DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment uif and Notch4

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:XP_006523861.1 Gene:Notch4 / 18132 MGIID:107471 Length:1968 Species:Mus musculus


Alignment Length:1806 Identity:441/1806 - (24%)
Similarity:605/1806 - (33%) Gaps:610/1806 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1875 CPRGYYQNRDRQGTCLRCPAGTYTKEEGTKSQADCIP-----VCGYGTYSPTGLVPCLE---CPR 1931
            |..|        |||||...|        :....|.|     .|.:..       ||.:   | :
Mouse    36 CANG--------GTCLRLSRG--------QGICQCAPGFLGETCQFPD-------PCRDTQLC-K 76

  Fly  1932 NSFTAE-----PPTGGFKDCQACPAQSFTYQPAASNKDLCRAK----CAPGTYSATGLAPCSPCP 1987
            |..:.:     ||:.........|..|.|. |:....|.|:..    |.|...|..|        
Mouse    77 NGGSCQALLPTPPSSRSPTSPLTPHFSCTC-PSGFTGDRCQTHLEELCPPSFCSNGG-------- 132

  Fly  1988 LHHYQGAAGAQSCNECPSNMRTDSPASKGREQCK-PVVCGEGACQHGGLCVPMGHDIQCFCPAGF 2051
             |.|..|:|...|: |       .|...| |||: ...|....|.:||:|:.....|||.||.||
Mouse   133 -HCYVQASGRPQCS-C-------EPGWTG-EQCQLRDFCSANPCANGGVCLATYPQIQCRCPPGF 187

  Fly  2052 SGRRCEQDIDECASQP----------------------------------------CYNGGQCKD 2076
            .|..||:||:||..:|                                        |.|||.|:.
Mouse   188 EGHTCERDINECFLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCKLRKGACPPGSCLNGGTCQL 252

  Fly  2077 LPQGYR----CECPAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVT 2137
            :|:|:.    |.||.|::|::|:....||....|...|.|.:  |....||||...:.|..|...
Mouse   253 VPEGHSTFHLCLCPPGFTGLDCEMNPDDCVRHQCQNGATCLD--GLDTYTCLCPKTWKGWDCSED 315

  Fly  2138 IDPCTANGNP-CGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQ 2201
            ||.|.|.|.| |.||.:||. ..|.:.|.||.||.|..||:|::||:...|..|:.|.|.|..|.
Mouse   316 IDECEARGPPRCRNGGTCQN-TAGSFHCVCVSGWGGAGCEENLDDCAAATCAPGSTCIDRVGSFS 379

  Fly  2202 CACPPGFTGKRCEQKIDLCLSEPCK-HGTCVDRLFDHE--CVCHPGWTGSACDINIDDCE----- 2258
            |.||||.||..|..: |:|||:||. :..|........  |:|.||::||.|..::|:|:     
Mouse   380 CLCPPGRTGLLCHLE-DMCLSQPCHVNAQCSTNPLTGSTLCICQPGYSGSTCHQDLDECQMAQQG 443

  Fly  2259 NRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVG 2323
            ..||.:.|:|::....::|.|.|||||..|:...::|.|.||..|:||:|.|..|.|.|.||..|
Mouse   444 PSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEG 508

  Fly  2324 LSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRV 2388
            ..||.|::||.|:||  :....|.||.|.|:|:|..||.|..|..|:|:|.:.||.|.|.|||:.
Mouse   509 RLCEVEVNECTSNPC--LNQAACHDLLNGFQCLCLPGFTGARCEKDMDECSSTPCANGGRCRDQP 571

  Fly  2389 GGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCE--------- 2444
            |.|.|.|.||:.|..||::|..| ...||...|||:||...:||:|..|..|:.||         
Mouse   572 GAFYCECLPGFEGPHCEKEVDEC-LSDPCPVGASCLDLPGAFFCLCRPGFTGQLCEVPLCTPNMC 635

  Fly  2445 -------------------------------------------------TAPE------RCIGDP 2454
                                                             |.||      .||..|
Mouse   636 QPGQQCQGQEHRAPCLCPDGSPGCVPAEDNCPCHHGHCQRSLCVCDEGWTGPECETELGGCISTP 700

  Fly  2455 CMHGGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNC 2519
            |.|||.|....||.||:|||.|.|:.|..|..||....|.||.:|.....||||.|.|..|||:|
Mouse   701 CAHGGTCHPQPSGYNCTCPAGYMGLTCSEEVTACHSGPCLNGGSCSIRPEGYSCTCLPSHTGRHC 765

  Fly  2520 EQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPS----------- 2573
            :..:..|...||..|.|||:....|:|.|.....|..|.:.         ::||           
Mouse   766 QTAVDHCVSASCLNGGTCVNKPGTFFCLCATGFQGLHCEEK---------TNPSCADSPCRNKAT 821

  Fly  2574 -----RSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSG 2633
                 |.......|..||.:..                   ||..:.:.:........||:..| 
Mouse   822 CQDTPRGARCLCSPGYTGSSCQ-------------------TLIDLCARKPCPHTARCLQSGPS- 866

  Fly  2634 VQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYL 2698
            .|....:....|...|                   .:|.|...:::|:                 
Mouse   867 FQCLCLQGWTGALCDF-------------------PLSCQKAAMSQGI----------------- 895

  Fly  2699 WAVLGLPQPYGL-----SNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEP------ 2752
             .:.||.|..||     |:.......||||.:               .|..|..|...|      
Mouse   896 -EISGLCQNGGLCIDTGSSYFCRCPPGFQGKL---------------CQDNVNPCEPNPCHHGST 944

  Fly  2753 -VLYPGLILNWAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLVVD--KEPPVVEH------ 2808
             |..|      :||             :|   :|..||.|.||.: |:|  :..|...|      
Mouse   945 CVPQP------SGY-------------VC---QCAPGYEGQNCSK-VLDACQSQPCHNHGTCTSR 986

  Fly  2809 -------CPGDLWVIAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDA 2866
                   ||.....:...|.               |.:..:|..|.|||.......:..| ....
Mouse   987 PGGFHCACPPGFVGLRCEGD---------------VDECLDRPCHPSGTAACHSLANAFY-CQCL 1035

  Fly  2867 AGNTAS-CSFKVSLLTDFCPALADPVGGSQVCKDWGAGGQFKVCEI--------ACNAGLRFSEP 2922
            .|:|.. |..::    |.|.        ||.|.:.|:      |||        .|:....|..|
Mouse  1036 PGHTGQRCEVEM----DLCQ--------SQPCSNGGS------CEITTGPPPGFTCHCPKGFEGP 1082

  Fly  2923 V--PEFYTCGAE-----GFWRPTREPSMP--------------LVYP------------------ 2948
            .  .:..:||..     |...|:.:|..|              |..|                  
Mouse  1083 TCSHKALSCGIHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCLHNGTCT 1147

  Fly  2949 ------------SCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSV-----NGLNRDWN 2996
                        :|.|..|..|             |.:.|.:....:..:..     :|...||:
Mouse  1148 ETPGLGNPGFQCTCPPDSPGPR-------------CQRPGASGCEGRGGDGTCDAGCSGPGGDWD 1199

  Fly  2997 --FCSYAI------------------EG-------TREC----KDIQIDVKC---------DHYR 3021
              .||..:                  :|       :.||    .|.:|.:.|         ||:.
Mouse  1200 GGDCSLGVPDPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPLTCIPAYDQYCRDHFH 1264

  Fly  3022 GTQNNRVRRQAK---DGGVYVMEAE----------LPVVNDDDDD---------LTLTGRQG--- 3061
            .....:....|:   |||....|.|          |.|:.....|         |:||.|.|   
Mouse  1265 NGHCEKGCNNAECGWDGGDCRPEGEDSEGRPSLALLVVLRPPALDQQLLALARVLSLTLRVGLWV 1329

  Fly  3062 RQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLE- 3125
            |:.:.|    ..:.||..........:|.|              |..:.:...|.|.|.....| 
Mouse  1330 RKDSEG----RNMVFPYPGTRAKEELSGAR--------------DSSSWERQAPPTQPLGKETES 1376

  Fly  3126 LGSEYACPVGQVVMIPDCVP---------------------CAIGTFYDSANKTCIAC--SRGTY 3167
            ||:.:...:|  |.:..|.|                     .|:|..........:|.  ..||.
Mouse  1377 LGAGFVVVMG--VDLSRCGPEHPASRCPWDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTR 1439

  Fly  3168 QSEAGQLQ----CSKCPVIA----------------------GR----PGVTAGPGARSAADCKE 3202
            .| |.||.    ||  ||:.                      |.    ||....|..:.|.. :.
Mouse  1440 PS-ANQLPWPILCS--PVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPH-RR 1500

  Fly  3203 RCPAGK--------YFDAE-----TGLCRSCGHGFYQPNEGSFSCEL----CGLGQTTRSTEATS 3250
            |.|.|:        ..:||     ..:|.....|..:....:..|:|    .|.|:..::...|.
Mouse  1501 RPPLGEDNIGLKALKPEAEVDEDGVAMCSGPEEGEAEETASASRCQLWPLNSGCGELPQAAMLTP 1565

  Fly  3251 RKECRDECSSGQQLGADGRCEPCPRGTYRLQGVQPSCAACP----LGRTTP 3297
            .:||..|.......|.|| ..|.....: ..|||.:..|.|    ||...|
Mouse  1566 PQECESEVLDVDTCGPDG-VTPLMSAVF-CGGVQSTTGASPQRLGLGNLEP 1614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 8/33 (24%)
GCC2_GCC3 1916..1966 CDD:285001 11/57 (19%)
GCC2_GCC3 1973..2020 CDD:285001 11/46 (24%)
EGF 2025..2055 CDD:278437 13/29 (45%)
EGF_CA 2059..2095 CDD:238011 17/79 (22%)
EGF_CA 2138..2176 CDD:238011 18/38 (47%)
EGF_CA 2178..2214 CDD:238011 16/35 (46%)
EGF_CA 2253..2289 CDD:238011 13/40 (33%)
EGF_CA 2292..2327 CDD:238011 15/34 (44%)
EGF_CA 2330..2366 CDD:238011 15/35 (43%)
EGF_CA 2369..2405 CDD:238011 17/35 (49%)
EGF_CA 2411..2444 CDD:238011 13/32 (41%)
EGF_CA 2486..2520 CDD:238011 15/33 (45%)
EGF_CA 2522..2557 CDD:238011 11/34 (32%)
LamG 2590..2735 CDD:304605 21/149 (14%)
DUF5011 2799..2877 CDD:295940 16/93 (17%)
GCC2_GCC3 3149..3200 CDD:285001 17/82 (21%)
GCC2_GCC3 3207..3254 CDD:285001 10/63 (16%)
GCC2_GCC3 3268..3307 CDD:285001 10/34 (29%)
GCC2_GCC3 3315..3362 CDD:285001
Notch4XP_006523861.1 EGF_CA 162..193 CDD:238011 12/30 (40%)
EGF_CA 195..233 CDD:214542 5/37 (14%)
EGF_CA 315..354 CDD:238011 18/39 (46%)
EGF_CA 356..391 CDD:238011 16/34 (47%)
EGF_CA 433..474 CDD:238011 13/40 (33%)
EGF_CA 476..512 CDD:238011 15/35 (43%)
EGF_CA 515..550 CDD:238011 15/36 (42%)
EGF_CA 552..588 CDD:238011 17/35 (49%)
EGF_CA 591..626 CDD:238011 14/35 (40%)
EGF_CA <700..727 CDD:238011 15/26 (58%)
EGF_CA 769..804 CDD:238011 11/34 (32%)
EGF_CA <814..843 CDD:238011 4/28 (14%)
EGF_CA 896..928 CDD:238011 10/46 (22%)
EGF_CA 930..965 CDD:238011 12/56 (21%)
EGF_CA 970..1004 CDD:238011 5/33 (15%)
EGF_CA 1006..1044 CDD:238011 9/53 (17%)
NL 1207..1245 CDD:197463 3/37 (8%)
Notch 1257..1285 CDD:365847 6/27 (22%)
Ank_2 <1575..1663 CDD:372319 12/42 (29%)
ANK repeat 1582..1629 CDD:293786 11/35 (31%)
ANK repeat 1633..1663 CDD:293786
Ank_2 1637..1730 CDD:372319
ANKYR 1644..1819 CDD:223738
ANK repeat 1665..1697 CDD:293786
ANK repeat 1699..1730 CDD:293786
ANK repeat 1732..1763 CDD:293786
ANK repeat 1765..1796 CDD:293786
ANK repeat 1798..1826 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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