DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment uif and notch1

DIOPT Version :9

Sequence 1:NP_001162899.1 Gene:uif / 33983 FlyBaseID:FBgn0031879 Length:3589 Species:Drosophila melanogaster
Sequence 2:NP_001090757.1 Gene:notch1 / 100037842 XenbaseID:XB-GENE-479318 Length:2522 Species:Xenopus tropicalis


Alignment Length:2114 Identity:502/2114 - (23%)
Similarity:724/2114 - (34%) Gaps:760/2114 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1776 ILSILPAVRQPQLYDLC--GSTLNLIFDLSVPYASAVIDDLLNIANIGNQC--PPLRALKSQISR 1836
            :|.:...:|..|..::|  |....:     .|..:.|.  |.:.:..|.:|  |...|||:|...
 Frog    13 LLGLAQGLRCTQTAEMCLNGGRCEM-----TPGGTGVC--LCSSSYFGERCQYPNPCALKNQCMN 70

  Fly  1837 GFNCN---VGEVLNMDTSDVPRCLHCPAG----TYVSEGQNSCTY--CPRGYYQNRDRQGTC--- 1889
            ...|.   :|..::.      .| |||.|    ..::...|:|..  |..|        |||   
 Frog    71 FGTCEPVLLGNAIDF------TC-HCPVGFTDKVCLTPVDNACVNNPCRNG--------GTCELL 120

  Fly  1890 -------LRCPAGTYTKEEGTKSQAD------------CIPV-------CGYGTYSPTGLVPCLE 1928
                   .|||.| :|.:  :..|||            |:|.       |..|.:..|......|
 Frog   121 SSVSDYRCRCPPG-WTGD--SCQQADPCASNPCANGGKCLPFETQYICKCPSGFHGATCKQDINE 182

  Fly  1929 CPRNSFTAEPPTGGFKDCQACPAQSFTYQPAASNKDLCRAKCAPGTYSATGLAPCSPCPLHH--- 1990
            |.:|...    .||     .|..:..:|:....|:       ..|........||:|.|..:   
 Frog   183 CSQNPCR----NGG-----QCLNEFGSYRCNCQNR-------FTGRNCEEPYVPCNPSPCLNGGT 231

  Fly  1991 --------YQ-----GAAGAQSCNE----CPS-NMRTDSPASKGRE----QCKPVVCGE------ 2027
                    |:     |.:| |:|.|    ||| |.|.......|..    ||.|...|:      
 Frog   232 CRQTDDTSYECTCLPGFSG-QNCEENIDDCPSNNCRNGGTCVDGVNTYNCQCPPDWTGQYCTEDV 295

  Fly  2028 -------GACQHGGLCVPMGHDIQCFCPAGFSGRRCEQDIDECASQPCYNGGQCKDLPQGYRCEC 2085
                   .|||:||.|........|.|..|::|..|.::||:||:..|::|..|.|....:.|||
 Frog   296 DECQLMPNACQNGGTCHNTYGGYNCVCVNGWTGEDCSENIDDCANAACHSGATCHDRVASFFCEC 360

  Fly  2086 PAGYSGINCQ----------EEASDCGNDTCPARAMCKNEPGYK--------------------- 2119
            |.|.:|:.|.          .|.|:|..:....:|:|...|||.                     
 Frog   361 PHGRTGLLCHLDNACISNPCNEGSNCDTNPVNGKAICTCPPGYTGPACNNDVDECSLGANPCEHG 425

  Fly  2120 --------NVTCLCRSGYTGDQCDVTIDPCTANGNPCGNGASCQALEQ-GRYKCECVPGWEGIHC 2175
                    :..|.|..||.|.:|::.::.|.:  |||.|.|:|  |:| |.::|.|:||:||::|
 Frog   426 GRCTNTLGSFQCNCPQGYAGPRCEIDVNECLS--NPCQNDATC--LDQIGEFQCICMPGYEGLYC 486

  Fly  2176 EQNINDCSENPCLLGANCTDLVNDFQCACP----------------------------------- 2205
            |.||::|:.||||....|.|.:|:|.|.||                                   
 Frog   487 ETNIDECASNPCLHNGKCVDKINEFHCECPTGFNGNLCQHHVDECASTPCKNGAKCLDGPNSYTC 551

  Fly  2206 ---PGFTGKRCEQKIDLCLSEPCKHGTCVDRLFDHECVCHPGWTGSACDINIDDCENRPCANEGT 2267
               .||||:.|||.|:.|:.:||.:|||.|.:....|:|.||:||..||.:|::|.::||.|.|.
 Frog   552 QCTEGFTGRHCEQDINECIPDPCHYGTCKDGIATFTCLCRPGYTGRLCDNDINECLSQPCQNGGQ 616

  Fly  2268 CVDLVDGYSCNCEPGYTGKNCQHTIDDCASNPCQHGATCVDQLDGFSCKCRPGYVGLSCEAEIDE 2332
            |.|..:||.|.|..|.||.||:..:||||||||.:| .|:|::||:.|.|.|||.|..|...|||
 Frog   617 CTDRENGYICTCPKGTTGVNCETNLDDCASNPCDYG-KCIDKIDGYECTCEPGYTGKMCNINIDE 680

  Fly  2333 CLSDPCNPVGTERCLDLDNKFECVCRDGFKGPLCATDIDDCEAQPCLNNGICRDRVGGFECGCEP 2397
            |.|:||...||  |.|..|.|.|||.||:...:|.:::::|.:.||: :|.|.|.:.|::|.|:.
 Frog   681 CASNPCRNGGT--CKDKINGFTCVCPDGYHDHMCLSEVNECNSNPCI-HGTCHDGINGYKCDCDA 742

  Fly  2398 GWSGMRCEQQVTTCGAQAPCQNDASCIDLFQDYFCVCPSGTDGKNCET----------------- 2445
            ||||..|:.....|.:. ||.|..:|.|:...|.|.|.:|..|.||:|                 
 Frog   743 GWSGSNCDVNNNECESN-PCMNGGTCKDMTGAYICTCRAGFSGPNCQTNINECASNPCLNRGTCI 806

  Fly  2446 -----------------------APERCIGDPCMHGGKC---QDFGSGLNCSCPADYSGIGCQYE 2484
                                   ||  |.|.||.:||:|   :|:.: .:|.||..:.|..|:.:
 Frog   807 DDVAGYKCNCMLPYTGAICEAVLAP--CSGSPCKNGGRCKESEDYET-FSCECPPGWQGQTCEID 868

  Fly  2485 YDACEEHVCQNGATCVDNGAGYSCQCPPGFTGRNCEQDIVDCKDNSCPPGATCVDLTNGFYCQCP 2549
            .:.|....|:|||.|.:....|.|.|.||:.||:||.||.||:.|.|..|.:|.|..|.|:|.||
 Frog   869 MNECVNRPCRNGAMCQNTNGSYKCNCKPGYAGRHCETDIDDCQPNPCHNGGSCSDGINMFFCNCP 933

  Fly  2550 FNMTGDDCRKAIQVDYDLYFSDPSRSTAAQVVPFPTGEANSLTVAMWVQFAQKDDRGIFFTLYGV 2614
            ....|..|.:    |.:...|:|.::.|.     .|...||.|..                    
 Frog   934 AGFRGPKCEE----DINECASNPCKNGAN-----CTDCVNSYTCT-------------------- 969

  Fly  2615 QSARMTQQRRMLLQAHSSGVQVSLFEDQPDAFLSFGEYTSVNDGQWHHVAVVWDGISGQLQLITE 2679
                        .|...||:...  .:.||.    .|.:..|.|      ...|||:        
 Frog   970 ------------CQPGFSGIHCE--NNTPDC----TESSCFNGG------TCIDGIN-------- 1002

  Fly  2680 GLIASKMEYGAGGSLPGYLWAVLGLPQPYGLSNELAYSDSGFQGTITKAQVWARALDITSEIQKQ 2744
                                 ......|.|.:.:..                          |..
 Frog  1003 ---------------------TFSCQCPPGFTGDYC--------------------------QHD 1020

  Fly  2745 VRDCRSEPVLYPGLIL-NWAGYEVTSGGVERNVPSLCGQRKCPVGYTGANCQQLV--VDKEPPVV 2806
            :.:|.|:|.|..|... ::..|:.|                ||.||||.|||.||  .|..|   
 Frog  1021 INECDSKPCLNGGTCQDSYGAYKCT----------------CPQGYTGLNCQNLVRWCDSSP--- 1066

  Fly  2807 EHCP--GDLWVI-------AKNGSAVVSWDEPHFSDNIGVTKIYERNGHRSGTTLLWGTYDITYI 2862
              |.  |..|..       .|:|...|..|.|..|..:..    ::.|           .||.::
 Frog  1067 --CKNGGKCWQTNNFYRCECKSGWTGVYCDVPSVSCEVAA----KQQG-----------VDIAHL 1114

  Fly  2863 ASDA-----AGNTASCSFKVSLLTDFCPALAD-----PVGGSQVCKDWGAGGQFKVCE-IACNAG 2916
            ..::     .|||..|..:......:|....|     |......|.|:..|..   || :|...|
 Frog  1115 CRNSGMCVDTGNTHFCRCQAGYTGSYCEEQVDECSPNPCQNGATCTDYLGGYS---CECVAGYHG 1176

  Fly  2917 LRFSEPVPEFYTCGAEGFWRPTREPSMPLVYPSCSPSKPAQRVFRIKMLFPSDVLCNKAGQAVLR 2981
            :..||.:.|   |               |.:|                       |:..|     
 Frog  1177 VNCSEEINE---C---------------LSHP-----------------------CHNGG----- 1195

  Fly  2982 QKVTNSVNGLNRDWNFCSYAIEGTRECKDIQIDVKCDHYRGTQNNRVRRQAKDGGVYVMEAELPV 3046
                                     .|.|:....||...||||           ||:.      .
 Frog  1196 -------------------------TCIDLINTYKCSCPRGTQ-----------GVHC------E 1218

  Fly  3047 VNDDD-----DDLTLTGR---QGR--QQTGGDTYTLEIAFPAANDPVVHTSTGERSTVKQLLEKL 3101
            :|.||     |.::|..:   .|:  .:.||........|           .|||          
 Frog  1219 INVDDCTPFYDSVSLEPKCFNNGKCIDRVGGYNCICPPGF-----------VGER---------- 1262

  Fly  3102 ILEDDQFAVQEILPNTVPDPAS----LELGSEYACPVGQVV-------MIPDC--VPCAIGTFYD 3153
             .|.|   |.|.|.|.. ||..    ::|.::|.|...|..       ::..|  :||..|    
 Frog  1263 -CEGD---VNECLSNPC-DPRGTQNCIQLVNDYRCECRQGFTGRRCDSVVDGCKGLPCRNG---- 1318

  Fly  3154 SANKTCIACSRGTYQSEAGQLQCSKCPVIAGRPGVTAGPGARSAADCKERCPAGKYFDAETGLCR 3218
               .||...|    .:|.|.: | |||     ||.       ..|.|:        :||     |
 Frog  1319 ---GTCAVAS----NTERGFI-C-KCP-----PGF-------DGATCE--------YDA-----R 1349

  Fly  3219 SCGHGFYQPNEGSFSCELCGLGQTTRSTEATSRKECRDECSSGQQLGADGRCEPCPRGTYRLQGV 3283
            :||:                                 ..|.:|      |.|         :..:
 Frog  1350 TCGN---------------------------------LRCQNG------GTC---------ISVL 1366

  Fly  3284 QPSCAACPLGRTTPKVGASSVEECTLPVCSAGTYLNATQNMCIECRKGYYQSESQQTSCLQCPPN 3348
            :.|...|..|.|    ||:    |..||.|.     .....|.......:..|.....|. ||.|
 Frog  1367 KSSKCVCSEGYT----GAT----CQYPVVSP-----CASRPCYNGGTCQFSPEEPFFQCF-CPTN 1417

  Fly  3349 HS----------------TKITGATSKSECTN-PCEHIAEGKPHCDVNAYCIMVPETSDFKC--- 3393
            .:                ..||...::..|.| .|..:|:.| .|  ||.|      ::..|   
 Frog  1418 FNGLFCHILDYGFIGGLGKNITPPDNEEICENEQCAELADNK-IC--NANC------NNHACGWD 1473

  Fly  3394 --ECKPGFNGTGMACTD-----------VCDGFCENSGACVKD----LKGTPSCR------CVGS 3435
              :|...||.....||.           .||..|.||| |:.|    .|....|.      |...
 Frog  1474 GGDCSLNFNDPWKNCTQSLQCWKYFNDGKCDSQCNNSG-CLYDGFDCQKVEVQCNPLYDQYCRDH 1537

  Fly  3436 FTGPHCAERSEFA----------YIAGGIAGAVIFIIIIVLLIWMICVRSTKRRDPKKMLTPAID 3490
            |...||.:....|          .:...:|...:.|::::              .|:|:      
 Frog  1538 FQDGHCDQGCNNAECEWDGLDCDNMPENLAEGTLLIVVLM--------------PPEKL------ 1582

  Fly  3491 QTGSQVNFYYGAHTPYAESIAPSHHSTYAHYYDDEEDGWEMPNFYNETYMKDGLHGGKMSTLARS 3555
             ..:.|||        ...::...|:......|.:.:....|.:.||..:|      |.....||
 Frog  1583 -KNNSVNF--------LRELSRVLHTNVVFKKDSKGEYKIYPYYGNEEELK------KHHIKKRS 1632

  Fly  3556 NASLYGTKEDLYDRLKRHAYTGKKEKSDSDSEVQ 3589
            .||.......::..:|.....|::.:.....||:
 Frog  1633 AASWSDAPTAIFSTMKESVLPGRRRRELDQMEVR 1666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
uifNP_001162899.1 CLECT 36..167 CDD:214480
LDLa 172..206 CDD:238060
CUB 220..319 CDD:238001
CUB 326..435 CDD:238001
CUB 439..550 CDD:238001
PHA02927 <568..733 CDD:222943
CCP 675..731 CDD:153056
CCP 736..791 CDD:153056
EGF_CA 792..829 CDD:214542
FA58C 828..977 CDD:214572
FA58C 833..976 CDD:238014
FXa_inhibition 988..>1016 CDD:291342
CCP 1051..1106 CDD:153056
FA58C 1297..1444 CDD:214572
FA58C 1303..1443 CDD:238014
DUF5011 1463..1547 CDD:295940
DUF5011 1548..1631 CDD:295940
GCC2_GCC3 1862..1909 CDD:285001 16/74 (22%)
GCC2_GCC3 1916..1966 CDD:285001 10/49 (20%)
GCC2_GCC3 1973..2020 CDD:285001 17/71 (24%)
EGF 2025..2055 CDD:278437 11/42 (26%)
EGF_CA 2059..2095 CDD:238011 14/35 (40%)
EGF_CA 2138..2176 CDD:238011 16/38 (42%)
EGF_CA 2178..2214 CDD:238011 18/73 (25%)
EGF_CA 2253..2289 CDD:238011 16/35 (46%)
EGF_CA 2292..2327 CDD:238011 19/34 (56%)
EGF_CA 2330..2366 CDD:238011 18/35 (51%)
EGF_CA 2369..2405 CDD:238011 13/35 (37%)
EGF_CA 2411..2444 CDD:238011 12/32 (38%)
EGF_CA 2486..2520 CDD:238011 13/33 (39%)
EGF_CA 2522..2557 CDD:238011 15/34 (44%)
LamG 2590..2735 CDD:304605 15/144 (10%)
DUF5011 2799..2877 CDD:295940 18/91 (20%)
GCC2_GCC3 3149..3200 CDD:285001 13/50 (26%)
GCC2_GCC3 3207..3254 CDD:285001 5/46 (11%)
GCC2_GCC3 3268..3307 CDD:285001 8/38 (21%)
GCC2_GCC3 3315..3362 CDD:285001 8/62 (13%)
notch1NP_001090757.1 EGF_CA 108..140 CDD:238011 10/42 (24%)
EGF 145..175 CDD:278437 4/29 (14%)
EGF_CA 179..215 CDD:238011 9/51 (18%)
EGF_CA 223..254 CDD:238011 6/31 (19%)
EGF_CA 256..292 CDD:238011 10/35 (29%)
EGF_CA 294..331 CDD:238011 10/36 (28%)
EGF_CA 334..369 CDD:238011 14/34 (41%)
EGF_CA 411..449 CDD:238011 5/37 (14%)
EGF_CA 451..487 CDD:238011 16/39 (41%)
EGF_CA 489..525 CDD:238011 14/35 (40%)
EGF_CA 528..563 CDD:238011 4/34 (12%)
EGF_CA 565..599 CDD:238011 14/33 (42%)
EGF_CA 602..638 CDD:238011 16/35 (46%)
EGF_CA 640..674 CDD:238011 19/34 (56%)
EGF_CA 677..712 CDD:238011 18/36 (50%)
EGF_CA 716..749 CDD:238011 13/33 (39%)
EGF_CA 754..788 CDD:238011 12/34 (35%)
EGF_CA 790..826 CDD:238011 0/35 (0%)
EGF_CA 833..866 CDD:238011 11/33 (33%)
Plasmod_Pvs28 837..1005 CDD:283826 60/250 (24%)
EGF_CA 868..904 CDD:238011 13/35 (37%)
EGF_CA 906..942 CDD:238011 15/35 (43%)
EGF_CA 944..980 CDD:238011 11/72 (15%)
EGF_CA 987..1018 CDD:238011 8/91 (9%)
EGF_CA 1020..1056 CDD:238011 14/51 (27%)
EGF_CA 1145..1179 CDD:238011 9/36 (25%)
EGF_CA 1183..1218 CDD:238011 16/122 (13%)
EGF_CA <1237..1264 CDD:238011 7/48 (15%)
EGF_CA 1266..1303 CDD:238011 11/40 (28%)
EGF_CA <1314..1345 CDD:238011 15/55 (27%)
NL 1440..1477 CDD:197463 10/45 (22%)
LNR 1 1447..1487 13/48 (27%)
Notch 1485..1520 CDD:278494 10/35 (29%)
LNR 2 1488..1529 12/41 (29%)
Notch 1525..1560 CDD:278494 6/34 (18%)
LNR 3 1530..1564 5/33 (15%)
NOD 1564..1615 CDD:284282 9/79 (11%)
NODP 1666..1728 CDD:284987 0/1 (0%)
ANKYR <1870..1980 CDD:223738
ANK <1870..1979 CDD:238125
ANK repeat 1877..1923 CDD:293786
ANK 1 1877..1920
ANK repeat 1925..1956 CDD:293786
ANK 2 1925..1954
Ank_5 1945..2000 CDD:290568
ANK 1953..2079 CDD:238125
ANK repeat 1958..1990 CDD:293786
ANK 3 1958..1988
ANK repeat 1992..2023 CDD:293786
ANK 4 1992..2021
Ank_2 1997..2089 CDD:289560
ANK repeat 2025..2089 CDD:293786
ANK 5 2025..2054
ANK 6 2058..2087
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2146..2229
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2365..2404
DUF3454 2446..2507 CDD:288764
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2449..2522
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12916
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.020

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