DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCDC39 and myo-5

DIOPT Version :9

Sequence 1:	NP_852091.1	Gene:	CCDC39 / 339829	HGNCID:	25244	Length:	941	Species:	Homo sapiens
Sequence 2:	NP_505094.1	Gene:	myo-5 / 179190	WormBaseID:	WBGene00019064	Length:	1974	Species:	Caenorhabditis elegans

Alignment Length:	1014	Identity:	217/1014 - (21%)
Similarity:	391/1014 - (38%)	Gaps:	222/1014 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    21 NEENKLLEDQLSKLKD--------------ERASLQDELREYEERINSMTSHFKNVKQ------- 64
            |:....||..|.:|:|              :|..::.||:..:|.|..:..|....:|
Worm  1031 NKTKAKLESTLDELEDTLEREKRGRQDCEKQRRKVEGELKIAQELIEELNRHKHEQEQVIKKKDI 1095

Human    65 ELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLE-----------------NEMASIL 112
            |||..||       ..|.|:...|..||::..:...||.||                 |||...|
Worm  1096 ELSSIQS-------RLEDEQSLVAKLQRQIKELLARIQELEEELDAERNSRSKAEKARNEMQMEL 1153

Human   113 EKKSDKENGIFKATQKLDGLKCQMNWDQQA----LEAWLEESA-------------HKD-----S 155
            |:..|:.:....|||    .:.::|..::|    |...||::|             |.|     |
Worm  1154 EELGDRLDEAGGATQ----AQIELNKKREAELAKLRQDLEDAAINSETSMAALRKKHNDAVAELS 1214

Human   156 DAL-TLQ----KYAQQDDNKIRALTLQLERLTLE------CNQKRKILDNELTETISAQLELDKA 209
            |.| |:|    |..::.::|.|.:....:...:|      |.:..|.|:.:||:......|..:.
Worm  1215 DQLDTIQKMRGKLEREKNDKQREVDELQQSADVEAKQRQNCERMAKQLEAQLTDMTLKSDEQARL 1279

Human   210 AQDF----RKIHNERQELIKQWENTIEQMQKRDGDIDNCAL------------ELAR-IKQETRE 257
            .|:.    .|:|||.|:|.:|.|         |.:...|||            ||.| :.|||||
Worm  1280 IQELTMGKNKVHNENQDLNRQLE---------DAEAQLCALNRIKQQQHSQLEELKRTLDQETRE 1335

Human   258 KENLVKEKIKF----------LESEIGNNTEFEKRISVADRKLLKCRTAY--------QDHETSR 304
            :::|..:...:          ||.|....|:.::::|.|:.::.:.|..:        ::.|.:|
Worm  1336 RQSLHSQVSNYQLECEQFRESLEEEQDAKTDVQRQLSKANSEIQQWRAKFEGEGVSRAEELEETR 1400

Human   305 IQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMS 369
            .:|..::..::..:...:..:..|.||..::..|:.:......:..:....::.|.|...:....
Worm  1401 RKLTHKVQEMQEQLENANQKIGTLEKNKQRLAHDLEDAQVDADRANSIASSLEKKQKGFDKVLDE 1465

Human   370 VEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEI--------EGT 426
            ...|...|...:::.:::.:....:...::..|.:..::.:....:.||:..|:        ||.
Worm  1466 WRRKCEALVAEVEQSQRETRAAATETFRLRNQLEESGEQTEAVKRENKALAQELKDIADQLGEGG 1530

Human   427 RSSLKHLNHQLQK----LDFETLKQQEIMYSQDFHIQQVERRMSRLK---GEINSEEKQALEAK- 483
            :|.     |.|||    |:.|..:.|:.:...:..::..|.::.|.:   .:|.||.::.|:.|
Worm  1531 KSV-----HDLQKMRRRLEIEKEELQQALDEAECALEAEEAKVMRAQIEVSQIRSEIEKRLQEKE 1590

Human   484 -------------IVELRKSLE-EKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
                         |..::.||| |.:....||:|: |||..|                     :|
Worm  1591 EEFENTRKNHSRTIESMQVSLETESRGRAELLKTK-KKLEGD---------------------VN 1633

Human   535 ELNLFIDRSEK-ELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEE 598
            ||.:.:|.|.| .:|..|..|:   ::|.:        ||:.:...||..||.:.:.....| |.
Worm  1634 ELEIALDHSNKLNVDGQKSMKK---LQDTI--------RELQYQVEEEQRSLSESRDHANLA-ER 1686

Human   599 RTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYY 663
            |::.::..|..||......::.|.....|..|....:.:|.|...:|.......||:.:..|:
Worm  1687 RSQVLQQEKEDLAIIYEQSERTRRQAELELAEVKDSVNELSNSNSLLLATKRKVEGDLQLLQS-- 1749

Human   664 VIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQ 728
                  |.||...:....|.|..||..:...|.:.|:......:|..||  |.|..|...:|:::
Worm  1750 ------EIEEAMSDAKTSDEKAKKAIMDASKLADELRSEQEHASNLNQS--KKTLESQVKDLQMR 1806

Human   729 LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQK 793
            |:|.:.|   ..:..:||:.:|...|..:|..|:.........::.|..|.....:|..:.:|.|
Worm  1807 LDEAEAA---GIKGGKRQLAKLDMRIHELETELEGENRRHAETQKVLRNKDRKCRELQFQVDEDK 1868

Human   794 PKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQT 858
            ...||:.....||.::|:..|...::........|.:.:|...|::    |..|........||.
Worm  1869 KSQERMYDLIEKLQQKIKTYKRQIEDAESLASGNLAKYRQLQHVVE----DAQERADAAENALQK 1929

Human   859 YFQQSGLELPTASTK---GSRQSSRSPSHTSLSARSSRS 894
                  |.|...||.   |.|..:.|.|.|.::.|...|
Worm  1930 ------LRLKGRSTSGVFGPRGLAHSMSTTGVNMRRGGS 1962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCDC39	NP_852091.1	Smc	22..848	CDD:224117	202/962 (21%)
CCDC39	NP_852091.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..941		9/30 (30%)
myo-5	NP_505094.1	Myosin_N	31..68	CDD:280832
		Myosin_head	83..776	CDD:278492
		MYSc_class_II	95..776	CDD:276951
		Myosin_tail_1	853..1933	CDD:279860	207/983 (21%)
		DUF4795	954..1129	CDD:292662	25/104 (24%)
		Prefoldin	1111..1243	CDD:298833	32/135 (24%)
		Tmemb_cc2	<1212..1322	CDD:287269	28/118 (24%)
		DUF881	1746..>1838	CDD:303034	26/104 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000