DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and CRB1

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:XP_016856341.1 Gene:CRB1 / 23418 HGNCID:2343 Length:1451 Species:Homo sapiens


Alignment Length:1710 Identity:400/1710 - (23%)
Similarity:595/1710 - (34%) Gaps:539/1710 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  2025 CGEGACQHGGLCVPMGHDIQCFC--PAGFSGRRCEQDIDECASQPCYNGGQCKDLP--QGYRCEC 2085
            |...:||:...|.....|..|.|  .|....:.|:...|.|.|.||.....|.:.|  :.:.|:|
Human    34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKC 98

  Fly  2086 PAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGN 2150
            |.||||..|:.....||.::|....:|..:|.|.  .|:|.:||.|..|::..|.|.:  :||.|
Human    99 PPGYSGTICETTIGSCGKNSCQHGGICHQDPIYP--VCICPAGYAGRFCEIDHDECAS--SPCQN 159

  Fly  2151 GASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQ 2215
            ||.||....| |.|.||||::|.||:..:::|:.:||...|.|.:.:..:.|.||..::|..||.
Human   160 GAVCQDGIDG-YSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCEL 223

  Fly  2216 KIDLCLSEPCKHG-TCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNC 2279
            :||.|.|:||.:| ||.|.|..:.|.|.||:.|..|::|.|:|.::||.:.|.|||..:.|||||
Human   224 EIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNC 288

  Fly  2280 E-PGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGT 2343
            . .|:||.:|:..:..|.|.||.:.|||.|.:|.::|.|.|||.|..||.:::||.|:||...| 
Human   289 TGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNG- 352

  Fly  2344 ERCLDLDNK--------------------FECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRV 2388
             .|::|.::                    :.|:|:.||.|..|..|:::|.:.||.|.|.|.:..
Human   353 -ECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLP 416

  Fly  2389 GGFECGC------EPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQD----YFCVCPSGTDGKNC 2443
            |.:.|.|      ...:.|..|...:..|..| .|.|:.:||..|||    :.|:||||..|..|
Human   417 GNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQ-QCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLC 480

  Fly  2444 ETAPERCI-GDPCM--HGGKCQDFGSGLNCSCP-------------------------ADYSGIG 2480
            |.|..... ||..:  ..|.....||..|.:..                         :.|..:.
Human   481 EIATTLSFEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLS 545

  Fly  2481 CQYEY----------------------------------DACEE--------------HVC--QN 2495
            .|...                                  |:|:|              .:|  ||
Human   546 IQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQN 610

  Fly  2496 --------GATCVDNGAG----YSCQCPPGFTGRNCEQDI-VD---------------------- 2525
                    |.|  .||..    |:....|.|.|  |.||| :|                      
Human   611 SFLGGLPVGMT--SNGVALLNFYNMPSTPSFVG--CLQDIKIDWNHITLENISSGSSLNVKAGCV 671

  Fly  2526 ----CKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTG 2586
                |:...|.....|::|...:.|.|.....|.:|.:                      .:..|
Human   672 RKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLR----------------------EYVAG 714

  Fly  2587 EANSLTVAMWVQFAQKDDRG-IFFTL---YG-----VQSARMTQQRRMLLQAHSSGVQ------- 2635
                       :|.|.|..| :.|||   ||     ....|..|...:||...:|..|       
Human   715 -----------RFGQDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLE 768

  Fly  2636 ----VSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPG 2696
                ..|..:.|...:.|    .:|||..|                   ||:.|:          
Human   769 RGRLAMLTPNSPKLVVKF----VLNDGNVH-------------------LISLKI---------- 800

  Fly  2697 YLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILN 2761
                     :||.:  || |..|...|.|: |..|        :|:|       ..|:|.|.:.:
Human   801 ---------KPYKI--EL-YQSSQNLGFIS-ASTW--------KIEK-------GDVIYIGGLPD 837

  Fly  2762 WAGYEVTSG-------GVERNVPSLCGQRKCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKN 2819
            ....|:..|       .|..|..:|   ...|.....|:...::|:    |.:.|.||       
Human   838 KQETELNGGFFKGCIQDVRLNNQNL---EFFPNPTNNASLNPVLVN----VTQGCAGD------- 888

  Fly  2820 GSAVVSWDEPHFSDNIG--VTKIYERNGHRSGTTLL------WGTYDITYIASDAAG-----NTA 2871
                   :......|:|  :|::..| |.:...:|.      |.|.:..:::|...|     |..
Human   889 -------NSCKRQTNVGRALTELGSR-GPKYQVSLFRFCVGSWATGNTFFLSSIKPGSNPCHNGG 945

  Fly  2872 SCSFKVSLLTDFCPALADPVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWR 2936
            .|..:....:..||||...                |.||              |...||      
Human   946 VCHSRWDDFSCSCPALTSG----------------KACE--------------EVQWCG------ 974

  Fly  2937 PTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLR------QKVTNSVNGL-NRD 2994
                      :..|......|.|.:......:.|...::||.:.|      :::||...|. .||
Human   975 ----------FSPCPHGAQCQPVLQGFECIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRD 1029

  Fly  2995 WNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDDDDDLTLTGR 3059
            .|......|...|..:|.|          |::|:..|.:.|..:.|             |:||..
Human  1030 ANVIILHAEKEPEFLNISI----------QDSRLFFQLQSGNSFYM-------------LSLTSL 1071

  Fly  3060 QGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILP---NTVPDP 3121
            |..........||.:     .||:..||..:..         :..:..|....|..   |.:.|.
Human  1072 QSVNDGTWHEVTLSM-----TDPLSQTSRWQME---------VDNETPFVTSTIATGSLNFLKDN 1122

  Fly  3122 ASLELGSEYACPVGQVVMIPDCV-PCAIGTFYDS--------ANKTCIACSRGTYQSEAGQLQCS 3177
            ..:.:|..   .:..:..:..|: ...||..|.|        .||          ..|...|:.|
Human  1123 TDIYVGDR---AIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINK----------PQEEQFLKIS 1174

  Fly  3178 KCPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLCRS--CGHG-----FYQPNEGSFSCE 3235
            ...|:.|                   |       .:..:|.|  |.||     .|    .|:.|.
Human  1175 TNSVVTG-------------------C-------LQLNVCNSNPCLHGGNCEDIY----SSYHCS 1209

  Fly  3236 LCGLGQTTRSTEATSRKECR---DECSSGQQLGADGRCEPCPRGTYRLQGVQPSCAACPLGRTTP 3297
             |.||        .|.|.|.   |||.|          .||..|....:.....| .|..|.|  
Human  1210 -CPLG--------WSGKHCELNIDECFS----------NPCIHGNCSDRVAAYHC-TCEPGYT-- 1252

  Fly  3298 KVGAS---SVEECTLPVCSAGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPNHSTKI--TGAT 3357
              |.:   .::.|....|:.|    ||   ||....||        ||| |..|.:.|.  ....
Human  1253 --GVNCEVDIDNCQSHQCANG----AT---CISHTNGY--------SCL-CFGNFTGKFCRQSRL 1299

  Fly  3358 SKSECTNPCEHIAEGKPHCDVNAYCIMVPETSDFKCECKPGFNGTGMAC---TDVC-DGFCENSG 3418
            ..:.|.|...::.     |.....|  ....::.||.|:|||  ||..|   .|.| ...|.|.|
Human  1300 PSTVCGNEKTNLT-----CYNGGNC--TEFQTELKCMCRPGF--TGEWCEKDIDECASDPCVNGG 1355

  Fly  3419 ACVKDLKGTPSCRCVGSFTGPHC-AERSE--FAYIAGGIAGAVIFIIIIVLLIWMICVRSTKRRD 3480
            .| :||.....|.|..:|.|..| .:.::  .:.|...|....:.:::|:||..:..|.::.:|.
Human  1356 LC-QDLLNKFQCLCDVAFAGERCEVDLADDLISDIFTTIGSVTVALLLILLLAIVASVVTSNKRA 1419

  Fly  3481 PKKMLTPA-IDQTGSQVNFY 3499
            .:...:|: .::.||:|..:
Human  1420 TQGTYSPSRQEKEGSRVEMW 1439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001
GCC2_GCC3 1916..1966 CDD:285001
GCC2_GCC3 1973..2020 CDD:285001
EGF 2025..2055 CDD:278437 8/31 (26%)
EGF_CA 2059..2095 CDD:238011 14/37 (38%)
EGF_CA 2138..2176 CDD:238011 18/37 (49%)
EGF_CA 2178..2214 CDD:238011 9/35 (26%)
EGF_CA 2253..2289 CDD:238011 17/36 (47%)
EGF_CA 2292..2327 CDD:238011 15/34 (44%)
EGF_CA 2330..2366 CDD:238011 13/55 (24%)
EGF_CA 2369..2405 CDD:238011 11/41 (27%)
EGF_CA 2411..2444 CDD:238011 15/36 (42%)
EGF_CA 2486..2520 CDD:238011 14/61 (23%)
EGF_CA 2522..2557 CDD:238011 10/61 (16%)
LamG 2590..2735 CDD:304605 35/164 (21%)
DUF5011 2799..2877 CDD:295940 17/90 (19%)
GCC2_GCC3 3149..3200 CDD:285001 10/58 (17%)
GCC2_GCC3 3207..3254 CDD:285001 13/53 (25%)
GCC2_GCC3 3268..3307 CDD:285001 8/41 (20%)
GCC2_GCC3 3315..3362 CDD:285001 13/48 (27%)
CRB1XP_016856341.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147105
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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