Protein Alignment snRNP-U1-70K and SRSF2

DIOPT Version :10

• Sequence 1: NP_477205.1
• Gene: snRNP-U1-70K / 33982
• FlyBaseID: FBgn0016978
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_003007.2
• Gene: SRSF2 / 6427
• HGNCID: 10783
• Length: 221
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 77/274 - (28%)
• Similarity: 109/274 - (39%)
• Gaps: 69/274 - (25%)

  Fly    90 PTEIKNATEDPFRTLFIARINYDTSESKLRREFEFYGPIKKIVLIHDQESGKPKGYAFIEYEHER 154
            |.:::..|     :|.:..:.|.||...|||.||.||.:..:.:..|:.:.:.:|:||:.:..:|
Human     7 PPDVEGMT-----SLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKR 66

  Fly   155 DMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRRLGGGLGGTRRGGNDVNIKHSGREDNERER 219
            |...|....||..:|.:.:.|.:.|.                     |...:..||.|....|
Human    67 DAEDAMDAMDGAVLDGRELRVQMARY---------------------GRPPDSHHSRRGPPPR-- 108

  Fly   220 ERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSRSRERRDRERDRGRGAVASNGRSRSR 284
             ||              |||          |:|   |||||..||.|.|.|.|    |..|||||
Human   109 -RY--------------GGG----------GYG---RRSRSPRRRRRSRSRSR----SRSRSRSR 141

  Fly   285 SRERRKR---RAGSRERYDEFDRRDRRDRERERDRDREREKKKKRSKSR------ERESSRERRE 340
            ||..|.:   |..||.|.....|..||.:.:.....|.|.:.:.||:||      :|||....|.
Human   142 SRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRS 206

  Fly   341 RKRERRDRERGTGS 354
            :...:...|.|..|
Human   207 KSPPKSPEEEGAVS 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_477205.1	U1snRNP70_N	3..92	CDD:432406	1/1 (100%)
		RRM_snRNP70	101..188	CDD:409682	23/86 (27%)
SRSF2	NP_003007.2	RRM_SRSF2_SRSF8	16..88	CDD:409751	21/71 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..221		52/184 (28%)