DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and Crb2

DIOPT Version :10

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001157038.1 Gene:Crb2 / 241324 MGIID:2679260 Length:1282 Species:Mus musculus


Alignment Length:1513 Identity:380/1513 - (25%)
Similarity:527/1513 - (34%) Gaps:461/1513 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2140 PCTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDL---VNDFQ 2201
            |.....:||..|..|||.|.|.|.||          ...:..|:..||..||.|...   .|.|:
Mouse    43 PSVCASDPCAPGTKCQATESGGYTCE----------PSELGGCATQPCHHGALCVPQGPDPNSFR 97

  Fly  2202 CACPPGFTGKRCEQKIDLCLSEPCKHGTCVDRLFDH-ECVCHPGWTGSACDINIDDCENRPCANE 2265
            |.|.|||.|..||..||.|.|.||:||.....|.|| ||.|..|:.|..|:..:|:|.:.||.:.
Mouse    98 CYCVPGFQGPHCELDIDECASRPCQHGGTCQNLADHYECHCPLGYAGVTCEAEVDECSSAPCLHG 162

  Fly  2266 GTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCR-PGYVGLSCEAE 2329
            |:|:|.|..|.|.|.|||.|.|||..:|:|.|.||.||..|.|.::||.|.|. .||.|..||.|
Mouse   163 GSCLDGVGSYRCVCAPGYAGANCQLDVDECQSQPCAHGGVCHDLVNGFRCDCADTGYEGARCEQE 227

  Fly  2330 IDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECG 2394
            :.||.|.||  .....|||....|.|:|..||.|..|..|.|:|.:.||.|.|.|..|       
Mouse   228 VLECASAPC--AHNASCLDGFRSFRCLCWPGFSGERCEVDEDECASGPCQNGGQCLQR------- 283

  Fly  2395 CEPGWSGMRCEQQVTTCGAQA--PCQNDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMH 2457
            .:|...|          |.||  |   .|........:.|.||.|..|.:|....:.|...||::
Mouse   284 SDPTLYG----------GVQAIFP---GAFSFSHAAGFLCSCPLGFAGNDCSMDVDECASGPCLN 335

  Fly  2458 GGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCEQD 2522
            ||.|||..:|..|.|...|:|:.||.:.|.|:...|.:|.||.|..|||.||||..:.|.:|...
Mouse   336 GGSCQDLPNGFQCYCQDGYTGLTCQEDMDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSVQ 400

  Fly  2523 IVDCKDNSCPPGATCVDL----TNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPF 2583
            :..|:.::||..|||:..    .:|::|:||....|..|.:      :..||..|.|:...:|| 
Mouse   401 LTGCQGHTCPLAATCIPTFKSGLHGYFCRCPPGTYGPFCGQ------NTTFSVVSGSSVWGLVP- 458

  Fly  2584 PTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQA----HSSGVQVSLFEDQPD 2644
               .|.||.:|:  :|......|...||...:.:........:|||    |.:.|.:....|   
Mouse   459 ---AAASLGLAL--RFRTTLLAGTLATLKDTRDSLELVLVGAVLQATLSRHGTAVLILTLPD--- 515

  Fly  2645 AFLSFGEYTSVNDGQWHHVAV----------VW-DGISGQLQLITEGLIASKMEYGAGGSLPGYL 2698
                    .::|||.||.|.|          :| :|..||| .:..|.:|:    |...|:..  
Mouse   516 --------LALNDGHWHQVEVTLHLGTLELRLWHEGCPGQL-CVASGPVAT----GPTASVAS-- 565

  Fly  2699 WAVLGLPQPYGLSNELAYSDSG-FQGTITKAQVWARALDITSEIQKQV-------RDCRSEPVLY 2755
                |.|..|.:     |...| |.|.....:|....| :..|::..|       ..|:..|..:
Mouse   566 ----GPPGSYSI-----YLGGGVFAGCFQDVRVEGHLL-LPEELKGTVLLGCERREPCQPLPCAH 620

  Fly  2756 PGLILN-WAGYEVTSGGVERNVPSLCGQRKCPVGYTGANC------------------------- 2794
            .|..:: |..:.             |   .||..|.||.|                         
Mouse   621 GGACVDLWTHFR-------------C---DCPRPYRGATCTDEVPAATFGLGGATSSASFLLHQL 669

  Fly  2795 -QQLVVD-----KEP-----PVVEHCPGDLWVIAKNGS---------AVV---SWDE--PHF--- 2831
             ..|.|.     :||     .........|.|....|.         |||   .||:  ||.   
Mouse   670 GPNLTVSFFLRTREPAGLLLQFANDSVASLTVFLSEGQIRAEGLGHPAVVLPGRWDDGLPHLVML 734

  Fly  2832 ------SDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVSLLTDFCPALADP 2890
                  ..::| .::|.........|.|||            |....|...:.|.:...|..:.|
Mouse   735 SFGPDQLQDLG-QRLYVGGRFYPDDTQLWG------------GPFRGCLQDLQLNSIHLPFFSSP 786

  Fly  2891 VGGSQVCKDWGAG-----GQFKVCEIACNAGLRFSEPVP------------EFYTCGAEGFWRPT 2938
            :..|....:..||     .|..|.|..||       |.|            :||...:|.|..||
Mouse   787 MENSSWPSELEAGQSSNLTQGCVSEDTCN-------PNPCFNGGTCHVTWNDFYCTCSENFTGPT 844

  Fly  2939 --------REPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQ---------KVTN 2986
                    |:|        |.|....:.|       |...:|  ..:|..|:         .|::
Mouse   845 CAQQRWCPRQP--------CLPPATCEEV-------PDGFVC--VAEATFREGPPAVFTGHNVSS 892

  Fly  2987 SVNGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNN---RVRRQAKDGGV--YVMEAELPV 3046
            |::||...:.        ||:.:...:  :.....|..:|   .||..:..|.|  .|:.|..|.
Mouse   893 SLSGLTLAFR--------TRDSEAGLL--RAVSAAGAHSNIWLAVRNGSLAGDVAGSVLPAPGPR 947

  Fly  3047 VNDDDDDLTLTGRQGRQQTGGDTYTLEIA--FP-------------AANDPVVHTSTGERSTVKQ 3096
            |.|                 |..:.:.:|  ||             ||....:|...|:...::.
Mouse   948 VAD-----------------GAWHRVRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQG 995

  Fly  3097 LLEKLILEDDQFAVQEILPNTVPDPASLELGSEYACPVGQVVM----IPDCVPCAIGTFYDSANK 3157
                              |..||    |.|...:...:|:|.:    :| ..|...|| ...|.:
Mouse   996 ------------------PGAVP----LLLAENFTGCLGRVALGDFPLP-LAPPRSGT-VSGARE 1036

  Fly  3158 TCIACSRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLCRSCGH 3222
            ..:|..    .|.|..|.|...||.:..|.:..|.       |::      .|||   ...|||.
Mouse  1037 HFVAWP----GSPAVSLGCRGGPVCSPSPCLHGGA-------CRD------LFDA---FACSCGP 1081

  Fly  3223 GFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECSSGQQLGADGRCEPCPRGTYRLQGVQPSC 3287
            .:..|.     ||:  .....|||          .|..||       |...|.|.:..:      
Mouse  1082 AWEGPR-----CEI--RADPCRST----------PCVRGQ-------CHARPDGRFECR------ 1116

  Fly  3288 AACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPNHSTK 3352
              ||.|.:.|:        |.|||...|..||:|      |:.|                     
Mouse  1117 --CPPGFSGPR--------CRLPVLPQGCNLNST------CKDG--------------------- 1144

  Fly  3353 ITGATSKSECTNPCEHIAEGKPHCDVNAYCIMVPETSDFKCECKPGFNGTGMACTDV---CDGF- 3413
                       .||    ||.|              ....|.|:.|.  .|:.|..:   |:.. 
Mouse  1145 -----------APC----EGGP--------------LGTNCSCQEGL--AGLRCQSLDKPCEASP 1178

  Fly  3414 CENSGACVKDLKGTPSCRCVGSFTGPHCAERSEFAY--------IAGGIAGAVIFIIIIVLLIWM 3470
            |.|.|.| :...|...|.|...|:|..|........        :|...|.|.:.::::.||..:
Mouse  1179 CLNGGTC-RVASGIFECTCSAGFSGQFCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGI 1242

  Fly  3471 ICVRSTKRRDPKKMLTPA 3488
            :..|  |||..:...:|:
Mouse  1243 LAAR--KRRQSEGTYSPS 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
PHA02639 697..>834 CDD:165022
FA58C 833..976 CDD:330301
FXa_inhibition 988..>1016 CDD:464251
CCP 1051..1106 CDD:153056
FA58C 1303..1443 CDD:330301
HYR 1463..1547 CDD:460572
HYR 1548..1631 CDD:460572
Ephrin_rec_like 1862..1909 CDD:429604
Ephrin_rec_like 1916..1966 CDD:429604
Ephrin_rec_like 1973..2020 CDD:429604
EGF 2025..2055 CDD:394967
EGF_CA 2059..2095 CDD:238011
EGF_CA 2138..2176 CDD:238011 12/35 (34%)
EGF_CA 2178..2214 CDD:238011 14/38 (37%)
EGF_CA 2253..2289 CDD:238011 16/35 (46%)
EGF_CA 2292..2327 CDD:238011 16/35 (46%)
EGF_CA 2369..2405 CDD:238011 11/35 (31%)
EGF_CA 2411..2444 CDD:238011 10/34 (29%)
EGF_CA 2486..2520 CDD:238011 15/33 (45%)
EGF_CA 2522..2557 CDD:238011 11/38 (29%)
LamG 2590..2735 CDD:473984 37/160 (23%)
HYR 2799..2877 CDD:460572 21/110 (19%)
Ephrin_rec_like 3149..3200 CDD:429604 12/50 (24%)
Ephrin_rec_like 3207..3254 CDD:429604 12/46 (26%)
Ephrin_rec_like 3268..3307 CDD:429604 7/38 (18%)
Ephrin_rec_like 3315..3362 CDD:429604 6/46 (13%)
Crb2NP_001157038.1 EGF_CA <79..110 CDD:238011 13/30 (43%)
EGF_CA 112..148 CDD:238011 16/35 (46%)
EGF_CA 151..186 CDD:238011 16/34 (47%)
EGF_CA 188..225 CDD:238011 16/36 (44%)
EGF_CA 230..263 CDD:238011 14/34 (41%)
EGF_CA 324..360 CDD:238011 13/35 (37%)
EGF_CA 362..397 CDD:238011 15/34 (44%)
Laminin_G_2 469..592 CDD:460494 34/149 (23%)
EGF 613..643 CDD:394967 9/45 (20%)
LamG 666..776 CDD:238058 22/122 (18%)
EGF 814..844 CDD:394967 8/36 (22%)
LamG 875..1014 CDD:238058 33/187 (18%)
EGF_CA 1058..1089 CDD:238011 10/51 (20%)
EGF_CA 1175..1206 CDD:238011 9/31 (29%)
Interaction with EPB41L5. /evidence=ECO:0000250|UniProtKB:Q5IJ48 1246..1282 5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

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