Protein Alignment uif and LOC1272275

DIOPT Version :10

• Sequence 1: NP_001162899.1
• Gene: uif / 33983
• FlyBaseID: FBgn0031879
• Length: 3589
• Species: Drosophila melanogaster
• Sequence 2: XP_311214.6
• Gene: LOC1272275 / 1272275
• VectorBaseID: AGAMI1_009594
• Length: 2280
• Species: Anopheles gambiae
• Alignment Length: 3136
• Identity: 602/3136 - (19%)
• Similarity: 927/3136 - (29%)
• Gaps: 1210/3136 - (38%)

  Fly   526 SGEMLIKFTSDALHNAAGWSATF---SADCPELQPGIGALASSRDTAFGTLV-------SFTCPI 580
            :.|....||.|:|.:....|.|:   ..:.|:|:.. |:.|.:.|...||:.       |.|...
Mosquito    29 TSESANSFTEDSLSSGEEDSTTWQLPEQEYPDLEQA-GSTAENNDQQSGTVTEDLDQTPSTTASP 92

  Fly   581 GQEFATGKTRLVTEC--LRGGNWSVSYIPKCQEVYCGPVPQIDNGFSIGSSNVTYRGIAMYQCYA 643
            .:.......|.....  |:..|      .:...|:.     ||...|:|.:|.......:.:..|
Mosquito    93 DRRLEQANARFQANIGRLKRSN------DRLDIVFL-----IDASSSVGRANFHSELRFVKKLLA 146

  Fly   644 GF------------AFASGAP----IEKISCLPDGRWERQPHCMASQCA----ALPEVAHANVTL 688
            ||            .|:|...    ::.||         ||.....:|.    .||.:.::
Mosquito   147 GFDVSVNRTRVALVTFSSRKKVIRHVDHIS---------QPLPGNDKCLLLNYQLPGIEYS---- 198

  Fly   689 LNGGGRSYGTIVQYECEPGYERNGHP--VLTCMSNGTWSGDVPRCTRKRCFEFPTIANGFVVDS- 750
             .||..:||.:  :|.|..:.|:.:|  ::..:::|..:|..|....:|..:     ||..:.|
Mosquito   199 -GGGTYTYGAL--WEAEEIFARDSYPERIIFLITDGYSNGQSPIPIAERLKQ-----NGVQIFSI 255

  Fly   751 --------------TRA---YLFGDEARVQCFKGYKLIGSNIMRCSEAQKFEQPPT--------C 790
                          |.|   ||.|.      |:.::    :::|.:....:...|:        |
Mosquito   256 GIESGNEEELTSIATSAEHRYLLGS------FEQFE----SLVRQALHLDYRHGPSVPLANGSLC 310

  Fly   791 EDI----------NECSSSQCDL-TTTECQNTNGSFHCQCRTGFTAT---TECRPVGDLGLGNGG 841
            :.:          :|..:..||. ....|..|:|.:.|.||.|||.:   .:|.|.
Mosquito   311 DRLCDRGKVREHGSELVAGCCDAHAVCSCLTTSGHYRCICRPGFTGSGLRGDCHPC--------- 366

  Fly   842 IPDDSITTSVSEPGYSKEQLRLNTNG--WCGGS---SEPGANWILIDLKAPTILRGFRTMSVQRP 901
                                   .||  |..||   |.|.|..|.:.|.|.:
Mosquito   367 -----------------------PNGTYWTAGSTCESCPHARHITLTLGATS------------- 395

  Fly   902 DGNVAFSSAVRLQYTNDLTDVFKDYANPDGTAVEFRILEPTLSILNLPLPIEARYIRFRIQDYVG 966
                                                                             
Mosquito   396 ----------------------------------------------------------------- 395

  Fly   967 APCLRMELMGCTRLDCVDINECSKNNGGCDQKCINSPGGFACGCNTGYQLYTSNGTAGYHIERSE 1031
                                         :::|:         |..|||             .:|
Mosquito   396 -----------------------------EKECV---------CPRGYQ-------------ENE 409

  Fly  1032 SGERDGDTYQRNKTCVPLMCPELEAPENGQLLSDKN--DYHFGDVVRFQCHFGYIMSGSSAALCL 1094
            .|.           ||.:.||||:|||||..:.:..  ..........:|..||.::|||..||.
Mosquito   410 DGR-----------CVAITCPELQAPENGYFVMEPKPCSQVLNAACGTRCRPGYELTGSSIRLCQ 463

  Fly  1095 SSGQWNASVPECNYAKC--VSLPDDKLEGLTVARPDPESVLVPFRDNVTITCGSPGRQLRATASS 1157
            .:|:|:.:..:|...||  :::|   ..|:.|                   |.:|...|
Mosquito   464 ENGEWSGTEAKCTMKKCPPLNIP---YYGMAV-------------------CSNPDLDL------ 500

  Fly  1158 GFRQCVYDPKPGLPDYWLSGMQPSCPRVDCYSPMPTPGAEYGQFVDTRYQSSFFFGCQNTFKLAG 1222
                 :||..|....: |.....|..|..  ..||         :||...    |.|...|.|.|
Mosquito   501 -----LYDYTPRNKSF-LQNYSMSAERFT--EAMP---------IDTECS----FTCGPGFYLKG 544

  Fly  1223 QTGRHDNVVRCGADGIWDFGDLRCEGPVCEDPGRPADGRQIARSYEQS----SEVYFGCNRPGYI 1283
            ...|:     |.....||.....|:..:|     ||..:....:|:.:    |:..||.|
Mosquito   545 SHNRN-----CLPLSKWDGLQTTCKQILC-----PALPKVAFATYDPTDCAESKSAFGTN----- 594

  Fly  1284 LINPRPITCIREPECKVIKPLGLSSGRIPDSAINATSERPNYEAKNIRLNSATGWCGKQEAFTYV 1348
                          |.:|...|                   :|.|.   ..:|..||
Mosquito   595 --------------CTLICDFG-------------------FEMKG---GPSTKQCG-------- 615

  Fly  1349 SVDLGQIYRVKAILVKGVVTNDIVGRPTEIRFFYKQAESENYVVYFPNFNLTMRDPGNYGELAMI 1413
                                    |:.|                            |.:.:|
Mosquito   616 ------------------------GKRT----------------------------GTWSKL--- 625

  Fly  1414 TLPKFVQARFVILGIVSYMDNACLKFELMGCEEPKQEPLLGYDYGYSPCVDNEPPIFQNCPQQPI 1478
                                           :.|:             |:|..||..: ||....
Mosquito   626 -------------------------------KTPR-------------CIDIAPPYIE-CPGNYT 645

  Fly  1479 VVRRDENGGVLPVNFTEPTAVDNSGS----IARLEIKPQNFRTPSYIFKDTVVKYVAFDYDGNVA 1539
            |:..|:....|.....:|...||||.    .::..||....|   ....|....|:|.|...|.|
Mosquito   646 VLMDDDFPHALVRRLQQPYVFDNSGDNFTYWSKPGIKEDGIR---LALGDHEFSYIAMDAFKNKA 707

  Fly  1540 ICEINITVPDVTPPLL-QC---PQSYVIELVDRQDSYT-----VNFNDTRKRIKTSDDTGDVRLQ 1595
            .|...:||.|:|||:. ||   |..||.:..:||:::.     :.::::.:.:..   |.:|...
Mosquito   708 RCSFTVTVIDLTPPVFEQCLDGPVHYVSDSANRQETFVRWEEPLVYDNSGRNVTV---TQNVTFG 769

  Fly  1596 FSPESANIKIGNFENVTVTATDKYNNRAACHFQVSVKASPCVDWELQPPANGAINCLPGDRGIEC 1660
            :.|...:.       |...|.|...|.|.|..:|.||...|.  .:..|.||...|........|
Mosquito   770 YLPAGRHA-------VRYLAVDASGNEAECVLRVEVKQYTCD--HIPEPRNGYSICAYNASHAWC 825

  Fly  1661 IATCKPGFRFT--DGEPLKTFSCETSRLWRPTSVVPDCV----SENTEQAAYHVTASITYRANGA 1719
            ...||..:.|:  ..|.::......:..|.....||:|.    |...|:.       ||.|.:..
Mosquito   826 EIGCKEDYMFSLQPEETIRLVCDRANPTWGEQLEVPECSKVIGSSGVEKI-------ITIRLDDE 883

  Fly  1720 VAQSCLGQ---YQEVLAQHYGGLNQLLSQRCSAVNVNMNVTFVKSVPM---------LLEENVVK 1772
            :.......   ..||......||.|   :.|..   ..:.|.:.::|.         ..|:..|:
Mosquito   884 MDPGLCNDTDAINEVSEAFSDGLRQ---EMCGD---QADCTLMTTLPACPAGNGGADTAEDTAVR 942

  Fly  1773 MDFILSILPAVRQPQLYDLCGSTLNLIFDLSVPYASAVIDDLLNIANIGNQCPPLRALKSQI--- 1834
            ...:...:.|  ||......|...:... :.:.....|..:|......|.|...::.:|.::
Mosquito   943 YSIVKRSVNA--QPSTTPDPGRANDRAM-VKIFVYKRVSQELGLWRPDGKQSENIKRIKEELEKI 1004

  Fly  1835 --SRGFNCNVGEVLNMDTSDVPR----------------CLHCPAGTYVSEGQNSCTYCPRGYYQ 1881
              .:.....:| .||:|.|.:..                |:|||.|||.:...|||..||.|.|.
Mosquito  1005 NGKKKLRRRLG-ALNLDLSVLKLDEKIRCANGSISKKLVCVHCPRGTYHNYTTNSCLSCPIGSYN 1068

  Fly  1882 NRDRQGTCLRCPAGTYTKEEGTKSQADCIPVCGYGTYSPTGLVPCLECPRNSFTAEPPTGGFKDC 1946
            ::..|.:|..||....|::...|...:|.|.|      |.|.|..|:..:.:    .|.||  :.
Mosquito  1069 DQTGQTSCQPCPEHHSTRKLNAKHAHECKPQC------PPGTVARLKLLKKT----KPNGG--NV 1121

  Fly  1947 QACPAQSFTYQPAASNKDLCRAKCAPGTYSATGLAPCSPCPLHHYQGAAGAQSCNECPSNMRTDS 2011
            ........|..|      .||. |.||.|.            ..|..|    .|..||||  ..|
Mosquito  1122 NGAVKYHKTLMP------FCRL-CEPGQYQ------------EQYNRA----QCLACPSN--HSS 1161

  Fly  2012 P-ASKGREQCKPV---VCG---EGACQHGGLCVP-----MGHDIQCFCPAGFSGRRCEQDIDECA 2064
            | .||....|.|:   :|.   ...|..||.||.     :|:  ||.|...:.|..||..::.|.
Mosquito  1162 PRGSKSAADCFPIGGQLCNGTVGNVCGVGGRCVVDPSSLLGY--QCVCDENYVGEHCEIALNPCG 1224

  Fly  2065 SQPCYNGGQC-KDLPQGYRCECPAGYSGINCQEEASDCGNDTCPARAMCKNEPGYKNVTCLCRSG 2128
            |.||||||:| .:...|:.|.|...|:|
Mosquito  1225 SAPCYNGGRCVSNGSAGFVCHCQPPYTG------------------------------------- 1252

  Fly  2129 YTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYKCECVPGWEGIHCEQNINDCSENPCLLGANC 2193
              |..|:..:|||  ..:.|.||.||..:: ||..||
Mosquito  1253 --GPLCEFYVDPC--RSDHCKNGGSCVEVD-GRPFCE---------------------------- 1284

  Fly  2194 TDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCKHGTCVDRLFDHECVCHPGWTGSACDINIDDCE 2258
                      ||.|:.|:|||.:.|.|...||:.
Mosquito  1285 ----------CPLGYDGERCEWRKDFCTPNPCEF------------------------------- 1308

  Fly  2259 NRPCANEGTCVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVG 2323
                  ||.||::.:||||.|..|.||:.|.  ::.|...||..|:.|::..:..:.......|.
Mosquito  1309 ------EGMCVNVDEGYSCACPSGKTGRRCH--LEPCDYLPCPAGSMCLNGANDTAAGNDRFTVA 1365

  Fly  2324 LSCEAEIDECLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRV 2388
            |..:       ..|.|. |:     |...:.|||..|.:|..|| ::|:    ||..:..||
Mosquito  1366 LQTQ-------QLPSNS-GS-----LAYSYRCVCPVGLRGTSCA-ELDN----PCETSRYCR--- 1409

  Fly  2389 GGFECGCEPGWSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGD 2453
                                                              :|..||.|..|.:|
Mosquito  1410 --------------------------------------------------NGATCEPAKLRVVG- 1423

  Fly  2454 PCMHGGKCQDFGSGLNCSCPADYSGIGCQYEYDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRN 2518
                            .|...||.        |.....|              .|.|||.:.|..
Mosquito  1424 ----------------ASTAEDYD--------DESYRKV--------------RCHCPPEYHGSR 1450

  Fly  2519 CEQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPF 2583
            ||                 :.|:..|..:.|        |..:|. |....:|.|.:|
Mosquito  1451 CE-----------------LLLSAAFELEFP--------RTGVQA-YVKLVADSSDAT------- 1482

  Fly  2584 PTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSA------RMTQQRRMLLQAHSSGVQVSLFEDQ 2642
               :..::::..|.   :.||...:.||....:|      .:|....::|..:.:.|..::
Mosquito  1483 ---DLRAISMCGWY---RTDDDFNYGTLLSYATATVDNAFTLTDYSGLVLYVNGAHVVTNV---- 1537

  Fly  2643 PDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEG---LIASKMEYGA---GGSLPGYLWA- 2700
                       |:|||:||.|.|.|....|:..|..:|   ...|.:..||   .|.|  |::.
Mosquito  1538 -----------SLNDGEWHFVCVSWTSAGGRYVLYVDGERSAYGSSLSEGAPIQSGGL--YVFGQ 1589

  Fly  2701 ---VLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNW 2762
               |||    .|.|...:|     :|.:....:|.|.|:: .|:.:..|.|..    |.|.::.|
Mosquito  1590 EQDVLG----GGFSETESY-----RGRMAYVDLWKRELEL-EEVGRLYRTCAP----YSGDLVRW 1640

  Fly  2763 AGYEVTSGGVERNV-PSLCGQRKCPVGYTGANCQQLVVDKEPPVVEHCPGDLWVIAKNGS----- 2821
            ....:.:.|:.|.| .|.|  |.||..::                          ..|||
Mosquito  1641 IDLRLQTVGLVRIVASSFC--RDCPRNHS--------------------------LPNGSVRYDG 1677

  Fly  2822 --AVVSWDE------PHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYIASDAAGNTASCSFKVS 2878
              ||...||      |.||:.:              .|..|               ||...|  .
Mosquito  1678 TRAVFQCDEGYELIGPSFSECL--------------RTSQW---------------TAGVQF--C 1711

  Fly  2879 LLTDFCPALADPVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEFYTCGAEGFWRPTREPSM 2943
            .||. |..:..|:.|..:......||:   ...:|:.|  |.....|...|.|.|.|.......:
Mosquito  1712 KLTR-CGTIGAPLNGQVLLTKTSFGGE---ARFSCDDG--FLIAGAELLHCTARGTWSGPPPDCI 1770

  Fly  2944 PLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDWNFC--SYAIEGTR 3006
            .:|  .|.|........|..:::.::       :.|::|.:.:...|:..:.. |  .||:....
Mosquito  1771 SIV--KCPPLVLEAHDGRAPVIYATE-------RGVIQQHLDSYDVGVLAEVR-CLPEYALTEDN 1825

  Fly  3007 ---------------ECKDIQIDVKCDHYRGTQNN---RVRR--------QAKDGGVYVMEAELP 3045
                           ||..|......:..|.||..   ||.|        |.:|   |:.....|
Mosquito  1826 LLTCLESGQWDLPLPECVPIPPTTTPEPSRDTQPALIIRVNRRPDVHFWKQLRD---YLFHGCTP 1887

  Fly  3046 ------------------VVNDDDDDLT--LTGRQGRQQTGGDT----YTLEIAFPAAN------ 3080
                              :..::..||:  ...|...:.|..|.    :.:....|..|
Mosquito  1888 PAVPGRGLSLFCYSATGTIAGNNWTDLSGFSLQRDAPRLTNIDVRLLGFLMRTVKPNLNRVVPQN 1952

  Fly  3081 ----------DPVV-------HTSTGERSTVKQLLEKLILE-----DDQFAV---QEILPNT--- 3117
                      ||:.       |.....|..:.|.::.::::     ||:..|   ||...||
Mosquito  1953 LLHFILYGSVDPIAPEMRYPGHIENAYRFVICQFIDVILMDRELNYDDELVVDIGQEENTNTKIK 2017

  Fly  3118 ----------VPDPASL--ELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCIACSRGTYQSE 3170
                      .|....|  |..:..:..:.:::.:.|.||.:..|...:...|.....|
Mosquito  2018 HLLKNVAHAVYPQYQRLLEERSARESAALKKIIELADRVPGSTSTTTTTTTTTAAPPKR------ 2076

  Fly  3171 AGQLQCSKCPVIAGRPGVTAGPGARSAADCKERCPAGKY-----------FDAETGLCRSCGHGF 3224
                    || ::..|...........|......|||::           .|....:...|..||
Mosquito  2077 --------CP-LSHLPSPPIDSHVAMVALATLHRPAGEWRLEQLLSSGQLADPGDRIQFGCDAGF 2132

  Fly  3225 YQPNEGSFSCELCGL-GQTTRSTEATSRKECRDECSSGQQLGADG--------------RCEPCP 3274
            ..  .|| :..:||. |:.|..........|....:....|.|.|              ||||
Mosquito  2133 SM--RGS-AVTVCGADGRWTMVEGFCEGAVCEHPPTRANMLIAPGSRDKQYYVDDEIEYRCEP-- 2192

  Fly  3275 RGTYRLQGVQPSCAACPLGRTTPKVGASSVEEC----TLPVC--SAGTYLNATQNMCIECRKGYY 3333
              .|.::| .|.....|.||.||.|...:...|    .||:.  .||:......::.:.||:...
Mosquito  2193 --GYTIKG-HPIVKCLPNGRWTPMVARCTRISCGRPKNLPMAYILAGSSFLYGDSLKVRCRQSSI 2254

  Fly  3334 ----QSESQQTSCLQC 3345
                ||..|.||..||
Mosquito  2255 DITCQSTGQWTSFDQC 2270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
uif	NP_001162899.1	CLECT	36..167	CDD:214480
		LDLa	172..206	CDD:238060
		CUB	220..319	CDD:238001
		CUB	326..435	CDD:238001
		CUB	439..550	CDD:238001	7/26 (27%)
		PHA02927	<568..733	CDD:222943	36/195 (18%)
		CCP	675..731	CDD:153056	14/61 (23%)
		PHA02639	697..>834	CDD:165022	35/178 (20%)
		FA58C	833..976	CDD:330301	11/147 (7%)
		FXa_inhibition	988..>1016	CDD:464251	4/27 (15%)
		CCP	1051..1106	CDD:153056	19/56 (34%)
		FA58C	1303..1443	CDD:330301	10/139 (7%)
		HYR	1463..1547	CDD:460572	23/87 (26%)
		HYR	1548..1631	CDD:460572	21/91 (23%)
		Ephrin_rec_like	1862..1909	CDD:429604	16/46 (35%)
		Ephrin_rec_like	1916..1966	CDD:429604	9/49 (18%)
		Ephrin_rec_like	1973..2020	CDD:429604	13/47 (28%)
		EGF	2025..2055	CDD:394967	11/37 (30%)
		EGF_CA	2059..2095	CDD:238011	14/36 (39%)
		EGF_CA	2138..2176	CDD:238011	12/37 (32%)
		EGF_CA	2178..2214	CDD:238011	5/35 (14%)
		EGF_CA	2253..2289	CDD:238011	12/35 (34%)
		EGF_CA	2292..2327	CDD:238011	7/34 (21%)
		EGF_CA	2369..2405	CDD:238011	5/35 (14%)
		EGF_CA	2411..2444	CDD:238011	1/32 (3%)
		EGF_CA	2486..2520	CDD:238011	7/33 (21%)
		EGF_CA	2522..2557	CDD:238011	3/34 (9%)
		LamG	2590..2735	CDD:473984	36/160 (23%)
		HYR	2799..2877	CDD:460572	15/90 (17%)
		Ephrin_rec_like	3149..3200	CDD:429604	7/50 (14%)
		Ephrin_rec_like	3207..3254	CDD:429604	11/58 (19%)
		Ephrin_rec_like	3268..3307	CDD:429604	14/52 (27%)
		Ephrin_rec_like	3315..3362	CDD:429604	10/35 (29%)
LOC1272275	XP_311214.6	None