DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment uif and Elapor1

DIOPT Version :9

Sequence 1:	NP_001162899.1	Gene:	uif / 33983	FlyBaseID:	FBgn0031879	Length:	3589	Species:	Drosophila melanogaster
Sequence 2:	NP_001333447.1	Gene:	Elapor1 / 229722	MGIID:	1923930	Length:	1013	Species:	Mus musculus

Alignment Length:	1037	Identity:	213/1037 - (20%)
Similarity:	308/1037 - (29%)	Gaps:	383/1037 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1589 TGDVRLQFSPESANIKIGNFENVTVTATDKYNNRAACHFQVSVKASPCVDWELQPPANGAINCLP 1653
            |..|.|...||....|...: :...||.|...:|    ::|:|..||.:...|..|.
Mouse    35 TFQVTLGTGPELHACKESEY-HFEYTACDSTGSR----WRVAVPHSPGLCTSLPDPV-------- 86

  Fly  1654 GDRGIECIATCKPGFRFTDGEPLKTFSCETSRLWRPTSVVPDCVSENTEQAAYHVTASITYRANG 1718
              :|.||..:|..| .|.|   :|..||:            .|.     :..|.:...|.:
Mouse    87 --KGTECSFSCNAG-EFLD---MKDQSCK------------PCA-----EGRYSLGTGIRF---- 124

  Fly  1719 AVAQSCLGQYQEVLAQHYGGLNQLLSQRCSAVNVNMNVTFVKSVPMLLEENVVKMDFILS----- 1778
                   .::.| |...:..|:..|....|......|.|..|.||        :.|:|.|
Mouse   125 -------DEWDE-LPHGFASLSANLEVDDSISESTENCTSSKWVP--------RGDYIASNTDEC 173

  Fly  1779 ---ILPAVRQPQLYDLCGSTLNLIFDLSVPYASAVIDDLLNIANIGNQCPP----LRALKS---- 1832
               ::.||...|     ..|:|  |:...|.:|.:.:..:.    .:||.|    .|.:|:
Mouse   174 TATLMYAVNLKQ-----SGTVN--FEYYYPDSSIIFEFFVQ----NDQCQPSADDSRWMKTTEKG 227

  Fly  1833 ------QISRGFN------------CNVGE---VLNMDTSDV---PRCLHCPAGTYVS-EGQNSC 1872
                  :::||.|            ..|.:   |.|:..:.|   ..|..|..|||.: :|...|
Mouse   228 WEFHSVELNRGNNVLYWRTTAFSVWSKVSKPVLVRNIAITGVAYTSECFPCKPGTYAAKQGSPFC 292

  Fly  1873 TYCPRGYYQNRDRQGTCLRCPAGTYTKEEGTKSQADCIPVCGYGTYSPTGLVPCLECPRNSFTAE 1937
            ..||..||.|:. :.:|..|.|..|: |:|: |.....|.|....|
Mouse   293 KLCPANYYSNKG-ETSCHPCDADKYS-EKGS-STCKVRPACTDKDY------------------- 335

  Fly  1938 PPTGGFKDCQACPAQSFT---YQ-----------------PAASNKDLCRAKCAPGTYSATGLAP 1982
                 |....||.||..|   |:                 ||:..|..| ..|.||.:. |..:.
Mouse   336 -----FYTHTACDAQGETQLMYKWAIPKICGEDLEGAVKLPASGVKTRC-PPCNPGFFK-TDNST 393

  Fly  1983 CSPCPLHHYQGAAGAQSC---------------NECPSNMRTD---------------------- 2010
            |.|||...|...:....|               |..||||.|.
Mouse   394 CEPCPYGSYSNGSDCTHCPAGTEPAVGFEYKWWNTLPSNMETTVLSGINFEYKGLTGWEVAGDHI 458

  Fly  2011 ----------------------SPAS-----KGREQCKPVVCGEGACQ-HGGLCVPMGHDIQCFC 2047
                                  .|.|     :.:|..:.....|..|. :..|...:|.:.:...
Mouse   459 YTAVGASDNDFMILTLVVPGFRPPQSVVADTENKEVARITFVFETICSVNCELYFMVGMNSRTNT 523

  Fly  2048 PA----GFSGRRC-EQDIDECAS---------QPCYNGGQ--CKDLPQGYRCECPAGYSGI---- 2092
            |.    |..|::. ...|:|.|:         ...:..|:  ..|:.:.|.........|:
Mouse   524 PVETWKGTKGKQSYTYTIEENATVSFTWAFQRTTLHETGRKYTNDVAKIYSINVTNVMGGVASYC 588

  Fly  2093 -NCQEEASDCGND--TCPARAMCKNEPGYKNVTC-LCRSG--------YTGDQCDVTIDPCTANG 2145
             .|..||||.|:.  :|||......:.|    || ||.|.        |....|
Mouse   589 RPCALEASDLGSSCTSCPAGHYINRDSG----TCHLCPSNTILKAHQPYGAQAC----------- 638

  Fly  2146 NPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCS---ENPC-LLGANCTDLVNDFQCACPP 2206
            .|||.|.....:....|                 |||:   ..|. :...|.:.|......|..|
Mouse   639 VPCGPGTKNNKIHSLCY-----------------NDCTFSRNTPSRIFNYNFSALAGTVSLAGVP 686

  Fly  2207 GFTGKRCEQ----KIDLCLSEPCKHGTCVD-----RLFDHECVCHPGWTGSACDINIDDCENRPC 2262
            .||.|..:.    .:.||.::..|...|.|     |:.|.|.......|...|.:.|...|
Mouse   687 SFTSKGLKYFHHFTLSLCGNQGKKMAVCTDNVTDLRIPDGEAGFSKSVTAYVCQVVIIPSE---- 747

  Fly  2263 ANEGTCVDLVDGYSC--NCEP-----GYTGKNCQHTIDDCASNPCQ--HGATC-VDQLDGFSCKC 2317
                     |.||..  :.:|     ...|.:...|::...| |.:  |..|. :..:..|   .
Mouse   748 ---------VMGYKAGVSSQPVSLADRLVGVSTDMTLEGIVS-PVELFHPETSGIPDIVFF---F 799

  Fly  2318 RPGYVGLSCEAEIDECLSDPCNPV----GTERCLDLDNKFECVCRDG--------------FKGP 2364
            |...|..||.:.....:...|||:    ||.|       ...:|.||              ...|
Mouse   800 RSNDVTQSCSSGRSTTIRLRCNPMKAAPGTLR-------LPSMCSDGTCDGCNFHFLWESVAACP 857

  Fly  2365 LCA-----TDIDDCEA----------QPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTC 2411
            ||:     |.:..|.|          :|.|               |..|.|  ..||:||.|
Mouse   858 LCSASDYHTFVSSCVAGIQKTTYMWREPKL---------------CSGGIS--LPEQRVTIC 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uif	NP_001162899.1	CLECT	36..167	CDD:214480
		LDLa	172..206	CDD:238060
		CUB	220..319	CDD:238001
		CUB	326..435	CDD:238001
		CUB	439..550	CDD:238001
		PHA02927	<568..733	CDD:222943
		CCP	675..731	CDD:153056
		CCP	736..791	CDD:153056
		EGF_CA	792..829	CDD:214542
		FA58C	828..977	CDD:214572
		FA58C	833..976	CDD:238014
		FXa_inhibition	988..>1016	CDD:291342
		CCP	1051..1106	CDD:153056
		FA58C	1297..1444	CDD:214572
		FA58C	1303..1443	CDD:238014
		DUF5011	1463..1547	CDD:295940
		DUF5011	1548..1631	CDD:295940	11/41 (27%)
		GCC2_GCC3	1862..1909	CDD:285001	17/47 (36%)
		GCC2_GCC3	1916..1966	CDD:285001	11/69 (16%)
		GCC2_GCC3	1973..2020	CDD:285001	17/110 (15%)
		EGF	2025..2055	CDD:278437	7/34 (21%)
		EGF_CA	2059..2095	CDD:238011	7/51 (14%)
		EGF_CA	2138..2176	CDD:238011	5/37 (14%)
		EGF_CA	2178..2214	CDD:238011	11/39 (28%)
		EGF_CA	2253..2289	CDD:238011	7/42 (17%)
		EGF_CA	2292..2327	CDD:238011	8/37 (22%)
		EGF_CA	2330..2366	CDD:238011	10/53 (19%)
		EGF_CA	2369..2405	CDD:238011	7/45 (16%)
		EGF_CA	2411..2444	CDD:238011	1/1 (100%)
		EGF_CA	2486..2520	CDD:238011
		EGF_CA	2522..2557	CDD:238011
		LamG	2590..2735	CDD:304605
		DUF5011	2799..2877	CDD:295940
		GCC2_GCC3	3149..3200	CDD:285001
		GCC2_GCC3	3207..3254	CDD:285001
		GCC2_GCC3	3268..3307	CDD:285001
		GCC2_GCC3	3315..3362	CDD:285001
Elapor1	NP_001333447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	992..1013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7782
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950