQH--GGTCLNLPGSYRC-QCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQ--TGD 241

  Fly  1897 YTKE-------EGTKSQA---DC---------IPVCGYGTYS----P--TG------LVPCLECP 1930
            :|.|       ||:..:.   ||         :.|.|..||:    |  ||      :..||..|
  Rat   242 FTSECHCLPGFEGSNCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQP 306

  Fly  1931 ---RNSFTAEPPTGGFKDCQACPAQSFTYQPAASNKDLCR-AKCAPGTYSATGLAPCS-PCPLHH 1990
               :|..|.....||: .| .| ...::....:.|.|.|. |.|.||:.....:|..| .||   
  Rat   307 NACQNGGTCTNRNGGY-GC-VC-VNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCLCP--- 365

  Fly  1991 YQGAAGAQSC---NECPSNMRTDSPASKGREQCKPVVCGEGACQHGGLC--VPMGHDIQCFCPAG 2050
             :|.||. .|   :.|.||                      .|..|.||  .|:.....|.||.|
  Rat   366 -EGKAGL-LCHLDDACISN----------------------PCHKGALCDTNPLNGQYICTCPQG 406

  Fly  2051 FSGRRCEQDIDECA---SQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAMC 2112
            :.|..|.:|:||||   |.||.:.|:|.:....:.|||..||:|..|:.:.::|.:|.|...|.|
  Rat   407 YKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATC 471

  Fly  2113 KNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCEQ 2177
            .::.|  ..||||..|:.|..|::.::.|  ..|||.|...| ..:..|::|.|.||:.|..|:.
  Rat   472 LDKIG--GFTCLCMPGFKGVHCELEVNEC--QSNPCVNNGQC-VDKVNRFQCLCPPGFTGPVCQI 531

  Fly  2178 NINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKHGTCVDRLFDHECVCH 2242
            :|:|||..|||.||.|.|..|.::|.|..||||..|::.||.|..:||.||.|.|.:..:.|:|:
  Rat   532 DIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGTLCDENIDNCDPDPCHHGQCQDGIDSYTCICN 596

  Fly  2243 PGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCV 2307
            ||:.|:.|...||:|.:.||.|:|.|:|||:||.|||:||.:|.||:...||||||||.||| ||
  Rat   597 PGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCLHGA-CV 660

  Fly  2308 DQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDD 2372
            |.::.:||.|.||:.|..|..:||||.|:||....|  |::..|.|.|:|.:|...|.|.:.:::
  Rat   661 DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGAT--CINDVNGFRCMCPEGPHHPSCYSQVNE 723

  Fly  2373 CEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCPSG 2437
            |.:.||: :|.|...:.|::|.|:.||.|:.||.....| ...||||..:|.:|...|.|.|..|
  Rat   724 CLSSPCI-HGNCTGGLSGYKCLCDAGWVGINCEVDKNEC-LSNPCQNGGTCNNLVNGYRCTCKKG 786

  Fly  2438 TDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHVCQNGAT---- 2498
            ..|.||:...:.|..:||::.|.|.|..||..|.|...|:|..||.....|..:.|:|.|.    
  Rat   787 FKGYNCQVNIDECASNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEA 851

  Fly  2499 ------------------------------CVDNG------AGYSCQCPPGFTGRNCEQDIVDCK 2527
                                          |::||      ..|.|:|||||:|.:||:||.||.
  Rat   852 PNFESFTCLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECPPGFSGMDCEEDINDCL 916

  Fly  2528 DNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRS--TAAQVVPFPTGEANS 2590
            .|.|..|.:|||..|.|.|.|.....||.|    |.|.:...|:|.::  |.:..|       ||
  Rat   917 ANPCQNGGSCVDKVNTFSCLCLPGFVGDKC----QTDMNECLSEPCKNGGTCSDYV-------NS 970

  Fly  2591 LTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSV 2655
            .|......|            :||..                       |:..|   ...|.:..
  Rat   971 YTCTCPAGF------------HGVHC-----------------------ENNID---ECTESSCF 997

  Fly  2656 NDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYLWAVLGLPQPYGLSNELAYSDSG 2720
            |.|      ...|||:....|.                             |.|.:......|  
  Rat   998 NGG------TCVDGINSFSCLC-----------------------------PVGFTGPFCLHD-- 1025

  Fly  2721 FQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNWAG-YEVTSGGVERNVPSLCGQRK 2784
                                    :.:|.|.|.|..|..::..| |..|                
  Rat  1026 ------------------------INECSSNPCLNSGTCVDGLGTYRCT---------------- 1050

  Fly  2785 CPVGYTGANCQQLVVDKEPPVVEH--------------CPGDLWVIAKNGSAVVSWDEPHFSDNI 2835
            ||:||||.|||.||....|...::              ||             ..||        
  Rat  1051 CPLGYTGKNCQTLVNLCSPSPCKNKGTCAQEKARPRCLCP-------------PGWD-------- 1094

  Fly  2836 GVTKIYERNGHRSGTTLLWGTY-DITYIASDA---------------------AGNTASCSFKVS 2878
                               |.| |:..::..|                     ||||..|...:.
  Rat  1095 -------------------GAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLG 1140

  Fly  2879 LLTDFCPALAD-----PVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPT 2938
            ....:|....|     |......|.|:..|                       |.|         
  Rat  1141 YTGSYCEEQLDECASNPCQHGATCSDFIGG-----------------------YRC--------- 1173

  Fly  2939 REPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDWNFCSYAIE 3003
                      .|.|                                  ...|:|     |.|.::
  Rat  1174 ----------ECVP----------------------------------GYQGVN-----CEYEVD 1189

  Fly  3004 ----------GTRECKDIQIDVKCDHYRGTQNNRVRRQAKD--GGVYVMEAELPVVNDDDDDLTL 3056
                      ||  |.|:....||....||:.........|  ||.:                .|
  Rat  1190 ECQNQPCQNGGT--CIDLVNHFKCSCPPGTRGLLCEENIDDCAGGPH----------------CL 1236

  Fly  3057 TGRQGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDP 3121
            .|.|...:.||.:......|           .|||           .|.|   :.|.|.|.....
  Rat  1237 NGGQCVDRIGGYSCRCLPGF-----------AGER-----------CEGD---INECLSNPCSSE 1276

  Fly  3122 ASL---ELGSEYACPVGQVVMIPDCVPCAIGTFYD-SANKTCIACSRGTYQSEAGQLQCSKCPVI 3182
            .||   :|.:.|.|..........|     .||.| ...|.|:........|........:||  
  Rat  1277 GSLDCIQLKNNYQCVCRSAFTGRHC-----ETFLDVCPQKPCLNGGTCAVASNVPDGFICRCP-- 1334

  Fly  3183 AGRPGVTAGPGARSAADCKE-RCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTTRST 3246
               ||.:   |||..:.|.: :|..|:          .|.|....|:     | .|         
  Rat  1335 ---PGFS---GARCQSSCGQVKCRRGE----------QCVHTASGPH-----C-FC--------- 1368

  Fly  3247 EATSRKECRDECSSGQQLGADGRCEPCPRGTYRLQGVQPSCAACPLGRTTPKVGASSVEECTLPV 3311
              .:||:|...|:|          .||..|.......||...:|   |.:|....|..|..|.| 
  Rat  1369 --LNRKDCESGCAS----------NPCQHGGTCYPQRQPPYYSC---RCSPPFWGSHCESYTAP- 1417

  Fly  3312 CSAGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPNHSTKITGATSKSECTNPCEHIAEGKPHC 3376
                     |......|...|...:::...|.:...:|:.:..|    .:|:...|         
  Rat  1418 ---------TSTPPATCLSQYCADKARDGICDEACNSHACQWDG----GDCSLTME--------- 1460

  Fly  3377 DVNAYCIMVPETSDFKCECKPGFNGTGMACTDVCDGFCENSGACVKD----LKGTPSCR----CV 3433
            |..|.|     ||..:|         .....:.||..| |:..|:.|    .:.:.:|:    |.
  Rat  1461 DPWANC-----TSSLRC---------WEYINNQCDELC-NTAECLFDNFECQRNSKTCKYDKYCA 1510

  Fly  3434 GSFTGPHC-----------------AERSEFAYIAGGIAGAVIFIIIIVLL 3467
            ..|...||                 |::.|  .:|.||      ::|:|||
  Rat  1511 DHFKDNHCDKGCNNEECGWDGLDCAADQPE--NLAEGI------LVIVVLL 1553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 17/70 (24%)
GCC2_GCC3 1916..1966 CDD:285001 16/64 (25%)
GCC2_GCC3 1973..2020 CDD:285001 12/50 (24%)
EGF 2025..2055 CDD:278437 10/31 (32%)
EGF_CA 2059..2095 CDD:238011 16/38 (42%)
EGF_CA 2138..2176 CDD:238011 12/37 (32%)
EGF_CA 2178..2214 CDD:238011 18/35 (51%)
EGF_CA 2253..2289 CDD:238011 20/35 (57%)
EGF_CA 2292..2327 CDD:238011 20/34 (59%)
EGF_CA 2330..2366 CDD:238011 15/35 (43%)
EGF_CA 2369..2405 CDD:238011 11/35 (31%)
EGF_CA 2411..2444 CDD:238011 13/32 (41%)
EGF_CA 2486..2520 CDD:238011 15/73 (21%)
EGF_CA 2522..2557 CDD:238011 16/34 (47%)
LamG 2590..2735 CDD:304605 17/144 (12%)
DUF5011 2799..2877 CDD:295940 14/113 (12%)
GCC2_GCC3 3149..3200 CDD:285001 13/51 (25%)
GCC2_GCC3 3207..3254 CDD:285001 8/46 (17%)
GCC2_GCC3 3268..3307 CDD:285001 10/38 (26%)
GCC2_GCC3 3315..3362 CDD:285001 6/46 (13%)
Notch2NP_077334.2 EGF_CA 109..143 CDD:238011 3/39 (8%)
EGF_CA 182..218 CDD:238011 14/38 (37%)
EGF_CA 260..296 CDD:238011 9/35 (26%)
EGF_CA 298..335 CDD:238011 9/39 (23%)
EGF_CA 415..454 CDD:238011 16/38 (42%)
EGF_CA 456..492 CDD:238011 12/37 (32%)
EGF_CA 495..530 CDD:238011 12/37 (32%)
EGF_CA 532..567 CDD:238011 18/34 (53%)
EGF_CA 570..604 CDD:238011 14/33 (42%)
EGF_CA 608..643 CDD:238011 20/34 (59%)
EGF_CA 645..679 CDD:238011 20/34 (59%)
EGF_CA 682..717 CDD:238011 15/36 (42%)
EGF_CA 757..793 CDD:238011 13/36 (36%)
EGF_CA 795..831 CDD:238011 12/35 (34%)
EGF_CA 873..909 CDD:238011 11/35 (31%)
EGF_CA 911..947 CDD:238011 17/39 (44%)
EGF_CA 949..985 CDD:238011 11/77 (14%)
EGF_CA 987..1022 CDD:238011 10/72 (14%)
EGF_CA 1025..1061 CDD:238011 16/77 (21%)
EGF_CA 1117..1147 CDD:238011 5/29 (17%)
EGF_CA 1151..1185 CDD:238011 11/114 (10%)
EGF_CA 1188..1223 CDD:238011 8/36 (22%)
EGF_CA 1225..1262 CDD:238011 12/74 (16%)
EGF_CA 1264..1302 CDD:238011 10/45 (22%)
EGF_CA <1312..1343 CDD:238011 9/38 (24%)
Notch 1423..1456 CDD:278494 5/36 (14%)
Negative regulatory region (NRR). /evidence=ECO:0000250 1425..1677 33/165 (20%)
Notch 1463..1497 CDD:278494 11/48 (23%)
Notch 1501..1534 CDD:278494 5/32 (16%)
NOD 1540..1591 CDD:284282 8/22 (36%)
NODP 1619..1673 CDD:284987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1794..1813
Ank_2 <1820..1907 CDD:289560
ANK repeat 1827..1874 CDD:293786
ANK 1 1827..1871
ANK 1872..1997 CDD:238125
ANK 2 1876..1905
ANK repeat 1877..1907 CDD:293786
Ank_2 1881..1974 CDD:289560
ANK 3 1909..1939
ANK 1938..2062 CDD:238125
ANK repeat 1943..1974 CDD:293786
ANK 4 1943..1972
Ank_2 1948..2040 CDD:289560
ANK repeat 1976..2007 CDD:293786
ANK 5 1976..2005
ANK repeat 2009..2040 CDD:293786
ANK 6 2009..2038
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2097..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2380..2471
DUF3454 2381..2439 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10641
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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