DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snRNP-U1-70K and TIAL1

DIOPT Version :9

Sequence 1:	NP_001260173.1	Gene:	snRNP-U1-70K / 33982	FlyBaseID:	FBgn0016978	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001029097.1	Gene:	TIAL1 / 7073	HGNCID:	11804	Length:	392	Species:	Homo sapiens

Alignment Length:	190	Identity:	39/190 - (20%)
Similarity:	77/190 - (40%)	Gaps:	29/190 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLALFAAREPIPFMPPVDKLPHEKKSRGYLGVAKFMADFEDPKDTPLPKTVETRQERLERRRREK 73
            :|.||:...|......:.:.|..::....:|.:.......||.     ..||..:      .|:.
Human    25 ILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPY-----CFVEFYE------HRDA 78

  Fly    74 AEQVAYK-----LEREIAL-W--DPTEIKNATEDPFRTLFIARINYDTSESKLRREFEFYGPIKK 130
            |..:|..     |.:|:.: |  .|:..|..|.:.|. :|:..::.:.:...::..|..:|.|..
Human    79 AAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFH-VFVGDLSPEITTEDIKSAFAPFGKISD 142

  Fly   131 IVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRR 190
            ..::.|..:||.|||.|:.:.::.|...|..|..|:.:..:::       ||  .|..|:
Human   143 ARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQI-------RT--NWATRK 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_001260173.1	U1snRNP70_N	2..92	CDD:289024	17/90 (19%)
		RRM	<97..>179	CDD:223796	17/81 (21%)
		RRM_snRNP70	101..188	CDD:240682	19/86 (22%)
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	17/92 (18%)
		RRM2_TIAR	113..192	CDD:410029	19/88 (22%)
		RRM3_TIAR	222..294	CDD:241064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910