Protein Alignment snRNP-U1-70K and NCL

DIOPT Version :10

• Sequence 1: NP_477205.1
• Gene: snRNP-U1-70K / 33982
• FlyBaseID: FBgn0016978
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_005372.2
• Gene: NCL / 4691
• HGNCID: 7667
• Length: 710
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 55/271 - (20%)
• Similarity: 100/271 - (36%)
• Gaps: 85/271 - (31%)

  Fly   111 RDDPLSAHMFAIEGQKWRTLRAKLSPTFTSGRIKMTLPLITQV---CERFCEHLNESLQSSDEIE 172
            |:||      :|.|:|          |.:.||...| |...|.   |..:.|...:.|:|.:.:.
Human  1061 REDP------SILGKK----------TKSPGRAPGT-PAPVQEENDCTAYMETPKQKLESIENLT 1108

  Fly   173 VHDLLSRYTIDVIGACAFGIECNSFREPDNEFRRYGKIAFDKLRHSPLVVYLMKAF--------- 228
            .....||...|:.|.      .:||:.||:             .:.||||...|..
Human  1109 GLRKQSRTPKDITGF------QDSFQIPDH-------------ANGPLVVVKTKKMFFNSPQPES 1154

  Fly   229 -----------RAHANALGMK----------QLHDDVSGFFM---RVVKDTVEYREREQIVRNDF 269
                       ||..:.:.:|          ||.:.|..|.:   :|::.:.:..:|:
Human  1155 AITRKSRERQSRASISKIDVKEELLESEEHLQLGEGVDTFQVSTNKVIRSSRKPAKRK------- 1212

  Fly   270 MDLLLKLKNTGRLEADGEEIGRLTFEEIAAQAFIFFTAGY--DTSSTAMSYTLYELALNPEVQER 332
            :|....:.|:.|:....:: .....|::.....:|...||  |:.:|.:| |:  ||.:|::...
Human  1213 LDSTAGMPNSKRMRCSSKD-NTPCLEDLNGFQELFQMPGYANDSLTTGIS-TM--LARSPQLGPV 1273

  Fly   333 ARECVKQTLQK 343
            ..:..|::|.|
Human  1274 RTQINKKSLPK 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_477205.1	U1snRNP70_N	3..92	CDD:432406
		RRM_snRNP70	101..188	CDD:409682	20/79 (25%)
NCL	NP_005372.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..303
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	307..381	CDD:409837
		RRM2_NCL	390..465	CDD:409838
		RRM3_NCL	485..557	CDD:409839
		RRM4_NCL	572..649	CDD:409840
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..710