DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and Crb1

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_573502.2 Gene:Crb1 / 170788 MGIID:2136343 Length:1405 Species:Mus musculus


Alignment Length:1680 Identity:399/1680 - (23%)
Similarity:596/1680 - (35%) Gaps:503/1680 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  2025 CGEGACQHGGLCVPMGHDIQCFC--PAGFSGRRCEQDIDECASQPCYNGGQCKDLP-QG-YRCEC 2085
            |..|.||:...|.....|..| |  .|....:.||...|.|.|.||.....|..:| :| :.|:|
Mouse    34 CLSGPCQNNSTCKHFPQDNNC-CLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGNFLCQC 97

  Fly  2086 PAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGN 2150
            |.||||:||:...:.||.:.|.....|:.:|  ::..|:|..||.|..|:...:.|.:  :||.|
Mouse    98 PPGYSGLNCETATNSCGGNLCQHGGTCRKDP--EHPVCICPPGYAGRFCETDHNECAS--SPCHN 158

  Fly  2151 GASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTDLVNDFQCACPPGFTGKRCEQ 2215
            ||.||....| |.|.||||::|.||:..:::|..:||...|.|.:.:..:.|.||..|:|..||.
Mouse   159 GAMCQDGING-YSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCLNEIGRYTCVCPQEFSGVNCEL 222

  Fly  2216 KIDLCLSEPCKHG-TCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNC 2279
            :||.|.|:||.|| ||.|....:.|.|.||:.|..|::::::||::||.:.|.|||..:.|.|:|
Mouse   223 EIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQPCLHGGLCVDGRNSYHCDC 287

  Fly  2280 E-PGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGT 2343
            . .|:||.:|:..|..|.|.||.:.|||.|.:|.:.|.|||||.|..||.:|:||.|:||...| 
Mouse   288 TGSGFTGMHCESLIPLCWSKPCHNDATCEDTVDSYICHCRPGYTGALCETDINECSSNPCQFWG- 351

  Fly  2344 ERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQV 2408
             .|::|.:       :|..|....           |.:........|:.|.|:||::|:.||:.|
Mouse   352 -ECVELSS-------EGLYGNTAG-----------LPSSFSYVGASGYVCICQPGFTGIHCEEDV 397

  Fly  2409 TTCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCP 2473
                                                   :.|:..||::||.|::......|.||
Mouse   398 ---------------------------------------DECLLHPCLNGGTCENLPGNYACHCP 423

  Fly  2474 AD------YSGIGCQYEYDACEEHVCQNGATCV---DNGA-GYSCQCPPGFTGRNCEQDIVDCKD 2528
            .|      |.|..|......|..|.|.|...|:   .||. |::|||..|:.|..||        
Mouse   424 FDDTSRTFYGGENCSEILLGCTHHQCLNNGKCIPHFQNGQHGFTCQCLSGYAGPLCE-------- 480

  Fly  2529 NSCPPGATCVDL---TNGFYCQCPFNMT--GDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEA 2588
                   |...|   :|||......:.|  |.:|..:::                    |.|.:.
Mouse   481 -------TVTTLSFGSNGFLWVTSGSHTGIGPECNISLR--------------------FHTVQP 518

  Fly  2589 NSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVSL-FEDQPDAFLSFGEY 2652
            |:|.:                       .|..:...|.|:..:..|.:|: ..:|....||....
Mouse   519 NALLL-----------------------IRGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHN 560

  Fly  2653 TSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLP------------GYLWAVLGLP 2705
            ||  ||:||.|.|.   |:..|.|...| .:.|.:.....|:|            .:|.   |||
Mouse   561 TS--DGEWHFVEVT---IAETLTLALVG-GSCKEKCTTKSSVPVENHQSICALQDSFLG---GLP 616

  Fly  2706 QPYGLSNELAY--------SDSGFQGTITKAQVWARAL---DITSEIQKQVRD-------CRSEP 2752
            .  |.:|....        |...|.|.:...:.....:   :::|.:...|:.       |.|:|
Mouse   617 M--GTANNSVSVLNIYNVPSTPSFVGCLQDIRFDLNHITLENVSSGLSSNVKAGCLGKDWCESQP 679

  Fly  2753 VLYPGLILN-WAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVI 2816
            ....|..:| |.||                |.:|...|||:||          :.|:..|.....
Mouse   680 CQNRGRCINLWQGY----------------QCECDRPYTGSNC----------LKEYVAGRFGQD 718

  Fly  2817 AKNGSAVVSWDEPHFSDNIGVT---KIYERNGHRSGTTL-----------LW-----------GT 2856
            ...|.|..|     .:||.|..   .::.|.....|..|           :|           |:
Mouse   719 DSTGYAAFS-----VNDNYGQNFSLSMFVRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGS 778

  Fly  2857 --YDITYIASDAAGNTASCSFKV----------SLLTDFCPALADP-----------VGG----- 2893
              :.:.:..||  ||....|.::          |....|   ::.|           :||     
Mouse   779 PKFMVNFFLSD--GNVHLISLRIKPNEIELYQSSQNLGF---ISVPTWTIRRGDVIFIGGLPDRE 838

  Fly  2894 -SQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSMPLVYPSC-----SP 2952
             ::|     .||.||    .|...:|.:....||:.......:   .:|.:..|...|     ..
Mouse   839 KTEV-----YGGFFK----GCVQDVRLNSQTLEFFPNSTNNAY---DDPILVNVTQGCPGDNTCK 891

  Fly  2953 SKPAQRVFRIKMLFPSDVLC----NKAGQA-------------------VLRQK---VTNSV-NG 2990
            |.|.........|: .|..|    |.||:|                   :|.|.   :.|:| :|
Mouse   892 SNPCHNGGVCHSLW-DDFSCSCPTNTAGRACEQVQWCQLSPCPPTAECQLLPQGFECIANAVFSG 955

  Fly  2991 LNRDWNFCSYAIEG--TRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDDDDD 3053
            |:|:..|.|   .|  |||..:|....:               ..|..|.::.||     .:.:.
Mouse   956 LSREILFRS---NGNITRELTNITFAFR---------------THDTNVMILHAE-----KEPEF 997

  Fly  3054 LTLTGRQGR----QQTGGDTYTL--------------EIAFPAANDPVVHTSTGERSTVKQLLEK 3100
            |.::.:..|    .::|...|||              ::.| :..|||..||..:...       
Mouse   998 LNISIQDARLFFQLRSGNSFYTLHLMGSQLVNDGTWHQVTF-SMIDPVAQTSRWQMEV------- 1054

  Fly  3101 LILEDDQ--FAVQEILP---NTVPDPASLELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCI 3160
                :||  |.:.|:..   |.:.|...:.:|.       |.|..|..:...:.|.         
Mouse  1055 ----NDQTPFVISEVATGSLNFLKDNTDIYVGD-------QSVDNPKGLQGCLSTI--------- 1099

  Fly  3161 ACSRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGL--------- 3216
                     |.|.:..|....:.|.||               :....::....|.:         
Mouse  1100 ---------EIGGIYLSYFENLHGFPG---------------KPQEEQFLKVSTNMVLTGCLPSN 1140

  Fly  3217 -CRS--CGHGFYQPN-EGSFSCELCGLGQTTRSTEATSRKECR---DECSSGQQLGADGRCEPCP 3274
             |.|  |.||   .| |.|:|...|.      .....|...|.   |||.|          .||.
Mouse  1141 ACHSSPCLHG---GNCEDSYSSYRCA------CLSGWSGTHCEINIDECFS----------SPCI 1186

  Fly  3275 RGTYRLQGVQPSCAACPLGRTTPKVGAS---SVEECTLPVCSAGTYLNATQNMCIECRKGYYQSE 3336
            .|... .||......|..|.|    |.:   .|:.|....|:.|    ||   |:....||    
Mouse  1187 HGNCS-DGVAAYHCRCEPGYT----GVNCEVDVDNCKSHQCANG----AT---CVPEAHGY---- 1235

  Fly  3337 SQQTSCLQCPPNHSTKIT--GATSKSECTNPCEHIAEGKPHCDVNAYCIMVPETSDFKCECKPGF 3399
                ||| |..|.:.:..  .....:.|.|...:..     |.....|.|..|  |::|.|.|||
Mouse  1236 ----SCL-CFGNFTGRFCRHSRLPSTVCGNEKRNFT-----CYNGGSCSMFQE--DWQCMCWPGF 1288

  Fly  3400 NGTGMAC----TDVCDGFCENSGACVKDLKGTPSCRCVGSFTGPHCA-----ERSEFAYIAGGIA 3455
              ||..|    .:.....|.|.|.| :||.....|.|..:|.|..|.     :|....:.|.|..
Mouse  1289 --TGEWCEEDINECASDPCINGGLC-RDLVNRFLCICDVAFAGERCELDLADDRLLGIFTAVGSG 1350

  Fly  3456 GAVIFIIIIVLLIWMICVRSTKRRDPKKMLTPAIDQTGSQVNFYYGAHTPYAESI 3510
            ...:|.|:::..:..: :.|.||...........::.|.:|..:.....|..|.:
Mouse  1351 TLALFFILLLAGVASL-IASNKRATQGTYSPSGQEKAGPRVEMWIRMPPPALERL 1404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001
GCC2_GCC3 1916..1966 CDD:285001
GCC2_GCC3 1973..2020 CDD:285001
EGF 2025..2055 CDD:278437 9/31 (29%)
EGF_CA 2059..2095 CDD:238011 16/37 (43%)
EGF_CA 2138..2176 CDD:238011 17/37 (46%)
EGF_CA 2178..2214 CDD:238011 10/35 (29%)
EGF_CA 2253..2289 CDD:238011 14/36 (39%)
EGF_CA 2292..2327 CDD:238011 17/34 (50%)
EGF_CA 2330..2366 CDD:238011 11/35 (31%)
EGF_CA 2369..2405 CDD:238011 7/35 (20%)
EGF_CA 2411..2444 CDD:238011 0/32 (0%)
EGF_CA 2486..2520 CDD:238011 13/37 (35%)
EGF_CA 2522..2557 CDD:238011 7/39 (18%)
LamG 2590..2735 CDD:304605 33/165 (20%)
DUF5011 2799..2877 CDD:295940 18/104 (17%)
GCC2_GCC3 3149..3200 CDD:285001 7/50 (14%)
GCC2_GCC3 3207..3254 CDD:285001 12/59 (20%)
GCC2_GCC3 3268..3307 CDD:285001 10/41 (24%)
GCC2_GCC3 3315..3362 CDD:285001 11/48 (23%)
Crb1NP_573502.2 EGF 113..143 CDD:394967 10/31 (32%)
EGF_CA 147..182 CDD:238011 16/37 (43%)
EGF_CA 186..221 CDD:238011 10/34 (29%)
EGF_CA 224..259 CDD:238011 16/34 (47%)
EGF_CA 262..298 CDD:238011 14/35 (40%)
EGF_CA <308..336 CDD:238011 14/27 (52%)
EGF_CA 338..394 CDD:238011 18/75 (24%)
EGF_CA 396..437 CDD:214542 13/79 (16%)
Laminin_G_2 513..648 CDD:396680 36/168 (21%)
EGF_CA 675..706 CDD:238011 13/46 (28%)
Laminin_G_2 742..859 CDD:396680 22/130 (17%)
EGF_CA 888..922 CDD:238011 9/34 (26%)
Laminin_G_2 979..1104 CDD:396680 29/181 (16%)
EGF_CA 1140..1174 CDD:238011 11/42 (26%)
EGF_CA 1176..1211 CDD:238011 13/49 (27%)
EGF_CA 1213..1248 CDD:238011 14/50 (28%)
EGF_CA 1296..1332 CDD:238011 10/36 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837050
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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