DRSC/TRiP Functional Genomics Resources

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Protein Alignment uif and notch2

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:XP_002939126.3 Gene:notch2 / 100486344 XenbaseID:XB-GENE-6046917 Length:2455 Species:Xenopus tropicalis


Alignment Length:2104 Identity:487/2104 - (23%)
Similarity:684/2104 - (32%) Gaps:829/2104 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1652 LPGDRGIECIATCKP----GFRFTDGEPLKTFSCETSRLWRPTSVVPDCVSENTEQAAYHVTASI 1712
            :||..|::|....:|    |...|:.:......|..:      .|...|..:|..|.        
 Frog    16 MPGCDGLQCRGASEPCLNEGKCITNDDGSAYCKCTDA------FVGKYCQLQNPCQE-------- 66

  Fly  1713 TYRANGAVAQ--SCLGQYQEVLAQHYGGLN--QLLSQRCSAVNVNMNVTFVKSVPMLLEENVVKM 1773
            |...||...:  |.|.:.....|..:||.|  |.::..||.....||                  
 Frog    67 TICLNGGTCKVSSDLSKGVCTCAPGFGGENCKQPVANVCSLTQPCMN------------------ 113

  Fly  1774 DFILSILPAVRQPQLYDLCGSTLNL----IFDLSVPYASAVIDDLLNIANIGNQCPPLRALKSQ- 1833
                               |.|.:|    ::|...|:...           ||.|..:.|..|| 
 Frog   114 -------------------GGTCHLLTLELYDCICPFGWR-----------GNDCKFIDACASQP 148

  Fly  1834 ISRGFNCNVGEVLNMDTSDVPRCLHCPAGTYVSEGQNSCTYCPRGYYQNRDRQGTCLRCPAGTYT 1898
            .:.|..|            :|           :|.|.:|:                  |.|| ||
 Frog   149 CANGSTC------------IP-----------NENQYTCS------------------CQAG-YT 171

  Fly  1899 KEEGTKSQADCIPVCGYGTYSPTGLVPCLECPRNSFTAEPPTGGFKDCQACPAQSFTYQPAASNK 1963
               |.|.:.| :..||     |.|:     | :|..|.|...|.:: ||..|..:          
 Frog   172 ---GLKCEVD-VNECG-----PPGM-----C-KNGGTCENFPGSYR-CQCHPGYT---------- 210

  Fly  1964 DLCRAKCAPGTYSATGLAPCSPCPLHH----YQGAAGAQSCN--------ECPSNMRTDSPASKG 2016
                     |....:...||||.|..:    .|.:..|..||        .|.:|: .|.|:.| 
 Frog   211 ---------GQRCESPFIPCSPSPCMNGGTCRQTSEFAYECNCLPGFDGKNCETNI-DDCPSHK- 264

  Fly  2017 REQCKPVVCGEGACQHGGLCVPMGHDIQCFCPAGFSGRRCEQDIDECASQP--CYNGGQCKDLPQ 2079
                         ||:||.||...:...|.||..::|:.|.:|:|||..||  |.|||.|.:...
 Frog   265 -------------CQNGGTCVDGVNTYNCRCPPQWTGQFCTEDVDECQLQPNACQNGGTCTNSNG 316

  Fly  2080 GYRCECPAGYSGINCQEEASDCG--------------------------------NDTC------ 2106
            ||.|.|..|:||.:|.:...||.                                ||.|      
 Frog   317 GYNCVCVNGWSGDDCSQNIDDCATAACANGSTCIDRVASFICVCPEGKIGLLCHKNDACFSNPCH 381

  Fly  2107 ----------PARAMCKNEPGYKNVTCL------------------------------CRSGYTG 2131
                      ..:|:|....|||...|.                              |..|:||
 Frog   382 MGSLCDTNPLTGQAICTCPSGYKGTACTEDIDECSLVNSNPCEHAGKCVNTEGSFYCECSKGFTG 446

  Fly  2132 DQCDVTIDPCTANGNPCGNGASCQALEQ-GRYKCECVPGWEGIHCEQNINDCSENPCLLGANCTD 2195
            .:|::.|:.|.:  .||.|.|:|  |:: |.:.|.|:||::|||||..||:|..|||:....|.|
 Frog   447 PRCEMDINECLS--EPCQNDATC--LDKIGGFTCLCMPGYKGIHCEIEINECLSNPCVNNGECVD 507

  Fly  2196 LVNDFQCACPPGFTGKRCEQKIDLCLSEPCK---------------------------------- 2226
            .||.|.|.|||||||..|:..||.|.|.||:                                  
 Frog   508 KVNRFVCICPPGFTGSVCQIDIDDCSSTPCQNGAKCVDHPSGYDCICATGFTGVLCEENINNCEP 572

  Fly  2227 ----HGTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGTCVDLVDGYSCNCEPGYTGKN 2287
                :|||.|.:..:.|:|.||:.|:.|...||:|.:.||.|||.|||||:||.|||.||.:|..
 Frog   573 PPCHYGTCQDGIDSYTCICEPGYMGAICSDQIDECLSNPCLNEGRCVDLVNGYQCNCLPGTSGPR 637

  Fly  2288 CQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDECLSDPCNPVGTERCLDLDNK 2352
            |:..:||||||||.:| .|||.::.:.|.|.||:.|..|:.:||||.|:||:..||  |::..|:
 Frog   638 CEKNVDDCASNPCTYG-NCVDGINRYDCVCSPGFTGPQCKDDIDECASNPCHNGGT--CVNEQNR 699

  Fly  2353 FECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEPGWSGMRCEQQVTTCGAQAPC 2417
            |.|:|.:||:.|.|.:.:|:|...||: :|.|.|.|.|::|.|:|||:|.:||.....| ...||
 Frog   700 FRCICPEGFRQPSCFSQVDECVNNPCI-HGNCTDDVNGYKCLCQPGWTGKKCEVDKNEC-LSNPC 762

  Fly  2418 QNDASCIDLFQDYFCVCPSGTDGKNCETAPERCIGDPCMHGGKCQDFGSGLNCSCPADYSGIGCQ 2482
            ||..:|.:|...|.|.|..|..|.||:...:.|..:||::.|.|:|..:|..|.|...|:|..||
 Frog   763 QNGGTCDNLVNGYRCSCKKGFKGYNCQIDIDECASNPCLNHGTCRDGINGYTCHCGLPYTGTNCQ 827

  Fly  2483 ----------------------------------------YEYDACEEHVCQNGATCVDNGAGYS 2507
                                                    .:.|.|..:.|:|...|.:...||.
 Frog   828 NILTPCSPEPCHNGGICQESEDFKSFSCLCATGWHGQRCTIDIDECITNPCKNYGRCQNTKGGYI 892

  Fly  2508 CQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQCPFNMTGDDCRKAIQVDYDLYFSDP 2572
            |.|..||.|.|||.:|.||..|.|..||:|||..|.|.|.|.....||.|:|    |.|...|:|
 Frog   893 CHCFEGFNGVNCENNIDDCLSNPCQNGASCVDGINTFSCNCLAGFHGDKCQK----DVDECASNP 953

  Fly  2573 SRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGVQSARMTQQRRMLLQAHSSGVQVS 2637
            .::..:     .|...||.|..                                .|....|:...
 Frog   954 CKNGGS-----CTDYVNSYTCK--------------------------------CQPGFDGIHCD 981

  Fly  2638 LFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITEGLIASKMEYGAGGSLPGYLWAVL 2702
            ...|:......|...|.|:                                              
 Frog   982 NNIDECTDTSCFNGATCVD---------------------------------------------- 1000

  Fly  2703 GLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQVRDCRSEPVLYPGLILNWAG-YE 2766
                  |:::.......||.|.....               ::.:|.|.|.:..|..::..| |.
 Frog  1001 ------GINSFTCQCPQGFTGQFCLF---------------EINECGSHPCINGGTCVDGMGTYH 1044

  Fly  2767 VTSGGVERNVPSLCGQRKCPVGYTGANCQQLV----------------VDKEPPVVEHCPGDLWV 2815
            .|                |||||.|.||::||                |..||..:  ||     
 Frog  1045 CT----------------CPVGYRGKNCEELVDLCSGFPCKNRGICKQVKTEPKCI--CP----- 1086

  Fly  2816 IAKNGSAVVSWDEPHFSDNI-----GV--------------TKIYERNGHRSGTTLLWGTYDITY 2861
               .|...:..|.|..|..:     ||              |....|...|.|           |
 Frog  1087 ---TGWTGIYCDIPDVSCEVAASQRGVAVQDLCQHAGICINTGFSHRCQCRQG-----------Y 1137

  Fly  2862 IASDAAGNTASCSFKVSLLTDFCPALADPVGGSQVCKDWGAGGQFKVCEIACNAGLRFSEPVPEF 2926
            |.|...|....|:             ::|...|..|.|...|                       
 Frog  1138 IGSYCEGELDECA-------------SNPCQNSATCVDRHGG----------------------- 1166

  Fly  2927 YTCGAEGFWRPTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLRQKVTNSVNGL 2991
            |.|                   .|.|                                  ...|:
 Frog  1167 YEC-------------------KCLP----------------------------------GYQGV 1178

  Fly  2992 NRDWNFCSYAIE----------GTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPV 3046
            |     |.|.|:          ||  |.|:....:|....||:.                   |:
 Frog  1179 N-----CEYEIDECQIQPCHNGGT--CVDLVNQFRCSCPPGTRG-------------------PL 1217

  Fly  3047 VNDDDDDLT--------LTGRQGRQQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKLIL 3103
            ..::.||..        ..|.:...:.||  |:.| ..|.        ..|||           .
 Frog  1218 CEENIDDCAPSSEGPHCFNGGRCLDKIGG--YSCE-CLPG--------FAGER-----------C 1260

  Fly  3104 EDDQFAVQEILPNTVPDPASL---ELGSEYACPVGQVVMIPDCVPCAIGTFYDSANKTCIA--CS 3163
            |.|   |.|.|.|......||   :|.:.|.|         .|.|...|...::....|..  |.
 Frog  1261 EGD---VNECLSNPCSAKGSLDCIQLDNNYLC---------KCKPGFTGRHCETIQDLCPTRPCL 1313

  Fly  3164 RGTYQSEAGQLQCSKCPVIAGRP-GVTAGPGARSAADCKERCPAGKYFDAETGLCR----SCGHG 3223
            .|           ..|.|....| |.|.            :||.|  |....  |:    :||| 
 Frog  1314 NG-----------GTCAVAVNMPEGFTC------------QCPPG--FSGSK--CQYSNNTCGH- 1350

  Fly  3224 FYQPNEGSFSCELCGLGQTTRSTEATSRKEC-----RDECSSGQQLGADGRCEPCPRGTYRLQGV 3283
             |:          |.:|:....|....|..|     .:.|.|  :||.  ..:||.......:..
 Frog  1351 -YK----------CKVGENCIKTPLGPRCYCPTGPAGNACQS--KLGC--ASQPCKNNGVCQRKD 1400

  Fly  3284 QP---SCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNMCIECRKGYYQSESQQTSCL-- 3343
            ||   :| .||.|....:.....::.|.|..|..            :.|.||...|.....||  
 Frog  1401 QPPYYTC-NCPNGIVGLQCEILLIDGCHLHHCPD------------KARDGYCDQECNTHECLWD 1452

  Fly  3344 --QCPPNHSTKITGATSKSEC----TNPCEHIAEGKPHCDVNAYCIMVPETSDFKCECKPGFNGT 3402
              .|...........:|..:|    ...|:.:. ..|.|..:          :|:|:.|      
 Frog  1453 GGDCSLTMEDPWANCSSSLKCWEYFNGQCDELC-NTPECLFD----------NFECQEK------ 1500

  Fly  3403 GMACTDVC--DGFCEN---SGACVKDLKGTPSCRCVGSFTGPHCA-ERSEFAYIAGGIAGAVIFI 3461
                ..:|  |.:||:   :|.|.|.. .|..|    .:.|..|: ::.|  .:|.|.      :
 Frog  1501 ----ESICKYDKYCEDHYANGHCDKSC-NTKEC----GWDGLDCSTDKPE--NLAEGT------L 1548

  Fly  3462 IIIVLLIWMICVRSTKRRDPKKML 3485
            :|:||:            .||::|
 Frog  1549 VIVVLM------------PPKELL 1560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 10/46 (22%)
GCC2_GCC3 1916..1966 CDD:285001 10/49 (20%)
GCC2_GCC3 1973..2020 CDD:285001 15/58 (26%)
EGF 2025..2055 CDD:278437 10/29 (34%)
EGF_CA 2059..2095 CDD:238011 18/37 (49%)
EGF_CA 2138..2176 CDD:238011 16/38 (42%)
EGF_CA 2178..2214 CDD:238011 19/35 (54%)
EGF_CA 2253..2289 CDD:238011 21/35 (60%)
EGF_CA 2292..2327 CDD:238011 17/34 (50%)
EGF_CA 2330..2366 CDD:238011 17/35 (49%)
EGF_CA 2369..2405 CDD:238011 15/35 (43%)
EGF_CA 2411..2444 CDD:238011 13/32 (41%)
EGF_CA 2486..2520 CDD:238011 13/33 (39%)
EGF_CA 2522..2557 CDD:238011 16/34 (47%)
LamG 2590..2735 CDD:304605 12/144 (8%)
DUF5011 2799..2877 CDD:295940 20/96 (21%)
GCC2_GCC3 3149..3200 CDD:285001 9/53 (17%)
GCC2_GCC3 3207..3254 CDD:285001 11/50 (22%)
GCC2_GCC3 3268..3307 CDD:285001 8/41 (20%)
GCC2_GCC3 3315..3362 CDD:285001 8/50 (16%)
notch2XP_002939126.3 EGF_CA 141..176 CDD:238011 16/79 (20%)
EGF_CA 178..215 CDD:238011 14/68 (21%)
EGF_CA 256..292 CDD:238011 14/50 (28%)
EGF_CA 294..331 CDD:238011 18/36 (50%)
EGF_CA 334..369 CDD:238011 2/34 (6%)
EGF_CA 411..450 CDD:238011 4/38 (11%)
EGF_CA 452..488 CDD:238011 16/39 (41%)
EGF_CA 491..526 CDD:238011 19/34 (56%)
EGF_CA 528..564 CDD:238011 6/35 (17%)
EGF_CA 566..600 CDD:238011 9/33 (27%)
EGF_CA 604..639 CDD:238011 21/34 (62%)
EGF_CA 641..676 CDD:238011 17/35 (49%)
EGF_CA 678..713 CDD:238011 17/36 (47%)
EGF_CA 717..751 CDD:238011 15/34 (44%)
EGF_CA 753..789 CDD:238011 13/36 (36%)
EGF_CA 791..827 CDD:238011 11/35 (31%)
EGF_CA 869..905 CDD:238011 13/35 (37%)
EGF_CA 907..943 CDD:238011 16/35 (46%)
EGF_CA 945..980 CDD:238011 10/71 (14%)
EGF_CA 983..1018 CDD:238011 8/86 (9%)
EGF_CA 1022..1057 CDD:238011 14/50 (28%)
EGF_CA 1147..1181 CDD:238011 12/127 (9%)
EGF_CA 1184..1219 CDD:238011 9/55 (16%)
EGF_CA 1221..1261 CDD:238011 11/61 (18%)
EGF_CA 1263..1301 CDD:238011 13/49 (27%)
EGF_CA <1311..1342 CDD:238011 11/57 (19%)
Notch 1430..1456 CDD:395019 7/37 (19%)
Notch 1469..1497 CDD:395019 6/38 (16%)
Notch 1506..1535 CDD:395019 9/33 (27%)
NOD 1541..1595 CDD:399654 9/40 (23%)
NODP 1621..1676 CDD:400155
JMTM_Notch_APP 1661..1742 CDD:425406
PHA03095 <1822..>2032 CDD:222980
ANK repeat 1829..1876 CDD:293786
ANK repeat 1879..1909 CDD:293786
ANK repeat 1911..1976 CDD:293786
ANK repeat 1978..2009 CDD:293786
PTZ00322 1984..>2086 CDD:140343
ANK repeat 2011..2042 CDD:293786
DUF3454 2371..2431 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11316
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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