DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and Notch3

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:XP_017172782.1 Gene:Notch3 / 18131 MGIID:99460 Length:2330 Species:Mus musculus


Alignment Length:1708 Identity:443/1708 - (25%)
Similarity:590/1708 - (34%) Gaps:538/1708 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1856 CLH---CPAGTYVSEGQNSCTYCPRGYYQNRDRQGTCLRCPAGTYTKEEG----TKSQADCIPVC 1913
            |:|   |..|   .:|:.:|. ||.| ||.:..|.....|.:||..:..|    |.....|....
Mouse   129 CVHGAPCSVG---PDGRFACA-CPPG-YQGQSCQSDIDECRSGTTCRHGGTCLNTPGSFRCQCPL 188

  Fly  1914 GY-GTYSPTGLVPCLECP-RNSFTAEPPTGGFKDCQACPAQSFTYQPAASNKDLCRA-KCAPGTY 1975
            || |......:|||...| ||..|....:....||...|  .|..|....|.|.|.. :|..|..
Mouse   189 GYTGLLCENPVVPCAPSPCRNGGTCRQSSDVTYDCACLP--GFEGQNCEVNVDDCPGHRCLNGGT 251

  Fly  1976 SATGL----APCSPCPLHHYQGAAGAQSCNECPSNMRTDSPASKGREQCKPVVCGEGACQHGGLC 2036
            ...|:    ..|.|    .:.|....:..:||               |.:|     .||.:||.|
Mouse   252 CVDGVNTYNCQCPP----EWTGQFCTEDVDEC---------------QLQP-----NACHNGGTC 292

  Fly  2037 VPM--GHDIQCFCPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEAS 2099
            ..:  ||  .|.|..|::|..|.|:||:||:..|::|..|.|....:.|.||.|.:|:.|..:.:
Mouse   293 FNLLGGH--SCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDA 355

  Fly  2100 DCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYKC 2164
             |.::.|...|:|...|......|.|..|:||..||..:|.|:...|||.:...| ...||.:.|
Mouse   356 -CVSNPCHEDAICDTNPVSGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRC-VNTQGSFLC 418

  Fly  2165 ECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKH-G 2228
            :|..|:.|..||.::|:|...||...|.|.|.:..|.|.|..||||..||..||.|.|.||.: |
Mouse   419 QCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGG 483

  Fly  2229 TCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTID 2293
            .|.||:....|.|..|::||.|.:::|:|.:.||.|...|||..|||.|.|..|:.|..|:..:|
Mouse   484 VCKDRVNGFSCTCPSGFSGSMCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVD 548

  Fly  2294 DCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCR 2358
            ||:.:||.|| .|||.:..|||.|.|||.|:.||:::|||.|.||...|  :||||.:|:.|.|.
Mouse   549 DCSPDPCHHG-RCVDGIASFSCACAPGYTGIRCESQVDECRSQPCRYGG--KCLDLVDKYLCRCP 610

  Fly  2359 DGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASC 2423
            .|..|..|..:||||.:.|| ..|:|||.:..::|.|:||::|..|..::..| |.:||....||
Mouse   611 PGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINEC-ASSPCGEGGSC 673

  Fly  2424 IDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQYEY--D 2486
            :|....:.|:||.|:....|..|...|...||.| |.|.|...|..|.|...:||..|....  |
Mouse   674 VDGENGFHCLCPPGSLPPLCLPANHPCAHKPCSH-GVCHDAPGGFRCVCEPGWSGPRCSQSLAPD 737

  Fly  2487 ACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCE------------------------------- 2520
            |||...||.|.||..:|.|:.|.|.|||.|..||                               
Mouse   738 ACESQPCQAGGTCTSDGIGFRCTCAPGFQGHQCEVLSPCTPSLCEHGGHCESDPDRLTVCSCPPG 802

  Fly  2521 -------QDIVDCKDNS-CPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTA 2577
                   ||:.:|...| |.|..||.:|...|.|.|....||..|      |.|:...||:    
Mouse   803 WQGPRCQQDVDECAGASPCGPHGTCTNLPGNFRCICHRGYTGPFC------DQDIDDCDPN---- 857

  Fly  2578 AQVVPFPTGEANSLTVAMWVQFAQKDDRGIF--FTLYGVQSARMTQQRRMLLQAHSSGVQVSLFE 2640
                  |.....|.          :|..|.|  ..|.|....|..:                   
Mouse   858 ------PCLHGGSC----------QDGVGSFSCSCLDGFAGPRCAR------------------- 887

  Fly  2641 DQPDAFLS--FGEYTSVNDGQWHHVAVV-------WDGISGQLQLITEGLIASKMEYGAGGSLPG 2696
             ..|..||  .|..|..:     |||..       :.|...::.|..    .|......||:...
Mouse   888 -DVDECLSSPCGPGTCTD-----HVASFTCACPPGYGGFHCEIDLPD----CSPSSCFNGGTCVD 942

  Fly  2697 YLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILN 2761
                        |:|:.......|:.||               ..|.:...|.|.|.|:.| |.|
Mouse   943 ------------GVSSFSCLCRPGYTGT---------------HCQYEADPCFSRPCLHGG-ICN 979

  Fly  2762 --WAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKNGSAVV 2824
              ..|:|.|                |..|:||:.||.                          .|
Mouse   980 PTHPGFECT----------------CREGFTGSQCQN--------------------------PV 1002

  Fly  2825 SWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVSLLTDFCPALAD 2889
            .|          .::...:||.|...|   |.|.|                        ||    
Mouse  1003 DW----------CSQAPCQNGGRCVQT---GAYCI------------------------CP---- 1026

  Fly  2890 PVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSMPLVYPSCSPSK 2954
                        .|...::|:|                             .|:|     |:.: 
Mouse  1027 ------------PGWSGRLCDI-----------------------------QSLP-----CTEA- 1044

  Fly  2955 PAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDWNFCSYAIEGTRECKDIQIDVKCDH 3019
            .||...|::.      ||.:.|:.:.:.:....|....|..:.|.:.::   .|    ....|.|
Mouse  1045 AAQMGVRLEQ------LCQEGGKCIDKGRSHYCVCPEGRTGSHCEHEVD---PC----TAQPCQH 1096

  Fly  3020 YRGTQNNRVRRQAKDGGVYVMEAELPVVNDDDDDLTLTGRQGRQQTGGDTYTLEIAFPAANDPVV 3084
             .||....:       |.||.|.......|..:|..........|.||....|...:..:..|  
Mouse  1097 -GGTCRGYM-------GGYVCECPAGYAGDSCEDNIDECASQPCQNGGSCIDLVARYLCSCPP-- 1151

  Fly  3085 HTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLELGSEYACPVGQVVMIPDCVPCAIG 3149
                   .|:..|.|  |.|||                                       |.:|
Mouse  1152 -------GTLGVLCE--INEDD---------------------------------------CDLG 1168

  Fly  3150 TFYDSANKTCIAC-SRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAE 3213
            ...||.    :.| ..||.....|..:|: ||     ||.|   |....||..| |..|....|.
Mouse  1169 PSLDSG----VQCLHNGTCVDLVGGFRCN-CP-----PGYT---GLHCEADINE-CRPGACHAAH 1219

  Fly  3214 TGLCRSCGHGFYQPNEGSFSCELCGLGQT-TRSTEATSRKECRDE-CSSGQQ----LGADG---- 3268
            |   |.|    .|...|.|.| :|..|.| .|...|.|  .|..: |..|.|    ||..|    
Mouse  1220 T---RDC----LQDPGGHFRC-VCHPGFTGPRCQIALS--PCESQPCQHGGQCRHSLGRGGGLTF 1274

  Fly  3269 --RCEPCPRGTYRLQGVQPSC--AACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNMCIECR 3329
              .|.| |....|.:.|..||  ..||:|                                |.| 
Mouse  1275 TCHCVP-PFWGLRCERVARSCRELQCPVG--------------------------------IPC- 1305

  Fly  3330 KGYYQSESQQTS----CLQCPPNHS--------TKITGATSKSECTNPCEHIAEGKPHCDVNAYC 3382
                    |||:    | .|||..|        ...:|||:.|..:.||.|          ...|
Mouse  1306 --------QQTARGPRC-ACPPGLSGPSCRVSRASPSGATNASCASAPCLH----------GGSC 1351

  Fly  3383 IMVPETSDFKCECKPGFNG----TGMACTDV-------------------CDGFCENSGACVKDL 3424
            :.|.....|:|.|.||:.|    |..|..:|                   ||..|          
Mouse  1352 LPVQSVPFFRCVCAPGWGGPRCETPSAAPEVPEEPRCPRAACQAKRGDQNCDREC---------- 1406

  Fly  3425 KGTPSCRCVGSFTGPHCA 3442
             .||.|    .:.|..|:
Mouse  1407 -NTPGC----GWDGGDCS 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 14/50 (28%)
GCC2_GCC3 1916..1966 CDD:285001 15/50 (30%)
GCC2_GCC3 1973..2020 CDD:285001 7/50 (14%)
EGF 2025..2055 CDD:278437 11/31 (35%)
EGF_CA 2059..2095 CDD:238011 13/35 (37%)
EGF_CA 2138..2176 CDD:238011 12/37 (32%)
EGF_CA 2178..2214 CDD:238011 14/35 (40%)
EGF_CA 2253..2289 CDD:238011 15/35 (43%)
EGF_CA 2292..2327 CDD:238011 18/34 (53%)
EGF_CA 2330..2366 CDD:238011 16/35 (46%)
EGF_CA 2369..2405 CDD:238011 15/35 (43%)
EGF_CA 2411..2444 CDD:238011 11/32 (34%)
EGF_CA 2486..2520 CDD:238011 17/33 (52%)
EGF_CA 2522..2557 CDD:238011 13/35 (37%)
LamG 2590..2735 CDD:304605 25/155 (16%)
DUF5011 2799..2877 CDD:295940 9/77 (12%)
GCC2_GCC3 3149..3200 CDD:285001 15/51 (29%)
GCC2_GCC3 3207..3254 CDD:285001 15/47 (32%)
GCC2_GCC3 3268..3307 CDD:285001 11/46 (24%)
GCC2_GCC3 3315..3362 CDD:285001 14/58 (24%)
Notch3XP_017172782.1 EGF_CA 159..196 CDD:238011 9/36 (25%)
EGF_CA 237..273 CDD:238011 9/39 (23%)
EGF_CA 275..312 CDD:238011 15/58 (26%)
EGF_CA 315..350 CDD:238011 13/34 (38%)
EGF_CA 392..430 CDD:238011 12/38 (32%)
EGF_CA 432..468 CDD:238011 14/35 (40%)
EGF_CA 470..506 CDD:238011 15/35 (43%)
EGF_CA 508..544 CDD:238011 15/35 (43%)
EGF_CA 546..581 CDD:238011 18/35 (51%)
EGF_CA 584..619 CDD:238011 16/36 (44%)
EGF_CA 621..655 CDD:238011 15/34 (44%)
EGF_CA 659..>687 CDD:238011 10/28 (36%)
EGF_CA 697..730 CDD:238011 12/33 (36%)
EGF_CA 737..771 CDD:238011 17/33 (52%)
EGF_CA 811..847 CDD:238011 13/35 (37%)
EGF_CA 850..885 CDD:238011 10/54 (19%)
EGF_CA 888..923 CDD:238011 9/39 (23%)
EGF_CA 930..961 CDD:238011 8/57 (14%)
EGF_CA 965..999 CDD:238011 14/50 (28%)
EGF_CA 1086..1121 CDD:238011 10/49 (20%)
EGF_CA 1123..1159 CDD:238011 7/44 (16%)
EGF_CA 1172..1204 CDD:238011 13/44 (30%)
NL 1381..1418 CDD:197463 8/51 (16%)
NL 1422..1459 CDD:197463
Notch 1475..1501 CDD:365847
NOD 1506..1558 CDD:369091
NODP 1579..1634 CDD:369464
ANKYR <1786..1906 CDD:223738
ANK repeat 1801..1849 CDD:293786
ANK repeat 1851..1882 CDD:293786
ANKYR 1871..2037 CDD:223738
ANK repeat 1884..1916 CDD:293786
ANK repeat 1918..1949 CDD:293786
ANK repeat 1951..1982 CDD:293786
ANK repeat 1984..2015 CDD:293786
PHA03247 <2040..2327 CDD:223021
DUF3454 2224..2286 CDD:371809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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