DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and glp-1

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_499014.1 Gene:glp-1 / 176286 WormBaseID:WBGene00001609 Length:1295 Species:Caenorhabditis elegans


Alignment Length:1508 Identity:339/1508 - (22%)
Similarity:492/1508 - (32%) Gaps:558/1508 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  2025 CG-EGACQHGGLCVPMGHDIQ---CFCPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCEC 2085
            || ||||...|.|. .|..|:   |.|..||.|..||::.|    ..|..|.:|.....|....|
 Worm    23 CGREGACSVNGKCY-NGKLIETYWCRCKKGFGGAFCERECD----LDCKRGEKCIYDVYGENPTC 82

  Fly  2086 PAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVT----IDPCTANGN 2146
                   .||    ||.::|.|.....|.          |..||.|..|...    ::||  :.:
 Worm    83 -------ICQ----DCEDETPPTERTQKG----------CEEGYGGPDCKTPLFSGVNPC--DSD 124

  Fly  2147 PCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGK 2211
            ||.||. |... .|.::|.|..|:.|.:||:.|:.|::|.|..|:.|.:.|.::.|.||.|.:|:
 Worm   125 PCNNGL-CYPF-YGGFQCICNNGYGGSYCEEGIDHCAQNECAEGSTCVNSVYNYYCDCPIGKSGR 187

  Fly  2212 RCEQKIDLCLSEPCKHGTCV-----DRLFDHECVCHPGWTGSACDINIDDC-ENRPCANEGTCVD 2270
            .||:.....:...|.||.|:     |:.|  .|||..|:.|..|:.:.::| ....|.|..||.:
 Worm   188 YCERTECALMGNICNHGRCIPNRDEDKNF--RCVCDSGYEGEFCNKDKNECLIEETCVNNSTCFN 250

  Fly  2271 LVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFS-CKCRPGYVGLSCEAEIDECL 2334
            |...::|.|:|||.||.|:..||.|....||:...|....:... |.|..|:.|..||.|     
 Worm   251 LHGDFTCTCKPGYAGKYCEEAIDMCKDYVCQNDGYCAHDSNQMPICYCEQGFTGQRCEIE----- 310

  Fly  2335 SDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDID--DCEAQ--PCLNNGICRDRVGGFECGC 2395
                                  |..||.|..|...:.  .|...  .|.|:|.|   :.|| |.|
 Worm   311 ----------------------CPSGFGGIHCDLPLQRPHCSRSNGTCYNDGRC---INGF-CVC 349

  Fly  2396 EPGWSGMRCE--------QQVTTCGAQAPCQNDASCIDLFQD-YFCVCPSGTDGKNCETAPERCI 2451
            ||.:.|.|||        ..:.:| ...||.|:|:||||... |.|.||.|..|.||| ....|.
 Worm   350 EPDYIGDRCEINRKDFKFPDIQSC-KYNPCVNNATCIDLKNSGYSCHCPLGFYGLNCE-QHLLCT 412

  Fly  2452 GDPCMHGGKCQDFGSGLNCSCPADYSGIGCQY-EYDACEEHVCQNGATCVDNGAGYSCQCPPGFT 2515
            ...|.:||.|:.....:.|:||..:||..|:. :...|..|.|:||..|  ...|| |:|..|:|
 Worm   413 PTTCANGGTCEGVNGVIRCNCPNGFSGDYCEIKDRQLCSRHPCKNGGVC--KNTGY-CECQYGYT 474

  Fly  2516 GRNCEQDIV-----------------------------------------DCKD-----NSCPPG 2534
            |..||:.:|                                         ||..     :.|...
 Worm   475 GPTCEEVLVIEKSKETVIRDLCEQRKCMDLASNGICNPECNLEECNFDGGDCSGGQRPFSKCQYP 539

  Fly  2535 ATCVD----------------LTNGFYCQ-----CPFNM------------------------TG 2554
            |.|.|                |.:|..||     ||.::                        .|
 Worm   540 ARCADQFANGVCNQECNNEECLYDGLDCQSELFRCPAHIRKHCIERRGDGVCNLECSFIGCGFDG 604

  Fly  2555 DDC------------RKAIQVDYDLYFSDPSRSTAAQVVPFPTGEAN-SLTVAMWVQFAQKDDRG 2606
            .||            |..:|:| .:.|......|..|:      .|| ..||.:     |:|:.|
 Worm   605 GDCNNGTEAIILSDIRIKVQID-PIEFQATGGETLMQI------SANLRATVRI-----QRDELG 657

  Fly  2607 -IFFTLYG--------VQSARMTQQ------RRMLLQAHSSGVQVSLFEDQ---PDAFLSFGEYT 2653
             :.|...|        :.|:::..|      .|...||..:|:.:.|..::   |: |..|....
 Worm   658 PLVFRWDGEHEMERVEMNSSKLEDQFVLSHHVRRYRQAVVTGIVLYLEVEEICKPE-FCRFSTAQ 721

  Fly  2654 SVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYLWAVLGLPQPYGLSNELAYSD 2718
            ||.|                  ||..||:.|      .|.:.      ||||             
 Worm   722 SVVD------------------LIAAGLVKS------DGRMS------LGLP------------- 743

  Fly  2719 SGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNWAGYEVTSGGVERNVPSLCGQR 2783
                  ||:|.|   |:...:||.:..  .||:.:|: ..|...|...|.:|.:.:|.|....:|
 Worm   744 ------ITEAMV---AVPKRNEIDEGW--SRSQVILF-ACIAFLAFGTVVAGVIAKNGPERSRKR 796

  Fly  2784 KCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRS 2848
            |..                                  :|.| |..|..|.|        ..|.| 
 Worm   797 KMV----------------------------------NATV-WMPPMESTN--------EKGRR- 817

  Fly  2849 GTTLLWGTYDITYIASDAAGNTASCSFKVSLLTDFCPALADPVGGSQVCKDWGAGGQFKVCEIAC 2913
                                |.::.|.:.|||.:  .|...| ...:.|.|:..|..        
 Worm   818 --------------------NQSNHSSQCSLLDN--SAYYHP-NTKRHCSDYSTGYN-------- 851

  Fly  2914 NAGLRFSEPVPEFYTCGAEG--------FWRPTREPS------MPLVYPSCSP------------ 2952
              |.::|:..|:....|..|        |...|..|:      :||...:..|            
 Worm   852 --GEQYSQIYPQTLANGYPGDYNELNFDFQSETFAPADLPADEIPLHVQAAGPDAITAPITNESV 914

  Fly  2953 ----SKPAQRVF-------RIKMLFPSDVL------CNKAGQ---------------AVLRQKVT 2985
                ||..:||.       |.|   |.||:      |.|||.               ||...:|.
 Worm   915 NQVDSKYRRRVLHWLAANVRGK---PEDVITTEAIRCLKAGADVNARDCDENTALMLAVRAHRVR 976

  Fly  2986 NSV-------------NG---------LNRDWNFCSYAIEGTRECKDI----------------- 3011
            .||             |.         :|:|.....:.:...|..|:|                 
 Worm   977 LSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKRLLKEIDELDRNGMTALMLVARE 1041

  Fly  3012 ----QIDV---------KCDHYRGTQNNRVRRQAKDGGVYVMEAEL--PVVNDDDDDLTLTGRQG 3061
                |:::         |.| |.|...       ||...|.....|  ..::|:::.:.:..|:.
 Worm  1042 LGKHQVEMAELLLSKGAKLD-YDGAAR-------KDSNKYKGRTALHYAAMHDNEEMVIMLVRRS 1098

  Fly  3062 ----RQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDPA 3122
                :|...|.|            |::   ...:...::.::.|.|.|....:.:.:..|....|
 Worm  1099 SNKDKQDEDGRT------------PIM---LAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVA 1148

  Fly  3123 SLELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSEAGQLQCSKCPVIAGRPG 3187
            ......|.|..:.||                 ||:        .::::..:.|.           
 Worm  1149 EASYHHELAAFLRQV-----------------ANE--------RHRNDIMRQQI----------- 1177

  Fly  3188 VTAGPGARSAADC--------KERCPAGKYFDAETGLCRSCGHGFYQPNEGSFSCELCGLGQTTR 3244
            |.:|.||:|....        ..:.|.......||      .|....|::||||........||.
 Worm  1178 VKSGHGAKSGRQTVKNIKRAGSRKTPTSAASSRET------NHLTPPPSDGSFSSPSPHYYPTTT 1236

  Fly  3245 STEATSRKECRDE 3257
            ||  .:|.|...|
 Worm  1237 ST--PNRMETSPE 1247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001
GCC2_GCC3 1916..1966 CDD:285001
GCC2_GCC3 1973..2020 CDD:285001
EGF 2025..2055 CDD:278437 15/33 (45%)
EGF_CA 2059..2095 CDD:238011 6/35 (17%)
EGF_CA 2138..2176 CDD:238011 12/37 (32%)
EGF_CA 2178..2214 CDD:238011 12/35 (34%)
EGF_CA 2253..2289 CDD:238011 13/36 (36%)
EGF_CA 2292..2327 CDD:238011 10/35 (29%)
EGF_CA 2330..2366 CDD:238011 4/35 (11%)
EGF_CA 2369..2405 CDD:238011 13/39 (33%)
EGF_CA 2411..2444 CDD:238011 16/33 (48%)
EGF_CA 2486..2520 CDD:238011 13/33 (39%)
EGF_CA 2522..2557 CDD:238011 14/125 (11%)
LamG 2590..2735 CDD:304605 34/162 (21%)
DUF5011 2799..2877 CDD:295940 10/77 (13%)
GCC2_GCC3 3149..3200 CDD:285001 8/50 (16%)
GCC2_GCC3 3207..3254 CDD:285001 13/46 (28%)
GCC2_GCC3 3268..3307 CDD:285001
GCC2_GCC3 3315..3362 CDD:285001
glp-1NP_499014.1 EGF_CA 118..152 CDD:238011 12/37 (32%)
EGF_CA 155..190 CDD:238011 12/34 (35%)
EGF_CA 232..269 CDD:238011 13/36 (36%)
EGF_CA 369..406 CDD:238011 16/37 (43%)
EGF_CA 451..479 CDD:238011 12/30 (40%)
NL 489..526 CDD:197463 0/36 (0%)
Notch 533..568 CDD:278494 6/34 (18%)
Notch 573..608 CDD:278494 4/34 (12%)
NOD 612..661 CDD:284282 13/60 (22%)
NODP 698..755 CDD:284987 23/109 (21%)
ANK repeat 921..959 CDD:293786 11/40 (28%)
ANK 926..1054 CDD:238125 21/130 (16%)
Ank_5 949..1002 CDD:290568 9/52 (17%)
ANK 956..1127 CDD:238125 26/193 (13%)
ANK repeat 961..992 CDD:293786 5/30 (17%)
ANK repeat 994..1028 CDD:293786 5/33 (15%)
Ank_2 999..1105 CDD:289560 16/113 (14%)
ANK repeat 1030..1061 CDD:293786 2/30 (7%)
ANK repeat 1071..1105 CDD:293786 4/33 (12%)
Ank_2 1079..1171 CDD:289560 18/131 (14%)
ANK repeat 1107..1138 CDD:293786 6/45 (13%)
ANK repeat 1140..1170 CDD:293786 8/54 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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