DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snRNP-U1-70K and SNRNP70

DIOPT Version :9

Sequence 1:	NP_001260173.1	Gene:	snRNP-U1-70K / 33982	FlyBaseID:	FBgn0016978	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_003080.2	Gene:	SNRNP70 / 6625	HGNCID:	11150	Length:	437	Species:	Homo sapiens

Alignment Length:	406	Identity:	212/406 - (52%)
Similarity:	271/406 - (66%)	Gaps:	59/406 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQYLPPNLLALFAAREPIPFMPPVDKLPHEK-KSRGYLGVAKFMADFEDPKDTPLPKTVETRQE 64
            |||:||||||||||.|:|||::||::|||||| .::.|.|:|.::.:||||:|.|.|...|||:|
Human     1 MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREE 65

  Fly    65 RLERRRREKAEQVAYKLEREIALWDPTEIKNATEDPFRTLFIARINYDTSESKLRREFEFYGPIK 129
            |:||:||||.|:...::|.|:.:|||....||..|.|:|||:||:||||:|||||||||.|||||
Human    66 RMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIK 130

  Fly   130 KIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRRLGGG 194
            :|.:::.:.||||:||||||||||||||:|||||||||||.:||||||||.||||||.|||||||
Human   131 RIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGG 195

  Fly   195 LGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSR 259
            ||||||||.||||:||||:|..|          .::|.||         ...|.|    :|.|.|
Human   196 LGGTRRGGADVNIRHSGRDDTSR----------YDERPGP---------SPLPHR----DRDRDR 237

  Fly   260 SRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKK 324
            .||||:|.|:|.:    ...|.|||||:||:|   ||.|    |:.:|| |.|||.:|::|::|:
Human   238 ERERRERSRERDK----ERERRRSRSRDRRRR---SRSR----DKEERR-RSRERSKDKDRDRKR 290

  Fly   325 KRSKSRERESSRERRERKRERRDRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYPTFDYQN 389
            :.|:||||  :|..||||.|.|      |.|||:.|..         :..:.|.|||.|
Human   291 RSSRSRER--ARRERERKEELR------GGGGDMAEPS---------EAGDAPPDDGPP------ 332

  Fly   390 ATIKREIDDEDEEKYR 405
            ..:..:..|..|||.|
Human   333 GELGPDGPDGPEEKGR 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_001260173.1	U1snRNP70_N	2..92	CDD:289024	51/90 (57%)
		RRM	<97..>179	CDD:223796	61/81 (75%)
		RRM_snRNP70	101..188	CDD:240682	68/86 (79%)
SNRNP70	NP_003080.2	U1snRNP70_N	3..93	CDD:403437	50/89 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..79		19/30 (63%)
		Required for interaction with U1 RNA. /evidence=ECO:0000269\|PubMed:2467746	92..202		83/109 (76%)
		RRM_snRNP70	102..187	CDD:409682	66/84 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..437		90/220 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158887
Domainoid	1	1.000	144	1.000	Domainoid score	I4641
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2039
Isobase	1	0.950	-	0	Normalized mean entropy	S1470
OMA	1	1.010	-	-		QHG54339
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005136
OrthoInspector	1	1.000	-	-		oto89895
orthoMCL	1	0.900	-	-		OOG6_102349
Panther	1	1.100	-	-	LDO	PTHR13952
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1267
SonicParanoid	1	1.000	-	-		X3654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.880