DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and notch4

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:XP_031747113.1 Gene:notch4 / 100488695 XenbaseID:XB-GENE-22063929 Length:2106 Species:Xenopus tropicalis


Alignment Length:1812 Identity:439/1812 - (24%)
Similarity:626/1812 - (34%) Gaps:554/1812 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1910 IPVCGYGTYSPTGL---VPCLECPRNSFTAEPPTGGFKDCQACPAQSFTYQPAASNKDLC-RAKC 1970
            :|:|       .||   :||    ||.........|.:.|:....:..||      :|.| ..:|
 Frog    13 LPLC-------QGLDCQIPC----RNGGVCLSLENGTQICRCPDGEDCTY------RDPCLSVQC 60

  Fly  1971 APGTYSATGLAPCSPCPLHHYQGAAGAQSCNECPSNMRTDSPASKGREQCKPV-VCGEGACQHGG 2034
            ..|          ..|    |:.:|....| :|.:...        .:.|:.: .|....|::.|
 Frog    61 KNG----------GSC----YRFSATDYRC-QCETGWT--------GKNCEYLDFCTPNRCKNNG 102

  Fly  2035 LCVPMGHDIQCFCPAGFSGRRCEQDIDEC-ASQPCYNGGQCKDLPQGYRCECPAGYSGINCQEEA 2098
            .|:.|....:|.||.||.|..||:|:||| |:..|.|||.|::|...::||||..|.|..|:...
 Frog   103 KCINMVPSFRCQCPIGFEGESCEKDVDECQAADTCRNGGTCENLVGSFKCECPESYHGTRCEMRR 167

  Fly  2099 SDCGNDTCPARAMCKNEPGYKNVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQGRYK 2163
            ..|..|:|..:..|:....|| ..|:|.:||||.:|:..||.|.  .:.|.||.||:. ..|:|.
 Frog   168 GVCAADSCLNKGKCQQMEFYK-YQCVCPTGYTGSKCEENIDDCI--NHRCENGGSCKD-GLGKYT 228

  Fly  2164 CECVPGWEGIHCEQNINDCSENP--CLLGANCTDLVNDFQCACPPGFTGKRCEQKIDLCLSEPCK 2226
            |:|.||::|.:|..:|::| :.|  |..|..|.::...::|.|..|:.|..||..||.|.:..|.
 Frog   229 CQCTPGFKGWYCSNDIDEC-QTPAICKNGGTCQNIPGGYKCVCVNGWDGDNCEHNIDDCATATCA 292

  Fly  2227 HG-TCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTC-VDLVDGYSCNCEPGYTGKNCQ 2289
            .| ||:|.:....|:|.||..|..|... |.|.|.||..|.|| ..|.....|.|:|||||..|.
 Frog   293 EGATCIDHVGTFLCMCPPGRIGLLCTTQ-DGCVNNPCHPEATCDSQLTSVALCRCQPGYTGPTCH 356

  Fly  2290 HTIDDC--ASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNK 2352
            ..:|:|  .|:||:||..||:....|.|.|..|:.|..||....||..:||:...|  ||||...
 Frog   357 QDLDECQLGSSPCEHGGQCVNTPGSFYCSCPRGFTGARCETVQAECQPNPCHNKAT--CLDLLGH 419

  Fly  2353 FECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPC 2417
            |||:|..|:||..|..:||:|::.||.|.|.|.|.:..:.|.|..|:.|.:||..|..| :.:||
 Frog   420 FECLCVPGYKGERCELEIDECQSSPCQNGGSCTDLLNDYICSCPQGYQGPQCEDDVDEC-SSSPC 483

  Fly  2418 QNDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQ 2482
            :|...|.:....|.|.||.|..|..|||....|...|| |.|.|:|......|.|...|:|..|:
 Frog   484 KNGGQCHNQPGSYNCSCPGGFQGSVCETDINECASSPC-HFGSCEDNPGFFTCHCDPGYTGTVCE 547

  Fly  2483 YEYDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQ 2547
            .|.|.||...|..||.|.....|:.|.|.||.||..|::||.:|..:.|..|..|.:...||.|.
 Frog   548 KEIDVCESQPCHFGAQCQARKNGFMCICQPGTTGTLCDEDINECHSSPCLNGGACNNTQGGFLCH 612

  Fly  2548 CPFNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQ-FAQKDDRGIFFTL 2611
            ||                           ...:.|..|.:.|:.|....|. ..||         
 Frog   613 CP---------------------------PGTIQPLCTLQDNNCTNVTCVHGNCQK--------- 641

  Fly  2612 YGVQSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQL 2676
                     |..|.                           |.:.|..|                
 Frog   642 ---------QNNRT---------------------------TCICDEGW---------------- 654

  Fly  2677 ITEGLIASKMEYGAGGSLPGYLWAVL------GLPQPYGLSNELAYSDSGFQGTITKAQVWARAL 2735
                         .|.....|:..|.      |:.||: ....:....||:.|            
 Frog   655 -------------KGSVCDTYIQCVTNPCQNGGVCQPF-QERFICSCVSGYTG------------ 693

  Fly  2736 DITSEIQKQVRDCRSEPVLYPGLILNWAGYEVTSGGV-----ERNVPSLCGQRKCPVGYTGANCQ 2795
               ...:..:..|.|.|              .::||.     ::||.    |..||.|:.|::|:
 Frog   694 ---PNCETLLSPCYSNP--------------CSNGGTCHHYPDQNVI----QCDCPAGWQGSSCE 737

  Fly  2796 QLV--VDKEP----------PVVEHCPGDLWVIAKNGSAVVSWDEPHFSDNIGVTKIYERNGHRS 2848
            ..|  .:|.|          |...||   :.:....|:...:..:|..||..           ::
 Frog   738 LDVNECEKRPCKNGGRCVNTPGAHHC---ICLPDYTGTLCEALVDPCLSDKC-----------QN 788

  Fly  2849 GTTLLWGTY---------------DITYIASDAAGNTASCSFKVSLLTDFCPALADPVGGSQVCK 2898
            |.|.:..|:               ||....|....|.|||..|.:               |.:|.
 Frog   789 GGTCVSETFSCLCPAGYTGEHCEEDIDECVSSPCQNGASCQNKAN---------------SYICV 838

  Fly  2899 -DWGAGGQFKVCEI--------AC-NAGLRFSEPVPEFYTC--GAEGFW--RPTR--------EP 2941
             |.|..|:  .|||        :| |.|           ||  |...||  .|.|        |.
 Frog   839 CDEGYEGE--KCEINTMDCTTSSCLNGG-----------TCVDGIASFWCLCPERFTGKHCQEEL 890

  Fly  2942 SMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGLNRDW--NFCSYA-IE 3003
            |..|..| |:.....|.:       |....|:          ......|.|.:.  :|||.| .:
 Frog   891 SRCLSNP-CTNRGICQHI-------PGGYFCS----------CPYGYTGANCEMAVDFCSTAPCQ 937

  Fly  3004 GTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPVVNDDDDDLTLTGRQGRQQTGGD 3068
            ....|....|..||....|...:              ..|.|                       
 Frog   938 NGGSCSQSGISYKCHCASGWIGS--------------HCETP----------------------- 965

  Fly  3069 TYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLILEDDQFAVQEILPNTVPDPASLELGSEYACP 3133
                           :|   |.|:.|.|.:|...|.:..             ...::.|..|.| 
 Frog   966 ---------------LH---GCRARVSQDVETTALCNGH-------------GTCVDSGHSYIC- 998

  Fly  3134 VGQVVMIPDCVP------CAIGTFYDSANKTCIACSRGTY-QSEAGQLQCSKCPVIAGRPGVTAG 3191
                    .|.|      |.:.|.:...|    .|..|.: |.:.|...|...|...|:      
 Frog   999 --------HCFPGYTGSLCEVKTGFCQPN----PCQNGAHCQEQDGSFLCQCLPGFLGQ------ 1045

  Fly  3192 PGARSAADCKERCPAGKYFDAETGLCRSCGH-GFYQPNEGSFSCELCGLGQTTRSTEATSRKECR 3255
                   .|.||.|.         |.|.|.| |......|.:.|: |..|        |....|.
 Frog  1046 -------TCTERDPC---------LSRPCFHNGVCVAQGGEYKCQ-CPSG--------TQGIHCE 1085

  Fly  3256 ---DECSSGQQLGADGRCEPCPRGTYRLQGVQPSCAACP---LGRTTPKVGASSVEECTLPVC-S 3313
               |:|::   :.::.:|  ...||.|.:....|| .||   :||..    ...|.||....| .
 Frog  1086 INPDDCAT---VSSEPKC--FHGGTCRDEIGGFSC-FCPPGFVGRRC----EGDVNECLSNPCHP 1140

  Fly  3314 AGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPNHSTKITGATSKSECTNPCEHIAEGKPHCDV 3378
            .||      .:|::....|        .| :|   |.. .||    .:|..|....|...  |..
 Frog  1141 IGT------EICVQLNNAY--------KC-KC---HRL-YTG----QKCDQPINFCANNP--CFN 1180

  Fly  3379 NAYCIMVPETS-DFKCECKPGFNGTGMACTD---VCDGF-CENSGACVKDLKGTPSCRCVGSFTG 3438
            ...|.:...|. .|.|.|..||:|.  .|::   .|... |.|.|.||.|..|...|.|...::|
 Frog  1181 GGSCAVTANTPLGFTCSCPKGFSGA--TCSEPILPCSPHTCNNGGKCVSDTNGRYYCHCSNGYSG 1243

  Fly  3439 PHCAERSEFAYIAGGIAGAVIFIIIIVLLIWMICVRSTKRRDP----KKMLTPAI--DQTGSQVN 3497
            |||.| |...|.|...:...:             :.....|.|    ||:....:  ....::..
 Frog  1244 PHCLE-SIMPYTASASSSPPV-------------LPEPSNRCPYIDCKKVFKNGVCDKHCNNEQC 1294

  Fly  3498 FYYGAHTPYAESIAPSHHSTYAHYY---------DDEEDGWEMPNFYNE-------------TYM 3540
            .|.|......::..|.:::....::         |:.|.||:..:..||             :|.
 Frog  1295 LYDGFDCNATQACNPLYNNYCLDHFANGHCERGCDNVECGWDGGDCSNEERKKSEGSLILVLSYA 1359

  Fly  3541 KDGLHGGKMSTLARSNASLY---------------------GTKEDLY-DRLKRHAY 3575
            ...||..:::.|.|:.:.|.                     .:.::|: |||:|..|
 Frog  1360 PPVLHQREINALLRNLSMLIRAGIRLQKDSSGNMLFRYRRSDSLDELFPDRLQRWEY 1416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001
GCC2_GCC3 1916..1966 CDD:285001 11/52 (21%)
GCC2_GCC3 1973..2020 CDD:285001 6/46 (13%)
EGF 2025..2055 CDD:278437 11/29 (38%)
EGF_CA 2059..2095 CDD:238011 17/36 (47%)
EGF_CA 2138..2176 CDD:238011 15/37 (41%)
EGF_CA 2178..2214 CDD:238011 10/37 (27%)
EGF_CA 2253..2289 CDD:238011 16/36 (44%)
EGF_CA 2292..2327 CDD:238011 14/36 (39%)
EGF_CA 2330..2366 CDD:238011 16/35 (46%)
EGF_CA 2369..2405 CDD:238011 13/35 (37%)
EGF_CA 2411..2444 CDD:238011 11/32 (34%)
EGF_CA 2486..2520 CDD:238011 14/33 (42%)
EGF_CA 2522..2557 CDD:238011 11/34 (32%)
LamG 2590..2735 CDD:304605 18/151 (12%)
DUF5011 2799..2877 CDD:295940 19/102 (19%)
GCC2_GCC3 3149..3200 CDD:285001 9/51 (18%)
GCC2_GCC3 3207..3254 CDD:285001 10/47 (21%)
GCC2_GCC3 3268..3307 CDD:285001 11/41 (27%)
GCC2_GCC3 3315..3362 CDD:285001 9/46 (20%)
notch4XP_031747113.1 EGF_CA 94..125 CDD:238011 10/30 (33%)
EGF_CA 127..164 CDD:238011 17/36 (47%)
EGF_CA 205..240 CDD:238011 15/37 (41%)
EGF_CA 243..280 CDD:238011 10/37 (27%)
EGF_CA 282..318 CDD:238011 13/35 (37%)
EGF_CA 358..396 CDD:238011 14/37 (38%)
EGF_CA 401..434 CDD:238011 16/34 (47%)
EGF_CA 437..472 CDD:238011 13/34 (38%)
EGF_CA 474..510 CDD:238011 12/36 (33%)
EGF_CA 512..547 CDD:238011 11/35 (31%)
EGF_CA 587..>616 CDD:214542 11/55 (20%)
EGF_CA <668..697 CDD:238011 6/44 (14%)
EGF_CA 739..775 CDD:238011 7/38 (18%)
EGF_CA 778..811 CDD:238011 6/43 (14%)
EGF_CA 813..849 CDD:238011 13/52 (25%)
EGF_CA <860..887 CDD:238011 10/37 (27%)
EGF_CA <896..925 CDD:238011 7/46 (15%)
EGF_CA 928..963 CDD:238011 9/48 (19%)
EGF_CA 1017..1048 CDD:238011 8/47 (17%)
EGF_CA 1089..1127 CDD:238011 12/47 (26%)
EGF_CA 1170..1207 CDD:238011 10/40 (25%)
Notch 1275..1301 CDD:395019 4/25 (16%)
Notch 1311..1340 CDD:395019 4/28 (14%)
NOD 1349..1399 CDD:399654 6/49 (12%)
JMTM_Notch4 1478..1568 CDD:411988
ANK repeat 1640..1689 CDD:293786
PHA03095 1673..>1865 CDD:222980
ANK repeat 1692..1722 CDD:293786
Ank_2 1696..1789 CDD:403870
ANK repeat 1724..1756 CDD:293786
ANK repeat 1758..1789 CDD:293786
ANK repeat 1791..1822 CDD:293786
ANK repeat 1824..1855 CDD:293786
DUF3454 2059..>2106 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I10904
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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