DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snRNP-U1-70K and Snrnp70

DIOPT Version :9

Sequence 1:	NP_001260173.1	Gene:	snRNP-U1-70K / 33982	FlyBaseID:	FBgn0016978	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	XP_006229163.1	Gene:	Snrnp70 / 361574	RGDID:	1307120	Length:	451	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	212/415 - (51%)
Similarity:	270/415 - (65%)	Gaps:	62/415 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQYLPPNLLALFAAREPIPFMPPVDKLPHEK-KSRGYLGVAKFMADFEDPKDTPLPKTVETRQE 64
            |||:||||||||||.|:|||::||::|||||| .::.|.|:|.::.:||||:|.|.|...|||:|
  Rat     1 MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREE 65

  Fly    65 RLERRRREKAEQVAYKLEREIALWDPTEIKNATEDPFRTLFIARINYDTSESKLRREFEFYGPIK 129
            |:||:||||.|:...::|.|:.:|||....||..|.|:|||:||:||||:|||||||||.|||||
  Rat    66 RMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIK 130

  Fly   130 KIVLIHDQESGKPKGYAFIEYEHERDMHAAYKHADGKKIDSKRVLVDVERARTVKGWLPRRLGGG 194
            :|.:::.:.||||:||||||||||||||:|||||||||||.:||||||||.||||||.|||||||
  Rat   131 RIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGG 195

  Fly   195 LGGTRRGGNDVNIKHSGREDNERERERYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSR 259
            ||||||||.||||:||||:|..|          .::|.||         ...|.|    :|.|.|
  Rat   196 LGGTRRGGADVNIRHSGRDDTSR----------YDERPGP---------SPLPHR----DRDRDR 237

  Fly   260 SRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKK 324
            .||||:|.|:|.:    ...|.|||||:|| ||:.||:       :|.|.|.|||.:|::|::|:
  Rat   238 ERERRERSRERDK----ERERRRSRSRDRR-RRSRSRD-------KDERRRSRERSKDKDRDRKR 290

  Fly   325 KRSKSRERESSRERRERKRERR---------DRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDD 380
            :.|:||||  :|..||||.|.|         ....|.|.|||:.|..         :..:...||
  Rat   291 RSSRSRER--ARRERERKEELRGGGGGGGGGGGGGGGGGGGDMAEPS---------EAGDGAPDD 344

  Fly   381 GYPTFDYQNATIKREIDDEDEEKYR 405
            |.|      ..:..|..|..|||.|
  Rat   345 GPP------GELGPEGPDGPEEKGR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snRNP-U1-70K	NP_001260173.1	U1snRNP70_N	2..92	CDD:289024	51/90 (57%)
		RRM	<97..>179	CDD:223796	61/81 (75%)
		RRM_snRNP70	101..188	CDD:240682	68/86 (79%)
Snrnp70	XP_006229163.1	U1snRNP70_N	2..93	CDD:289024	51/90 (57%)
		RRM	26..>182	CDD:223796	98/155 (63%)
		RRM_snRNP70	102..187	CDD:240682	66/84 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4559
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1962
OMA	1	1.010	-	-		QHG54339
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102349
Panther	1	1.100	-	-	LDO	PTHR13952
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970